Sierra Palumbos
@palumbos.bsky.social
Cellular neuroscientist. Postdoc in Holzbaur lab. Educator. Asking what neurons do with their trash.
sierrapalumbos.com
sierrapalumbos.com
Very excited to share my postdoc work- out now at PNAS!
Learn more about how neurons facing chronic autophagic stress compensate by upregulating two secretion pathways
Autophagic stress activates distinct compensatory secretory pathways in neurons | PNAS www.pnas.org/doi/10.1073/...
Learn more about how neurons facing chronic autophagic stress compensate by upregulating two secretion pathways
Autophagic stress activates distinct compensatory secretory pathways in neurons | PNAS www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
July 7, 2025 at 7:38 PM
Very excited to share my postdoc work- out now at PNAS!
Learn more about how neurons facing chronic autophagic stress compensate by upregulating two secretion pathways
Autophagic stress activates distinct compensatory secretory pathways in neurons | PNAS www.pnas.org/doi/10.1073/...
Learn more about how neurons facing chronic autophagic stress compensate by upregulating two secretion pathways
Autophagic stress activates distinct compensatory secretory pathways in neurons | PNAS www.pnas.org/doi/10.1073/...
Reposted by Sierra Palumbos
This is going to hurt science. 🧪
What hurts science hurts healthcare. 🩺
What hurts healthcare hurts you. 🫵
Call, email, and if possible visit, your representatives. This is personal whether you want it to be or not.
What hurts science hurts healthcare. 🩺
What hurts healthcare hurts you. 🫵
Call, email, and if possible visit, your representatives. This is personal whether you want it to be or not.
This morning, the US National Science Foundation fired 168 employees, approximately 10% of its workforce, for no cause other than they were the agency's most recent hires. 🧪
Co-workers are leaving supportive messages before they have to clear out of the building at 5 p.m. Sent to me by a source ⬇️
Co-workers are leaving supportive messages before they have to clear out of the building at 5 p.m. Sent to me by a source ⬇️
February 18, 2025 at 11:11 PM
This is going to hurt science. 🧪
What hurts science hurts healthcare. 🩺
What hurts healthcare hurts you. 🫵
Call, email, and if possible visit, your representatives. This is personal whether you want it to be or not.
What hurts science hurts healthcare. 🩺
What hurts healthcare hurts you. 🫵
Call, email, and if possible visit, your representatives. This is personal whether you want it to be or not.
Reposted by Sierra Palumbos
Very good source to understand indirect costs by Sally Rockey, former Deputy Director for Extramural Activities at NIH.
Very thorough and clear.
If you want to understand indirect costs or have family or friends who are pestering you to explain IDC, send them this...
www.aau.edu/key-issues/i...
Very thorough and clear.
If you want to understand indirect costs or have family or friends who are pestering you to explain IDC, send them this...
www.aau.edu/key-issues/i...
Indirect Costs 101, Sally J. Rockey | Association of American Universities (AAU)
Sally Rockey, explains indirect costs and how they support research.
www.aau.edu
February 11, 2025 at 1:24 PM
Very good source to understand indirect costs by Sally Rockey, former Deputy Director for Extramural Activities at NIH.
Very thorough and clear.
If you want to understand indirect costs or have family or friends who are pestering you to explain IDC, send them this...
www.aau.edu/key-issues/i...
Very thorough and clear.
If you want to understand indirect costs or have family or friends who are pestering you to explain IDC, send them this...
www.aau.edu/key-issues/i...
Reposted by Sierra Palumbos
This is the end of science as we know it if it stands—15% IDCs for all NIH Grants.
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 7, 2025 at 11:05 PM
This is the end of science as we know it if it stands—15% IDCs for all NIH Grants.
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
Reposted by Sierra Palumbos
⚠️ Effective Monday 2/10/25, NIH indirect rate capped at 15%. Applies to existing & future grants.
—> Deep budget cuts & program closures coming to a university near you.
Is this the break the glass moment for university administrators who have been silent so far about the attack on science?
—> Deep budget cuts & program closures coming to a university near you.
Is this the break the glass moment for university administrators who have been silent so far about the attack on science?
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 7, 2025 at 11:33 PM
⚠️ Effective Monday 2/10/25, NIH indirect rate capped at 15%. Applies to existing & future grants.
—> Deep budget cuts & program closures coming to a university near you.
Is this the break the glass moment for university administrators who have been silent so far about the attack on science?
—> Deep budget cuts & program closures coming to a university near you.
Is this the break the glass moment for university administrators who have been silent so far about the attack on science?
Revised and Extended: What's Happening Inside the NIH and NSF | Science | AAAS www.science.org/content/blog...
Revised and Extended: What's Happening Inside the NIH and NSF
www.science.org
February 6, 2025 at 1:08 AM
Revised and Extended: What's Happening Inside the NIH and NSF | Science | AAAS www.science.org/content/blog...
Reposted by Sierra Palumbos
Shout out to Dr. Bishal Basak in @erikaholzbaur.bsky.social at @upenn.bsky.social for spearheading the work on identifying a new stress response pathway that regulates mitophagy in neurons!
➡️Read pre-print here: doi.org/10.1101/2024...
➡️Read pre-print here: doi.org/10.1101/2024...
🎉 We are celebrating Bishal Basak from CRN Team Hurley as our January #NetworkSpotlight. Bishal worked on a Team paper where he identified a novel, neuron-specific mitophagy pathway. Thank you, Bishal!
Check out Bishal's paper: www.biorxiv.org/content/10.1...
Check out Bishal's paper: www.biorxiv.org/content/10.1...
January 29, 2025 at 7:12 PM
Shout out to Dr. Bishal Basak in @erikaholzbaur.bsky.social at @upenn.bsky.social for spearheading the work on identifying a new stress response pathway that regulates mitophagy in neurons!
➡️Read pre-print here: doi.org/10.1101/2024...
➡️Read pre-print here: doi.org/10.1101/2024...
Reposted by Sierra Palumbos
If you’re a federal govt employee targeted for leave or termination on the basis of your DEI work, please file an EEO (Equal Employment Opportunity) complaint & retain legal counsel.
I’m a former NIH PI. Happy to refer you to a law firm that has successfully sued the govt many times!
Pls repost 🙏❤️
I’m a former NIH PI. Happy to refer you to a law firm that has successfully sued the govt many times!
Pls repost 🙏❤️
January 24, 2025 at 10:02 AM
If you’re a federal govt employee targeted for leave or termination on the basis of your DEI work, please file an EEO (Equal Employment Opportunity) complaint & retain legal counsel.
I’m a former NIH PI. Happy to refer you to a law firm that has successfully sued the govt many times!
Pls repost 🙏❤️
I’m a former NIH PI. Happy to refer you to a law firm that has successfully sued the govt many times!
Pls repost 🙏❤️
Reposted by Sierra Palumbos
I just reached out to my senators about the NIH situation. If you need to find out how much impact NIH has in your state in terms of dollars in and their economic impact here's a link: www.unitedformedicalresearch.org/nih-in-your-...
NIH In Your State - United For Medical Research
Select a state on the map to see the impact of NIH funding across America.
www.unitedformedicalresearch.org
January 22, 2025 at 9:34 PM
I just reached out to my senators about the NIH situation. If you need to find out how much impact NIH has in your state in terms of dollars in and their economic impact here's a link: www.unitedformedicalresearch.org/nih-in-your-...
Reposted by Sierra Palumbos
Step 1) find your rep
www.congress.gov/members/find...
Step 2) send an email or call their office
Step 3) tell them that federal spending on scientific advancement is the best hope we have to “win against china” or whatever these guys are obsessed with these days
www.congress.gov/members/find...
Step 2) send an email or call their office
Step 3) tell them that federal spending on scientific advancement is the best hope we have to “win against china” or whatever these guys are obsessed with these days
www.congress.gov
January 22, 2025 at 7:35 PM
Step 1) find your rep
www.congress.gov/members/find...
Step 2) send an email or call their office
Step 3) tell them that federal spending on scientific advancement is the best hope we have to “win against china” or whatever these guys are obsessed with these days
www.congress.gov/members/find...
Step 2) send an email or call their office
Step 3) tell them that federal spending on scientific advancement is the best hope we have to “win against china” or whatever these guys are obsessed with these days
Reposted by Sierra Palumbos
Study sections are the review panels that allocate NIH research grants. They bring in experts from around the country and have to be scheduled many months in advance; they provide the funds that keep the nation's biomedical research going.
It's hard to overstate the disruption this causes.
It's hard to overstate the disruption this causes.
All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.
January 22, 2025 at 11:20 PM
Study sections are the review panels that allocate NIH research grants. They bring in experts from around the country and have to be scheduled many months in advance; they provide the funds that keep the nation's biomedical research going.
It's hard to overstate the disruption this causes.
It's hard to overstate the disruption this causes.
Reposted by Sierra Palumbos
All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.
January 22, 2025 at 8:46 PM
All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.
Reposted by Sierra Palumbos
The United States built a publicly funded scientific enterprise that worked miracles. We went to the moon and mars, laid the groundwork for computing revolutions, turned AIDS from a death sentence to a chronic condition, drastically cut cancer deaths. And now we're just going to dismantle it?
January 23, 2025 at 1:48 AM
The United States built a publicly funded scientific enterprise that worked miracles. We went to the moon and mars, laid the groundwork for computing revolutions, turned AIDS from a death sentence to a chronic condition, drastically cut cancer deaths. And now we're just going to dismantle it?
Reposted by Sierra Palumbos
Microscopy Nodes is now up on bioRxiv! 🚀
This is a Blender extension that seamlessly integrates and visualizes 3D microscopy data (TIF & @zarr.dev).
High-quality volume rendering for anyone, in both EM and fluorescence, regardless of computational expertise! 🔬
www.biorxiv.org/content/10.1...
This is a Blender extension that seamlessly integrates and visualizes 3D microscopy data (TIF & @zarr.dev).
High-quality volume rendering for anyone, in both EM and fluorescence, regardless of computational expertise! 🔬
www.biorxiv.org/content/10.1...
January 15, 2025 at 1:39 PM
Microscopy Nodes is now up on bioRxiv! 🚀
This is a Blender extension that seamlessly integrates and visualizes 3D microscopy data (TIF & @zarr.dev).
High-quality volume rendering for anyone, in both EM and fluorescence, regardless of computational expertise! 🔬
www.biorxiv.org/content/10.1...
This is a Blender extension that seamlessly integrates and visualizes 3D microscopy data (TIF & @zarr.dev).
High-quality volume rendering for anyone, in both EM and fluorescence, regardless of computational expertise! 🔬
www.biorxiv.org/content/10.1...
Reposted by Sierra Palumbos
📣Now that @mito911.bsky.social is on Bluesky, let's highlight the research run in our team! Check out the pre-print by @palumbos.bsky.social Palumbos et al. and colleagues from the @erikaholzbaur.bsky.social!
@asapresearch.bsky.social
⬇️
@asapresearch.bsky.social
⬇️
Excited to share this new preprint from Sierra Palumbos, tracking the effects of dysfunctional autophagy in neurons: www.biorxiv.org/content/10.1...
Autophagic stress activates distinct compensatory secretory pathways in neurons
Autophagic dysfunction is a hallmark of neurodegenerative disease, leaving neurons vulnerable to the accumulation of damaged organelles and proteins. However, the late onset of diseases suggests that ...
www.biorxiv.org
November 25, 2024 at 6:21 PM
📣Now that @mito911.bsky.social is on Bluesky, let's highlight the research run in our team! Check out the pre-print by @palumbos.bsky.social Palumbos et al. and colleagues from the @erikaholzbaur.bsky.social!
@asapresearch.bsky.social
⬇️
@asapresearch.bsky.social
⬇️
Reposted by Sierra Palumbos
Read the recent pre-print by @palumbos.bsky.social now on BioRxiv. In the meanwhile, find below and read a thread for a sweet preview of her work! 👩🔬 🧫
@asapresearch.bsky.social
@asapresearch.bsky.social
Happy to be here and excited to share my postdoc work, "Autophagic stress activates distinct compensatory secretory pathways in neurons"
Now on BioRxiv www.biorxiv.org/content/10.1...
Many thanks to @erikaholzbaur.bsky.social and @asapresearch.bsky.social
Now on BioRxiv www.biorxiv.org/content/10.1...
Many thanks to @erikaholzbaur.bsky.social and @asapresearch.bsky.social
November 25, 2024 at 6:25 PM
Read the recent pre-print by @palumbos.bsky.social now on BioRxiv. In the meanwhile, find below and read a thread for a sweet preview of her work! 👩🔬 🧫
@asapresearch.bsky.social
@asapresearch.bsky.social
Reposted by Sierra Palumbos
Do you teach neuroscience? Here’s a list I’ve compiled of mostly free online neuroscience textbooks, simulations and datasets you can use for your course! If I’m missing something, let me know so I can add it! docs.google.com/document/d/1...
Free Neuroscience Textbooks and Online Tutorials
Free Neuroscience Textbooks and Online Tutorials (Compiled by Carlos Aizenman, Brown University, Dept. of Neuroscience) Maintaining a current list of digital educational resources is tricky. Softwar...
docs.google.com
November 20, 2024 at 8:08 PM
Do you teach neuroscience? Here’s a list I’ve compiled of mostly free online neuroscience textbooks, simulations and datasets you can use for your course! If I’m missing something, let me know so I can add it! docs.google.com/document/d/1...
Reposted by Sierra Palumbos
Here are some free/open-source sites for the preparation of scientific illustrations, including icon libraries: bioicons.com, scidraw.io, bioart.niaid.nih.gov, inkscape.org, biogdp.com, reactome.org/icon-lib
November 17, 2024 at 4:04 PM
Here are some free/open-source sites for the preparation of scientific illustrations, including icon libraries: bioicons.com, scidraw.io, bioart.niaid.nih.gov, inkscape.org, biogdp.com, reactome.org/icon-lib
Reposted by Sierra Palumbos
If you are interested in mitochondria, mitophagy and/or PD follow the mito911 Webinar series! Events calendar and registration at this link parkinsonsroadmap.org/events/
Events
Aligning Science Across Parkinson’s (ASAP) aims to foster collaboration and discovery by supporting virtual and in-person events that facilitate connections and provide an avenue for sharing ideas. Se...
parkinsonsroadmap.org
November 15, 2024 at 10:37 PM
If you are interested in mitochondria, mitophagy and/or PD follow the mito911 Webinar series! Events calendar and registration at this link parkinsonsroadmap.org/events/
Reposted by Sierra Palumbos
Just going in to lab hoping no one in Congress notices me feeding mice little sweet treats to see if they really want it or just merely like it
November 15, 2024 at 2:29 PM
Just going in to lab hoping no one in Congress notices me feeding mice little sweet treats to see if they really want it or just merely like it
Reposted by Sierra Palumbos
Excited to share this new preprint from Sierra Palumbos, tracking the effects of dysfunctional autophagy in neurons: www.biorxiv.org/content/10.1...
Autophagic stress activates distinct compensatory secretory pathways in neurons
Autophagic dysfunction is a hallmark of neurodegenerative disease, leaving neurons vulnerable to the accumulation of damaged organelles and proteins. However, the late onset of diseases suggests that ...
www.biorxiv.org
November 13, 2024 at 3:26 PM
Excited to share this new preprint from Sierra Palumbos, tracking the effects of dysfunctional autophagy in neurons: www.biorxiv.org/content/10.1...
Reposted by Sierra Palumbos
So proud of Adam Fenton and his work defining the role of FMRP in the local regulation of mitochondrial fission in neurons via local translation: www.nature.com/articles/s41...
FMRP regulates MFF translation to locally direct mitochondrial fission in neurons - Nature Cell Biology
Fenton et al. show that FMRP granules dock at the mitochondrial midzone in a Rab7-dependent manner in axons and dendrites, where they promote local MFF synthesis and fission at the mitochondrial midzo...
www.nature.com
November 15, 2024 at 4:57 PM
So proud of Adam Fenton and his work defining the role of FMRP in the local regulation of mitochondrial fission in neurons via local translation: www.nature.com/articles/s41...
Happy to be here and excited to share my postdoc work, "Autophagic stress activates distinct compensatory secretory pathways in neurons"
Now on BioRxiv www.biorxiv.org/content/10.1...
Many thanks to @erikaholzbaur.bsky.social and @asapresearch.bsky.social
Now on BioRxiv www.biorxiv.org/content/10.1...
Many thanks to @erikaholzbaur.bsky.social and @asapresearch.bsky.social
November 15, 2024 at 6:11 PM
Happy to be here and excited to share my postdoc work, "Autophagic stress activates distinct compensatory secretory pathways in neurons"
Now on BioRxiv www.biorxiv.org/content/10.1...
Many thanks to @erikaholzbaur.bsky.social and @asapresearch.bsky.social
Now on BioRxiv www.biorxiv.org/content/10.1...
Many thanks to @erikaholzbaur.bsky.social and @asapresearch.bsky.social