Manoj Kumar Valluru
@mkvalluru.bsky.social
Postdoc @ Kidney Genetics Group @Ong_Lab @ShefUni_ClinMed
Reposted by Manoj Kumar Valluru
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
November 5, 2025 at 9:18 AM
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Manoj Kumar Valluru
What an amazing paper from the Bonasio lab! Domesticated retroviral proteins and RNA-modifying enzymes that regulate RNA loading into and transportation via extracellular vesicles (1/2). www.biorxiv.org/content/10.1...
Pseudouridine selects RNAs for extracellular transport
RNAs move through the extracellular space to transmit information between cells, including mammalian neurons, yet how specific RNAs are channeled into these extracellular routes is unknown. Using geno...
www.biorxiv.org
November 5, 2025 at 2:20 PM
What an amazing paper from the Bonasio lab! Domesticated retroviral proteins and RNA-modifying enzymes that regulate RNA loading into and transportation via extracellular vesicles (1/2). www.biorxiv.org/content/10.1...
Reposted by Manoj Kumar Valluru
Review article from Quan Sun and Yun Li at UNC Genetics and Biostatistics
New online! Advances in haplotype phasing and genotype imputation
Advances in haplotype phasing and genotype imputation
Nature Reviews Genetics, Published online: 24 September 2025; doi:10.1038/s41576-025-00895-2Haplotype phasing and genotype imputation improve genomic analyses by determining which variants occur together on a chromosome and inferring unobserved varants, respectively. In this Review, Sun and Li describe how tools for haplotype phasing and genotype imputation have evolved to accommodate increasingly larger genomic datasets and new sequencing technologies.
www.nature.com
September 25, 2025 at 12:51 PM
Review article from Quan Sun and Yun Li at UNC Genetics and Biostatistics
Reposted by Manoj Kumar Valluru
The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data!
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.
Start mining data now: dataminer.depmap.sanger.ac.uk
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.
Start mining data now: dataminer.depmap.sanger.ac.uk
September 20, 2025 at 7:43 AM
The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data!
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.
Start mining data now: dataminer.depmap.sanger.ac.uk
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.
Start mining data now: dataminer.depmap.sanger.ac.uk
Reposted by Manoj Kumar Valluru
Thinking about who's hanging out with you RNA in cells? Here's a super overview of the (many!) things you can do to find out. Many thanks @mardakheh.bsky.social @shechnerlab.bsky.social #RNA #RNAinteractome
Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!
tinyurl.com/ydn6e3ac
tinyurl.com/ydn6e3ac
July 1, 2025 at 5:36 AM
Thinking about who's hanging out with you RNA in cells? Here's a super overview of the (many!) things you can do to find out. Many thanks @mardakheh.bsky.social @shechnerlab.bsky.social #RNA #RNAinteractome
This biologist aims to solve the cell’s biggest mystery. Could it help cancer patients, too? | Science | AAAS www.science.org/content/arti...
This biologist aims to solve the cell’s biggest mystery. Could it help cancer patients, too?
Four decades after his lab found odd, massive particles inside cells, Leonard Rome is still determined to figure out what “vaults” do
www.science.org
June 22, 2025 at 11:53 AM
This biologist aims to solve the cell’s biggest mystery. Could it help cancer patients, too? | Science | AAAS www.science.org/content/arti...
In @elife: BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKD doi.org/10.7554/eLif...
BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKD
doi.org
June 11, 2025 at 2:43 PM
In @elife: BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKD doi.org/10.7554/eLif...
Reposted by Manoj Kumar Valluru
Archit, A., Freckmann, L., Nair, S., Khalid, N., Hilt, P., Rajashekar, V., Freitag, M., Teuber, C., Buckley, G., von Haaren, S., Gupta, S., Dengel, A., Ahmed, S., & Pape, C. (2025). Segment Anything for Microscopy. Nature methods, 22(3), 579–591. #EpithelialMechanics
buff.ly/yichKRV
buff.ly/yichKRV
June 4, 2025 at 10:02 AM
Archit, A., Freckmann, L., Nair, S., Khalid, N., Hilt, P., Rajashekar, V., Freitag, M., Teuber, C., Buckley, G., von Haaren, S., Gupta, S., Dengel, A., Ahmed, S., & Pape, C. (2025). Segment Anything for Microscopy. Nature methods, 22(3), 579–591. #EpithelialMechanics
buff.ly/yichKRV
buff.ly/yichKRV
Reposted by Manoj Kumar Valluru
For over 40 years, we have driven research in efforts to find a cure for PKD. Now, a 57% cut to CDMRP funding threatens that progress. Urge Congress to protect this critical funding, PKD research depends on it!
Take action now: p2a.co/5rwekfw
Take action now: p2a.co/5rwekfw
March 14, 2025 at 8:23 PM
For over 40 years, we have driven research in efforts to find a cure for PKD. Now, a 57% cut to CDMRP funding threatens that progress. Urge Congress to protect this critical funding, PKD research depends on it!
Take action now: p2a.co/5rwekfw
Take action now: p2a.co/5rwekfw
Reposted by Manoj Kumar Valluru
For all of you who cannot access pubmed, here is a good alternative:
europepmc.org
europepmc.org
Europe PMCHome - Europe PMC
Europe PMC is an archive of life sciences journal literature.
europepmc.org
March 2, 2025 at 9:56 AM
For all of you who cannot access pubmed, here is a good alternative:
europepmc.org
europepmc.org
Reposted by Manoj Kumar Valluru
'For example, whereas more than 13,000 research articles have been published on TP53, half of human genes are barely mentioned in the literature (Fig. 1). It is estimated that 75% of all research on protein-coding genes has been focused on fewer than 10% of proteins'
www.nature.com/articles/s41...
www.nature.com/articles/s41...
MorPhiC Consortium: towards functional characterization of all human genes - Nature
This Perspective discusses strategies and challenges for the Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Consortium as it aims to catalogue the molecular and cellular phenotypes associated...
www.nature.com
February 12, 2025 at 9:40 PM
'For example, whereas more than 13,000 research articles have been published on TP53, half of human genes are barely mentioned in the literature (Fig. 1). It is estimated that 75% of all research on protein-coding genes has been focused on fewer than 10% of proteins'
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Manoj Kumar Valluru
Barai, A., Soleilhac, M., Xi, W., Lin, S. Z., Karnat, M., Bazellieres, E., ... & Delacour, D. (2024). A multicellular actin star network underpins epithelial organization and connectivity. BioRxiv, 2024-07. https://doi.org/10.1101/2024.07.26.605277 #EpithelialMechanics
A multicellular actin star network underpins epithelial organization and connectivity
Epithelial tissues serve as physical barriers against various external pressures yet remarkably maintain structural stability. Various cellular apparatus including bicellular junction and actomyosin…
doi.org
February 4, 2025 at 6:00 AM
Barai, A., Soleilhac, M., Xi, W., Lin, S. Z., Karnat, M., Bazellieres, E., ... & Delacour, D. (2024). A multicellular actin star network underpins epithelial organization and connectivity. BioRxiv, 2024-07. https://doi.org/10.1101/2024.07.26.605277 #EpithelialMechanics
Reposted by Manoj Kumar Valluru
Fantastic @natrevneph.bsky.social disease primer on #kidney adaptation to injury, the devlopment of #CKD, its progression, and how to stop it.
@hjanders.bsky.social @romagnanilab.bsky.social
🔥 #NephSky #MedSky 🔥
🔗 rdcu.be/d71Rj
@hjanders.bsky.social @romagnanilab.bsky.social
🔥 #NephSky #MedSky 🔥
🔗 rdcu.be/d71Rj
February 3, 2025 at 9:23 AM
Fantastic @natrevneph.bsky.social disease primer on #kidney adaptation to injury, the devlopment of #CKD, its progression, and how to stop it.
@hjanders.bsky.social @romagnanilab.bsky.social
🔥 #NephSky #MedSky 🔥
🔗 rdcu.be/d71Rj
@hjanders.bsky.social @romagnanilab.bsky.social
🔥 #NephSky #MedSky 🔥
🔗 rdcu.be/d71Rj
Reposted by Manoj Kumar Valluru
🚨🚨 MEGA JOB ALERT 🚨🚨
Independent Group Leader Positions in Computational Biology @humantechnopole.bsky.social!
Are you ready to start your own lab? Do you know someone who is? Repost this + share with everyone who might want to know about it. Thanks!!! 🙏
More details below... check it out! 🧵 1/3
Independent Group Leader Positions in Computational Biology @humantechnopole.bsky.social!
Are you ready to start your own lab? Do you know someone who is? Repost this + share with everyone who might want to know about it. Thanks!!! 🙏
More details below... check it out! 🧵 1/3
January 29, 2025 at 10:40 AM
🚨🚨 MEGA JOB ALERT 🚨🚨
Independent Group Leader Positions in Computational Biology @humantechnopole.bsky.social!
Are you ready to start your own lab? Do you know someone who is? Repost this + share with everyone who might want to know about it. Thanks!!! 🙏
More details below... check it out! 🧵 1/3
Independent Group Leader Positions in Computational Biology @humantechnopole.bsky.social!
Are you ready to start your own lab? Do you know someone who is? Repost this + share with everyone who might want to know about it. Thanks!!! 🙏
More details below... check it out! 🧵 1/3
Reposted by Manoj Kumar Valluru
How a WHO Staff Member Turned the US Withdrawal into an Act of Solidarity
who.foundation/blogs-post/h...
who.foundation/blogs-post/h...
How a WHO Staff Member Turned the US Withdrawal into an Act of Solidarity
who.foundation
January 25, 2025 at 7:21 AM
How a WHO Staff Member Turned the US Withdrawal into an Act of Solidarity
who.foundation/blogs-post/h...
who.foundation/blogs-post/h...
A Homozygous Nonsense Variant in the BICC1 Gene Associated With Fetal Cystic Kidney Disease and Lower Limb Post‐Axial Polydactyly - Tamhankar - American Journal of Medical Genetics Part A - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
A Homozygous Nonsense Variant in the BICC1 Gene Associated With Fetal Cystic Kidney Disease and Lower Limb Post‐Axial Polydactyly
Click on the article title to read more.
onlinelibrary.wiley.com
January 15, 2025 at 7:29 PM
A Homozygous Nonsense Variant in the BICC1 Gene Associated With Fetal Cystic Kidney Disease and Lower Limb Post‐Axial Polydactyly - Tamhankar - American Journal of Medical Genetics Part A - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Manoj Kumar Valluru
Very excited to announce that the single cell/nuc. RNA/ATAC/multi-ome resource from ENCODE4 is now officially public. This includes raw data, processed data, annotations and pseudobulk products. Covers many human & mouse tissues. 1/
www.encodeproject.org/single-cell/...
www.encodeproject.org/single-cell/...
Single cell – ENCODEHomo sapiens clickable body map
www.encodeproject.org
January 7, 2025 at 9:29 PM
Very excited to announce that the single cell/nuc. RNA/ATAC/multi-ome resource from ENCODE4 is now officially public. This includes raw data, processed data, annotations and pseudobulk products. Covers many human & mouse tissues. 1/
www.encodeproject.org/single-cell/...
www.encodeproject.org/single-cell/...
Reposted by Manoj Kumar Valluru
BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKD https://www.biorxiv.org/content/10.1101/2024.08.27.608867v1
BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKD https://www.biorxiv.org/content/10.1101/2024.08.27.608867v1
Background: Autosomal dominant polycystic kidney disease (ADPKD) is primarily of adult-onset and cau
www.biorxiv.org
August 28, 2024 at 5:33 AM
BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKD https://www.biorxiv.org/content/10.1101/2024.08.27.608867v1