The cave populations of Astyanax mexicanus in northeastern Mexico are the subject of intensive study as a model for investigating evolutionary processes in subterranean environments. Investigating key...

From 2009 to 2025, we have recorded the physicochemical parameters of the water and the hydrological regimes at localities hosting Astyanax mexicanus cavefish and surface fish populations in Mexico. ...

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Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Temporal patterning of retinal progenitor cells governs the sequential generation of retinal cell types, with gliogenesis occurring late in development. Sox8 and Sox9, members of the SoxE transcription factor family, are highly expressed in late-stage retinal progenitor cells and mature Müller glia, yet their functional roles remain incompletely defined. Here we employed gain- and loss-of-function approaches, single-cell multiomic profiling, and injury models to investigate Sox8/9 function. Overexpression of SOX8 and/or SOX9 in early-stage retinal progenitor cells suppressed early-born cell fates and promoted photoreceptor generation, consistent with a role in late-stage temporal identity. Conversely, conditional deletion of Sox8 and/or Sox9 in late-stage progenitors did not impair Müller glia specification, but caused radial displacement of Müller glia nuclei into the outer retina and modest changes in glial gene expression. Loss of Sox8/9 in mature Müller glia modestly increased proliferation post-injury without inducing neurogenic competence. These findings suggest that Sox8/9 are dispensable for gliogenesis and repression of neurogenic competence, but are essential for proper laminar positioning and maturation of retinal Müller glia. ### Competing Interest Statement S.B. is a cofounder, shareholder, and scientific advisory board member of CDI Labs LLC, and receives research support from Genentech. National Eye Institute, https://ror.org/03wkg3b53, R01EY036173

Grâce à son parcours autodidacte remarquable, Valérie Lavallée a connu une progression de carrière constante jusqu’à être nommée responsable de la plateforme de zootechnie de l’Institut des Neurosciences Paris-Saclay (NeuroPSI - CNRS/Université Paris-Saclay), situé sur le campus du CEA Saclay. En 2021, elle a notamment relevé le défi de l’installation d’une plateforme de zootechnie multi-espèces lors du déménagement du laboratoire. En 2025, le CNRS décernera la médaille de cristal à Valérie Lavallée pour la qualité de son travail et pour son rôle majeur dans ce déménagement, qui a permis le regroupement des sites zootechniques de Gif-sur-Yvette et Orsay vers le nouveau bâtiment de NeuroPSI. Cette plateforme est désormais une vitrine de l’excellence en zootechnie scientifique.

Axolotls can regenerate optic nerves, retinas, and parts of their brain. Provost's Undergraduate Research Award-winner Ted Chor wants to understand how.

The vertebrate retina serves as a model for studying neurogenesis and cell fate specification, with retinal progenitor cells following a tightly regulated temporal sequence to generate distinct cell t...

Loss of function of Ptbp1 in retinal progenitors leads to changes in RNA splicing but does not affect neurogenesis and cell fate specification.

Stem cell–derived mesodermal organoids reveal how signaling centers guide cell fate and tissue organization.