Klaus Kaestner
@kkaestner.bsky.social
Professor of Genetics, UPenn. Diabetes and organ development. Member of the Human Pancreas Analysis Program.
house mouse maintains constant telomere length throughout life url: academic.oup.com/nar/article/...
The house mouse maintains constant telomere length throughout life
Abstract. Telomeres protect the chromosome ends from deleterious DNA damage response and repair activities. In humans, telomerase maintains telomere length
academic.oup.com
August 28, 2025 at 11:11 PM
house mouse maintains constant telomere length throughout life url: academic.oup.com/nar/article/...
Happy to announce that HPAP now has some 180 human pancreatic analyzed by highly multiplexed CODEX analysis. Thanks to Dr. Powers and the whole HPAP team! Here is the link to the experiment data download page: hpap.pmacs.upenn.edu/explore/down...
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hpap.pmacs.upenn.edu
June 30, 2025 at 7:21 PM
Happy to announce that HPAP now has some 180 human pancreatic analyzed by highly multiplexed CODEX analysis. Thanks to Dr. Powers and the whole HPAP team! Here is the link to the experiment data download page: hpap.pmacs.upenn.edu/explore/down...
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Very proud indeed to have been together on a stage celebrating NIDDK's 75th anniversary at the recent ADA meeting in Chicago with Drs Rogers, Cefalu, Gubitosi-Klug and Kirscher. Always grateful for NIDDK's support of our research! 🧪
June 25, 2025 at 7:10 PM
Very proud indeed to have been together on a stage celebrating NIDDK's 75th anniversary at the recent ADA meeting in Chicago with Drs Rogers, Cefalu, Gubitosi-Klug and Kirscher. Always grateful for NIDDK's support of our research! 🧪
June 25, 2025 at 7:03 PM
Very happy to share the results of a multi-national scientific collaboration on the factors that control telomere length. Hope you like it! Best, Klaus
academic.oup.com/nar/article-...
academic.oup.com/nar/article-...
Separation of telomere protection from length regulation by two different point mutations at amino acid 492 of RTEL1
Abstract. RTEL1 is an essential DNA helicase that plays multiple roles in genome stability and telomere length regulation. The ultra-long telomeres of the
academic.oup.com
June 18, 2025 at 5:46 PM
Very happy to share the results of a multi-national scientific collaboration on the factors that control telomere length. Hope you like it! Best, Klaus
academic.oup.com/nar/article-...
academic.oup.com/nar/article-...
I was truly honored to contribute as Keynote speaker to the 25th meeting of the European Islet Study Group in Malmo, Sweden. Fantastic meeting, lots of progress on all fronts! See you all next year in Barcelona!
June 17, 2025 at 12:28 PM
I was truly honored to contribute as Keynote speaker to the 25th meeting of the European Islet Study Group in Malmo, Sweden. Fantastic meeting, lots of progress on all fronts! See you all next year in Barcelona!
Thank you, Christos, for the shoutout! It was a great honor to be invited as Keynote speaker to the European Islet Study Group conference in Malmo. Great meeting, I learned a lot!
Great overview of HPAP consortium and exciting new projects by @kkaestner.bsky.social to start day 3 at @eisg2025.bsky.social #eisg2025
June 13, 2025 at 9:53 AM
Thank you, Christos, for the shoutout! It was a great honor to be invited as Keynote speaker to the European Islet Study Group conference in Malmo. Great meeting, I learned a lot!
What really happens at the onset of type 1 diabetes? The HPAP team profiled the immune system of the lymph nodes near the pancreas, the reservoir of the relevant immune cells. Read more here: www.nature.com/articles/s41...
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Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset - Nature Communications
The status of immune cells within human pancreatic lymphatic tissues during the onset and progression of type 1 diabetes (T1D) is underexplored. Here, by flow cytometry and CITEseq, the authors profil...
www.nature.com
May 23, 2025 at 1:36 PM
What really happens at the onset of type 1 diabetes? The HPAP team profiled the immune system of the lymph nodes near the pancreas, the reservoir of the relevant immune cells. Read more here: www.nature.com/articles/s41...
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Reposted by Klaus Kaestner
Two new, NIH funded postdoc positions available. (1) Somatic mutations as primary causes of autoimmune disease and (2) Epigenetic drivers of diabetes in humans. Send CV and names of references to kaestner@upenn.edu
May 20, 2025 at 4:49 PM
Two new, NIH funded postdoc positions available. (1) Somatic mutations as primary causes of autoimmune disease and (2) Epigenetic drivers of diabetes in humans. Send CV and names of references to kaestner@upenn.edu
A wonderful day, celebration the recently graduated Dr. Michelle Lee at the UPenn hooding ceremony.
May 20, 2025 at 4:51 PM
A wonderful day, celebration the recently graduated Dr. Michelle Lee at the UPenn hooding ceremony.
Two new, NIH funded postdoc positions available. (1) Somatic mutations as primary causes of autoimmune disease and (2) Epigenetic drivers of diabetes in humans. Send CV and names of references to kaestner@upenn.edu
May 20, 2025 at 4:49 PM
Two new, NIH funded postdoc positions available. (1) Somatic mutations as primary causes of autoimmune disease and (2) Epigenetic drivers of diabetes in humans. Send CV and names of references to kaestner@upenn.edu
Do the islet biology community, we have good news.
Good news- the HPAP islet perifusion dashboard for glucagon and insulin secretion is now live on PANC-DB:
hpap.pmacs.upenn.edu/explore/peri...
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Good news- the HPAP islet perifusion dashboard for glucagon and insulin secretion is now live on PANC-DB:
hpap.pmacs.upenn.edu/explore/peri...
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hpap.pmacs.upenn.edu
April 28, 2025 at 4:46 PM
Do the islet biology community, we have good news.
Good news- the HPAP islet perifusion dashboard for glucagon and insulin secretion is now live on PANC-DB:
hpap.pmacs.upenn.edu/explore/peri...
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Good news- the HPAP islet perifusion dashboard for glucagon and insulin secretion is now live on PANC-DB:
hpap.pmacs.upenn.edu/explore/peri...
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Reposted by Klaus Kaestner
One of the most powerful moments of the day came from Emily Whitehead who told the story of how she was the first pediatric patient to receive CAR T-cell therapy for her leukemia at age 5: “I stand up for science because science saved my life. And that’s a fact.” @standupforscience.bsky.social
March 8, 2025 at 1:18 PM
One of the most powerful moments of the day came from Emily Whitehead who told the story of how she was the first pediatric patient to receive CAR T-cell therapy for her leukemia at age 5: “I stand up for science because science saved my life. And that’s a fact.” @standupforscience.bsky.social
Great to see thousands at the rally to save science in Philadelphia today! A truly inspiring event!
March 7, 2025 at 10:03 PM
Great to see thousands at the rally to save science in Philadelphia today! A truly inspiring event!
Dear Friends,
Happy to share our new preprint which describes the discovery of a new alpha to beta cell transitional cell type in the human pancreas using singe cell multiomic and genetic lineage tracing. www.biorxiv.org/content/10.1...
Happy to share our new preprint which describes the discovery of a new alpha to beta cell transitional cell type in the human pancreas using singe cell multiomic and genetic lineage tracing. www.biorxiv.org/content/10.1...
Single-cell multiome analysis supports α-to-β transdifferentiation in human pancreas
Spontaneous transdifferentiation of pancreatic glucagon-producing alpha to insulin secreting beta cells has been observed in mouse but not in human islets1. Here, we analyzed the largest single cell d...
www.biorxiv.org
February 20, 2025 at 4:24 PM
Dear Friends,
Happy to share our new preprint which describes the discovery of a new alpha to beta cell transitional cell type in the human pancreas using singe cell multiomic and genetic lineage tracing. www.biorxiv.org/content/10.1...
Happy to share our new preprint which describes the discovery of a new alpha to beta cell transitional cell type in the human pancreas using singe cell multiomic and genetic lineage tracing. www.biorxiv.org/content/10.1...
While it may be true, as claimed by Mr. Bannon, that in the IT industry H1b visas have been abused to bring in cheap labor, in biomedical research progress can only be made by recruitment of foreign fellows. There simply are not a sufficient pool of US born Ph.D.s left who want to work in academia
February 5, 2025 at 6:59 PM
While it may be true, as claimed by Mr. Bannon, that in the IT industry H1b visas have been abused to bring in cheap labor, in biomedical research progress can only be made by recruitment of foreign fellows. There simply are not a sufficient pool of US born Ph.D.s left who want to work in academia
I do hope that President Trump and Mr Musk realize that US biomedical research is still one of our strengths and only possible because of NIH funding
February 5, 2025 at 6:56 PM
I do hope that President Trump and Mr Musk realize that US biomedical research is still one of our strengths and only possible because of NIH funding
It appears that NIH study sections (IRGs) are operating again
February 5, 2025 at 6:55 PM
It appears that NIH study sections (IRGs) are operating again
Reposted by Klaus Kaestner
I should have put 🧪 in the first time to get this in the science feed. US science folks: Call!
www.politico.com/news/2025/02...
Politico is reporting that cuts ranging from 1/4 to 1/2 of the National Science Foundation’s personnel are on the horizon. The quote from a program officer that such cuts would be catastrophic for the US position in global scientific leadership is not hyperbole.
Politico is reporting that cuts ranging from 1/4 to 1/2 of the National Science Foundation’s personnel are on the horizon. The quote from a program officer that such cuts would be catastrophic for the US position in global scientific leadership is not hyperbole.
Science funding agency threatened with mass layoffs
National Science Foundation staff heard the plans at a meeting Tuesday.
www.politico.com
February 5, 2025 at 6:50 PM
I should have put 🧪 in the first time to get this in the science feed. US science folks: Call!
My NIH Commons login stopped working today- anyone have similar issues?
February 3, 2025 at 8:55 PM
My NIH Commons login stopped working today- anyone have similar issues?
Reposted by Klaus Kaestner
ft. K. Trang, M. Pahl, J. Pippin, C. Su, S. Littleton, P. Sharma, N. Kulkarni, L. Ghanem, N. Terry, S. Anderson, B. Zemel, @alessandrachesi.bsky.social A. Wells, @struangrant.bsky.social, J. O'Brien, W. Yang, @ptitchenell.bsky.social P. Seale & @kkaestner.bsky.social elifesciences.org/articles/95411
January 23, 2025 at 3:20 PM
ft. K. Trang, M. Pahl, J. Pippin, C. Su, S. Littleton, P. Sharma, N. Kulkarni, L. Ghanem, N. Terry, S. Anderson, B. Zemel, @alessandrachesi.bsky.social A. Wells, @struangrant.bsky.social, J. O'Brien, W. Yang, @ptitchenell.bsky.social P. Seale & @kkaestner.bsky.social elifesciences.org/articles/95411
Reposted by Klaus Kaestner
Up front & free to read in our Jan issue #editorspicks: Targeting the NLRP3 inflammasome–IL-1β pathway in type 2 diabetes and obesity tinyurl.com/bdf9ec33
Targeting the NLRP3 inflammasome–IL-1β pathway in type 2 diabetes and obesity - Diabetologia
Increased activity of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome–IL-1β pathway is observed in obesity and contributes to the development of type 2 diabetes and its compli...
tinyurl.com
January 7, 2025 at 10:22 AM
Up front & free to read in our Jan issue #editorspicks: Targeting the NLRP3 inflammasome–IL-1β pathway in type 2 diabetes and obesity tinyurl.com/bdf9ec33
Reposted by Klaus Kaestner
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Hi #climatesky community! I wrote a short piece in Nature, Worldview located here: rdcu.be/d6sWa. It explores what we can expect from Trump 2.0 on the environment & ways to push back. We can counter Trump's environmental actions & make progress on climate mitigation at the subnational level. A 🧵 1/
Trump will weaken climate action — the rest of the US must not follow suit | Nature
Researchers, governments and others can all play a part in ensuring climate policies remain in the interest of all. Researchers, governments and others can all play a part in ensuring climate policies remain in the interest of all.
rdcu.be
January 16, 2025 at 5:56 PM
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