Another #TopRead developed a novel TOX-nanoluciferase-based reporter system that can be used to monitor TOX expression and facilitate the screening of molecules that modulate cytotoxic T-cell exhaustion. Learn more: ow.ly/O9oW50WijyF.
A novel TOX-nanoluciferase reporter mouse for exploring modulators of T cell exhaustion
The Editors have selected this article as a highlight of the issue.
ow.ly
July 7, 2025 at 6:40 PM
Another #TopRead developed a novel TOX-nanoluciferase-based reporter system that can be used to monitor TOX expression and facilitate the screening of molecules that modulate cytotoxic T-cell exhaustion. Learn more: ow.ly/O9oW50WijyF.
June #TopRead from @ualberta.bsky.social and @wchriuofa.bsky.social found distinct gene expression profiles in CD71+ erythroid cells at various developmental stages, suggesting a critical role for Gal-3 in modulating erythropoiesis and enhancing immunoregulation. Read more: ow.ly/L8uv50WiiFm.
Galectin-3 regulates erythropoiesis and enhances the immunoregulatory properties of CD71+ erythroid cells across developmental stages
The Editors have selected this article as a highlight of the issue.
ow.ly
July 3, 2025 at 2:07 PM
June #TopRead from @ualberta.bsky.social and @wchriuofa.bsky.social found distinct gene expression profiles in CD71+ erythroid cells at various developmental stages, suggesting a critical role for Gal-3 in modulating erythropoiesis and enhancing immunoregulation. Read more: ow.ly/L8uv50WiiFm.
Dr. John V Williams and his team characterized the role of CD4+ helper T Cells in response to human metapneumovirus (HMPV), identifying a dominant CD4+ T cell epitope and constructing the first MHC-II tetramer for HMPV. Learn more in this #TopRead article: ow.ly/Hern50WJAB3
August 26, 2025 at 5:17 PM
Dr. John V Williams and his team characterized the role of CD4+ helper T Cells in response to human metapneumovirus (HMPV), identifying a dominant CD4+ T cell epitope and constructing the first MHC-II tetramer for HMPV. Learn more in this #TopRead article: ow.ly/Hern50WJAB3
Our final March #TopRead is from Dr. Carl Ware, @sbpdiscovery.bsky.social, who described the first method to directly quantify the HVEM-BTLA cis-complex. Find it in The JI: ow.ly/nElT50VAjzY.
April 18, 2025 at 3:24 PM
Our final March #TopRead is from Dr. Carl Ware, @sbpdiscovery.bsky.social, who described the first method to directly quantify the HVEM-BTLA cis-complex. Find it in The JI: ow.ly/nElT50VAjzY.
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#HorrorBooks #ScaryReads #ThrillerFiction
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December 7, 2024 at 11:07 AM
In this #TopRead article, data demonstrated that TNFR family member CD27 is a metabolic regulator in activated human CD4+ cells, suggesting its essential contribution to T-cell metabolism and its relevance as a therapeutic target. Read more in The JI: ow.ly/bCJk50WJAwi.
August 27, 2025 at 12:45 PM
In this #TopRead article, data demonstrated that TNFR family member CD27 is a metabolic regulator in activated human CD4+ cells, suggesting its essential contribution to T-cell metabolism and its relevance as a therapeutic target. Read more in The JI: ow.ly/bCJk50WJAwi.
Targeting the immune checkpoint inhibitory receptor VISTA improved disease severity in a mouse model of neutrophil-mediated arthritis. Researchers investigate the novel therapeutic opportunity for targeting VISTA in this September #TopRead article: ow.ly/iueJ50X6mlo
The role of VISTA engagement in limiting neutrophil-mediated inflammation
The Editors have selected this article as a highlight of the issue.
ow.ly
October 9, 2025 at 1:28 PM
Targeting the immune checkpoint inhibitory receptor VISTA improved disease severity in a mouse model of neutrophil-mediated arthritis. Researchers investigate the novel therapeutic opportunity for targeting VISTA in this September #TopRead article: ow.ly/iueJ50X6mlo
Bought old Mondo Brutto in comic shop today: 14 pages on Plasmatics, 22 on Atléti, 4 on Television Personalities, 8 on old perfumes #topread
December 9, 2024 at 1:57 PM
Bought old Mondo Brutto in comic shop today: 14 pages on Plasmatics, 22 on Atléti, 4 on Television Personalities, 8 on old perfumes #topread
Today’s #TopRead from Dr. De’Broski R. Herbert investigated mice infected with the parasitic helminth Strongyloides ratti to understand mechanisms of anamnestic immunity at the skin barrier, uncovering an unknown mechanism of type 2 immunity. Find it here: ow.ly/EHth50VAjc6.
Myeloid-derived IL-33 drives γδ T cell–dependent resistance against cutaneous infection by Strongyloides ratti
The Editors have selected this article as a highlight of the issue.
ow.ly
April 16, 2025 at 1:33 PM
Today’s #TopRead from Dr. De’Broski R. Herbert investigated mice infected with the parasitic helminth Strongyloides ratti to understand mechanisms of anamnestic immunity at the skin barrier, uncovering an unknown mechanism of type 2 immunity. Find it here: ow.ly/EHth50VAjc6.
#TopRead and #clinical study from Dr. Celestine Wanjalla, MD PhD, found that circulating CD3+ T-cell: CD14+ monocyte pairs may contribute to inflammation and cardiometabolic disease pathogenesis, potentially originating or maintained by chronic viral infections.
🔗 ow.ly/X37Y50VAjr8
🔗 ow.ly/X37Y50VAjr8
CD3+ T-cell: CD14+ monocyte complexes are dynamic and increased with HIV and glucose intolerance
The Editors have selected this article as a highlight of the issue.
ow.ly
April 17, 2025 at 2:46 PM
#TopRead and #clinical study from Dr. Celestine Wanjalla, MD PhD, found that circulating CD3+ T-cell: CD14+ monocyte pairs may contribute to inflammation and cardiometabolic disease pathogenesis, potentially originating or maintained by chronic viral infections.
🔗 ow.ly/X37Y50VAjr8
🔗 ow.ly/X37Y50VAjr8
A June #TopRead identified different subtypes of neutrophils in #tuberculosis (TB) patients, indicating that neutrophils might be promising targets for TB host-directed therapy. Learn more: ow.ly/gBgR50WiiCr.
Neutrophils from tuberculosis patients are polarized toward pro-inflammatory and anti-inflammatory phenotypes according to the disease severity
The Editors have selected this article as a highlight of the issue.
ow.ly
July 2, 2025 at 5:23 PM
A June #TopRead identified different subtypes of neutrophils in #tuberculosis (TB) patients, indicating that neutrophils might be promising targets for TB host-directed therapy. Learn more: ow.ly/gBgR50WiiCr.
#TopRead: Data indicates a high-salt diet drives #depression by inducing the production of IL-17A and identified gamma-delta T17 cells as a key source of IL-17A. Xiaojun Chen says the work supports novel interventions and therapeutics. Read more: ow.ly/5FWX50VJHZJ.
High-salt diet drives depression-like behavior in mice by inducing IL-17A production
The Editors have selected this article as a highlight of the issue.
ow.ly
May 13, 2025 at 6:14 PM
#TopRead: Data indicates a high-salt diet drives #depression by inducing the production of IL-17A and identified gamma-delta T17 cells as a key source of IL-17A. Xiaojun Chen says the work supports novel interventions and therapeutics. Read more: ow.ly/5FWX50VJHZJ.
This #TopRead article in April from Dr. Joan Cook-Mills at Indiana University Medical School found that although eosinophils are not necessary during oral food allergen-induced anaphylaxis, they play a critical role in the early development of food allergy.
🔗 ow.ly/1eqI50VJHT0
#FoodAllergies
🔗 ow.ly/1eqI50VJHT0
#FoodAllergies
Depletion of eosinophils during sensitization but not challenge phase in mice blocks the development of food allergy early in life
The Editors have selected this article as a highlight of the issue.
ow.ly
May 13, 2025 at 6:17 PM
This #TopRead article in April from Dr. Joan Cook-Mills at Indiana University Medical School found that although eosinophils are not necessary during oral food allergen-induced anaphylaxis, they play a critical role in the early development of food allergy.
🔗 ow.ly/1eqI50VJHT0
#FoodAllergies
🔗 ow.ly/1eqI50VJHT0
#FoodAllergies
A #TopRead article from Dr. Jesse Bruijnesteijn found that a diverse repertoire of killer cell immunoglobulin-like receptors (KIRs) contributes to the protection of individuals and populations against pathogen evasion and subversion. Read it in The JI: ow.ly/vJRk50VJI7H
Exploring the genetic mechanisms driving KIR diversification
The Editors have selected this article as a highlight of the issue.
ow.ly
May 14, 2025 at 9:32 PM
A #TopRead article from Dr. Jesse Bruijnesteijn found that a diverse repertoire of killer cell immunoglobulin-like receptors (KIRs) contributes to the protection of individuals and populations against pathogen evasion and subversion. Read it in The JI: ow.ly/vJRk50VJI7H
An August #TopRead from @carpenterlab.bsky.social demonstrates that heterogeneous nuclear ribonucleoprotein A2B1 is essential for optimal macrophage function, highlighting the role for RNA-binding proteins in mounting effective immune defenses. Read more: ow.ly/NSx150WTnSr.
September 10, 2025 at 1:26 PM
An August #TopRead from @carpenterlab.bsky.social demonstrates that heterogeneous nuclear ribonucleoprotein A2B1 is essential for optimal macrophage function, highlighting the role for RNA-binding proteins in mounting effective immune defenses. Read more: ow.ly/NSx150WTnSr.
In this April #TopRead Dr. Parvathi Ranganathan at @osuhematology.bsky.social identified dehydrogenase inhibition as an innovative treatment strategy in allo-HCT recipients to reduce graft-vs-host-disease severity while retaining graft-vs-leukemia response. Learn more: ow.ly/K7LK50VJIiW.
May 16, 2025 at 2:09 PM
In this April #TopRead Dr. Parvathi Ranganathan at @osuhematology.bsky.social identified dehydrogenase inhibition as an innovative treatment strategy in allo-HCT recipients to reduce graft-vs-host-disease severity while retaining graft-vs-leukemia response. Learn more: ow.ly/K7LK50VJIiW.
Today’s #TopRead Article in May from #ACareyLab at #DrexelMedicine provides insights on the age-specific role of cathelicidin-related antimicrobial peptide (CRAMP) in influenza viral pathogenesis. Learn more: ow.ly/S2cb50W0eR5
June 3, 2025 at 1:20 PM
Today’s #TopRead Article in May from #ACareyLab at #DrexelMedicine provides insights on the age-specific role of cathelicidin-related antimicrobial peptide (CRAMP) in influenza viral pathogenesis. Learn more: ow.ly/S2cb50W0eR5
If you haven’t read Quicksilver yet, it is time! 💕🔥 #quicksilver #love #books #booksky #fantasy #romantasy #read #obsessed #perfect #topread
January 3, 2025 at 5:41 AM
If you haven’t read Quicksilver yet, it is time! 💕🔥 #quicksilver #love #books #booksky #fantasy #romantasy #read #obsessed #perfect #topread
This week we’ll be sharing #TopRead articles from March, but #ICYMI a top read in Feb. From @wistar.org found that BNAb-preloaded CD64-transduced NK cells showed enhanced ability to mediate ADCC against HIV-1–infected CD4+ primary T cells. Read here: ow.ly/lRZa50VAiJA.
Gene-modified NK cells expressing CD64 and preloaded with HIV-specific BNAbs target autologous HIV-1–infected CD4+ T cells by ADCC
The Editors have selected this article as a highlight of the issue.
academic.oup.com
April 14, 2025 at 5:48 PM
This week we’ll be sharing #TopRead articles from March, but #ICYMI a top read in Feb. From @wistar.org found that BNAb-preloaded CD64-transduced NK cells showed enhanced ability to mediate ADCC against HIV-1–infected CD4+ primary T cells. Read here: ow.ly/lRZa50VAiJA.
We’re sharing the #TopRead articles from March! Read Dr. Gennaro’s research, which found that some kids with multisystem inflammatory syndrome carried rare heterozygous variants of LYST that may be a potential driver of #LongCOVID: ow.ly/REtf50VAiPG
A genetically modulated Toll-like receptor-tolerant phenotype in peripheral blood cells of children with multisystem inflammatory syndrome
The Editors have selected this article as a highlight of the issue.
ow.ly
April 14, 2025 at 8:49 PM
We’re sharing the #TopRead articles from March! Read Dr. Gennaro’s research, which found that some kids with multisystem inflammatory syndrome carried rare heterozygous variants of LYST that may be a potential driver of #LongCOVID: ow.ly/REtf50VAiPG
Our next March #TopRead is from Dr. Lewis Lanier and is the final paper of his career, demonstrating that SYK deletion in NK cells resulted in robust cytotoxic activity and cytokine production, providing a new strategy for cancer immunotherapy. Read more: ow.ly/UmtX50VAj25.
April 15, 2025 at 3:19 PM
Our next March #TopRead is from Dr. Lewis Lanier and is the final paper of his career, demonstrating that SYK deletion in NK cells resulted in robust cytotoxic activity and cytokine production, providing a new strategy for cancer immunotherapy. Read more: ow.ly/UmtX50VAj25.
The 4th Top Read article on Wikipedia happens to be《Magic cross piercing》which is this super painful male genitalia modification, involving inserting straight barbells through the glans.
WHY?
#Wikipedia #MessedUp #Monday #Reading #MaleGenitalia #Modification #TopRead #MagicCrossPiercing #Piercings
WHY?
#Wikipedia #MessedUp #Monday #Reading #MaleGenitalia #Modification #TopRead #MagicCrossPiercing #Piercings
Magic cross piercing - Wikipedia
en.wikipedia.org
May 26, 2025 at 2:03 AM
The 4th Top Read article on Wikipedia happens to be《Magic cross piercing》which is this super painful male genitalia modification, involving inserting straight barbells through the glans.
WHY?
#Wikipedia #MessedUp #Monday #Reading #MaleGenitalia #Modification #TopRead #MagicCrossPiercing #Piercings
WHY?
#Wikipedia #MessedUp #Monday #Reading #MaleGenitalia #Modification #TopRead #MagicCrossPiercing #Piercings
