Ranganath Muniyappa
@muniyappar.bsky.social
Senior Clinician and Endocrinologist NIDDK
with an interest in diabetes, obesity, and cardiovascular disease. Views/comments my own.
with an interest in diabetes, obesity, and cardiovascular disease. Views/comments my own.
Reposted by Ranganath Muniyappa
My quote of the day
If misunderstandings happen between the people, it is wiser to talk each other and explain your real purpose for the stable, and a stronger relationship than breaking that. Prove your good faith.
Ehsan Sehgal
If misunderstandings happen between the people, it is wiser to talk each other and explain your real purpose for the stable, and a stronger relationship than breaking that. Prove your good faith.
Ehsan Sehgal
November 17, 2025 at 1:42 PM
My quote of the day
If misunderstandings happen between the people, it is wiser to talk each other and explain your real purpose for the stable, and a stronger relationship than breaking that. Prove your good faith.
Ehsan Sehgal
If misunderstandings happen between the people, it is wiser to talk each other and explain your real purpose for the stable, and a stronger relationship than breaking that. Prove your good faith.
Ehsan Sehgal
Reposted by Ranganath Muniyappa
One of my fav tik tok accounts was chandler and his grandma.
November 14, 2025 at 6:57 PM
One of my fav tik tok accounts was chandler and his grandma.
Reposted by Ranganath Muniyappa
📣Understanding Hyperinsulinism and sharing our links is valuable because it leads to:
✅ Better support and understanding for individuals with HI
✅ Early Diagnosis and Prompt Intervention
✅New families are reached
✅New connections are made
https://linktr.ee/chcharityuk
✅ Better support and understanding for individuals with HI
✅ Early Diagnosis and Prompt Intervention
✅New families are reached
✅New connections are made
https://linktr.ee/chcharityuk
October 19, 2025 at 8:00 AM
📣Understanding Hyperinsulinism and sharing our links is valuable because it leads to:
✅ Better support and understanding for individuals with HI
✅ Early Diagnosis and Prompt Intervention
✅New families are reached
✅New connections are made
https://linktr.ee/chcharityuk
✅ Better support and understanding for individuals with HI
✅ Early Diagnosis and Prompt Intervention
✅New families are reached
✅New connections are made
https://linktr.ee/chcharityuk
Reposted by Ranganath Muniyappa
Here are some thoughts about higher education - specifically statistics & research methods - after grading some more papers written with "assistance" from LLMs.
🧵
🧵
October 12, 2025 at 2:10 PM
Here are some thoughts about higher education - specifically statistics & research methods - after grading some more papers written with "assistance" from LLMs.
🧵
🧵
Reposted by Ranganath Muniyappa
There is LOT more where that came from. If you like THEY KNEW, please spread the word about the $2.99 sale! I don't make hardly any money off this. I only want people to read the book and know the truth about our country, our past, and our future.
Thank you!
Thank you!
May 10, 2025 at 4:32 PM
There is LOT more where that came from. If you like THEY KNEW, please spread the word about the $2.99 sale! I don't make hardly any money off this. I only want people to read the book and know the truth about our country, our past, and our future.
Thank you!
Thank you!
Reposted by Ranganath Muniyappa
This is must-listen for all of us who are scientists - and all who question science
Great interview with Hasok Chang on 'Epistemic Iteration':
The idea that we don't often start scientific inquiries from a solid foundation. We knowingly start from an imperfect position, and use the outcomes to refine and correct the original starting point.
open.spotify.com/episode/6tbT...
The idea that we don't often start scientific inquiries from a solid foundation. We knowingly start from an imperfect position, and use the outcomes to refine and correct the original starting point.
open.spotify.com/episode/6tbT...
Audience Faves: Hasok Chang on 'Epistemic Iteration'
The HPS Podcast - Conversations from History, Philosophy and Social Studies of Science · Episode
open.spotify.com
May 10, 2025 at 1:50 PM
This is must-listen for all of us who are scientists - and all who question science
Reposted by Ranganath Muniyappa
I once asked a scientist whom I respect enormously her advice for a successful career and life in science.
Her advice: Leave every place better than you found it.
It surprises me that many people would try hard to do the compete opposite …
and we would elect them to run the country.
Her advice: Leave every place better than you found it.
It surprises me that many people would try hard to do the compete opposite …
and we would elect them to run the country.
May 10, 2025 at 9:18 PM
I once asked a scientist whom I respect enormously her advice for a successful career and life in science.
Her advice: Leave every place better than you found it.
It surprises me that many people would try hard to do the compete opposite …
and we would elect them to run the country.
Her advice: Leave every place better than you found it.
It surprises me that many people would try hard to do the compete opposite …
and we would elect them to run the country.
Reposted by Ranganath Muniyappa
Breaking News: A federal prosecutor interrogated the The New England Journal of Medicine — which is considered the world’s most prestigious medical journal — in what its editor described as a “vaguely threatening” letter.
‘Vaguely Threatening’: Federal Prosecutor Queries Leading Medical Journal
The New England Journal of Medicine received a letter suggesting that it was biased and compromised by external pressure. Other journals have also received the letter.
www.nytimes.com
April 25, 2025 at 9:17 PM
Breaking News: A federal prosecutor interrogated the The New England Journal of Medicine — which is considered the world’s most prestigious medical journal — in what its editor described as a “vaguely threatening” letter.
Reposted by Ranganath Muniyappa
Ah yes, the government asking Jews to register as Jewish, in the name of protecting the Jews. No way that could go wrong www.nytimes.com/2025/04/23/n...
U.S. Texts Barnard Employees and Asks if They Are Jewish
A questionnaire from a federal commission also inquired about whether professors and other college staff members had been harassed.
www.nytimes.com
April 24, 2025 at 1:24 AM
Ah yes, the government asking Jews to register as Jewish, in the name of protecting the Jews. No way that could go wrong www.nytimes.com/2025/04/23/n...
Reposted by Ranganath Muniyappa
Here’s the interview
New Interview: I talked to the Holocaust historian Deborah Lipstadt, who was Biden’s special envoy on antisemitism, about why she doesn’t oppose some student deportations, and why she wanted to keep some of her comments off the record. www.newyorker.com/news/q-and-a...
The Biden Official Who Doesn’t Oppose Trump’s Student Deportations
Why the Holocaust historian Deborah Lipstadt blames universities for “opening the door” to the Trump Administration’s professed campaign to tackle antisemitism.
www.newyorker.com
April 22, 2025 at 8:25 PM
Here’s the interview
Reposted by Ranganath Muniyappa
www.nytimes.com/2025/04/21/n...
“Mr. Khalil, a permanent resident detained in Louisiana, had requested a monitored furlough for the birth. His request was denied in less than an hour.”
No sense of decency.
“Mr. Khalil, a permanent resident detained in Louisiana, had requested a monitored furlough for the birth. His request was denied in less than an hour.”
No sense of decency.
Mahmoud Khalil’s Son Arrives After ICE Refuses to Let Him Attend Birth (Gift Article)
Mr. Khalil, a permanent resident detained in Louisiana, had requested a monitored furlough for the birth. His request was denied in less than an hour.
www.nytimes.com
April 22, 2025 at 12:09 AM
www.nytimes.com/2025/04/21/n...
“Mr. Khalil, a permanent resident detained in Louisiana, had requested a monitored furlough for the birth. His request was denied in less than an hour.”
No sense of decency.
“Mr. Khalil, a permanent resident detained in Louisiana, had requested a monitored furlough for the birth. His request was denied in less than an hour.”
No sense of decency.
Reposted by Ranganath Muniyappa
Yet here we are…
It has noting to do with discrimination in any case. Israel is a separate and sovereign nation, not a protected group under US civil rights law.
This is all laughably stupid.
This is all laughably stupid.
April 20, 2025 at 10:08 PM
Yet here we are…
Reposted by Ranganath Muniyappa
How might polygenic risk scores enhance the management of type 2 #diabetes #genetics @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Clinical use of polygenic scores in type 2 diabetes: challenges and possibilities - Diabetologia
Resulting from a combination of genetic and environmental factors, type 2 diabetes is highly heterogeneous in manifestation and disease progression, with the only common feature being chronic hypergly...
link.springer.com
April 5, 2025 at 8:31 PM
How might polygenic risk scores enhance the management of type 2 #diabetes #genetics @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Reposted by Ranganath Muniyappa
I think there is going to be a Red Rural Recession and soon if all the cuts continue as is
All the firings, cancelling of grants and contracts with companies , the closing of offices, disproportionately impact small towns, cities and states.
Their finances will be turned upside
All the firings, cancelling of grants and contracts with companies , the closing of offices, disproportionately impact small towns, cities and states.
Their finances will be turned upside
March 28, 2025 at 3:14 AM
I think there is going to be a Red Rural Recession and soon if all the cuts continue as is
All the firings, cancelling of grants and contracts with companies , the closing of offices, disproportionately impact small towns, cities and states.
Their finances will be turned upside
All the firings, cancelling of grants and contracts with companies , the closing of offices, disproportionately impact small towns, cities and states.
Their finances will be turned upside
Reposted by Ranganath Muniyappa
No books. No teachers. Just a centralized AI that serves as intercessor between each child and the world's knowledge.
It's literally a pre-reformation view, with Grok in the place of Yahweh.
It's literally a pre-reformation view, with Grok in the place of Yahweh.
March 23, 2025 at 11:35 PM
No books. No teachers. Just a centralized AI that serves as intercessor between each child and the world's knowledge.
It's literally a pre-reformation view, with Grok in the place of Yahweh.
It's literally a pre-reformation view, with Grok in the place of Yahweh.
Reposted by Ranganath Muniyappa
Reposted by Ranganath Muniyappa
A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved
March 23, 2025 at 4:17 PM
A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved
The U.S. knew COVID was airborne by Jan 2020. Taiwan flagged it Dec 31, 2019. The President admitted it “goes through the air” in Feb, and likely briefed in early Jan. Cloth masks and 6-ft rules were never going to work—and they knew it. But this elite Prof thinks she convinced Dr. Fauci?👇
😦
😦
March 23, 2025 at 12:39 AM
The U.S. knew COVID was airborne by Jan 2020. Taiwan flagged it Dec 31, 2019. The President admitted it “goes through the air” in Feb, and likely briefed in early Jan. Cloth masks and 6-ft rules were never going to work—and they knew it. But this elite Prof thinks she convinced Dr. Fauci?👇
😦
😦
Reposted by Ranganath Muniyappa
I've reviewed 10 consumer-facing companies that are in the business of promoting longevity and healthspan
erictopol.substack.com/p/the-busine...
Open-access, in the new edition of Ground Truths
erictopol.substack.com/p/the-busine...
Open-access, in the new edition of Ground Truths
March 22, 2025 at 5:14 PM
I've reviewed 10 consumer-facing companies that are in the business of promoting longevity and healthspan
erictopol.substack.com/p/the-busine...
Open-access, in the new edition of Ground Truths
erictopol.substack.com/p/the-busine...
Open-access, in the new edition of Ground Truths
Reposted by Ranganath Muniyappa
Great plain English essay open-access @science.org by @melaniemitchell.bsky.social on large reasoning models www.science.org/doi/10.1126/...
Artificial intelligence learns to reason
Julia has two sisters and one brother. How many sisters does her brother Martin have?Solving this tiny puzzle requires a bit of thinking. You might mentally picture the family of three girls and one b...
www.science.org
March 21, 2025 at 1:03 AM
Great plain English essay open-access @science.org by @melaniemitchell.bsky.social on large reasoning models www.science.org/doi/10.1126/...
Reposted by Ranganath Muniyappa
Hot off the press: my review of Csaba Szabo's book Unreliable; deevybee.blogspot.com/2025/03/book...
Book Review: Unreliable: Bias, Fraud, and the Reproducibility Crisis in Biomedical Research
by Csaba Szabo, Columbia University Press, 2025 This is a rollicking good read, written in an informal style, and enlivened by cartoons, wh...
deevybee.blogspot.com
March 16, 2025 at 5:04 PM
Hot off the press: my review of Csaba Szabo's book Unreliable; deevybee.blogspot.com/2025/03/book...
Reposted by Ranganath Muniyappa
it’s the cruelest form of irony
I’m struck by how close we’re getting to finally curing some of the world’s worst diseases—sickle cell, Alzheimers, pancreatic cancer, etc.—at the same time that the world’s worst people are destroying medical research and care around the world.
Looks like we've got a cure for sickle cell. www.cbsnews.com/newyork/news...
March 15, 2025 at 2:58 AM
it’s the cruelest form of irony
During rounds at the NIH Clinical Center: Why can't we use GLP-1 receptor agonists (GLP-1RAs) in patients with lipodystrophy?
Here’s the answer to that question.
Here’s the answer to that question.
Should we compare tirzepatide with leptin for some forms of lipodystrophy? The intriguing data continues to roll in diabetesjournals.org/care/article...
Metabolic Improvements With Tirzepatide in Lipodystrophy: A Novel Option?
OBJECTIVE. Lipodystrophy encompasses a group of rare disorders associated with severe metabolic disease. These disorders are defined by abnormal fat distri
diabetesjournals.org
March 11, 2025 at 12:26 AM
During rounds at the NIH Clinical Center: Why can't we use GLP-1 receptor agonists (GLP-1RAs) in patients with lipodystrophy?
Here’s the answer to that question.
Here’s the answer to that question.
Fathers
March 2, 2025 at 12:52 AM
Fathers