The Journal of Immunology
@jimmunol.bsky.social
The Journal of Immunology is an official journal of The American Association of Immunologists, journals.aai.org/jimmunol
Editor-in-Chief: Gail A. Bishop, Ph.D.
Editor-in-Chief: Gail A. Bishop, Ph.D.
In this #CuttingEdge article, researchers describe the pivotal role of uterine NK cells in pregnancy, offering novel insights into their lineage specification and revealing Eomesodermin as crucial to their establishment. Learn more: ow.ly/jA6550XsYGs
Eomesodermin defines uterine NK cells crucial for pregnancy success in mice
Abstract. Uterine natural killer cells have been thought to be critical for reproductive success, and their developmental origins remain unclear. Here, we
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November 17, 2025 at 4:44 PM
In this #CuttingEdge article, researchers describe the pivotal role of uterine NK cells in pregnancy, offering novel insights into their lineage specification and revealing Eomesodermin as crucial to their establishment. Learn more: ow.ly/jA6550XsYGs
The JI and @immunohorizons.bsky.social are looking for a biostatistics editor! This is a unique opportunity to contribute to the advancement of immunological research by ensuring the statistical rigor and methodological soundness of published work. Learn more: ow.ly/qYic50Xmu4V.
November 7, 2025 at 3:05 PM
The JI and @immunohorizons.bsky.social are looking for a biostatistics editor! This is a unique opportunity to contribute to the advancement of immunological research by ensuring the statistical rigor and methodological soundness of published work. Learn more: ow.ly/qYic50Xmu4V.
Learn how canine cancer models are evaluating new immunotherapies for osteosarcoma, glioma, non-Hodgkin lymphoma, melanoma, uroepithelial cancer, and head and neck cancers in humans in The JI’s special collection on non-traditional animal models: ow.ly/6FRH50XmtjP.
Role of companion dogs in cancer immunotherapy development
Abstract. Rodent models for evaluating new cancer immunotherapies often fail to fully recapitulate the complexity of immune interactions that occur in canc
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November 6, 2025 at 7:00 PM
Learn how canine cancer models are evaluating new immunotherapies for osteosarcoma, glioma, non-Hodgkin lymphoma, melanoma, uroepithelial cancer, and head and neck cancers in humans in The JI’s special collection on non-traditional animal models: ow.ly/6FRH50XmtjP.
Woodchucks are naturally affected by Woodchuck Hepatitis Virus, with disease progression very similar to hepatitis B in people. This review in the special collection on nontraditional animal models discusses the huge impact of this animal model.
🔗 ow.ly/EQ3r50Xmt9l.
🔗 ow.ly/EQ3r50Xmt9l.
Immunological aspects of naturally occurring model of hepatitis B virus (HBV) infection, hepatitis B, and HBV-associated hepatocellular carcinoma in the American woodchuck Marmota monax
Abstract. Infection of eastern North American woodchucks (Marmota monax) with woodchuck hepatitis virus (WHV) represents the most valuable immunopathogenic
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November 5, 2025 at 5:30 PM
Woodchucks are naturally affected by Woodchuck Hepatitis Virus, with disease progression very similar to hepatitis B in people. This review in the special collection on nontraditional animal models discusses the huge impact of this animal model.
🔗 ow.ly/EQ3r50Xmt9l.
🔗 ow.ly/EQ3r50Xmt9l.
As part of the special collection on non-traditional animal models, researchers discuss how understanding immunity in a range of large animals can expand awareness of immunological processes critical for the maintenance of human health. Learn more: ow.ly/bCtV50Xmt0s.
Contributions of large and agricultural animal models to immunology
Abstract. While studies with laboratory rodent models have defined molecular and cellular components of the human immune system, experiments in these small
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November 4, 2025 at 3:02 PM
As part of the special collection on non-traditional animal models, researchers discuss how understanding immunity in a range of large animals can expand awareness of immunological processes critical for the maintenance of human health. Learn more: ow.ly/bCtV50Xmt0s.
#DYK We published one of the 6 spookiest discoveries of the year according to @zmescience.bsky.social? As a ghost passes through a wall, the parasitic work Schistosoma mansoni can pass through your skin without being detected. Read more: ow.ly/yIUS50Xl7h3.
📘 ow.ly/189i50Xl7h4
📘 ow.ly/189i50Xl7h4
Zombie Ants, Spider Bait, and a Sneaky Burrowing Worm: The 6 Spookiest Science Discoveries of the Past Year
The natural world is full of discoveries that feel straight out of a Tim Burton fever dream.
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October 31, 2025 at 5:26 PM
#DYK We published one of the 6 spookiest discoveries of the year according to @zmescience.bsky.social? As a ghost passes through a wall, the parasitic work Schistosoma mansoni can pass through your skin without being detected. Read more: ow.ly/yIUS50Xl7h3.
📘 ow.ly/189i50Xl7h4
📘 ow.ly/189i50Xl7h4
A treat for you this Halloween: the October edition of The Journal of Immunology is online! Featuring a special collection titled. “Beyond the Mouse: Nontraditional Animal Models in Immunology” you don’t want to miss this one. Explore it all: ow.ly/jmK850Xj1K0
Volume 214 Issue 10 | The Journal of Immunology | Oxford Academic
The JI publishes peer-reviewed manuscripts describing novel findings in all areas of experimental immunology, including both basic and clinical studies.
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October 31, 2025 at 1:49 PM
A treat for you this Halloween: the October edition of The Journal of Immunology is online! Featuring a special collection titled. “Beyond the Mouse: Nontraditional Animal Models in Immunology” you don’t want to miss this one. Explore it all: ow.ly/jmK850Xj1K0
Mortality from Pneumocystis #pneumonia (PCP) continues to increase among non-HIV patients. A new study looks at the role of withdrawing glucocorticoid in disease progression to better understand disease progression. Read more in The JI: ow.ly/EXrx50Xj1CR.
Glucocorticoid-induced Pneumocystis pneumonia mice developed immune reconstitution inflammatory syndrome after glucocorticoid withdrawal
Abstract. Mortality from Pneumocystis pneumonia (PCP) continues to increase among non-human immunodeficiency virus (HIV) patients. Previous studies have re
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October 31, 2025 at 1:48 PM
Mortality from Pneumocystis #pneumonia (PCP) continues to increase among non-HIV patients. A new study looks at the role of withdrawing glucocorticoid in disease progression to better understand disease progression. Read more in The JI: ow.ly/EXrx50Xj1CR.
This #BriefReview discusses how molecular and blood profiling led to a therapeutic revolution for #AtopicDermatitis and highlights how this translational approach is being applied to advancing the therapeutic pipeline of #alopecia areata. Explore more: ow.ly/1kht50Xj1s5
October 28, 2025 at 1:45 PM
This #BriefReview discusses how molecular and blood profiling led to a therapeutic revolution for #AtopicDermatitis and highlights how this translational approach is being applied to advancing the therapeutic pipeline of #alopecia areata. Explore more: ow.ly/1kht50Xj1s5
Data establish c-di-AMP as a key PAMP of B. burgdorferi, the causative agent of #lymedisease which elicits a type I interferon response that can lead to the development of Lyme arthritis, for which a PAMP was previously unidentified. Read more online: ow.ly/jWcl50XesPS.
October 23, 2025 at 12:56 PM
Data establish c-di-AMP as a key PAMP of B. burgdorferi, the causative agent of #lymedisease which elicits a type I interferon response that can lead to the development of Lyme arthritis, for which a PAMP was previously unidentified. Read more online: ow.ly/jWcl50XesPS.
Don't delay! Submit your abstract for IMMUNOLOGY2026™ before 6 pm today.
Today is the deadline for Regular Abstract Submissions for IMMUNOLOGY2026™ at 6 PM ET. If you feel that you will miss today's deadline, we will open a second Regular Abstract submission period from Dec 2–16, 2025. It's also the final day to apply for a Travel Award. ow.ly/LB8P50XggzQ.
October 22, 2025 at 6:04 PM
Don't delay! Submit your abstract for IMMUNOLOGY2026™ before 6 pm today.
New data identified miR-124-3p as a critical regulator of macrophage polarization and acute lung injury (ALI) pathophysiology, providing a potential therapeutic target for managing ALI in lung transplant recipients. Learn more: ow.ly/XsVv50XesKz.
October 18, 2025 at 9:18 AM
New data identified miR-124-3p as a critical regulator of macrophage polarization and acute lung injury (ALI) pathophysiology, providing a potential therapeutic target for managing ALI in lung transplant recipients. Learn more: ow.ly/XsVv50XesKz.
Researchers investigated the role of lectin mannose-binding 1 (LMAN1) in house dust mite induced allergic asthma and found that the loss of LMAN1 led to opposing effects on airway hyperresponsiveness dependent on the sex of mice. Learn more: ow.ly/BZ0750Xb7vs.
Sex-dependent influence of LMAN1 on allergen-induced airway hyperresponsiveness
Abstract. Allergic asthma is a chronic inflammatory disease of the airways characterized by a type 2-high adaptive immune response towards common aeroantig
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October 15, 2025 at 3:14 PM
Researchers investigated the role of lectin mannose-binding 1 (LMAN1) in house dust mite induced allergic asthma and found that the loss of LMAN1 led to opposing effects on airway hyperresponsiveness dependent on the sex of mice. Learn more: ow.ly/BZ0750Xb7vs.
Data showed that high-mobility group protein B1 (HMGB1) inhibited IFN-gamma induced PD-L1 expression, enhancing the antitumor effects of T cells and confirming the role of HMGB1 as a prognostic indicator for #lungcancer treated with CAR-T cells. Read more: ow.ly/lZZG50Xb7mk.
October 14, 2025 at 2:59 PM
Data showed that high-mobility group protein B1 (HMGB1) inhibited IFN-gamma induced PD-L1 expression, enhancing the antitumor effects of T cells and confirming the role of HMGB1 as a prognostic indicator for #lungcancer treated with CAR-T cells. Read more: ow.ly/lZZG50Xb7mk.
When observing wild-type Raji and Jurkat cells following co-culture in the absence of cognate MHC and TCR or superantigen, only 'finger-like' projections were observed at the cell-cell interface. Find the research behind September’s cover image online: ow.ly/NOkn50X6mnH
October 9, 2025 at 5:27 PM
When observing wild-type Raji and Jurkat cells following co-culture in the absence of cognate MHC and TCR or superantigen, only 'finger-like' projections were observed at the cell-cell interface. Find the research behind September’s cover image online: ow.ly/NOkn50X6mnH
Targeting the immune checkpoint inhibitory receptor VISTA improved disease severity in a mouse model of neutrophil-mediated arthritis. Researchers investigate the novel therapeutic opportunity for targeting VISTA in this September #TopRead article: ow.ly/iueJ50X6mlo
The role of VISTA engagement in limiting neutrophil-mediated inflammation
The Editors have selected this article as a highlight of the issue.
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October 9, 2025 at 1:28 PM
Targeting the immune checkpoint inhibitory receptor VISTA improved disease severity in a mouse model of neutrophil-mediated arthritis. Researchers investigate the novel therapeutic opportunity for targeting VISTA in this September #TopRead article: ow.ly/iueJ50X6mlo
Reposted by The Journal of Immunology
Get ready for #IMMUNOLOGY2026™! We're heading to the vibrant city of Boston, MA. Prepare for groundbreaking science, incredible networking, and an unforgettable experience. Don't miss your chance to be part of the #immunology community! Learn more: immunology2026.aai.org/abstracts.
Join us for IMMUNOLOGY2026™
YouTube video by The American Association of Immunologists (AAI)
youtu.be
October 7, 2025 at 7:09 PM
Get ready for #IMMUNOLOGY2026™! We're heading to the vibrant city of Boston, MA. Prepare for groundbreaking science, incredible networking, and an unforgettable experience. Don't miss your chance to be part of the #immunology community! Learn more: immunology2026.aai.org/abstracts.
Congratulations to new Nobel Laureate and AAI Distinguished Fellow Shimon Sakaguchi, co-winner of the 2025 Nobel Prize in Physiology or Medicine for his foundational discoveries on regulatory T cells and peripheral immune tolerance! Published in The JI in 1995: ow.ly/LGk150X7984.
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
Abstract. Approximately 10% of peripheral CD4+ cells and less than 1% of CD8+ cells in normal unimmunized adult mice express the IL-2 receptor α-chain (CD2
academic.oup.com
October 6, 2025 at 3:26 PM
Congratulations to new Nobel Laureate and AAI Distinguished Fellow Shimon Sakaguchi, co-winner of the 2025 Nobel Prize in Physiology or Medicine for his foundational discoveries on regulatory T cells and peripheral immune tolerance! Published in The JI in 1995: ow.ly/LGk150X7984.
Reposted by The Journal of Immunology
Less than two weeks left to submit your #IMMUNOLOGY2026™ abstract! Get your research seen on a global stage in Boston, MA and network with your peers. Submit now: immunology2026.aai.org/abstracts.
October 2, 2025 at 6:14 PM
Less than two weeks left to submit your #IMMUNOLOGY2026™ abstract! Get your research seen on a global stage in Boston, MA and network with your peers. Submit now: immunology2026.aai.org/abstracts.
RTA-480 is currently a therapeutic for Friedrich’s Ataxia that activates NRF2. Researchers explored the therapeutic potential of RTA-408 in #IBD, finding that it modulates T cell homeostasis, metabolism, and inflammation. Learn more: ow.ly/kKKf50X32sk.
Therapeutic potential of NRF2 activating drug RTA-408 in suppressing T cell effector responses and inflammatory bowel disease
Abstract. RTA-408, also known as Omaveloxolone, is an FDA-approved drug for treating Friedrich’s Ataxia, a neurological disorder. It is a triterpenoid comp
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October 1, 2025 at 9:32 PM
RTA-480 is currently a therapeutic for Friedrich’s Ataxia that activates NRF2. Researchers explored the therapeutic potential of RTA-408 in #IBD, finding that it modulates T cell homeostasis, metabolism, and inflammation. Learn more: ow.ly/kKKf50X32sk.
Reposted by The Journal of Immunology
🚀 New from AAI: Immunology Explained — a hub for clear, evidence-based insights into how the immune system protects health.
Check it out: immunologyexplained.aai.org
Find and follow Immunology Explained on TikTok, Facebook, Instagram and YouTube
#ImmunologyExplained
Check it out: immunologyexplained.aai.org
Find and follow Immunology Explained on TikTok, Facebook, Instagram and YouTube
#ImmunologyExplained
October 1, 2025 at 4:30 PM
🚀 New from AAI: Immunology Explained — a hub for clear, evidence-based insights into how the immune system protects health.
Check it out: immunologyexplained.aai.org
Find and follow Immunology Explained on TikTok, Facebook, Instagram and YouTube
#ImmunologyExplained
Check it out: immunologyexplained.aai.org
Find and follow Immunology Explained on TikTok, Facebook, Instagram and YouTube
#ImmunologyExplained
Fall is here and so is the September issue of The JI! Available online and full of high-quality research. Read through all the September issue has to offer: ow.ly/uiQo50X32rC.
October 1, 2025 at 1:52 AM
Fall is here and so is the September issue of The JI! Available online and full of high-quality research. Read through all the September issue has to offer: ow.ly/uiQo50X32rC.
Neutrophils specialize in producing large amounts of reactive oxygen species to kill microbes. Data suggests that SOD1 is a novel regulatory factor in this oxidative burst that enables the full immunological response of neutrophils. Read more here: ow.ly/5kr350WYaCi.
SOD1 controls neutrophil oxidative burst and microbial killing
Abstract. Neutrophils are immune cells specialized in producing large amounts of reactive oxygen species (ROS) to kill microbes. However, the mechanisms by
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September 26, 2025 at 3:11 PM
Neutrophils specialize in producing large amounts of reactive oxygen species to kill microbes. Data suggests that SOD1 is a novel regulatory factor in this oxidative burst that enables the full immunological response of neutrophils. Read more here: ow.ly/5kr350WYaCi.
Data showed that aging in mice impairs the ability to produce anti-HMGB1 IgM, making mice susceptible to the development of insulin resistance, and provides insight into what drives age-related loss of tolerance to fatty foods. Learn more: ow.ly/26Vu50WYa7E.
Age-related decline in HMGB1-neutralizing IgM autoantibody response impairs resistance to high-fat diet in mice
Abstract. As we age, it becomes increasingly important to reduce the consumption of fatty foods. In mice, we also find that after consuming a high-fat diet
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September 24, 2025 at 12:30 PM
Data showed that aging in mice impairs the ability to produce anti-HMGB1 IgM, making mice susceptible to the development of insulin resistance, and provides insight into what drives age-related loss of tolerance to fatty foods. Learn more: ow.ly/26Vu50WYa7E.
Researchers characterized the molecular determinants of FcγRIIB expression in human immune models, paving the way for future investigation into the molecular mechanisms responsible for cell lineage-specific FcγR expression. Read more online: ow.ly/xmVB50WY9SI.
The ETS-family transcription factor PU.1 is a critical regulator of the inhibitory Fcγ receptor IIB expression in humans
Abstract. The inhibitory Fc gamma receptor IIB (FcγRIIB) is a critical determinant of humoral immunity. By providing feedback inhibition, through inhibitor
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September 23, 2025 at 2:37 PM
Researchers characterized the molecular determinants of FcγRIIB expression in human immune models, paving the way for future investigation into the molecular mechanisms responsible for cell lineage-specific FcγR expression. Read more online: ow.ly/xmVB50WY9SI.