Now, back for a 3rd nap in my FOREVER home.
Now, back for a 3rd nap in my FOREVER home.
ADAR1 (both p150 & p110 isoforms) ⬇️in 👤PAH (in 🫁vascular smooth muscle cell)
SMC ADAR1 KO🐭 excerbates PAH
SMC ⏫dsRNA➡️⏫PKR-eIF2B-IFNβ➡️
Macrophage M1 polarization➡️
SMC proliferation
@kekeyuan.bsky.social #CircRes 2025
www.ahajournals.org/doi/10.1161/...
ADAR1 (both p150 & p110 isoforms) ⬇️in 👤PAH (in 🫁vascular smooth muscle cell)
SMC ADAR1 KO🐭 excerbates PAH
SMC ⏫dsRNA➡️⏫PKR-eIF2B-IFNβ➡️
Macrophage M1 polarization➡️
SMC proliferation
@kekeyuan.bsky.social #CircRes 2025
www.ahajournals.org/doi/10.1161/...
#SciArt
Fibroblast PDGFRα KO🐭(P0)
👉⏬Perivascular Fibroblast & Perivascular Mφ coverage of penetrating vessels (P10)
👉↔️SMC/Astrocyte coverage
@hejcell.bsky.social
@siegenthalerlab.bsky.social
@devbiol.bsky.social 2025
www.sciencedirect.com/science/arti...
#SciArt
Fibroblast PDGFRα KO🐭(P0)
👉⏬Perivascular Fibroblast & Perivascular Mφ coverage of penetrating vessels (P10)
👉↔️SMC/Astrocyte coverage
@hejcell.bsky.social
@siegenthalerlab.bsky.social
@devbiol.bsky.social 2025
www.sciencedirect.com/science/arti...
Stereo-seq v1.3
Visium HD FFPE
CosMx 6k
Xenium 5k
Human Tumors
Ground truth CODEX, +scRNAseq
#NatComm 2025
www.nature.com/articles/s41...
Stereo-seq v1.3
Visium HD FFPE
CosMx 6k
Xenium 5k
Human Tumors
Ground truth CODEX, +scRNAseq
#NatComm 2025
www.nature.com/articles/s41...
She jumped in the plant and promptly got digging zoomies.
She jumped in the plant and promptly got digging zoomies.
4/8/12/20 mo
10 organs
15-protein (C4b Clu Hba-a1 Hbb-bs Hpx Igh2b/c/m Itih3 Fgb/g Nnt Rgn Pzp Slc4a1)⬆️
3-protein (Eif4g2 Emd Dnm1l)⬇️
with age across organs
NAD+ ⬇️in 7 organs but ⬆️in heart with age
#GenomeMed 2025
link.springer.com/article/10.1...
4/8/12/20 mo
10 organs
15-protein (C4b Clu Hba-a1 Hbb-bs Hpx Igh2b/c/m Itih3 Fgb/g Nnt Rgn Pzp Slc4a1)⬆️
3-protein (Eif4g2 Emd Dnm1l)⬇️
with age across organs
NAD+ ⬇️in 7 organs but ⬆️in heart with age
#GenomeMed 2025
link.springer.com/article/10.1...
giottosuite.com
Multi-slice/-modal registration
Joint cell type annotation⬅️ multiple segmentation
Integrated modalities-based Leiden clustering
@natmethods.nature.com 2025
www.nature.com/articles/s41...
giottosuite.com
Multi-slice/-modal registration
Joint cell type annotation⬅️ multiple segmentation
Integrated modalities-based Leiden clustering
@natmethods.nature.com 2025
www.nature.com/articles/s41...
📷: Red Squirrel in autumnal woodland, Cairngorms National Park, Scotland.
📷: Red Squirrel in autumnal woodland, Cairngorms National Park, Scotland.