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mitocarriers.bsky.social
MitoCarriers
@mitocarriers.bsky.social
Home of mitochondrial transport proteins
Recently, I saw a sun dog next to the cupola of Trinity Hall, Cambridge. It is a natural phenomena where hexagonal ice crystals in the sky deflect the sun light at a 22 degree angle. They function as a prism, like diamond dust, separating out the different wavelengths. Big shout out to Newton!
October 11, 2025 at 2:00 PM
Our review on the peculiar properties of mitochondrial carriers of the SLC25 family out: portlandpress.com/biochemj/art...
July 25, 2025 at 11:29 AM
Proposed pH-dependent mechanism of the mitochondrial pyruvate carrier. In the outward-open state, positively charged K49 and H86 bind pyruvate, initiating conformational changes to the inward-open state. The high matrix pH deprotonates H86, allowing pyruvate to leave.
www.science.org/doi/10.1126/...
April 18, 2025 at 10:02 PM
Our review on Current Understanding of Pathogenic Mechanisms and Disease Models of Citrin Deficiency is out! The disease is caused by the dysfunction or absence of the mitochondrial aspartate/glutamate carrier 2, also known as citrin doi.org/10.1002/jimd... #mitochondria
March 27, 2025 at 10:05 PM
It is believed that proton conductance by the mitochondrial uncoupling protein (UCP1) is inhibited specifically by purine nucleotides, but we show that pyrimidine nucleotides also inhibit UCP1 with similar affinities in a pH-dependent manner. #mitochondria
www.embopress.org/doi/full/10....
February 28, 2025 at 4:59 PM