Pegah Poursharifi
@pegpoursharifi.bsky.social
Assistant Professor, Dept. of Biochemistry and Molecular Biology @dalhousie.bsky.social
Obesity, adipose tissue, immunometabolism, inflammation
https://sites.google.com/view/poursharifi-lab/
Obesity, adipose tissue, immunometabolism, inflammation
https://sites.google.com/view/poursharifi-lab/
Reposted by Pegah Poursharifi
Here the Prentki lab proposes that inhibition of monoacylglycerol (MAG) hydrolase α/β-hydrolase domain-containing 6 (ABHD6) in WAT is a therapeutic strategy for improving the health of adipose tissue #obesity www.sciencedirect.com/science/arti...
Suppression of adipocyte ABHD6 favors anti-inflammatory and adipogenic programs to preserve adipose tissue fitness in obesity
Some individuals exhibit metabolically healthy obesity, characterized by the expansion of white adipose tissue (WAT) without associated complications.…
www.sciencedirect.com
August 29, 2025 at 6:28 PM
Here the Prentki lab proposes that inhibition of monoacylglycerol (MAG) hydrolase α/β-hydrolase domain-containing 6 (ABHD6) in WAT is a therapeutic strategy for improving the health of adipose tissue #obesity www.sciencedirect.com/science/arti...
Reposted by Pegah Poursharifi
FINALLY! 🔥 See you all TOMORROW, Monday August 18th at 17:00 for early registration and cocktails. Download the full #AdiposeBiology Conference program here: adiposebiology.com/program
Get ready for #ABC2025 @kazaklab.bsky.social @beaudrj.bsky.social @sunglab.bsky.social
Get ready for #ABC2025 @kazaklab.bsky.social @beaudrj.bsky.social @sunglab.bsky.social
August 17, 2025 at 5:48 PM
FINALLY! 🔥 See you all TOMORROW, Monday August 18th at 17:00 for early registration and cocktails. Download the full #AdiposeBiology Conference program here: adiposebiology.com/program
Get ready for #ABC2025 @kazaklab.bsky.social @beaudrj.bsky.social @sunglab.bsky.social
Get ready for #ABC2025 @kazaklab.bsky.social @beaudrj.bsky.social @sunglab.bsky.social
Reposted by Pegah Poursharifi
We just learned about a 3rd dimension of how Covid can affect our arteries.
erictopol.substack.com/p/covid-and-...
erictopol.substack.com/p/covid-and-...
Covid and Our Arteries
A new study on acceleration of vascular aging adds to the body of evidence
erictopol.substack.com
August 18, 2025 at 10:07 PM
We just learned about a 3rd dimension of how Covid can affect our arteries.
erictopol.substack.com/p/covid-and-...
erictopol.substack.com/p/covid-and-...
Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ–producing lymphocytes | Science Immunology www.science.org/doi/10.1126/...
Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ–producing lymphocytes
Brown adipose tissue hosts a distinct population of Treg cells that preserves thermogenesis by controlling local interferon-γ production.
www.science.org
July 29, 2025 at 1:41 PM
Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ–producing lymphocytes | Science Immunology www.science.org/doi/10.1126/...
Excited to share our timely and comprehensive review published in Physiological Reviews, bringing together insights from multiple leading labs in metabolism: Marc Prentki and Murthy Madiraju, Shingo Kajimura, @denispblondin.bsky.social, and Christopher Nolan.
journals.physiology.org/doi/abs/10.1...
journals.physiology.org/doi/abs/10.1...
Glycerolipid Cycling in Thermogenesis, Energy Homeostasis and Signaling | Physiological Reviews | American Physiological Society
Mammals maintain body heat by adaptive energy expenditure through different organ specific mechanisms. The glycerolipid/free fatty acid cycle (glycerolipid cycle), encompassing triglyceride lipolysis ...
journals.physiology.org
June 10, 2025 at 3:02 PM
Excited to share our timely and comprehensive review published in Physiological Reviews, bringing together insights from multiple leading labs in metabolism: Marc Prentki and Murthy Madiraju, Shingo Kajimura, @denispblondin.bsky.social, and Christopher Nolan.
journals.physiology.org/doi/abs/10.1...
journals.physiology.org/doi/abs/10.1...
Reposted by Pegah Poursharifi
I've been doing this for 30 years & I still can't believe that when people ask me what I do for a living I get to tell them "I'm a scientist". It feels like a kid's fantasy career that they dress up as for Halloween, like "astronaut" or "pirate". I feel very lucky I get to do this day in & day out.
April 4, 2025 at 1:29 PM
I've been doing this for 30 years & I still can't believe that when people ask me what I do for a living I get to tell them "I'm a scientist". It feels like a kid's fantasy career that they dress up as for Halloween, like "astronaut" or "pirate". I feel very lucky I get to do this day in & day out.
Reposted by Pegah Poursharifi
Today in @naturecomms.bsky.social we show the #FutileCreatineCycle plays a key role in #thermogenesis, independent of UCP1. We also challenge the belief that brown adipocytes lack enough ATP synthase for thermogenesis. Congrats to Jakub Bunk! @mcgillgci.bsky.social
Full paper: rdcu.be/egoV7
Full paper: rdcu.be/egoV7
The Futile Creatine Cycle powers UCP1-independent thermogenesis in classical BAT
Nature Communications - Thermogenesis by brown adipose tissue has long been thought to be solely controlled by uncoupling protein 1 (UCP1). Here, the authors show that energy expenditure in brown...
rdcu.be
April 4, 2025 at 3:04 PM
Today in @naturecomms.bsky.social we show the #FutileCreatineCycle plays a key role in #thermogenesis, independent of UCP1. We also challenge the belief that brown adipocytes lack enough ATP synthase for thermogenesis. Congrats to Jakub Bunk! @mcgillgci.bsky.social
Full paper: rdcu.be/egoV7
Full paper: rdcu.be/egoV7
Reposted by Pegah Poursharifi
For Canadian cancer researchers concerned about travelling to the US (🙋🏼♂️), please check out and plan to be at the Canadian Cancer Research Conference in Calgary this November. All welcome. www.ccra-acrc.ca/conference/
Conference - CCRA
www.ccra-acrc.ca
April 3, 2025 at 9:48 PM
For Canadian cancer researchers concerned about travelling to the US (🙋🏼♂️), please check out and plan to be at the Canadian Cancer Research Conference in Calgary this November. All welcome. www.ccra-acrc.ca/conference/
Reposted by Pegah Poursharifi
1 day left to apply!
We're looking for postdoctoral scholars to join our team in Vancouver 🇨🇦. We work on cell-based approaches aimed at curing type 1 diabetes. Bring your own ideas for projects or work on one that's already funded! More details here: www.nature.com/naturecareer...
Postdoctoral Research Fellow - Vancouver, British Columbia (CA) job with University of British Columbia Department of Surgery | 12837375
The successful candidate will work on a project developing cell-based therapies for those living with type 1 diabetes (T1D).
www.nature.com
April 4, 2025 at 2:42 AM
1 day left to apply!
Reposted by Pegah Poursharifi
Check out our First Person Language Guide: Addressing Weight Bias.
This guide aims to support the development of non-stigmatising research, project outputs and other communications. Thank you @xramossalas!
Download here: easo.org/person-first...
This guide aims to support the development of non-stigmatising research, project outputs and other communications. Thank you @xramossalas!
Download here: easo.org/person-first...
April 3, 2025 at 4:30 PM
Check out our First Person Language Guide: Addressing Weight Bias.
This guide aims to support the development of non-stigmatising research, project outputs and other communications. Thank you @xramossalas!
Download here: easo.org/person-first...
This guide aims to support the development of non-stigmatising research, project outputs and other communications. Thank you @xramossalas!
Download here: easo.org/person-first...
Reposted by Pegah Poursharifi
Spilling the skinny on fat cells!
@razanilab.bsky.social & team discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/UPFJ5sO
@razanilab.bsky.social & team discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/UPFJ5sO
March 31, 2025 at 1:20 PM
Spilling the skinny on fat cells!
@razanilab.bsky.social & team discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/UPFJ5sO
@razanilab.bsky.social & team discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/UPFJ5sO
Reposted by Pegah Poursharifi
Interested in studying cancer metabolism, recurrence & translational application of machine learning 4 biomarker discovery? NSERC has new programs. Got a MSc, apply for PhD positions in the Marignani Lab, Sept 2025 admissions. www.nserc-crsng.gc.ca/NewsDetail-D...
March 16, 2025 at 12:34 AM
Interested in studying cancer metabolism, recurrence & translational application of machine learning 4 biomarker discovery? NSERC has new programs. Got a MSc, apply for PhD positions in the Marignani Lab, Sept 2025 admissions. www.nserc-crsng.gc.ca/NewsDetail-D...
Reposted by Pegah Poursharifi
Looking forward to welcoming colleagues and friends to the Boston-Ithaca Islet Club meeting hosted this year at the CRCHUM in Montreal, 5,6 April. There's still time to register (closing April 4 th)! www.bostonithacaisletclub.com/32nd-meeting-1.
General 1 — Boston Ithaca Islet Club / BIIC
www.bostonithacaisletclub.com
March 29, 2025 at 7:33 PM
Looking forward to welcoming colleagues and friends to the Boston-Ithaca Islet Club meeting hosted this year at the CRCHUM in Montreal, 5,6 April. There's still time to register (closing April 4 th)! www.bostonithacaisletclub.com/32nd-meeting-1.
Reposted by Pegah Poursharifi
After ~8 years, happy to share work done w/
@natelewis3.bsky.social showing you can eliminate the Warburg effect in mammalian cells w/out impacting growth rate is out now in @natmetabolism.bsky.social!
www.nature.com/articles/s42...
#science #biotech #cancermetabolism
Thread below:
@natelewis3.bsky.social showing you can eliminate the Warburg effect in mammalian cells w/out impacting growth rate is out now in @natmetabolism.bsky.social!
www.nature.com/articles/s42...
#science #biotech #cancermetabolism
Thread below:
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells - Nature Metabolism
Hefzi et al. engineer cells to nearly eliminate lactate production and increase mitochondrial use of pyruvate by deleting both lactate dehydrogenases and pyruvate dehydrogenase kinases with the goal o...
www.nature.com
January 20, 2025 at 9:41 AM
After ~8 years, happy to share work done w/
@natelewis3.bsky.social showing you can eliminate the Warburg effect in mammalian cells w/out impacting growth rate is out now in @natmetabolism.bsky.social!
www.nature.com/articles/s42...
#science #biotech #cancermetabolism
Thread below:
@natelewis3.bsky.social showing you can eliminate the Warburg effect in mammalian cells w/out impacting growth rate is out now in @natmetabolism.bsky.social!
www.nature.com/articles/s42...
#science #biotech #cancermetabolism
Thread below:
Reposted by Pegah Poursharifi
💫NEW: Li & co report a central role for #AMPK in regulating aldolase B-mediated glycerol synthesis and excretion under hypoxia as a mechanism to balance the trade-off between reductive and energy stress during #tumor growth.
👉🏿https://rdcu.be/d8apH
www.nature.com/articles/s41...
👉🏿https://rdcu.be/d8apH
www.nature.com/articles/s41...
AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress - Nature Cell Biology
Zhai, Yang et al. report a central role for AMPK in regulating aldolase B-mediated glycerol synthesis and excretion under hypoxia as a mechanism to balance the trade-off between reductive and energy s...
www.nature.com
January 31, 2025 at 1:27 PM
💫NEW: Li & co report a central role for #AMPK in regulating aldolase B-mediated glycerol synthesis and excretion under hypoxia as a mechanism to balance the trade-off between reductive and energy stress during #tumor growth.
👉🏿https://rdcu.be/d8apH
www.nature.com/articles/s41...
👉🏿https://rdcu.be/d8apH
www.nature.com/articles/s41...
Reposted by Pegah Poursharifi
Very excited to announce that the single cell/nuc. RNA/ATAC/multi-ome resource from ENCODE4 is now officially public. This includes raw data, processed data, annotations and pseudobulk products. Covers many human & mouse tissues. 1/
www.encodeproject.org/single-cell/...
www.encodeproject.org/single-cell/...
Single cell – ENCODEHomo sapiens clickable body map
www.encodeproject.org
January 7, 2025 at 9:29 PM
Very excited to announce that the single cell/nuc. RNA/ATAC/multi-ome resource from ENCODE4 is now officially public. This includes raw data, processed data, annotations and pseudobulk products. Covers many human & mouse tissues. 1/
www.encodeproject.org/single-cell/...
www.encodeproject.org/single-cell/...
Reposted by Pegah Poursharifi
Happy New Year, everyone, and welcome to UdeM's first Bluesky account in English! (Our French one, @umontreal.ca , launched a month ago.) 🎓✨ If you're part of our community – or just want to learn more about what we do and what research we're engaged in – subscribe, share and say hello! #umontreal
January 7, 2025 at 4:29 PM
Happy New Year, everyone, and welcome to UdeM's first Bluesky account in English! (Our French one, @umontreal.ca , launched a month ago.) 🎓✨ If you're part of our community – or just want to learn more about what we do and what research we're engaged in – subscribe, share and say hello! #umontreal
Reposted by Pegah Poursharifi
It is finally here! Check out our website www.adiposebiology.com/registration with @kazaklab.bsky.social & @twinsdad0603.bsky.social, partnered with Sable Systems! See the speaker list, venue info, preliminary program, and registration deadlines.
📍Montreal, Canada
📅Aug 19-20, 2025
#adiposebiology
📍Montreal, Canada
📅Aug 19-20, 2025
#adiposebiology
January 1, 2025 at 6:33 PM
It is finally here! Check out our website www.adiposebiology.com/registration with @kazaklab.bsky.social & @twinsdad0603.bsky.social, partnered with Sable Systems! See the speaker list, venue info, preliminary program, and registration deadlines.
📍Montreal, Canada
📅Aug 19-20, 2025
#adiposebiology
📍Montreal, Canada
📅Aug 19-20, 2025
#adiposebiology
Reposted by Pegah Poursharifi
Early bird Registration is now open for the inaugural
Adipose Biology Conference: www.adiposebiology.com/registration
Amazing speakers. We have many slots for short talks from trainees and ECRs.
📍Montreal, Canada
📅Aug 19-20, 2025
#adiposebiology #adiposebiology2025
@sablesys.bsky.social
Adipose Biology Conference: www.adiposebiology.com/registration
Amazing speakers. We have many slots for short talks from trainees and ECRs.
📍Montreal, Canada
📅Aug 19-20, 2025
#adiposebiology #adiposebiology2025
@sablesys.bsky.social
Registration | Adipose Biology
www.adiposebiology.com
January 2, 2025 at 2:08 PM
Early bird Registration is now open for the inaugural
Adipose Biology Conference: www.adiposebiology.com/registration
Amazing speakers. We have many slots for short talks from trainees and ECRs.
📍Montreal, Canada
📅Aug 19-20, 2025
#adiposebiology #adiposebiology2025
@sablesys.bsky.social
Adipose Biology Conference: www.adiposebiology.com/registration
Amazing speakers. We have many slots for short talks from trainees and ECRs.
📍Montreal, Canada
📅Aug 19-20, 2025
#adiposebiology #adiposebiology2025
@sablesys.bsky.social
Reposted by Pegah Poursharifi
"The academic structure … makes planning for a family feel like an impossible luxury."
In this #ScienceWorkingLife, two postdocs share how, as women in academia, having children can feel impossible—and how talking about it makes them feel less alone. scim.ag/49BKZgp
In this #ScienceWorkingLife, two postdocs share how, as women in academia, having children can feel impossible—and how talking about it makes them feel less alone. scim.ag/49BKZgp
December 16, 2024 at 5:25 PM
"The academic structure … makes planning for a family feel like an impossible luxury."
In this #ScienceWorkingLife, two postdocs share how, as women in academia, having children can feel impossible—and how talking about it makes them feel less alone. scim.ag/49BKZgp
In this #ScienceWorkingLife, two postdocs share how, as women in academia, having children can feel impossible—and how talking about it makes them feel less alone. scim.ag/49BKZgp
@cellreports.bsky.social being artistic with the fabulous fat cells 🤩👏
November 28, 2024 at 12:20 PM
@cellreports.bsky.social being artistic with the fabulous fat cells 🤩👏