MitoCarriers
@mitocarriers.bsky.social
Home of mitochondrial transport proteins
Recently, I saw a sun dog next to the cupola of Trinity Hall, Cambridge. It is a natural phenomena where hexagonal ice crystals in the sky deflect the sun light at a 22 degree angle. They function as a prism, like diamond dust, separating out the different wavelengths. Big shout out to Newton!
October 11, 2025 at 2:00 PM
Recently, I saw a sun dog next to the cupola of Trinity Hall, Cambridge. It is a natural phenomena where hexagonal ice crystals in the sky deflect the sun light at a 22 degree angle. They function as a prism, like diamond dust, separating out the different wavelengths. Big shout out to Newton!
A brilliant new paper by @Marilia Meira Dias and @Thomas MacVicar and others is out! It has discovered that a mitochondrial carrier SLC25A45 is involved in the uptake of methylated lysine and arginine, a key step in carnitine biosynthesis!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis
Methylated amino acids accumulate upon the degradation of methylated proteins and are implicated in diverse metabolic and signaling pathways. Disturbe…
www.sciencedirect.com
October 11, 2025 at 1:42 PM
A brilliant new paper by @Marilia Meira Dias and @Thomas MacVicar and others is out! It has discovered that a mitochondrial carrier SLC25A45 is involved in the uptake of methylated lysine and arginine, a key step in carnitine biosynthesis!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by MitoCarriers
A microscopic Tardigrade (water bear), walking across a glass slide. Extremely resilient, they can survive decades without food or water and can survive in direct exposure to space.
August 23, 2025 at 12:51 PM
A microscopic Tardigrade (water bear), walking across a glass slide. Extremely resilient, they can survive decades without food or water and can survive in direct exposure to space.
Reposted by MitoCarriers
A harder form of diamond that has eluded scientists for decades can now be synthesised in the laboratory, and could be used to make extremely tough cutting and drilling tools.
Extra-hard hexagonal diamonds can now be grown in a lab
Hexagonal diamond up to 60 per cent stronger than normal diamonds could be used to create super-tough drilling and cutting tools for industrial applications
www.newscientist.com
July 30, 2025 at 7:31 PM
A harder form of diamond that has eluded scientists for decades can now be synthesised in the laboratory, and could be used to make extremely tough cutting and drilling tools.
Our review on the peculiar properties of mitochondrial carriers of the SLC25 family out: portlandpress.com/biochemj/art...
July 25, 2025 at 11:29 AM
Our review on the peculiar properties of mitochondrial carriers of the SLC25 family out: portlandpress.com/biochemj/art...
Reposted by MitoCarriers
The Queen of the Night (Epiphyllum oxypetalum) blooms once a year at night.
July 13, 2025 at 2:01 PM
The Queen of the Night (Epiphyllum oxypetalum) blooms once a year at night.
Reposted by MitoCarriers
While academic publishing may not be broken, it isn’t built to serve science either. It runs on a chain of perverse incentives, but everything we need to rebuild it is already in our hands.
#OpenScience #AcademicSky
buff.ly/oSesI1s
#OpenScience #AcademicSky
buff.ly/oSesI1s
July 12, 2025 at 10:01 AM
While academic publishing may not be broken, it isn’t built to serve science either. It runs on a chain of perverse incentives, but everything we need to rebuild it is already in our hands.
#OpenScience #AcademicSky
buff.ly/oSesI1s
#OpenScience #AcademicSky
buff.ly/oSesI1s
Reposted by MitoCarriers
The White House has concerns about allegedly risky research on viruses, bacteria, and other pathogens. In response, the National Institutes of Health is cracking down on dozens of studies it was funding. By @jocelynkaiser.bsky.social and @cohenjon.bsky.social. www.science.org/content/arti...
Exclusive: NIH suspends dozens of pathogen studies over ‘gain-of-function’ concerns
Trump executive order leads to pauses on U.S.-funded research into TB, influenza, COVID-19, and other diseases, dismaying some scientists
www.science.org
July 12, 2025 at 10:23 AM
The White House has concerns about allegedly risky research on viruses, bacteria, and other pathogens. In response, the National Institutes of Health is cracking down on dozens of studies it was funding. By @jocelynkaiser.bsky.social and @cohenjon.bsky.social. www.science.org/content/arti...
Reposted by MitoCarriers
Japanese snow fairy bird 🇯🇵 😃
May 25, 2025 at 1:46 PM
Japanese snow fairy bird 🇯🇵 😃
Reposted by MitoCarriers
Remember to look up
April 25, 2025 at 11:57 PM
Remember to look up
Trinity Hall covers our discovery
www.trinhall.cam.ac.uk/news/unwrapp...
Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier | Science Advances www.science.org/doi/10.1126/...
www.trinhall.cam.ac.uk/news/unwrapp...
Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier | Science Advances www.science.org/doi/10.1126/...
Unwrapping the secrets of sugar metabolism - Trinity Hall Cambridge
Ever wondered why eating something sugary gives you such an energy boost? It turns out that the secret lies within our cells, specifically in tiny structures called mitochondria, often dubbed the cell...
www.trinhall.cam.ac.uk
April 25, 2025 at 5:31 PM
Trinity Hall covers our discovery
www.trinhall.cam.ac.uk/news/unwrapp...
Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier | Science Advances www.science.org/doi/10.1126/...
www.trinhall.cam.ac.uk/news/unwrapp...
Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier | Science Advances www.science.org/doi/10.1126/...
Reposted by MitoCarriers
🎓Higher Education🎓
The UK’s universities are beleaguered and besieged. Redundancies continue to be announced. Cardiff, Dundee, Edinburgh, Kent, Queen’s Belfast, Sheffield; the list goes on and on. Perhaps 10,000 jobs will go in this academic year, and that’s just the beginning. #AcademicSky
The UK’s universities are beleaguered and besieged. Redundancies continue to be announced. Cardiff, Dundee, Edinburgh, Kent, Queen’s Belfast, Sheffield; the list goes on and on. Perhaps 10,000 jobs will go in this academic year, and that’s just the beginning. #AcademicSky
The UK’s academic recession is in full swing
This university crisis is a grim scrabble for numbers
www.ft.com
March 11, 2025 at 8:08 AM
🎓Higher Education🎓
The UK’s universities are beleaguered and besieged. Redundancies continue to be announced. Cardiff, Dundee, Edinburgh, Kent, Queen’s Belfast, Sheffield; the list goes on and on. Perhaps 10,000 jobs will go in this academic year, and that’s just the beginning. #AcademicSky
The UK’s universities are beleaguered and besieged. Redundancies continue to be announced. Cardiff, Dundee, Edinburgh, Kent, Queen’s Belfast, Sheffield; the list goes on and on. Perhaps 10,000 jobs will go in this academic year, and that’s just the beginning. #AcademicSky
Reposted by MitoCarriers
A colder frontier in cryo-EM 🧪🔬
Chris Russo’s group, inc. Joshua Dickerson, adapted #cryoEM to work at liquid helium temperatures (13 kelvins), where every frame captured contains more information than the equivalent using liquid nitrogen (81 kelvins).
Read more: tinyurl.com/mwwcunkc
#LMBResearch
Chris Russo’s group, inc. Joshua Dickerson, adapted #cryoEM to work at liquid helium temperatures (13 kelvins), where every frame captured contains more information than the equivalent using liquid nitrogen (81 kelvins).
Read more: tinyurl.com/mwwcunkc
#LMBResearch
April 23, 2025 at 8:49 AM
A colder frontier in cryo-EM 🧪🔬
Chris Russo’s group, inc. Joshua Dickerson, adapted #cryoEM to work at liquid helium temperatures (13 kelvins), where every frame captured contains more information than the equivalent using liquid nitrogen (81 kelvins).
Read more: tinyurl.com/mwwcunkc
#LMBResearch
Chris Russo’s group, inc. Joshua Dickerson, adapted #cryoEM to work at liquid helium temperatures (13 kelvins), where every frame captured contains more information than the equivalent using liquid nitrogen (81 kelvins).
Read more: tinyurl.com/mwwcunkc
#LMBResearch
Excellent summary of our paper and its implications for therapy.
wms-site.com/press-media/...
wms-site.com/press-media/...
Mitochondrial Pyruvate Carrier: A Gateway to Future Metabolic Therapies
Structural and mechanistic insights unveil MPC as a strategic target in cancer, liver disease, and mitochondrial medicine. World Mitochondria Society 2025 Copyright
Fifty years after the mitochondrial...
wms-site.com
April 23, 2025 at 10:21 AM
Excellent summary of our paper and its implications for therapy.
wms-site.com/press-media/...
wms-site.com/press-media/...
Proposed pH-dependent mechanism of the mitochondrial pyruvate carrier. In the outward-open state, positively charged K49 and H86 bind pyruvate, initiating conformational changes to the inward-open state. The high matrix pH deprotonates H86, allowing pyruvate to leave.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
April 18, 2025 at 10:02 PM
Proposed pH-dependent mechanism of the mitochondrial pyruvate carrier. In the outward-open state, positively charged K49 and H86 bind pyruvate, initiating conformational changes to the inward-open state. The high matrix pH deprotonates H86, allowing pyruvate to leave.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by MitoCarriers
🧵
Here is Earth's rotation realized in an unusual way: using a camera scanning the landscape of Tivoli, Namibia, Bartosz Wojczyński focused on the sky.
He created a timelapse spanning 24 h that has a focal point in the sky rather than on the ground.
➡️ apod.nasa.gov/apod/ap20070...
🔭 🧪 #galactic
Here is Earth's rotation realized in an unusual way: using a camera scanning the landscape of Tivoli, Namibia, Bartosz Wojczyński focused on the sky.
He created a timelapse spanning 24 h that has a focal point in the sky rather than on the ground.
➡️ apod.nasa.gov/apod/ap20070...
🔭 🧪 #galactic
April 17, 2025 at 10:22 PM
🧵
Here is Earth's rotation realized in an unusual way: using a camera scanning the landscape of Tivoli, Namibia, Bartosz Wojczyński focused on the sky.
He created a timelapse spanning 24 h that has a focal point in the sky rather than on the ground.
➡️ apod.nasa.gov/apod/ap20070...
🔭 🧪 #galactic
Here is Earth's rotation realized in an unusual way: using a camera scanning the landscape of Tivoli, Namibia, Bartosz Wojczyński focused on the sky.
He created a timelapse spanning 24 h that has a focal point in the sky rather than on the ground.
➡️ apod.nasa.gov/apod/ap20070...
🔭 🧪 #galactic
Throwing a ‘spanner in the works’ of our cells’ machinery could help fight cancer, fatty liver disease… and hair loss | EurekAlert! www.eurekalert.org/news-release...
Throwing a ‘spanner in the works’ of our cells’ machinery could help fight cancer, fatty liver disease… and hair loss
Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria, the ‘powerhouses’ of our cells, allows us to make the fuel we need from s...
www.eurekalert.org
April 18, 2025 at 9:18 PM
Throwing a ‘spanner in the works’ of our cells’ machinery could help fight cancer, fatty liver disease… and hair loss | EurekAlert! www.eurekalert.org/news-release...
Reposted by MitoCarriers
The Caribbean reef squid out on quite the show today. Wait for the dramatic 180 color change reverse off stage! 🦑🔄👻💨 #caribbeanreefsquid #reefsquid #squid #chromatophores #colorchange #poof #cephalopod #coral #coralcitycamera #miami #portmiami #biscaynebay #bfi #noaa #aoml #coralcity
April 18, 2025 at 2:24 PM
The Caribbean reef squid out on quite the show today. Wait for the dramatic 180 color change reverse off stage! 🦑🔄👻💨 #caribbeanreefsquid #reefsquid #squid #chromatophores #colorchange #poof #cephalopod #coral #coralcitycamera #miami #portmiami #biscaynebay #bfi #noaa #aoml #coralcity
Reposted by MitoCarriers
Albert Einstein died on this day, April 18, 1955.
It is incredible to hear Albert Einstein explain his famous formula, E=mc².
It is incredible to hear Albert Einstein explain his famous formula, E=mc².
April 18, 2025 at 1:12 PM
Albert Einstein died on this day, April 18, 1955.
It is incredible to hear Albert Einstein explain his famous formula, E=mc².
It is incredible to hear Albert Einstein explain his famous formula, E=mc².
Reposted by MitoCarriers
A leaked HHS proposal outlines an approximately 40% cut to the NIH budget and significant changes to its organization. That would spell destruction for U.S. science, Joshua Gordon told me.
My latest for @thetransmitter.bsky.social:
#neuroskyence 🧪
My latest for @thetransmitter.bsky.social:
#neuroskyence 🧪
“A 40 percent cut [in the NIH budget] would mean dramatic and immediate changes in the ability of scientists in the United States to conduct their work,” says Joshua Gordon, former director of the National Institute of Mental Health.
By @avaskham.bsky.social
www.thetransmitter.org/funding/prop...
By @avaskham.bsky.social
www.thetransmitter.org/funding/prop...
Proposed NIH budget cut threatens ‘massive destruction of American science’
A leaked draft of a Trump administration proposal includes an approximately 40 percent cut to the National Institutes of Health’s budget and a major reorganization of its 27 institutes and centers.
www.thetransmitter.org
April 17, 2025 at 7:00 PM
A leaked HHS proposal outlines an approximately 40% cut to the NIH budget and significant changes to its organization. That would spell destruction for U.S. science, Joshua Gordon told me.
My latest for @thetransmitter.bsky.social:
#neuroskyence 🧪
My latest for @thetransmitter.bsky.social:
#neuroskyence 🧪
Our paper is finally out: Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier | Science Advances www.science.org/doi/10.1126/...
#mitochondria #cryo-EM
#mitochondria #cryo-EM
Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier
The mitochondrial pyruvate carrier transport mechanism is ΔpH driven and is inhibited competitively by distinct compound classes.
www.science.org
April 18, 2025 at 6:16 PM
Our paper is finally out: Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier | Science Advances www.science.org/doi/10.1126/...
#mitochondria #cryo-EM
#mitochondria #cryo-EM
Reposted by MitoCarriers
Here’s the better link: www.bmj.com/content/388/...
Standing up for science in an age of political interference
Science is under siege. Political forces are undermining expertise, dismantling research institutions, and replacing evidence based policymaking with ideology. This is a global crisis. The covid-19 pa...
www.bmj.com
March 31, 2025 at 11:33 AM
Here’s the better link: www.bmj.com/content/388/...
Our review on Current Understanding of Pathogenic Mechanisms and Disease Models of Citrin Deficiency is out! The disease is caused by the dysfunction or absence of the mitochondrial aspartate/glutamate carrier 2, also known as citrin doi.org/10.1002/jimd... #mitochondria
March 27, 2025 at 10:05 PM
Our review on Current Understanding of Pathogenic Mechanisms and Disease Models of Citrin Deficiency is out! The disease is caused by the dysfunction or absence of the mitochondrial aspartate/glutamate carrier 2, also known as citrin doi.org/10.1002/jimd... #mitochondria
Reposted by MitoCarriers
Thought that only purine nucleotides could inhibit mitochondrial thermogenesis in brown adipose tissue? Edmund Kunji and coworkers @mitocarriers.bsky.social @mrc-mbu.bsky.social show that pyrimidines bind and inhibit UCP1 in similar manner
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
March 3, 2025 at 5:25 PM
Thought that only purine nucleotides could inhibit mitochondrial thermogenesis in brown adipose tissue? Edmund Kunji and coworkers @mitocarriers.bsky.social @mrc-mbu.bsky.social show that pyrimidines bind and inhibit UCP1 in similar manner
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....