Ryan MacDonald
@macdonaldlab.bsky.social
Glia biologist. Vision scientist. Interested in mechanisms of development and ageing in the retina. We love glia. You should too.
Reposted by Ryan MacDonald
Our work on the TET enzymes in retinal development is out. We identified that rod fate is inhibited when DNA demethylation is prevented by removal of the TET enzymes. Interestingly, photoreceptor numbers are normal. We utilized WGBS and bACE-seq to profile the precise localization of 5mC and 5hmC,…
TET enzymes remove #DNAmethylation markers; @ismaelhdeznunez.bsky.social @clark-lab-retina.bsky.social &co show that these enzymes are required for #photoreceptor cells to initiate the genetic program to become rods instead of cones, & for maturation of the #retina @plosbiology.org 🧪 plos.io/3UaVBfl
August 6, 2025 at 3:19 AM
Our work on the TET enzymes in retinal development is out. We identified that rod fate is inhibited when DNA demethylation is prevented by removal of the TET enzymes. Interestingly, photoreceptor numbers are normal. We utilized WGBS and bACE-seq to profile the precise localization of 5mC and 5hmC,…
Reposted by Ryan MacDonald
Hi all, we got a grant for a cool project that will follow up of our paper published a few months ago (see below). We will explore how light acts as a morphogen to instruct PCP. If you are looking for a postdoc position and interested in this topic, please reach out!
ICYMI our latest paper is now out officially in print (is there still such thing?). And since Dev Cell @cellpress.bsky.social did not select our submission for cover, I post it here. A really cool illustration from my son Zack. www.cell.com/developmenta...
July 25, 2025 at 9:08 PM
Hi all, we got a grant for a cool project that will follow up of our paper published a few months ago (see below). We will explore how light acts as a morphogen to instruct PCP. If you are looking for a postdoc position and interested in this topic, please reach out!
Reposted by Ryan MacDonald
#ZebrafishCareers 🇬🇧 (Postdoc) #killifish
Link to MacDonald Lab website: zebrafishucl.org/macdonald-la...
Link to MacDonald Lab website: zebrafishucl.org/macdonald-la...
April 3, 2025 at 10:50 AM
#ZebrafishCareers 🇬🇧 (Postdoc) #killifish
Link to MacDonald Lab website: zebrafishucl.org/macdonald-la...
Link to MacDonald Lab website: zebrafishucl.org/macdonald-la...
Reposted by Ryan MacDonald
My lab studies mechanisms of pediatric glaucoma and the development of tissues affected (Schlemm's canal and trabecular meshwork). I am getting creative with fundraising because, well... So if you know someone who might be interested in funding our work: joinus.cuimc.columbia.edu/index.cfm?fu...
I'm supporting Your Columbia!
Your Columbia is your opportunity to be a part of the unparalleled research, education, and clinical care that takes place every day at Columbia University Irving Medical Center. It’s a potent and imp...
joinus.cuimc.columbia.edu
March 27, 2025 at 4:33 PM
My lab studies mechanisms of pediatric glaucoma and the development of tissues affected (Schlemm's canal and trabecular meshwork). I am getting creative with fundraising because, well... So if you know someone who might be interested in funding our work: joinus.cuimc.columbia.edu/index.cfm?fu...
Reposted by Ryan MacDonald
#ZebrafishCareers 🇬🇧 (Postdoc) #killifish
We’re hiring a new research fellow. Come join us in London to study glial cells in the ageing retina using killifish as a model. www.ucl.ac.uk/work-at-ucl/...
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
www.ucl.ac.uk
February 7, 2025 at 4:32 PM
#ZebrafishCareers 🇬🇧 (Postdoc) #killifish
We’re hiring a new research fellow. Come join us in London to study glial cells in the ageing retina using killifish as a model. www.ucl.ac.uk/work-at-ucl/...
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
www.ucl.ac.uk
February 7, 2025 at 2:35 PM
We’re hiring a new research fellow. Come join us in London to study glial cells in the ageing retina using killifish as a model. www.ucl.ac.uk/work-at-ucl/...
Reposted by Ryan MacDonald
First post on this platform is to announce that our preprint is posted to bioRxiv:
bioRxiv 2025.02.03.636318; doi: doi.org/10.1101/2025...
bioRxiv 2025.02.03.636318; doi: doi.org/10.1101/2025...
doi.org
February 4, 2025 at 9:15 PM
First post on this platform is to announce that our preprint is posted to bioRxiv:
bioRxiv 2025.02.03.636318; doi: doi.org/10.1101/2025...
bioRxiv 2025.02.03.636318; doi: doi.org/10.1101/2025...