Phil Ross
@philippzross.com
Vaccine scientist at ArkeaBio | Biologically inspired design for a better planet | Runner and anime enthusiast
Reposted by Phil Ross
Great new postdoc fellowship for foundational plant research.
If you’re into genetics and genomics of plant reproductive evolution or adaptive convergence (incl in the cool and charismatic nightshades!) I’d be happy to talk about possible projects!
www.simonsfoundation.org/grant/simons...
If you’re into genetics and genomics of plant reproductive evolution or adaptive convergence (incl in the cool and charismatic nightshades!) I’d be happy to talk about possible projects!
www.simonsfoundation.org/grant/simons...
Simons Postdoctoral Fellowships in Plant Biology
Simons Postdoctoral Fellowships in Plant Biology on Simons Foundation
www.simonsfoundation.org
October 14, 2025 at 3:47 PM
Great new postdoc fellowship for foundational plant research.
If you’re into genetics and genomics of plant reproductive evolution or adaptive convergence (incl in the cool and charismatic nightshades!) I’d be happy to talk about possible projects!
www.simonsfoundation.org/grant/simons...
If you’re into genetics and genomics of plant reproductive evolution or adaptive convergence (incl in the cool and charismatic nightshades!) I’d be happy to talk about possible projects!
www.simonsfoundation.org/grant/simons...
Reposted by Phil Ross
Thrilled to announce our new preprint, “Protein Hunter: Exploiting Structure Hallucination within Diffusion for Protein Design,” in collaboration with @Griffin, @GBhardwaj8 and @sokrypton.org
🧬Code and notebooks will be released by the end of this week.
🎧Golden- Kpop Demon Hunters
🧬Code and notebooks will be released by the end of this week.
🎧Golden- Kpop Demon Hunters
October 13, 2025 at 3:45 PM
Thrilled to announce our new preprint, “Protein Hunter: Exploiting Structure Hallucination within Diffusion for Protein Design,” in collaboration with @Griffin, @GBhardwaj8 and @sokrypton.org
🧬Code and notebooks will be released by the end of this week.
🎧Golden- Kpop Demon Hunters
🧬Code and notebooks will be released by the end of this week.
🎧Golden- Kpop Demon Hunters
Reposted by Phil Ross
Out First Release in @science.org this week:
The development of a directed evolution strategy with proof of concept in plant immune protein engineering.
www.science.org/doi/10.1126/...
The development of a directed evolution strategy with proof of concept in plant immune protein engineering.
www.science.org/doi/10.1126/...
Engineered geminivirus replicons enable rapid in planta directed evolution
Directed evolution can rapidly generate genetic variants with new and enhanced properties, yet efficient platforms for performing such evolution directly in plant cells have been lacking. We developed...
www.science.org
October 7, 2025 at 9:54 AM
Out First Release in @science.org this week:
The development of a directed evolution strategy with proof of concept in plant immune protein engineering.
www.science.org/doi/10.1126/...
The development of a directed evolution strategy with proof of concept in plant immune protein engineering.
www.science.org/doi/10.1126/...
Reposted by Phil Ross
Yesterday the president demanded that evidence about Covid vaccines be shown to the public. Today @apoorvanyt.bsky.social & I run through some of the studies made public over the past 4+ years that show that the vaccines work. Gift link: nyti.ms/46k17Tq
nyti.ms
September 2, 2025 at 9:21 PM
Yesterday the president demanded that evidence about Covid vaccines be shown to the public. Today @apoorvanyt.bsky.social & I run through some of the studies made public over the past 4+ years that show that the vaccines work. Gift link: nyti.ms/46k17Tq
I feel this open.substack.com/pub/experime...
Use this magic bullet to shoot yourself in the foot
OR: Borg vibes
open.substack.com
September 2, 2025 at 9:37 PM
I feel this open.substack.com/pub/experime...
Reposted by Phil Ross
Interested in doing a postdoc at DFCI/Harvard on computationally designing and experimentally characterizing mini-protein binders for biomedical applications? Eric Fischer and I are looking for someone to work in our groups starting asap! Email me or my admin with a CV to apply!
August 19, 2025 at 4:21 PM
Interested in doing a postdoc at DFCI/Harvard on computationally designing and experimentally characterizing mini-protein binders for biomedical applications? Eric Fischer and I are looking for someone to work in our groups starting asap! Email me or my admin with a CV to apply!
Reposted by Phil Ross
Introducing the 1,000 Flower Collection 🧬🌹
I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes.
Here’s how I’m making it happen… and how you can join me on this journey 🧵(1/7)
I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes.
Here’s how I’m making it happen… and how you can join me on this journey 🧵(1/7)
August 11, 2025 at 6:54 PM
Introducing the 1,000 Flower Collection 🧬🌹
I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes.
Here’s how I’m making it happen… and how you can join me on this journey 🧵(1/7)
I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes.
Here’s how I’m making it happen… and how you can join me on this journey 🧵(1/7)
Reposted by Phil Ross
Very excited to present the Great Barrier Reef Microbial Genomes Database (GBR-MGD), a comprehensive DB of 1000s of high-quality prokaryote, virus, plasmid, and chromosome-level eukaryote MAGs using Nanopore long reads. Subthreads incoming. Please share widely. 🙂
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The planktonic microbiome of the Great Barrier Reef
Large genome databases have markedly improved our understanding of marine microorganisms. Although these resources have focused on prokaryotes, genomes from many dominant marine lineages, such as Pela...
www.biorxiv.org
May 21, 2025 at 7:34 AM
Very excited to present the Great Barrier Reef Microbial Genomes Database (GBR-MGD), a comprehensive DB of 1000s of high-quality prokaryote, virus, plasmid, and chromosome-level eukaryote MAGs using Nanopore long reads. Subthreads incoming. Please share widely. 🙂
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Phil Ross
We are looking to hire (yes, even in this economy!) a jr. specialist to train in protein prep/structural biology related to our AVOID-ome work as part of openadmet.org.
A great position for someone who is looking to be a tech for a few years before grad or med school.
aprecruit.ucsf.edu/JPF05424
A great position for someone who is looking to be a tech for a few years before grad or med school.
aprecruit.ucsf.edu/JPF05424
Junior/Assistant/Associate/Full Specialist Positions Available
University of California, San Francisco is hiring. Apply now!
aprecruit.ucsf.edu
May 20, 2025 at 5:26 PM
We are looking to hire (yes, even in this economy!) a jr. specialist to train in protein prep/structural biology related to our AVOID-ome work as part of openadmet.org.
A great position for someone who is looking to be a tech for a few years before grad or med school.
aprecruit.ucsf.edu/JPF05424
A great position for someone who is looking to be a tech for a few years before grad or med school.
aprecruit.ucsf.edu/JPF05424
Definitely one of my favorite things to learn recently: sweet proteins!
And that companies like Oobli and Amai already exist
And that companies like Oobli and Amai already exist
May 12, 2025 at 3:53 AM
Definitely one of my favorite things to learn recently: sweet proteins!
And that companies like Oobli and Amai already exist
And that companies like Oobli and Amai already exist
I remember having a drunken argument with @boughter.bsky.social over whether you focus efforts on exploring the earth's oceans or space first and I feel somewhat validated by this 😅
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
How little we’ve seen: A visual coverage estimate of the deep seafloor
In decades of deep-sea exploration, humans have observed only 0.001% of the deep seafloor, leaving 66% of planet Earth unseen.
www.science.org
May 10, 2025 at 1:01 AM
I remember having a drunken argument with @boughter.bsky.social over whether you focus efforts on exploring the earth's oceans or space first and I feel somewhat validated by this 😅
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Always a good day when I find out a new sensory receptor structure has been published!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
The structure of human sweetness
A single taste receptor initiates our reactions to both sugars and artificial sweeteners,
triggering a signaling process that drives our intense attraction to sweet foods.
Single-particle cryo-EM reve...
www.cell.com
May 9, 2025 at 6:38 PM
Always a good day when I find out a new sensory receptor structure has been published!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Phil Ross
Super excited to share a new preprint from our lab on design of small-molecule binding proteins using neural networks! The paper has a bit of everything. A new graph neural network, new design algorithms, and experimental validation. www.biorxiv.org/content/10.1...
🧵🧪
🧵🧪
Zero-shot design of drug-binding proteins via neural selection-expansion
Computational design of molecular recognition remains challenging despite advances in deep learning. The design of proteins that bind to small molecules has been particularly difficult because it requ...
www.biorxiv.org
April 28, 2025 at 3:22 PM
Super excited to share a new preprint from our lab on design of small-molecule binding proteins using neural networks! The paper has a bit of everything. A new graph neural network, new design algorithms, and experimental validation. www.biorxiv.org/content/10.1...
🧵🧪
🧵🧪
Reposted by Phil Ross
On the ancestry and evolution of the extinct dire wolf 🐺 www.biorxiv.org/content/10.1... 🧬🖥️🧪
Sequencing data: www.ncbi.nlm.nih.gov/bioproject/P...
Sequencing data: www.ncbi.nlm.nih.gov/bioproject/P...
April 12, 2025 at 1:03 AM
On the ancestry and evolution of the extinct dire wolf 🐺 www.biorxiv.org/content/10.1... 🧬🖥️🧪
Sequencing data: www.ncbi.nlm.nih.gov/bioproject/P...
Sequencing data: www.ncbi.nlm.nih.gov/bioproject/P...
Reposted by Phil Ross
Some glimmers of hope (but mostly confusion) this morning.
I have heard that no intramural tenure track investigators were supposed to be on the termination list although some folks clearly got termination notices.
I am actively checking into this every way I can.
1/2
I have heard that no intramural tenure track investigators were supposed to be on the termination list although some folks clearly got termination notices.
I am actively checking into this every way I can.
1/2
a picture of a pikachu with the words " i still have hope " written below it
ALT: a picture of a pikachu with the words " i still have hope " written below it
media.tenor.com
February 16, 2025 at 12:44 PM
Some glimmers of hope (but mostly confusion) this morning.
I have heard that no intramural tenure track investigators were supposed to be on the termination list although some folks clearly got termination notices.
I am actively checking into this every way I can.
1/2
I have heard that no intramural tenure track investigators were supposed to be on the termination list although some folks clearly got termination notices.
I am actively checking into this every way I can.
1/2
Reposted by Phil Ross
Thanks to all of the NIHers and their friends who reached out to me. I am still here (DM me or Signal jeremymberg.78)
I still have a very incomplete picture but based on what I have been told, the damage to NIH and to many wonderful people who work(ed) there is/was impossible for me to imagine
1/n
I still have a very incomplete picture but based on what I have been told, the damage to NIH and to many wonderful people who work(ed) there is/was impossible for me to imagine
1/n
February 16, 2025 at 6:32 AM
Thanks to all of the NIHers and their friends who reached out to me. I am still here (DM me or Signal jeremymberg.78)
I still have a very incomplete picture but based on what I have been told, the damage to NIH and to many wonderful people who work(ed) there is/was impossible for me to imagine
1/n
I still have a very incomplete picture but based on what I have been told, the damage to NIH and to many wonderful people who work(ed) there is/was impossible for me to imagine
1/n
This feels not only pertinent to me personally, but also to the current happenings in the federal government. But I’m trying to figure out: is the current administration viewing the government as a strong or weak link problem?
www.experimental-history.com/p/repost-sci...
www.experimental-history.com/p/repost-sci...
REPOST: Science is a strong-link problem
OR: How to eat fewer asparagus beetles
www.experimental-history.com
February 6, 2025 at 4:58 PM
This feels not only pertinent to me personally, but also to the current happenings in the federal government. But I’m trying to figure out: is the current administration viewing the government as a strong or weak link problem?
www.experimental-history.com/p/repost-sci...
www.experimental-history.com/p/repost-sci...
Reposted by Phil Ross
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.
Please amplify. If you are also able to host fly strains, add your name as well.
Please amplify. If you are also able to host fly strains, add your name as well.
January 28, 2025 at 9:45 PM
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.
Please amplify. If you are also able to host fly strains, add your name as well.
Please amplify. If you are also able to host fly strains, add your name as well.
Reposted by Phil Ross
This, my dear
is the greatest challenge
to being alive.
To witness injustice in the world
and to not allow it to consume
our light.
Thich Nhat Hahn
is the greatest challenge
to being alive.
To witness injustice in the world
and to not allow it to consume
our light.
Thich Nhat Hahn
January 21, 2025 at 4:15 AM
This, my dear
is the greatest challenge
to being alive.
To witness injustice in the world
and to not allow it to consume
our light.
Thich Nhat Hahn
is the greatest challenge
to being alive.
To witness injustice in the world
and to not allow it to consume
our light.
Thich Nhat Hahn
Reposted by Phil Ross
"An Intuitive Primer on Effective Functional Genomics Study Design" - Check out @ygilad.bsky.social 's new text book!
a.co/d/1bpE1zV
a.co/d/1bpE1zV
a.co
January 19, 2025 at 7:53 AM
"An Intuitive Primer on Effective Functional Genomics Study Design" - Check out @ygilad.bsky.social 's new text book!
a.co/d/1bpE1zV
a.co/d/1bpE1zV
Reposted by Phil Ross
I’m just remembering when companies sued kids for millions of dollars for sharing a few songs online.
Now big business is saying they can’t stay in business without stealing everyone’s copyright.
Now big business is saying they can’t stay in business without stealing everyone’s copyright.
"Sorry, we can't make this technology that sucks and nobody wants and that uses enough power to blow up the moon unless we *also* steal people's shit to throw into our content woodchipper in order to produce mediocre digital particleboard out of the cumulative artbarf."
futurism.com/the-byte/ope...
futurism.com/the-byte/ope...
OpenAI Pleads That It Can’t Make Money Without Using Copyrighted Materials for Free
OpenAI is begging Parliament to allow it to use copyrighted works because it's "impossible" for the company to make money without them.
futurism.com
January 5, 2025 at 9:18 PM
I’m just remembering when companies sued kids for millions of dollars for sharing a few songs online.
Now big business is saying they can’t stay in business without stealing everyone’s copyright.
Now big business is saying they can’t stay in business without stealing everyone’s copyright.
Just rewatched this great talk by Andy Dunn and wish more people thought this way about entrepreneurs and leaders in general
Andy Dunn: Lessons from losing my mind
Neurodiversity and innovation often go hand in hand, but does that mean visionary entrepreneurs get a free pass to say and do anything they want? Bonobos founder and mental health advocate Andy Dunn s...
www.ted.com
January 4, 2025 at 6:35 PM
Just rewatched this great talk by Andy Dunn and wish more people thought this way about entrepreneurs and leaders in general
Thrilled to finally share a manuscript from PhD work @UChicagoBMB all about peptides, protein structures, MHCs, and KIRs, inspired by a cool evolutionary backstory. Fun project started with @chaaawie, who was actually the first to teach me how to purify proteins!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Molecular characterization of the archaic HLA-B*73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2
HLA class I alleles of archaic origin may have been retained in modern humans because they provide immunity against diseases to which archaic humans had evolved resistance. According to this model, ar...
www.biorxiv.org
December 20, 2024 at 6:26 PM
Thrilled to finally share a manuscript from PhD work @UChicagoBMB all about peptides, protein structures, MHCs, and KIRs, inspired by a cool evolutionary backstory. Fun project started with @chaaawie, who was actually the first to teach me how to purify proteins!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...