Gradwohl Gérard
@pancint.bsky.social
Our work characterizing enteroendocrine cell (EEC) differentiation trajectories and the underlying GRNs in pluripotent stem cell-derived human intestinal organoids has been published today in @biologyopen.bsky.social. Thanks to all.
doi.org/10.1242/bio....
#organoids; #EEC; #Enteroendocrine cells
doi.org/10.1242/bio....
#organoids; #EEC; #Enteroendocrine cells
October 21, 2025 at 12:13 PM
Our work characterizing enteroendocrine cell (EEC) differentiation trajectories and the underlying GRNs in pluripotent stem cell-derived human intestinal organoids has been published today in @biologyopen.bsky.social. Thanks to all.
doi.org/10.1242/bio....
#organoids; #EEC; #Enteroendocrine cells
doi.org/10.1242/bio....
#organoids; #EEC; #Enteroendocrine cells
Symposium to Celebrate the career of Francois Guillemot at @ the Francis Crick Institute in London. Thanks for all Francois. Was great to catch up with all the friends.
May 31, 2025 at 11:08 AM
Symposium to Celebrate the career of Francois Guillemot at @ the Francis Crick Institute in London. Thanks for all Francois. Was great to catch up with all the friends.
Reposted by Gradwohl Gérard
Only one week left! We’ve already received many exciting applications and are expecting more. Maybe yours!
🚨3 weeks left to apply!🚨
We’re hiring 2 new Group Leaders at IGBMC – early career researchers welcome
🌟 We offer salary support for up to 3 years while you secure a permanent position in the French system.
Come join an international research environment in Strasbourg!
www.nature.com/naturecareer...
We’re hiring 2 new Group Leaders at IGBMC – early career researchers welcome
🌟 We offer salary support for up to 3 years while you secure a permanent position in the French system.
Come join an international research environment in Strasbourg!
www.nature.com/naturecareer...
Call For Two Group Leader Positions - Strasbourg-Ville, Bas-Rhin (FR) job with IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) | 12837602
The Institute of Genetics, Molecular and Cellular Biology (IGBMC) is seeking two outstanding group leaders to establish independent research teams.
www.nature.com
April 28, 2025 at 7:27 AM
Only one week left! We’ve already received many exciting applications and are expecting more. Maybe yours!
2/2 m
- Most EEC cells are specified during development through similar differentiation trajectories as observed in the adult intestine.
- Crypt-villus organization is not essential for EEC formation.
- Novel GRNs are identified governing human EEC differentiation in human intestinal organoids.
- Most EEC cells are specified during development through similar differentiation trajectories as observed in the adult intestine.
- Crypt-villus organization is not essential for EEC formation.
- Novel GRNs are identified governing human EEC differentiation in human intestinal organoids.
April 17, 2025 at 12:38 PM
2/2 m
- Most EEC cells are specified during development through similar differentiation trajectories as observed in the adult intestine.
- Crypt-villus organization is not essential for EEC formation.
- Novel GRNs are identified governing human EEC differentiation in human intestinal organoids.
- Most EEC cells are specified during development through similar differentiation trajectories as observed in the adult intestine.
- Crypt-villus organization is not essential for EEC formation.
- Novel GRNs are identified governing human EEC differentiation in human intestinal organoids.
1/2. I am pleased to announce that the preprint of our latest study characterizing mouse and human EEC development is now on BioRxiv. A great collaboration with the @molinalab.bsky.social and Maxime Mahe (not on bluesky)
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Unraveling Enteroendocrine Cell lineage dynamics and associated gene regulatory networks during intestinal development
Enteroendocrine cells (EECs) are rare intestinal epithelial cells producing multiple hormones that regulate essential aspects of digestion and energy. EEC subtypes, their hormone repertoire and differ...
www.biorxiv.org
April 17, 2025 at 12:34 PM
1/2. I am pleased to announce that the preprint of our latest study characterizing mouse and human EEC development is now on BioRxiv. A great collaboration with the @molinalab.bsky.social and Maxime Mahe (not on bluesky)
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Gradwohl Gérard
We are hiring PhD students! Interested in #ComputationalBiology and #MachineLearning? Join our lab at the @IGBMC! #PhDposition https://euraxess.ec.europa.eu/site/search?text=Nacho+Molina+IGBMC&antibot_key=f6b99bce6cc751c6716e2f0b89773e15
December 6, 2024 at 5:06 PM
We are hiring PhD students! Interested in #ComputationalBiology and #MachineLearning? Join our lab at the @IGBMC! #PhDposition https://euraxess.ec.europa.eu/site/search?text=Nacho+Molina+IGBMC&antibot_key=f6b99bce6cc751c6716e2f0b89773e15
Reposted by Gradwohl Gérard
The unintended (?) consequence of the tariffs is that the reduced consumption it'll drive will probably significantly reduce greenhouse gas emissions
April 2, 2025 at 9:16 PM
The unintended (?) consequence of the tariffs is that the reduced consumption it'll drive will probably significantly reduce greenhouse gas emissions
Reposted by Gradwohl Gérard
Important diabetes news. Unfortunately, while VX264 (Vertex's encapsulated stem cell derived islet product) has been safe in patients, the company has discontinued the trial due to insufficient function of the cells. investors.vrtx.com/news-release...
Vertex Announces Program Updates for Type 1 Diabetes Portfolio | Vertex Pharmaceuticals
The Investor Relations website contains information about Vertex Pharmaceuticals's business for stockholders, potential investors, and financial analysts.
investors.vrtx.com
April 2, 2025 at 1:50 PM
Important diabetes news. Unfortunately, while VX264 (Vertex's encapsulated stem cell derived islet product) has been safe in patients, the company has discontinued the trial due to insufficient function of the cells. investors.vrtx.com/news-release...
Reposted by Gradwohl Gérard
@novonordiskcom.bsky.social licenses a P2 ready triple agonist #obesity #diabetrs #MASH www.novonordisk.com/content/nnco...
March 24, 2025 at 10:12 AM
@novonordiskcom.bsky.social licenses a P2 ready triple agonist #obesity #diabetrs #MASH www.novonordisk.com/content/nnco...
Reposted by Gradwohl Gérard
NEW: Elon Musk’s X has suspended accounts of Turkish opposition groups, suppressing footage of anti-government protests.
So, best we share all the footage we can here!
This was last night’s massive demo against Erdogan’s government, which follows the arrest of his rival Ekrem İmamoğlu.
🇹🇷 #Turkey
So, best we share all the footage we can here!
This was last night’s massive demo against Erdogan’s government, which follows the arrest of his rival Ekrem İmamoğlu.
🇹🇷 #Turkey
March 22, 2025 at 5:48 PM
NEW: Elon Musk’s X has suspended accounts of Turkish opposition groups, suppressing footage of anti-government protests.
So, best we share all the footage we can here!
This was last night’s massive demo against Erdogan’s government, which follows the arrest of his rival Ekrem İmamoğlu.
🇹🇷 #Turkey
So, best we share all the footage we can here!
This was last night’s massive demo against Erdogan’s government, which follows the arrest of his rival Ekrem İmamoğlu.
🇹🇷 #Turkey
Reposted by Gradwohl Gérard
I guess this means I’m not going to the US for the next four years - at least.
Etats-Unis : un chercheur français refoulé pour avoir exprimé « une opinion personnelle sur la politique menée par l’administration Trump »
Etats-Unis : un chercheur français refoulé pour avoir exprimé « une opinion personnelle sur la politique menée par l’administration Trump »
Le ministre de la recherche a dit sa « préoccupation », mercredi, après cette décision des autorités américaines. Le chercheur du CNRS aurait subi un contrôle aléatoire à son arrivée, avant que son ordinateur et son téléphone ne soient fouillés.
www.lemonde.fr
March 19, 2025 at 7:43 PM
I guess this means I’m not going to the US for the next four years - at least.
Reposted by Gradwohl Gérard
Symposium on ‘Enhancer Sequences’ at beautiful @collegedefrance.bsky.social in Paris, by April 11th. Open and free, no registration. Come to relax listening to facts #TherapeuticEffects #VillageGauloix Final programme below. Tell your friends! 🙏🤘
March 17, 2025 at 2:28 PM
Symposium on ‘Enhancer Sequences’ at beautiful @collegedefrance.bsky.social in Paris, by April 11th. Open and free, no registration. Come to relax listening to facts #TherapeuticEffects #VillageGauloix Final programme below. Tell your friends! 🙏🤘
Reposted by Gradwohl Gérard
Reposted by Gradwohl Gérard
Yesterday's article in Le Monde regarding #StandUpforScience and the events planned tomorrow in France.
Here is the link to the English version, though partially paywalled.
www.lemonde.fr/en/science/a...
@standupforscience.bsky.social
@standupforscifr.bsky.social
Here is the link to the English version, though partially paywalled.
www.lemonde.fr/en/science/a...
@standupforscience.bsky.social
@standupforscifr.bsky.social
March 5, 2025 at 10:20 PM
Yesterday's article in Le Monde regarding #StandUpforScience and the events planned tomorrow in France.
Here is the link to the English version, though partially paywalled.
www.lemonde.fr/en/science/a...
@standupforscience.bsky.social
@standupforscifr.bsky.social
Here is the link to the English version, though partially paywalled.
www.lemonde.fr/en/science/a...
@standupforscience.bsky.social
@standupforscifr.bsky.social
Reposted by Gradwohl Gérard
We're hiring! The Development & Stem Cells department at @igbmc.bsky.social, Strasbourg 🇫🇷 is recruiting a group leader working in cell & developmental biology. Our Integrated Structural Biology department also has an open call. More details below! + contact me for informal enquiries #sciencejobs
February 28, 2025 at 9:01 AM
We're hiring! The Development & Stem Cells department at @igbmc.bsky.social, Strasbourg 🇫🇷 is recruiting a group leader working in cell & developmental biology. Our Integrated Structural Biology department also has an open call. More details below! + contact me for informal enquiries #sciencejobs
Reposted by Gradwohl Gérard
But: this isn’t a meeting that went badly for Zelenskyy. It’s a meeting that went horrifically for Americans: the Trump admin is isolated in its support for Russia here, as we saw just earlier this week when it took its place among Russia’s other client states to vote against Ukrainian sovereignty
February 28, 2025 at 6:47 PM
But: this isn’t a meeting that went badly for Zelenskyy. It’s a meeting that went horrifically for Americans: the Trump admin is isolated in its support for Russia here, as we saw just earlier this week when it took its place among Russia’s other client states to vote against Ukrainian sovereignty
Reposted by Gradwohl Gérard
After World War I, Germany had to fork over billions to cover damages. After World War II, Japan was forced to pay reparations. But with Ukraine, Trump is flipping history upside down by demanding that the invaded, not the invader, pay up. www.nytimes.com/2025/02/27/u...
With Trump, Alliances Come With Strings Attached
President Trump has little use for America’s traditional alliances, and tends to evaluate U.S. relationships according to whether countries are contributing economically to the United States.
www.nytimes.com
March 1, 2025 at 3:48 AM
After World War I, Germany had to fork over billions to cover damages. After World War II, Japan was forced to pay reparations. But with Ukraine, Trump is flipping history upside down by demanding that the invaded, not the invader, pay up. www.nytimes.com/2025/02/27/u...
Reposted by Gradwohl Gérard
Our job posting for 1 or more PDF positions in Vancouver Canada is now live here: tinyurl.com/4mrjw3m2
Please share/repost and apply soon!
Please share/repost and apply soon!
February 25, 2025 at 11:02 PM
Our job posting for 1 or more PDF positions in Vancouver Canada is now live here: tinyurl.com/4mrjw3m2
Please share/repost and apply soon!
Please share/repost and apply soon!
Reposted by Gradwohl Gérard
Paper out !!🥳big thanks to all authors @marliesoomen.bsky.social @diego-rt.bsky.social @kaessmannlab.bsky.social @jonathangoeke.bsky.social @lorenzamottes.bsky.social & 'bluesky-less'
Lots of interesting new TE (& genes) biology
Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/
Lots of interesting new TE (& genes) biology
Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/
February 21, 2025 at 3:50 PM
Paper out !!🥳big thanks to all authors @marliesoomen.bsky.social @diego-rt.bsky.social @kaessmannlab.bsky.social @jonathangoeke.bsky.social @lorenzamottes.bsky.social & 'bluesky-less'
Lots of interesting new TE (& genes) biology
Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/
Lots of interesting new TE (& genes) biology
Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/
I am devastated by so many irresponsable decisions www.bbc.com/news/article...
Donald Trump signs order shifting US back towards plastic straws
The president has long been a critic of paper straws, which he says don't work and dissolve too easily.
www.bbc.com
February 11, 2025 at 12:29 PM
I am devastated by so many irresponsable decisions www.bbc.com/news/article...
Reposted by Gradwohl Gérard
Reposted by Gradwohl Gérard
Mikael Chetboun & François Pattou comment on:
Long-term outcomes and challenges of #islet #transplantation in type 1 #diabetes thelancet.com/journals/lan... #T1D
Long-term outcomes and challenges of #islet #transplantation in type 1 #diabetes thelancet.com/journals/lan... #T1D
Long-term outcomes and challenges of islet transplantation in type 1 diabetes
β-cell replacement is a validated therapy for severe forms of type 1 diabetes.1 In
patients with frequent severe hypoglycaemic events, allogeneic pancreatic islet transplantation
results in better gly...
thelancet.com
February 8, 2025 at 7:58 AM
Mikael Chetboun & François Pattou comment on:
Long-term outcomes and challenges of #islet #transplantation in type 1 #diabetes thelancet.com/journals/lan... #T1D
Long-term outcomes and challenges of #islet #transplantation in type 1 #diabetes thelancet.com/journals/lan... #T1D
Reposted by Gradwohl Gérard
Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.
February 8, 2025 at 1:45 PM
Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.
Reposted by Gradwohl Gérard
I do hope that President Trump and Mr Musk realize that US biomedical research is still one of our strengths and only possible because of NIH funding
February 5, 2025 at 6:56 PM
I do hope that President Trump and Mr Musk realize that US biomedical research is still one of our strengths and only possible because of NIH funding
Reposted by Gradwohl Gérard
While it may be true, as claimed by Mr. Bannon, that in the IT industry H1b visas have been abused to bring in cheap labor, in biomedical research progress can only be made by recruitment of foreign fellows. There simply are not a sufficient pool of US born Ph.D.s left who want to work in academia
February 5, 2025 at 6:59 PM
While it may be true, as claimed by Mr. Bannon, that in the IT industry H1b visas have been abused to bring in cheap labor, in biomedical research progress can only be made by recruitment of foreign fellows. There simply are not a sufficient pool of US born Ph.D.s left who want to work in academia