@nbeaujean.bsky.social
Reposted
Need a quick and easy way to probe nuclear protein-protein interactions?
=> consider nxReLo assays 👀
🧫 cell culture-based (no rec. proteins needed)
🔬 direct read-out via protein co-localization (no IPs, no reporter genes)
⏱️ quick (transient transfection + imaging)
Kudos to the Jeske group!
=> consider nxReLo assays 👀
🧫 cell culture-based (no rec. proteins needed)
🔬 direct read-out via protein co-localization (no IPs, no reporter genes)
⏱️ quick (transient transfection + imaging)
Kudos to the Jeske group!
New preprint:
nxReLo: a simple assay to probe direct interactions between nuclear proteins in cells.
www.biorxiv.org/content/10.1...
Joint effort between Sherif, Jana, and Maria, and in collaboration with Peter Andersen @germline.bsky.social.
nxReLo: a simple assay to probe direct interactions between nuclear proteins in cells.
www.biorxiv.org/content/10.1...
Joint effort between Sherif, Jana, and Maria, and in collaboration with Peter Andersen @germline.bsky.social.
July 19, 2025 at 8:59 AM
Need a quick and easy way to probe nuclear protein-protein interactions?
=> consider nxReLo assays 👀
🧫 cell culture-based (no rec. proteins needed)
🔬 direct read-out via protein co-localization (no IPs, no reporter genes)
⏱️ quick (transient transfection + imaging)
Kudos to the Jeske group!
=> consider nxReLo assays 👀
🧫 cell culture-based (no rec. proteins needed)
🔬 direct read-out via protein co-localization (no IPs, no reporter genes)
⏱️ quick (transient transfection + imaging)
Kudos to the Jeske group!
Reposted
Early encouraging mitochondrial donation study produced 8 babies - long road ahead ipscell.com/2025/07/earl... #stemcells #stemcell I hope team will follow the babies for decades & then their babies. I was a concerned voice early on about the safety of this tech but it looks hopeful
Early encouraging mitochondrial donation study produced 8 babies but long road ahead - The Niche
Stem cell biologist reports on a new study on mitochondrial donation, which looks so far to be safe and potentially effective.
ipscell.com
July 18, 2025 at 3:45 PM
Early encouraging mitochondrial donation study produced 8 babies - long road ahead ipscell.com/2025/07/earl... #stemcells #stemcell I hope team will follow the babies for decades & then their babies. I was a concerned voice early on about the safety of this tech but it looks hopeful
Take a look at our last article! We managed to get iPS derived chimeric animals, healthy and with germline transmission 🐇 A wonderful result, thanks to the hard work of all the team. Bonus: lots of beautiful embryos stainings... www.nature.com/articles/s41...
Efficient generation of germline chimeras in a non-rodent species using rabbit induced pluripotent stem cells - Nature Communications
Pluripotent stem cells can integrate into embryos and contribute to all tissues, including the germline, when in a naïve state. Here, authors identify factors that reprogram rabbit iPSCs into a naïve-...
www.nature.com
June 4, 2025 at 5:27 AM
Take a look at our last article! We managed to get iPS derived chimeric animals, healthy and with germline transmission 🐇 A wonderful result, thanks to the hard work of all the team. Bonus: lots of beautiful embryos stainings... www.nature.com/articles/s41...
Reposted
Big thanks to @bryonyleeke.bsky.social and Imke Staffhorst for all their hard work on the planning and content, (and Imke's talented ilustrative work), to helpful reviewers, and to @dev-journal.bsky.social for a smooth and efficient review process.
May 14, 2025 at 3:30 PM
Big thanks to @bryonyleeke.bsky.social and Imke Staffhorst for all their hard work on the planning and content, (and Imke's talented ilustrative work), to helpful reviewers, and to @dev-journal.bsky.social for a smooth and efficient review process.
Reposted
📣 Register for the 6th Annual FSSCR Meeting in Paris and experience pioneering research in #stemcells biology & future clinical applications!
fsscr-meeting.org 👇🏻
ABSTRACT submission now available.
fsscr-meeting.org 👇🏻
ABSTRACT submission now available.
May 12, 2025 at 3:51 PM
📣 Register for the 6th Annual FSSCR Meeting in Paris and experience pioneering research in #stemcells biology & future clinical applications!
fsscr-meeting.org 👇🏻
ABSTRACT submission now available.
fsscr-meeting.org 👇🏻
ABSTRACT submission now available.
Reposted
How does metabolism act through generic chromatin modifiers promote specific cellular states? Simultaneous modification of transcription factors and chromatin, enhancing epigenetic signal to noise ratios.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Altering metabolism programs cell identity via NAD+-dependent deacetylation | The EMBO Journal
imageimageHow alterations in cell metabolism translate into specific developmental gene programs remains a major question. This study shows that forcing OXPHOS metabolism reprograms mouse embryonic stem cells (ESCs) to a more inner cell mass (ICM)-...
www.embopress.org
April 25, 2025 at 3:26 PM
How does metabolism act through generic chromatin modifiers promote specific cellular states? Simultaneous modification of transcription factors and chromatin, enhancing epigenetic signal to noise ratios.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted
Want to work with us on DNA methylation and rare genetic disease? Fully funded PhD project with deadline 16th May:
www.findaphd.com/phds/project...
Excited to collaborate with @hannahlong.bsky.social and Daria Bunina (@uoe-igc.bsky.social/@mdc-berlin.bsky.social).
Please share 🙏
#epigenetics
www.findaphd.com/phds/project...
Excited to collaborate with @hannahlong.bsky.social and Daria Bunina (@uoe-igc.bsky.social/@mdc-berlin.bsky.social).
Please share 🙏
#epigenetics
Fully Funded PhD Studentship in Human Genetics, Genomics and Disease: Dissecting DNMT3B functions in Immunodeficiency-centromeric instability facial anomalies syndrome at University of Edinburgh on Fi...
PhD Project - Fully Funded PhD Studentship in Human Genetics, Genomics and Disease: Dissecting DNMT3B functions in Immunodeficiency-centromeric instability facial anomalies syndrome at University of E...
www.findaphd.com
April 23, 2025 at 9:49 AM
Want to work with us on DNA methylation and rare genetic disease? Fully funded PhD project with deadline 16th May:
www.findaphd.com/phds/project...
Excited to collaborate with @hannahlong.bsky.social and Daria Bunina (@uoe-igc.bsky.social/@mdc-berlin.bsky.social).
Please share 🙏
#epigenetics
www.findaphd.com/phds/project...
Excited to collaborate with @hannahlong.bsky.social and Daria Bunina (@uoe-igc.bsky.social/@mdc-berlin.bsky.social).
Please share 🙏
#epigenetics
Reposted
Interested in Developmental Mechanics??? We are organizing a mechanobiology workshop in Baeza, Spain, October 21-23, 2025. Come join us (and please help us spread the word)!!!
April 25, 2025 at 2:08 PM
Interested in Developmental Mechanics??? We are organizing a mechanobiology workshop in Baeza, Spain, October 21-23, 2025. Come join us (and please help us spread the word)!!!
Reposted
✨ PLUS QUE DEUX MOIS avant #pint25 ✨
📍 +55 villes, du Parc naturel du Limousin à la Réunion et la Guyane
🔬 Des centaines de scientifiques passionné·e·s
🫂 500 organisateurs·trices à fond !
📱 Programme : 31 mars
🎟 Tickets : 14 avril
👉 pintofscience.fr
📍 +55 villes, du Parc naturel du Limousin à la Réunion et la Guyane
🔬 Des centaines de scientifiques passionné·e·s
🫂 500 organisateurs·trices à fond !
📱 Programme : 31 mars
🎟 Tickets : 14 avril
👉 pintofscience.fr
March 19, 2025 at 8:10 AM
✨ PLUS QUE DEUX MOIS avant #pint25 ✨
📍 +55 villes, du Parc naturel du Limousin à la Réunion et la Guyane
🔬 Des centaines de scientifiques passionné·e·s
🫂 500 organisateurs·trices à fond !
📱 Programme : 31 mars
🎟 Tickets : 14 avril
👉 pintofscience.fr
📍 +55 villes, du Parc naturel du Limousin à la Réunion et la Guyane
🔬 Des centaines de scientifiques passionné·e·s
🫂 500 organisateurs·trices à fond !
📱 Programme : 31 mars
🎟 Tickets : 14 avril
👉 pintofscience.fr
Reposted
L'IA va-t-elle remplacer les chercheurs ? J'essaye de faire le point en 2mn sur cette question bien plus actuelle et urgente que je ne le pensais...
youtube.com/shorts/4Y92w...
youtube.com/shorts/4Y92w...
L'IA va-t-elle remplacer les chercheurs ? (vidéo n°430)
YouTube video by Julien Bobroff
youtube.com
February 15, 2025 at 9:05 AM
L'IA va-t-elle remplacer les chercheurs ? J'essaye de faire le point en 2mn sur cette question bien plus actuelle et urgente que je ne le pensais...
youtube.com/shorts/4Y92w...
youtube.com/shorts/4Y92w...
Reposted
I put together a small guide on how to get started with Fiji. Please distribute to anyone who might benefit form this! zenodo.org/records/1477... #imageanalysis #fiji #imagej #training
Image handling using Fiji - training materials
Description:This training package provides a guide to image processing and analysis using ImageJ/Fiji, an open-source software widely used in biological and medical imaging. The manual includes step-b...
zenodo.org
January 30, 2025 at 3:10 PM
I put together a small guide on how to get started with Fiji. Please distribute to anyone who might benefit form this! zenodo.org/records/1477... #imageanalysis #fiji #imagej #training
Reposted
There's a new wave of discussion to improve the clarity of Fiji's original menus and plugins. If you have opinions or suggestions to make, don't hesitate to participate on the forum!
forum.image.sc/t/houseclean...
#microscopy #imagej #fiji
forum.image.sc/t/houseclean...
#microscopy #imagej #fiji
Housecleaning Fiji for the Java 21 update
Unrelated, but pertinent to the java 21 release: I don’t want to start unnecessary controversy, and please don’t be annoyed by this, but since this is going to be the GOAT of all releases, it seems a ...
forum.image.sc
January 23, 2025 at 12:17 PM
There's a new wave of discussion to improve the clarity of Fiji's original menus and plugins. If you have opinions or suggestions to make, don't hesitate to participate on the forum!
forum.image.sc/t/houseclean...
#microscopy #imagej #fiji
forum.image.sc/t/houseclean...
#microscopy #imagej #fiji
Reposted
I am thrilled to share our latest work, released today 🤩
www-nature-com.insb.bib.cnrs.fr/articles/s41...
It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.
www-nature-com.insb.bib.cnrs.fr/articles/s41...
It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.
January 21, 2025 at 10:34 AM
I am thrilled to share our latest work, released today 🤩
www-nature-com.insb.bib.cnrs.fr/articles/s41...
It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.
www-nature-com.insb.bib.cnrs.fr/articles/s41...
It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.