Reid Alderson
@reidalderson.bsky.social
Group Leader at Helmholtz Munich 🇩🇪 Disordered proteins 🍝, protein dynamics 🏃♂️, and #NMR 🧲
Past: UW 🦡, Oxford 🇬🇧, NIH 🇺🇸, Toronto 🇨🇦
Past: UW 🦡, Oxford 🇬🇧, NIH 🇺🇸, Toronto 🇨🇦
Reposted by Reid Alderson
Looking back on an inspiring and stimulating two days at the Ultra-Highfield NMR and 4D Structural Biology Symposium. Huge thanks to all speakers, participants, and organizers for making this such an insightful and engaging event! 🧲🧬
November 11, 2025 at 12:57 PM
Looking back on an inspiring and stimulating two days at the Ultra-Highfield NMR and 4D Structural Biology Symposium. Huge thanks to all speakers, participants, and organizers for making this such an insightful and engaging event! 🧲🧬
Reposted by Reid Alderson
Fantastic opportunity!
Great project with a great PI.
A no-miss opportunity
Great project with a great PI.
A no-miss opportunity
Postdoctoral position in the team of Alessandro Barducci in the CBS, focusing on multiscale simulations of RNA-driven condensates, with applications in synthetic biology.
More information :
www.cbs.cnrs.fr/images/jobs/...
The position is expected to start in early 2026, with some flexibility.
More information :
www.cbs.cnrs.fr/images/jobs/...
The position is expected to start in early 2026, with some flexibility.
November 7, 2025 at 4:33 PM
Fantastic opportunity!
Great project with a great PI.
A no-miss opportunity
Great project with a great PI.
A no-miss opportunity
Reposted by Reid Alderson
Misfolded proteins can cause #Alzheimers, #Parkinsons and #Cancer. Johannes Buchner, part of the CHAPEROME team, receives an #ERC Synergy Grant to study how chaperone #proteins keep cells healthy: go.tum.de/904052 👏
#ERCSyG #biotechnology
@erc.europa.eu
📷A. Heddergott
#ERCSyG #biotechnology
@erc.europa.eu
📷A. Heddergott
Highly endowed ERC Synergy Grant for Prof. Johannes Buchner
Disease-causing proteins – ERC Synergy Grant for research at TUM on the role of chaperone “helper proteins.”
go.tum.de
November 6, 2025 at 11:53 AM
Misfolded proteins can cause #Alzheimers, #Parkinsons and #Cancer. Johannes Buchner, part of the CHAPEROME team, receives an #ERC Synergy Grant to study how chaperone #proteins keep cells healthy: go.tum.de/904052 👏
#ERCSyG #biotechnology
@erc.europa.eu
📷A. Heddergott
#ERCSyG #biotechnology
@erc.europa.eu
📷A. Heddergott
Reposted by Reid Alderson
We are back with an exciting seminar on September 8 at 3pm CEST! We’ll hear from Prof. Birthe Kragelund and Maximilian Vieler (@uu.se).
Register to attend:
tinyurl.com/PMCseminar2
Recordings of previous seminars: www.youtube.com/@PMCModularity
Register to attend:
tinyurl.com/PMCseminar2
Recordings of previous seminars: www.youtube.com/@PMCModularity
August 15, 2025 at 3:36 PM
We are back with an exciting seminar on September 8 at 3pm CEST! We’ll hear from Prof. Birthe Kragelund and Maximilian Vieler (@uu.se).
Register to attend:
tinyurl.com/PMCseminar2
Recordings of previous seminars: www.youtube.com/@PMCModularity
Register to attend:
tinyurl.com/PMCseminar2
Recordings of previous seminars: www.youtube.com/@PMCModularity
Reposted by Reid Alderson
I’m carrying out a short survey of NMR TITAN users - if you’ve made use of this tool in your research, or have suggestions for its future development, I’d be grateful for your input: forms.gle/MMXYwSozszhi... #nmrchat
NMR TITAN user survey
This survey aims to assess the impact of NMR TITAN on biomolecular research and identify priorities for future development. The form should take approximately 5 minutes to complete. Your responses may...
forms.gle
August 28, 2025 at 2:13 PM
I’m carrying out a short survey of NMR TITAN users - if you’ve made use of this tool in your research, or have suggestions for its future development, I’d be grateful for your input: forms.gle/MMXYwSozszhi... #nmrchat
Reposted by Reid Alderson
Get important feedback from your community and move your work forward. Share your research at #bps2026!
Submit an abstract today buff.ly/oOjstk6
Submit an abstract today buff.ly/oOjstk6
BPS2026 Annual Meeting | Biophysical Society
The BPS2026 Annual Meeting in San Francisco will showcase Biophysics by the Bay, highlighting the exciting advances in science and technology brought forth by big data and AI. This year’s program…
www.biophysics.org
August 27, 2025 at 12:01 PM
Get important feedback from your community and move your work forward. Share your research at #bps2026!
Submit an abstract today buff.ly/oOjstk6
Submit an abstract today buff.ly/oOjstk6
Reposted by Reid Alderson
#HelmholtzMunich’s BNMRZ has joined Germany’s Instruct-ERIC Centre 🔬
Instruct-ERIC provides open access to advanced structural biology technologies. #BNMRZ advances innovation in #NMR methods, drug discovery, and imaging - boosting the German Centre’s capabilities.
👉 Read more: t1p.de/pjtyv
Instruct-ERIC provides open access to advanced structural biology technologies. #BNMRZ advances innovation in #NMR methods, drug discovery, and imaging - boosting the German Centre’s capabilities.
👉 Read more: t1p.de/pjtyv
August 13, 2025 at 7:15 AM
#HelmholtzMunich’s BNMRZ has joined Germany’s Instruct-ERIC Centre 🔬
Instruct-ERIC provides open access to advanced structural biology technologies. #BNMRZ advances innovation in #NMR methods, drug discovery, and imaging - boosting the German Centre’s capabilities.
👉 Read more: t1p.de/pjtyv
Instruct-ERIC provides open access to advanced structural biology technologies. #BNMRZ advances innovation in #NMR methods, drug discovery, and imaging - boosting the German Centre’s capabilities.
👉 Read more: t1p.de/pjtyv
Reposted by Reid Alderson
Nature Communications (open) Seedless: on-the-fly pulse calculation for NMR experiments, Charles J. Buchanan, Gaurav Bhole, Gogulan Karunanithy, Virginia Casablancas-Antràs, Adeline W. J. Poh, Benjamin G. Davis, Jonathan A. Jones* & Andrew J. Baldwin* www.nature.com/articles/s41... #NMRchat #NMR 🧲
Seedless: on-the-fly pulse calculation for NMR experiments - Nature Communications
The authors develop a computational tool to design NMR pulses, based on the GRadient Assisted Pulse Engineering approach, that can calculate optimal pulse shapes on the fly during the measurements, to...
www.nature.com
August 8, 2025 at 2:03 PM
Nature Communications (open) Seedless: on-the-fly pulse calculation for NMR experiments, Charles J. Buchanan, Gaurav Bhole, Gogulan Karunanithy, Virginia Casablancas-Antràs, Adeline W. J. Poh, Benjamin G. Davis, Jonathan A. Jones* & Andrew J. Baldwin* www.nature.com/articles/s41... #NMRchat #NMR 🧲
Reposted by Reid Alderson
Do you want to learn about all relevant aspects of biomolecular solid-state NMR, from theory to application?
Join the 10th European Solid-State NMR Summer School❗️
🗓️ October 20-24, 2025 | Garching, Germany
📌 Application Deadline: 01.09.2025
www.bio.nat.tum.de/ocb/upcoming...
#NMRchat #BioNMR
Join the 10th European Solid-State NMR Summer School❗️
🗓️ October 20-24, 2025 | Garching, Germany
📌 Application Deadline: 01.09.2025
www.bio.nat.tum.de/ocb/upcoming...
#NMRchat #BioNMR
European Solid-State NMR School
www.bio.nat.tum.de
August 5, 2025 at 2:46 PM
Do you want to learn about all relevant aspects of biomolecular solid-state NMR, from theory to application?
Join the 10th European Solid-State NMR Summer School❗️
🗓️ October 20-24, 2025 | Garching, Germany
📌 Application Deadline: 01.09.2025
www.bio.nat.tum.de/ocb/upcoming...
#NMRchat #BioNMR
Join the 10th European Solid-State NMR Summer School❗️
🗓️ October 20-24, 2025 | Garching, Germany
📌 Application Deadline: 01.09.2025
www.bio.nat.tum.de/ocb/upcoming...
#NMRchat #BioNMR
Reposted by Reid Alderson
BNMRZ Symposium Ultra-Highfield NMR and 4D Structural Biology – From Mechanisms to Therapies, November 6–7, 2025, TUM Institute for Advanced Study, Garching @ias-tum.bsky.social registration opens soon www.bnmrz.org/4dstructbiol #BNMRZ #NMRchat #NMR 🧲
August 4, 2025 at 8:16 PM
BNMRZ Symposium Ultra-Highfield NMR and 4D Structural Biology – From Mechanisms to Therapies, November 6–7, 2025, TUM Institute for Advanced Study, Garching @ias-tum.bsky.social registration opens soon www.bnmrz.org/4dstructbiol #BNMRZ #NMRchat #NMR 🧲
Reposted by Reid Alderson
And it's out!
I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025).
This paper describes a new mechanism for the initiation of autophagosome biogenesis.
We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.
I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025).
This paper describes a new mechanism for the initiation of autophagosome biogenesis.
We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.
July 25, 2025 at 9:43 AM
And it's out!
I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025).
This paper describes a new mechanism for the initiation of autophagosome biogenesis.
We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.
I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025).
This paper describes a new mechanism for the initiation of autophagosome biogenesis.
We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.
Reposted by Reid Alderson
Featuring: The 2026 Biophysical Society Lecture, Lewis E. Kay, University of Toronto, The Essentiality of Solution NMR Spectroscopy in the Post-AlphaFold Era, Monday, February 23, 8:00 PM, Moscone Center www.biophysics.org/2026meeting/... #NMRchat 🧲
July 3, 2025 at 5:08 PM
Featuring: The 2026 Biophysical Society Lecture, Lewis E. Kay, University of Toronto, The Essentiality of Solution NMR Spectroscopy in the Post-AlphaFold Era, Monday, February 23, 8:00 PM, Moscone Center www.biophysics.org/2026meeting/... #NMRchat 🧲
Reposted by Reid Alderson
We are happy to announce the “10th European solid-state NMR summer school” (October 19-24, 2025) that will take place at the Technical University Munich (@TUM.de) in Garching, Germany. #NMRchat #BioNMR
For more detailed information, please follow the link:
www.bio.nat.tum.de/ocb/upcoming...
For more detailed information, please follow the link:
www.bio.nat.tum.de/ocb/upcoming...
European Solid-State NMR School
www.bio.nat.tum.de
June 11, 2025 at 6:37 PM
We are happy to announce the “10th European solid-state NMR summer school” (October 19-24, 2025) that will take place at the Technical University Munich (@TUM.de) in Garching, Germany. #NMRchat #BioNMR
For more detailed information, please follow the link:
www.bio.nat.tum.de/ocb/upcoming...
For more detailed information, please follow the link:
www.bio.nat.tum.de/ocb/upcoming...
Reposted by Reid Alderson
New paper from the lab from Sriram Garg in my group. We introduce a general substitution matrix for structural phylogenetics. I think this is a big deal, so read on below if you think deep history is important. academic.oup.com/mbe/advance-...
A general substitution matrix for structural phylogenetics.
Abstract. Sequence-based maximum likelihood (ML) phylogenetics is a widely used method for inferring evolutionary relationships, which has illuminated the
academic.oup.com
June 11, 2025 at 2:01 PM
New paper from the lab from Sriram Garg in my group. We introduce a general substitution matrix for structural phylogenetics. I think this is a big deal, so read on below if you think deep history is important. academic.oup.com/mbe/advance-...
Reposted by Reid Alderson
🚨 We're hiring! Join our excellent Electron Microscopy Facility at @istaresearch.bsky.social as an a Cryo-EM Specialist, providing support for groundbreaking research in a fantastic environment: ist.ac.at/en/job/?titl... #CryoEM #MicroscopyJobs #ScienceCareers
Job details
Job details
ist.ac.at
June 10, 2025 at 7:57 AM
🚨 We're hiring! Join our excellent Electron Microscopy Facility at @istaresearch.bsky.social as an a Cryo-EM Specialist, providing support for groundbreaking research in a fantastic environment: ist.ac.at/en/job/?titl... #CryoEM #MicroscopyJobs #ScienceCareers
Reposted by Reid Alderson
Two postdoctoral positions in the group of Dr. Malene R. Jensen at the Institute for Structural Biology in Grenoble, France, protein kinase (MAPK) cell signaling pathways (incl NMR, X-ray crystallography and cryo-electron microscopy) www.jensen-nmr.fr #NMRjobs #NMRchat #NMR 🧲
> Malene R. Jensen @ IBS Grenoble
Research team of CNRS research director Malene Ringkjøbing Jensen at the Institut de Biologie Structurale, Grenoble, France
www.jensen-nmr.fr
June 5, 2025 at 12:46 PM
Two postdoctoral positions in the group of Dr. Malene R. Jensen at the Institute for Structural Biology in Grenoble, France, protein kinase (MAPK) cell signaling pathways (incl NMR, X-ray crystallography and cryo-electron microscopy) www.jensen-nmr.fr #NMRjobs #NMRchat #NMR 🧲
Reposted by Reid Alderson
Nice summary of our ipSAE score for rescoring protein-protein and protein/nucleic-acid interactions in AF2, AF3, and Boltz-1. It works better than ipTM for full-length Uniprot sequences.
As @rolanddunbrack.bsky.social recently discovered, one of the issues with the ipTM score used AF2 to represent the ipTM score is that it is biased by disordered regions of the protein outside the binding interface. To address this, he implemented a new metric, ipSAE.
levitate.bio/alphafold/mu...
levitate.bio/alphafold/mu...
Fixing the Flaws in AlphaFold’s Interface Scoring: Meet Dunbrack’s ipSAE
Predicting protein-protein interactions Since AlphaFold2 was published, one of the major applications of the model was accurately predicting the structure of protein-protein interactions. By taking as...
levitate.bio
June 3, 2025 at 10:50 PM
Nice summary of our ipSAE score for rescoring protein-protein and protein/nucleic-acid interactions in AF2, AF3, and Boltz-1. It works better than ipTM for full-length Uniprot sequences.
Reposted by Reid Alderson
Are you looking for homologous sequences but alignments do not seem to work? SHARK is available as a webserver: compare sequences or search against precomputed IDR datasets: bio-shark.org @narjournal.bsky.social @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
SHARK: web server for alignment-free homology assessment for intrinsically disordered and unalignable protein regions
Abstract. Whereas alignment has been fundamental to sequence-based assessments of protein homology, it is ineffective for intrinsically disordered regions
doi.org
May 28, 2025 at 9:24 PM
Are you looking for homologous sequences but alignments do not seem to work? SHARK is available as a webserver: compare sequences or search against precomputed IDR datasets: bio-shark.org @narjournal.bsky.social @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
Reposted by Reid Alderson
Our manuscript on dsRNA sensor OAS2 from the lab of @oliveiramann.bsky.social is now out in @cp-molcell.bsky.social ! Thanks again to the whole team for their effort putting this story together!
Online Now: Structural basis for OAS2 regulation and its antiviral function Online now:
Structural basis for OAS2 regulation and its antiviral function
Merold and Bekere et al. reveal that OAS2 exists as a zinc-mediated dimer in an autoinhibited state, preventing autoreactivity to short RNAs. Dimer-to-monomer transition, dsRNA binding to a non-canonical interface, and targeting to the Golgi by myristoylation are necessary for OAS2 activation and restriction of viruses that form double membrane vesicles.
dlvr.it
May 23, 2025 at 4:31 PM
Our manuscript on dsRNA sensor OAS2 from the lab of @oliveiramann.bsky.social is now out in @cp-molcell.bsky.social ! Thanks again to the whole team for their effort putting this story together!
Reposted by Reid Alderson
A Perspective by @stephanieaw.bsky.social and @fraserlab.com discusses ways macromolecules use conformational entropy to control binding, catalysis, and allostery
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Advances in uncovering the mechanisms of macromolecular conformational entropy - Nature Chemical Biology
Protein conformational entropy plays a vital role in functions like binding and catalysis. This Perspective discusses three ways macromolecules use conformational entropy: prepaying entropic costs, re...
www.nature.com
April 25, 2025 at 3:35 PM
A Perspective by @stephanieaw.bsky.social and @fraserlab.com discusses ways macromolecules use conformational entropy to control binding, catalysis, and allostery
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Reid Alderson
Reposted by Reid Alderson
Identifying functional motifs in disordered regions is challenging. We gave it a try. Check out SHARK-capture, an alignment-free method to detect SLiMs. Congrats Chi Fung Willis Chow @swlenz.bsky.social et al. @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social doi.org/10.1002/pro....
SHARK‐capture identifies functional motifs in intrinsically disordered protein regions
Increasing insights into how sequence motifs in intrinsically disordered regions (IDRs) provide functions underscore the need for systematic motif detection. Contrary to structured regions where moti...
doi.org
March 18, 2025 at 8:06 PM
Identifying functional motifs in disordered regions is challenging. We gave it a try. Check out SHARK-capture, an alignment-free method to detect SLiMs. Congrats Chi Fung Willis Chow @swlenz.bsky.social et al. @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social doi.org/10.1002/pro....
An open #PhD position is available in my lab in Munich 🇩🇪 If you are interested in structural biology, #AlphaFold, or disordered proteins, see below for more details.
jobs.helmholtz-muenchen.de/jobposting/b...
#science #PhD #research
jobs.helmholtz-muenchen.de/jobposting/b...
#science #PhD #research
PhD Position in Structural Biology (f/m/x)
jobs.helmholtz-muenchen.de
March 11, 2025 at 6:57 AM
An open #PhD position is available in my lab in Munich 🇩🇪 If you are interested in structural biology, #AlphaFold, or disordered proteins, see below for more details.
jobs.helmholtz-muenchen.de/jobposting/b...
#science #PhD #research
jobs.helmholtz-muenchen.de/jobposting/b...
#science #PhD #research
Reposted by Reid Alderson
We're looking for a #postdoc to join our team at KCL Chemistry @kingsnmes.bsky.social. If you're interested in disordered proteins, please get in touch!
3 year post. Ad closes 12 March: www.kcl.ac.uk/jobs/105866-...
3 year post. Ad closes 12 March: www.kcl.ac.uk/jobs/105866-...
Postdoctoral Research Associate in Disordered Protein Interactions
www.kcl.ac.uk
February 24, 2025 at 4:57 PM
We're looking for a #postdoc to join our team at KCL Chemistry @kingsnmes.bsky.social. If you're interested in disordered proteins, please get in touch!
3 year post. Ad closes 12 March: www.kcl.ac.uk/jobs/105866-...
3 year post. Ad closes 12 March: www.kcl.ac.uk/jobs/105866-...
Reposted by Reid Alderson
🧵 on our preprint: Zhang & Skolnick's TM score for comparing model of protein to experimental structures of same protein. The d_j are essentially the same as the aligned error in Alphafold. After any structure alignment, it's the displacement of model Calpha from experimental Calpha of residue j.
February 16, 2025 at 2:13 AM
🧵 on our preprint: Zhang & Skolnick's TM score for comparing model of protein to experimental structures of same protein. The d_j are essentially the same as the aligned error in Alphafold. After any structure alignment, it's the displacement of model Calpha from experimental Calpha of residue j.