Together, we describe two compensatory secretion pathways that could be important to delay neurodegeneration. However, prolonged upregulation of these pathways could contribute to neuroinflammation.

Additionally, we show the release of exosomes is upregulated and that this release is critical to stave off apoptosis

We find that the secretion of LC3+ autophagic membrane extracellular vesicles (SLAM-EVs) is upregulated in neurons harboring a Parkinson's disease causing mutation

SLAM-EVs contain known autophagic cargos including mitochondria and synaptic proteins

thank you, Xilma!

Would love to be added!

Been waiting for this one! Thank you!