Paola A. Marignani
@pmarignani.bsky.social
Scientist & Professor.
MarignaniLab.com
Precision Oncology/Model Systems/Signal Transduction/Single Cell Transcriptomics/AI/sometimes athlete.
Creative Destruction Lab (CDL) Scientist/Business Strategist
ORCID: 0000-0001-8070-905X
MarignaniLab.com
Precision Oncology/Model Systems/Signal Transduction/Single Cell Transcriptomics/AI/sometimes athlete.
Creative Destruction Lab (CDL) Scientist/Business Strategist
ORCID: 0000-0001-8070-905X
Reposted by Paola A. Marignani
Reposted by Paola A. Marignani
Devastated to learn of the passing of Dr. Kirsty Duncan. She was a brilliant scientist, a fierce advocate for safe sport, and a truly kind person.
Canada has lost a real champion for #STEM. Our hearts goes out to her family and loved ones. What a tremendous loss. #KirstyDuncan #CdnPoli
Canada has lost a real champion for #STEM. Our hearts goes out to her family and loved ones. What a tremendous loss. #KirstyDuncan #CdnPoli
January 27, 2026 at 2:25 AM
Devastated to learn of the passing of Dr. Kirsty Duncan. She was a brilliant scientist, a fierce advocate for safe sport, and a truly kind person.
Canada has lost a real champion for #STEM. Our hearts goes out to her family and loved ones. What a tremendous loss. #KirstyDuncan #CdnPoli
Canada has lost a real champion for #STEM. Our hearts goes out to her family and loved ones. What a tremendous loss. #KirstyDuncan #CdnPoli
Deeply saddened 2 hear about the passing of Dr. Kirsty Duncan. She was much more than a politician. A brilliant scientist, a fierce advocate for scientists & safe sport. 🇨🇦 has lost a champion for science & public service. My heart goes out to her family. What a tremendous loss.#KirstyDuncan #CdnPoli
January 27, 2026 at 2:23 AM
Deeply saddened 2 hear about the passing of Dr. Kirsty Duncan. She was much more than a politician. A brilliant scientist, a fierce advocate for scientists & safe sport. 🇨🇦 has lost a champion for science & public service. My heart goes out to her family. What a tremendous loss.#KirstyDuncan #CdnPoli
6 flight cancellations, 4 delays, 2 train delays, somewhere over Ontario? Quebec? Nova Scotia? Hard to distinguish after multiple snow storms.
Winter travel is always an exercise in logistics, patience and hoping the snow lets up for at least 12 hours.
Winter travel is always an exercise in logistics, patience and hoping the snow lets up for at least 12 hours.
January 19, 2026 at 5:17 PM
6 flight cancellations, 4 delays, 2 train delays, somewhere over Ontario? Quebec? Nova Scotia? Hard to distinguish after multiple snow storms.
Winter travel is always an exercise in logistics, patience and hoping the snow lets up for at least 12 hours.
Winter travel is always an exercise in logistics, patience and hoping the snow lets up for at least 12 hours.
❄️☕👩🏻💻 One of many mantras I have.
Art and Science are one in the same. New omics- Arteomics.
The Leonardo da Vinci DNA Project (LDVP), may have identified his 🧬 on a red chalk drawing, the “Holy Child” (dated to ~1472-1476).
Go Science 👏🏻
www.biorxiv.org/content/10.6...
Art and Science are one in the same. New omics- Arteomics.
The Leonardo da Vinci DNA Project (LDVP), may have identified his 🧬 on a red chalk drawing, the “Holy Child” (dated to ~1472-1476).
Go Science 👏🏻
www.biorxiv.org/content/10.6...
www.biorxiv.org
January 14, 2026 at 10:53 AM
❄️☕👩🏻💻 One of many mantras I have.
Art and Science are one in the same. New omics- Arteomics.
The Leonardo da Vinci DNA Project (LDVP), may have identified his 🧬 on a red chalk drawing, the “Holy Child” (dated to ~1472-1476).
Go Science 👏🏻
www.biorxiv.org/content/10.6...
Art and Science are one in the same. New omics- Arteomics.
The Leonardo da Vinci DNA Project (LDVP), may have identified his 🧬 on a red chalk drawing, the “Holy Child” (dated to ~1472-1476).
Go Science 👏🏻
www.biorxiv.org/content/10.6...
❄️☕👩🏻💻 ALK TKIs
@uhnresearch.ca
Weight, BSA, Toxicity, and Efficacy of Tyrosine Kinase Inhibitors for ALK-Mutated NSCLC www.jtocrr.org/article/S266...
@uhnresearch.ca
Weight, BSA, Toxicity, and Efficacy of Tyrosine Kinase Inhibitors for ALK-Mutated NSCLC www.jtocrr.org/article/S266...
Weight, BSA, Toxicity, and Efficacy of Tyrosine Kinase Inhibitors for ALK-Mutated NSCLC
ALK tyrosine kinase inhibitors (ALK TKIs) are started at a standard dose regardless
of patients’ weight and body surface area (BSA). In this retrospective analysis, the
authors explored whether body s...
www.jtocrr.org
January 13, 2026 at 9:12 AM
❄️☕👩🏻💻 ALK TKIs
@uhnresearch.ca
Weight, BSA, Toxicity, and Efficacy of Tyrosine Kinase Inhibitors for ALK-Mutated NSCLC www.jtocrr.org/article/S266...
@uhnresearch.ca
Weight, BSA, Toxicity, and Efficacy of Tyrosine Kinase Inhibitors for ALK-Mutated NSCLC www.jtocrr.org/article/S266...
🌞☕☕☕👩🏻💻👩🏻💻👩🏻💻
Single-cell atlas of >6.5M peripheral blood mononuclear cells from 1,047 patients & 19 diseases. Atlas expands current knowledge of the biology of inflammation of immune-mediated diseases, acute and chronic inflammatory diseases, infections & solid tumors.
www.nature.com/articles/s41...
Single-cell atlas of >6.5M peripheral blood mononuclear cells from 1,047 patients & 19 diseases. Atlas expands current knowledge of the biology of inflammation of immune-mediated diseases, acute and chronic inflammatory diseases, infections & solid tumors.
www.nature.com/articles/s41...
Client Challenge
www.nature.com
January 12, 2026 at 12:02 PM
🌞☕☕☕👩🏻💻👩🏻💻👩🏻💻
Single-cell atlas of >6.5M peripheral blood mononuclear cells from 1,047 patients & 19 diseases. Atlas expands current knowledge of the biology of inflammation of immune-mediated diseases, acute and chronic inflammatory diseases, infections & solid tumors.
www.nature.com/articles/s41...
Single-cell atlas of >6.5M peripheral blood mononuclear cells from 1,047 patients & 19 diseases. Atlas expands current knowledge of the biology of inflammation of immune-mediated diseases, acute and chronic inflammatory diseases, infections & solid tumors.
www.nature.com/articles/s41...
❄️☕👩🏻💻 Tribute to Dr. Frank Beier (1965–2025) www.oarsijournal.com/article/S106...
He was a champion of EDIA, leading meaningful policy changes & supporting opps 4 equity-deserving groups. Western has established an award in his name to support underrepresented students entering basic science research
He was a champion of EDIA, leading meaningful policy changes & supporting opps 4 equity-deserving groups. Western has established an award in his name to support underrepresented students entering basic science research
Tribute to Dr. Frank Beier (1965–2025)
The osteoarthritis and skeletal biology community lost one of its most influential
and beloved members with the passing of Dr. Frank Beier on July 18, 2025. Frank’s
life was a remarkable blend of scie...
www.oarsijournal.com
January 12, 2026 at 10:46 AM
❄️☕👩🏻💻 Tribute to Dr. Frank Beier (1965–2025) www.oarsijournal.com/article/S106...
He was a champion of EDIA, leading meaningful policy changes & supporting opps 4 equity-deserving groups. Western has established an award in his name to support underrepresented students entering basic science research
He was a champion of EDIA, leading meaningful policy changes & supporting opps 4 equity-deserving groups. Western has established an award in his name to support underrepresented students entering basic science research
❄️☕👩🏻💻
Spatial regulation of AMPK activity under oxidative stress requires LKB1 share.google/CSTUtCayCNF9...
Spatial regulation of AMPK activity under oxidative stress requires LKB1 share.google/CSTUtCayCNF9...
share.google
January 8, 2026 at 9:25 AM
❄️☕👩🏻💻
Spatial regulation of AMPK activity under oxidative stress requires LKB1 share.google/CSTUtCayCNF9...
Spatial regulation of AMPK activity under oxidative stress requires LKB1 share.google/CSTUtCayCNF9...
I appreciate your frustration. The delays U highlight also impact mid- & senior-career investigators. Further 2 this, discovery pipelines R stalled, funding decisions R delayed, & translation 2 translational output is impacted.
For 2026, can we pull the plug on stalling dissemination of science.
For 2026, can we pull the plug on stalling dissemination of science.
Chia-Hsuan Hsu waited 18 months before chasing an editor for a decision on a paper
go.nature.com/4j47KhM
go.nature.com/4j47KhM
Dear editors, your publication delays are damaging our careers
Chia-Hsuan Hsu waited 18 months before chasing an editor for a decision on a paper. The answer surprised him.
go.nature.com
January 1, 2026 at 8:23 PM
I appreciate your frustration. The delays U highlight also impact mid- & senior-career investigators. Further 2 this, discovery pipelines R stalled, funding decisions R delayed, & translation 2 translational output is impacted.
For 2026, can we pull the plug on stalling dissemination of science.
For 2026, can we pull the plug on stalling dissemination of science.
What starts off as a simple PEI potato, ends up as an exquisite gnocchi meal.
January 1, 2026 at 5:45 PM
What starts off as a simple PEI potato, ends up as an exquisite gnocchi meal.
All the very best for 2026.
Good health, good friendships and good science.
Good health, good friendships and good science.
January 1, 2026 at 1:08 PM
All the very best for 2026.
Good health, good friendships and good science.
Good health, good friendships and good science.
❄️☕👩🏻💻
Metabolic rebound after GLP-1 receptor agonist discontinuation: a systematic review and meta-analysis www.thelancet.com/journals/ecl...
Metabolic rebound after GLP-1 receptor agonist discontinuation: a systematic review and meta-analysis www.thelancet.com/journals/ecl...
Metabolic rebound after GLP-1 receptor agonist discontinuation: a systematic review and meta-analysis
The magnitude and consistency of these effects underscore the physiological consequences
of GLP-1RA discontinuation. As the clinical use of GLP-1RAs continues to grow in the
management of obesity and ...
www.thelancet.com
December 26, 2025 at 3:57 PM
❄️☕👩🏻💻
Metabolic rebound after GLP-1 receptor agonist discontinuation: a systematic review and meta-analysis www.thelancet.com/journals/ecl...
Metabolic rebound after GLP-1 receptor agonist discontinuation: a systematic review and meta-analysis www.thelancet.com/journals/ecl...
Reposted by Paola A. Marignani
As Christmas & the holidays near, I want 2 thank U all 4 supporting my research programs & team throughout 2025. I want 2 wish U a wonderful holiday season. Optimistic that 2026 will bring good health, good friendships & good science.
#BuonNatale #MerryChristmas #JoyeuxNoël #GodJul #HappyHolidays
#BuonNatale #MerryChristmas #JoyeuxNoël #GodJul #HappyHolidays
December 23, 2025 at 12:55 PM
As Christmas & the holidays near, I want 2 thank U all 4 supporting my research programs & team throughout 2025. I want 2 wish U a wonderful holiday season. Optimistic that 2026 will bring good health, good friendships & good science.
#BuonNatale #MerryChristmas #JoyeuxNoël #GodJul #HappyHolidays
#BuonNatale #MerryChristmas #JoyeuxNoël #GodJul #HappyHolidays
....now to marinate for the next 4 days.
Insalata di mare a la Ascolana.
Insalata di mare a la Ascolana.
December 20, 2025 at 11:13 PM
....now to marinate for the next 4 days.
Insalata di mare a la Ascolana.
Insalata di mare a la Ascolana.
🌨️☕👩🏻💻 Well, this is interesting.
Atlas Eon 100, the world's first scalable DNA data storage.
www.tomshardware.com/pc-component...
Atlas Eon 100, the world's first scalable DNA data storage.
www.tomshardware.com/pc-component...
'World's first scalable DNA data storage offering' announced offering a staggering ‘60PB in 60 cubic inches,’ enough to hold 660,000 4K movies — Atlas Data storage claims its solution is 1000x denser ...
The company’s first product, the Atlas Eon 100 scalable DNA data storage service, has been announced.
www.tomshardware.com
December 16, 2025 at 9:32 AM
🌨️☕👩🏻💻 Well, this is interesting.
Atlas Eon 100, the world's first scalable DNA data storage.
www.tomshardware.com/pc-component...
Atlas Eon 100, the world's first scalable DNA data storage.
www.tomshardware.com/pc-component...
Check out my new Colleague's labsite. @pegpoursharifi.bsky.social
Recruiting students, grad students, Fellows and technicians.
#ScienceIsFun
@dalhousieu.bsky.social
@cdnwomenstem.bsky.social
sites.google.com/view/poursha...
Recruiting students, grad students, Fellows and technicians.
#ScienceIsFun
@dalhousieu.bsky.social
@cdnwomenstem.bsky.social
sites.google.com/view/poursha...
Poursharifi Lab
Poursharifi Lab
Adipose tissue, Immunity & Metabolism
Department of Biochemistry & Molecular Biology
Faculty of Medicine Dalhousie University
sites.google.com
December 15, 2025 at 7:38 PM
Check out my new Colleague's labsite. @pegpoursharifi.bsky.social
Recruiting students, grad students, Fellows and technicians.
#ScienceIsFun
@dalhousieu.bsky.social
@cdnwomenstem.bsky.social
sites.google.com/view/poursha...
Recruiting students, grad students, Fellows and technicians.
#ScienceIsFun
@dalhousieu.bsky.social
@cdnwomenstem.bsky.social
sites.google.com/view/poursha...
Early morning walkabout. #PeggysCove #getfreshair
December 7, 2025 at 12:54 PM
Early morning walkabout. #PeggysCove #getfreshair
The 14 women who were murdered for studying #stEm:
Geneviève Bergeron,Hélène Colgan,Nathalie Croteau,Barbara Daigneault,Anne-Marie Edward,Maud Haviernick,Maryse Laganière,Maryse Leclair,Anne-Marie Lemay,Sonia Pelletier,Michèle Richard,Annie St-Arneault,Annie Turcotte,Barbara Klucznik-Widajewicz
Geneviève Bergeron,Hélène Colgan,Nathalie Croteau,Barbara Daigneault,Anne-Marie Edward,Maud Haviernick,Maryse Laganière,Maryse Leclair,Anne-Marie Lemay,Sonia Pelletier,Michèle Richard,Annie St-Arneault,Annie Turcotte,Barbara Klucznik-Widajewicz
Today, we remember the 14 young women whose lives were tragically cut short on December 6, 1989, at École Polytechnique in Montreal.
On this National Day of Remembrance and Action on Violence Against Women, we honour their memory. #MontrealMassacre #NeverForget #EndViolenceAgainstWomen
On this National Day of Remembrance and Action on Violence Against Women, we honour their memory. #MontrealMassacre #NeverForget #EndViolenceAgainstWomen
December 7, 2025 at 12:43 PM
The 14 women who were murdered for studying #stEm:
Geneviève Bergeron,Hélène Colgan,Nathalie Croteau,Barbara Daigneault,Anne-Marie Edward,Maud Haviernick,Maryse Laganière,Maryse Leclair,Anne-Marie Lemay,Sonia Pelletier,Michèle Richard,Annie St-Arneault,Annie Turcotte,Barbara Klucznik-Widajewicz
Geneviève Bergeron,Hélène Colgan,Nathalie Croteau,Barbara Daigneault,Anne-Marie Edward,Maud Haviernick,Maryse Laganière,Maryse Leclair,Anne-Marie Lemay,Sonia Pelletier,Michèle Richard,Annie St-Arneault,Annie Turcotte,Barbara Klucznik-Widajewicz
Ooooo. The algorithm read my mind! Polishing the gear!
Fernie, BC 2003
Marignani #Sisters.
#SnowBoarding
#FernieBC
Fernie, BC 2003
Marignani #Sisters.
#SnowBoarding
#FernieBC
December 4, 2025 at 1:28 AM
Ooooo. The algorithm read my mind! Polishing the gear!
Fernie, BC 2003
Marignani #Sisters.
#SnowBoarding
#FernieBC
Fernie, BC 2003
Marignani #Sisters.
#SnowBoarding
#FernieBC
Reposted by Paola A. Marignani
www.frontiersin.org/journals/cel...
Review: "The Tumor Suppressor Kinase LKB1: Metabolic Nexus"
LKB1 loss is associated with multiple malignancies and causes metabolic reprograming to increase glycolysis and lactate production, elevate hexosamine biosynthesis and glutamine metabolism.
Review: "The Tumor Suppressor Kinase LKB1: Metabolic Nexus"
LKB1 loss is associated with multiple malignancies and causes metabolic reprograming to increase glycolysis and lactate production, elevate hexosamine biosynthesis and glutamine metabolism.
November 25, 2025 at 1:26 AM
www.frontiersin.org/journals/cel...
Review: "The Tumor Suppressor Kinase LKB1: Metabolic Nexus"
LKB1 loss is associated with multiple malignancies and causes metabolic reprograming to increase glycolysis and lactate production, elevate hexosamine biosynthesis and glutamine metabolism.
Review: "The Tumor Suppressor Kinase LKB1: Metabolic Nexus"
LKB1 loss is associated with multiple malignancies and causes metabolic reprograming to increase glycolysis and lactate production, elevate hexosamine biosynthesis and glutamine metabolism.
Emma presenting her Honours project fall report.
👏🏻👏🏻👏🏻👏🏻
👏🏻👏🏻👏🏻👏🏻
November 21, 2025 at 7:37 PM
Emma presenting her Honours project fall report.
👏🏻👏🏻👏🏻👏🏻
👏🏻👏🏻👏🏻👏🏻