The Journal of Immunology
@jimmunol.bsky.social
The Journal of Immunology is an official journal of The American Association of Immunologists, journals.aai.org/jimmunol
Editor-in-Chief: Gail A. Bishop, Ph.D.
Editor-in-Chief: Gail A. Bishop, Ph.D.
The JI and @immunohorizons.bsky.social are looking for a biostatistics editor! This is a unique opportunity to contribute to the advancement of immunological research by ensuring the statistical rigor and methodological soundness of published work. Learn more: ow.ly/qYic50Xmu4V.
November 7, 2025 at 3:05 PM
The JI and @immunohorizons.bsky.social are looking for a biostatistics editor! This is a unique opportunity to contribute to the advancement of immunological research by ensuring the statistical rigor and methodological soundness of published work. Learn more: ow.ly/qYic50Xmu4V.
This #BriefReview discusses how molecular and blood profiling led to a therapeutic revolution for #AtopicDermatitis and highlights how this translational approach is being applied to advancing the therapeutic pipeline of #alopecia areata. Explore more: ow.ly/1kht50Xj1s5
October 28, 2025 at 1:45 PM
This #BriefReview discusses how molecular and blood profiling led to a therapeutic revolution for #AtopicDermatitis and highlights how this translational approach is being applied to advancing the therapeutic pipeline of #alopecia areata. Explore more: ow.ly/1kht50Xj1s5
Data establish c-di-AMP as a key PAMP of B. burgdorferi, the causative agent of #lymedisease which elicits a type I interferon response that can lead to the development of Lyme arthritis, for which a PAMP was previously unidentified. Read more online: ow.ly/jWcl50XesPS.
October 23, 2025 at 12:56 PM
Data establish c-di-AMP as a key PAMP of B. burgdorferi, the causative agent of #lymedisease which elicits a type I interferon response that can lead to the development of Lyme arthritis, for which a PAMP was previously unidentified. Read more online: ow.ly/jWcl50XesPS.
New data identified miR-124-3p as a critical regulator of macrophage polarization and acute lung injury (ALI) pathophysiology, providing a potential therapeutic target for managing ALI in lung transplant recipients. Learn more: ow.ly/XsVv50XesKz.
October 18, 2025 at 9:18 AM
New data identified miR-124-3p as a critical regulator of macrophage polarization and acute lung injury (ALI) pathophysiology, providing a potential therapeutic target for managing ALI in lung transplant recipients. Learn more: ow.ly/XsVv50XesKz.
Data showed that high-mobility group protein B1 (HMGB1) inhibited IFN-gamma induced PD-L1 expression, enhancing the antitumor effects of T cells and confirming the role of HMGB1 as a prognostic indicator for #lungcancer treated with CAR-T cells. Read more: ow.ly/lZZG50Xb7mk.
October 14, 2025 at 2:59 PM
Data showed that high-mobility group protein B1 (HMGB1) inhibited IFN-gamma induced PD-L1 expression, enhancing the antitumor effects of T cells and confirming the role of HMGB1 as a prognostic indicator for #lungcancer treated with CAR-T cells. Read more: ow.ly/lZZG50Xb7mk.
When observing wild-type Raji and Jurkat cells following co-culture in the absence of cognate MHC and TCR or superantigen, only 'finger-like' projections were observed at the cell-cell interface. Find the research behind September’s cover image online: ow.ly/NOkn50X6mnH
October 9, 2025 at 5:27 PM
When observing wild-type Raji and Jurkat cells following co-culture in the absence of cognate MHC and TCR or superantigen, only 'finger-like' projections were observed at the cell-cell interface. Find the research behind September’s cover image online: ow.ly/NOkn50X6mnH
Fall is here and so is the September issue of The JI! Available online and full of high-quality research. Read through all the September issue has to offer: ow.ly/uiQo50X32rC.
October 1, 2025 at 1:52 AM
Fall is here and so is the September issue of The JI! Available online and full of high-quality research. Read through all the September issue has to offer: ow.ly/uiQo50X32rC.
Researchers tested a single-cycle attenuation strategy that deleted glycoprotein L (essential for viral entry) to create strain 68-1 rhesus CMV vectors that generated high frequency, effector-memory-biased, SIV-specific CD8+ T-cell responses. Learn more: ow.ly/jrm450WV7Kx.
September 18, 2025 at 3:14 PM
Researchers tested a single-cycle attenuation strategy that deleted glycoprotein L (essential for viral entry) to create strain 68-1 rhesus CMV vectors that generated high frequency, effector-memory-biased, SIV-specific CD8+ T-cell responses. Learn more: ow.ly/jrm450WV7Kx.
This featured article describing a novel immunological method details how researchers combined in vitro culture of plasma cells (PC) with adoptive transfer and timestamping to track the population dynamics of resulting induced PCs in vivo. Learn more: ow.ly/RTt850WV7PC.
September 17, 2025 at 1:54 PM
This featured article describing a novel immunological method details how researchers combined in vitro culture of plasma cells (PC) with adoptive transfer and timestamping to track the population dynamics of resulting induced PCs in vivo. Learn more: ow.ly/RTt850WV7PC.
An August #TopRead from @carpenterlab.bsky.social demonstrates that heterogeneous nuclear ribonucleoprotein A2B1 is essential for optimal macrophage function, highlighting the role for RNA-binding proteins in mounting effective immune defenses. Read more: ow.ly/NSx150WTnSr.
September 10, 2025 at 1:26 PM
An August #TopRead from @carpenterlab.bsky.social demonstrates that heterogeneous nuclear ribonucleoprotein A2B1 is essential for optimal macrophage function, highlighting the role for RNA-binding proteins in mounting effective immune defenses. Read more: ow.ly/NSx150WTnSr.
In a #Top Read from August, @labwaggoner.bsky.social from @cincyresearch.bsky.social discovered that the transcription factor ASCL2 is required for recruitment of NK cells into the spleen and white pulp providing novel insights into NK cell biology. Read more: academic.oup.com/jimmunol/art...
September 8, 2025 at 5:15 PM
In a #Top Read from August, @labwaggoner.bsky.social from @cincyresearch.bsky.social discovered that the transcription factor ASCL2 is required for recruitment of NK cells into the spleen and white pulp providing novel insights into NK cell biology. Read more: academic.oup.com/jimmunol/art...
In this #TopRead article, data demonstrated that TNFR family member CD27 is a metabolic regulator in activated human CD4+ cells, suggesting its essential contribution to T-cell metabolism and its relevance as a therapeutic target. Read more in The JI: ow.ly/bCJk50WJAwi.
August 27, 2025 at 12:45 PM
In this #TopRead article, data demonstrated that TNFR family member CD27 is a metabolic regulator in activated human CD4+ cells, suggesting its essential contribution to T-cell metabolism and its relevance as a therapeutic target. Read more in The JI: ow.ly/bCJk50WJAwi.
Dr. John V Williams and his team characterized the role of CD4+ helper T Cells in response to human metapneumovirus (HMPV), identifying a dominant CD4+ T cell epitope and constructing the first MHC-II tetramer for HMPV. Learn more in this #TopRead article: ow.ly/Hern50WJAB3
August 26, 2025 at 5:17 PM
Dr. John V Williams and his team characterized the role of CD4+ helper T Cells in response to human metapneumovirus (HMPV), identifying a dominant CD4+ T cell epitope and constructing the first MHC-II tetramer for HMPV. Learn more in this #TopRead article: ow.ly/Hern50WJAB3
Phase 2 clinical trial data found that the combination of Imprime and pembrolizumab was safe and demonstrated immune activation in tumor tissues and peripheral blood in patients with triple negative #breastcancer. Learn more in The JI: ow.ly/3ZxY50WCL03.
August 13, 2025 at 11:52 AM
Phase 2 clinical trial data found that the combination of Imprime and pembrolizumab was safe and demonstrated immune activation in tumor tissues and peripheral blood in patients with triple negative #breastcancer. Learn more in The JI: ow.ly/3ZxY50WCL03.
Researchers discovered B cell follicles in nurse shark pancreas and saw antigen-specific antibodies were produced in the pancreas following immunization providing insight into how immune surveillance may function in the absence of lymph nodes. Read more: ow.ly/oF6q50WCKbg
August 11, 2025 at 2:04 PM
Researchers discovered B cell follicles in nurse shark pancreas and saw antigen-specific antibodies were produced in the pancreas following immunization providing insight into how immune surveillance may function in the absence of lymph nodes. Read more: ow.ly/oF6q50WCKbg
This Pillars of Immunology article in the Human and Clinical Immunology special collection provides a commentary on 2 pivotal articles from 1993 that shaped the CD40-CD40L field of immunology and impacted understanding of human health.
ow.ly/o78O50Wzsbt
ow.ly/o78O50Wzsbt
August 6, 2025 at 2:33 PM
This Pillars of Immunology article in the Human and Clinical Immunology special collection provides a commentary on 2 pivotal articles from 1993 that shaped the CD40-CD40L field of immunology and impacted understanding of human health.
ow.ly/o78O50Wzsbt
ow.ly/o78O50Wzsbt
Apply today to participate in the AAI Peer-Review Mentorship Program! This program is designed to provide mentorship from seasoned professionals to develop your skills as a peer reviewer of manuscripts submitted to AAI journals. Learn more: ow.ly/qLyn50WuPxA.
July 29, 2025 at 3:08 PM
Apply today to participate in the AAI Peer-Review Mentorship Program! This program is designed to provide mentorship from seasoned professionals to develop your skills as a peer reviewer of manuscripts submitted to AAI journals. Learn more: ow.ly/qLyn50WuPxA.
#ICYMI: The JI featured a special collection of articles curated by guest editor Patricia Gearhart, highlighting the impact of aging on the immune system with insights into the immunological effects of aging at the cellular level. Learn more: ow.ly/WwZn50WuPuA.
July 29, 2025 at 12:42 PM
#ICYMI: The JI featured a special collection of articles curated by guest editor Patricia Gearhart, highlighting the impact of aging on the immune system with insights into the immunological effects of aging at the cellular level. Learn more: ow.ly/WwZn50WuPuA.
In a #CuttingEdge article, researchers identified an in-del generated novel neoepitope that elicited in vivo tumor control in models of prophylaxis and therapy. CD8 T cells elicited by this neoepitope showed notably less exhaustion. Learn more: academic.oup.com/jimmunol/art....
July 14, 2025 at 5:18 PM
In a #CuttingEdge article, researchers identified an in-del generated novel neoepitope that elicited in vivo tumor control in models of prophylaxis and therapy. CD8 T cells elicited by this neoepitope showed notably less exhaustion. Learn more: academic.oup.com/jimmunol/art....
Researchers have described key events in the pulmonary anti-Influenza A (IAV) response of pigs, which open new avenues for developing IAV vaccines and therapies, and enable the better use of pigs as a model for human IAV infection and immunity. Learn more: ow.ly/xjnl50WlNLa
July 10, 2025 at 6:54 PM
Researchers have described key events in the pulmonary anti-Influenza A (IAV) response of pigs, which open new avenues for developing IAV vaccines and therapies, and enable the better use of pigs as a model for human IAV infection and immunity. Learn more: ow.ly/xjnl50WlNLa
Did you present research at #IMMUNOLOGY2025™? If so, The JI invites you to submit manuscripts based on your abstract for a special collection “Highlights of IMMUNOLOGY2025”! Expand your conference presentation and widely share your findings! Learn more: ow.ly/1Cj550WbZcv
June 26, 2025 at 1:36 PM
Did you present research at #IMMUNOLOGY2025™? If so, The JI invites you to submit manuscripts based on your abstract for a special collection “Highlights of IMMUNOLOGY2025”! Expand your conference presentation and widely share your findings! Learn more: ow.ly/1Cj550WbZcv
An editorial by Editor-in-Chief, Gail Bishop, Ph.D., discusses the negative pressures that early-career scientists face to publish their work in journals with high impact factors, both to achieve career metrics and to support grant applications.
🔗 ow.ly/HTKW50WbYX3
🔗 ow.ly/HTKW50WbYX3
June 23, 2025 at 3:10 PM
An editorial by Editor-in-Chief, Gail Bishop, Ph.D., discusses the negative pressures that early-career scientists face to publish their work in journals with high impact factors, both to achieve career metrics and to support grant applications.
🔗 ow.ly/HTKW50WbYX3
🔗 ow.ly/HTKW50WbYX3
Dr. Michael P. Cancro’s commentary on B cells serves as the cornerstone for the #aging special collection, as it provides a historical record of how aging became important to immunologists. Read the exciting piece in The JI: ow.ly/AZl750W6gV7.
June 10, 2025 at 2:28 PM
Dr. Michael P. Cancro’s commentary on B cells serves as the cornerstone for the #aging special collection, as it provides a historical record of how aging became important to immunologists. Read the exciting piece in The JI: ow.ly/AZl750W6gV7.
A special collection on #aging and the immune system highlights the expanding field of immune aging, featuring an invited commentary from a pioneer in the field and a collection of 5 brief reviews from leaders in aging research. Read the editorial: ow.ly/qxyM50W6fAx. #ReadTheJI
June 9, 2025 at 1:55 PM
A special collection on #aging and the immune system highlights the expanding field of immune aging, featuring an invited commentary from a pioneer in the field and a collection of 5 brief reviews from leaders in aging research. Read the editorial: ow.ly/qxyM50W6fAx. #ReadTheJI
The last May #TopRead from Dr. Ibrahim Hatipoglu found 2 lung-resident CD11b+ cDC2 subsets present in naïve mice that elaborated distinct and common functional responses regulated by IRF4 during IAV infection. Learn more: ow.ly/ksoE50W0aXS.
June 4, 2025 at 1:55 PM
The last May #TopRead from Dr. Ibrahim Hatipoglu found 2 lung-resident CD11b+ cDC2 subsets present in naïve mice that elaborated distinct and common functional responses regulated by IRF4 during IAV infection. Learn more: ow.ly/ksoE50W0aXS.