Disability studies has continually asked us to rethink the demands on our bodies and time by reminding us that not all humans are able to move and produce in line with these ever-mounting societal exp...

Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome is a disease of uncertain aetiology that affects up to 400,000 individuals in the UK. Exposure of cultured cells to the sera of people with ME has been proposed to cause phenotypic changes in these cells in vitro when compared to sera from healthy controls. ME serum factors causing these changes could inform the development of diagnostic tests. In this study, we performed a large-scale, pre-registered replication of an experiment from Fluge et al (2016) that reported an increase in maximal respiratory capacity in healthy myoblasts after treatment with serum from people with ME compared to serum from healthy controls. We replicated the original experiment with a larger sample size, using sera from 67 people with ME and 53 controls to treat healthy cultured myoblasts, and generated results from over 1,700 mitochondrial stress tests performed with a Seahorse Bioanalyser. We observed no significant differences between treatment with ME or healthy control sera for our primary outcome of interest, oxygen consumption rate at maximal respiratory capacity. Results from our study provide strong evidence against the hypothesis that ME blood factors differentially affect healthy myoblast mitochondrial phenotypes in vitro. ### Competing Interest Statement The authors have declared no competing interest. Action for ME, https://ror.org/0569v7v35, Clare Francis Research Fellowship

What Haben Girma and a longer lineage of Black advocates teach us about access

For more on Tuesday’s vote to end the partial government shutdown and the latest on the Justice Department’s release of the Epstein files, Geoff Bennett speaks with House Minority Leader Hakeem Jeffri...

Somewhat devastating news today from the CIA: One of CIA’s oldest and most recognizable intelligence publications, The World Factbook, has sunset. There's not even a hint as to why they …

A moderator at the r/aviation subreddit didn't look too kindly on a shot by astronaut Don Pettit, deeming it too "blurry" and taking it down.

Amazon.com : Amos Music Lollipop Candy, Audio Singing Lollipop, Individually Wrapped Natural Blueberry Flavor (1 Pack) : Grocery & Gourmet Food

YouTube video by Chicago Sun-Times

After a frightening pursuit by federal agents, suburban ICE observers say fear hasn’t stopped them from protecting their communities.

ICE bypassed the county medical examiner in favor of a military facility for the autopsy of a Nicaraguan man and won’t release a ruling to the public.