mia
@miarosenfeld.bsky.social
machine learning drug discovery scientist @ iambic tx | neuralplexer developer
computational biophysicist, glycoscientist, feminist, jewish, lover of sufjan stevens. she/they 🏳️🌈 ✡︎
📍 sf/nyc
computational biophysicist, glycoscientist, feminist, jewish, lover of sufjan stevens. she/they 🏳️🌈 ✡︎
📍 sf/nyc
Pinned
mia
@miarosenfeld.bsky.social
· Nov 15
hi #chemsky! i'm mia! i love mucins, physics-infused ML, proteins, & biophysics!
currently a biophysicist-turned-ML-scientist @ iambic tx, developing & utilizing structure prediction algorithms in drug disco
prev: phd w/ @rommieamaro.bsky.social, postdoc w/ bernie brooks & @jchodera.bsky.social 🤓
currently a biophysicist-turned-ML-scientist @ iambic tx, developing & utilizing structure prediction algorithms in drug disco
prev: phd w/ @rommieamaro.bsky.social, postdoc w/ bernie brooks & @jchodera.bsky.social 🤓
Mark your calendars for the ACS COMP *SUNDAY* Social on August 17, 2025! Free German 🥨&🍻 for COMP members, sponsored by OpenEye + Cadence 💻
RSVP link dropping soon in all ACS COMP members' email inboxes :)
RSVP link dropping soon in all ACS COMP members' email inboxes :)
July 22, 2025 at 8:47 PM
Reposted by mia
Well the NIH has cancelled the Women's Health Initiative, the largest study of women in history
It has been running continuously since 1991 and has provided massive key knowledge about diseases in women
Unreal
www.science.org/content/arti...
It has been running continuously since 1991 and has provided massive key knowledge about diseases in women
Unreal
www.science.org/content/arti...
NIH cancels its first and largest study centered on women
The Women’s Health Initiative has produced numerous influential findings
www.science.org
April 23, 2025 at 12:29 PM
Well the NIH has cancelled the Women's Health Initiative, the largest study of women in history
It has been running continuously since 1991 and has provided massive key knowledge about diseases in women
Unreal
www.science.org/content/arti...
It has been running continuously since 1991 and has provided massive key knowledge about diseases in women
Unreal
www.science.org/content/arti...
Reposted by mia
Register Now for Crash Course: Python For Cheminformatics-Driven Molecular Docking
This free virtual course will demonstrate the power and flexibility of python on May 1, 2025
pdb101.rcsb.org/news...
This free virtual course will demonstrate the power and flexibility of python on May 1, 2025
pdb101.rcsb.org/news...
PDB101: Register Now for Crash Course: Python For Cheminformatics-Driven Molecular Docking
PDB-101: Training, Outreach, and Education portal of RCSB PDB
pdb101.rcsb.org
April 4, 2025 at 4:12 PM
Register Now for Crash Course: Python For Cheminformatics-Driven Molecular Docking
This free virtual course will demonstrate the power and flexibility of python on May 1, 2025
pdb101.rcsb.org/news...
This free virtual course will demonstrate the power and flexibility of python on May 1, 2025
pdb101.rcsb.org/news...
@fionachembot.bsky.social opened up linkedin to this, and honestly, i can't help but immediately see a mucin rendering next to this depressing news headline... 😂
April 3, 2025 at 9:42 PM
@fionachembot.bsky.social opened up linkedin to this, and honestly, i can't help but immediately see a mucin rendering next to this depressing news headline... 😂
Reposted by mia
People/organizations with means and a vision for the future of biomedical science - we need an “Arc Institute” equivalent in the DMV area to sponge up all the incredible talent, opportunity of a lifetime for a visionary entrepreneur, I will help! @mcuban.bsky.social
April 1, 2025 at 4:03 PM
People/organizations with means and a vision for the future of biomedical science - we need an “Arc Institute” equivalent in the DMV area to sponge up all the incredible talent, opportunity of a lifetime for a visionary entrepreneur, I will help! @mcuban.bsky.social
Reposted by mia
Read: OpenAI raised $40B—i.e., the entire NIH budget.
OpenAI announced that it closed one of the largest private funding rounds in history.
According to a blog post on the company’s website, OpenAI raised $40 billion in a round that values the company at $300 billion post-money.
Read more here: tcrn.ch/4lbbzCf
According to a blog post on the company’s website, OpenAI raised $40 billion in a round that values the company at $300 billion post-money.
Read more here: tcrn.ch/4lbbzCf
April 1, 2025 at 7:03 PM
Read: OpenAI raised $40B—i.e., the entire NIH budget.
Reposted by mia
If you love drug candidates but weren't able to attend the #FirstTimeDisclosures symposium at #ACSSpring2025, check out my story about the session for @cenmag.bsky.social - with lots of cool-looking molecules.
cen.acs.org/acs-news/acs...
cen.acs.org/acs-news/acs...
12 drug candidates debut in San Diego
Structures unveiled during first-time disclosures symposium
cen.acs.org
March 28, 2025 at 4:53 PM
If you love drug candidates but weren't able to attend the #FirstTimeDisclosures symposium at #ACSSpring2025, check out my story about the session for @cenmag.bsky.social - with lots of cool-looking molecules.
cen.acs.org/acs-news/acs...
cen.acs.org/acs-news/acs...
Reposted by mia
🚨 PLEASE RT 🚨
Are you a comp chem trainee attending Spring ACS in San Diego? Would you like to expand your network with mentors in industry & academia at the COMP Mentor Lunch?
Fill out this form if you are interested in attending!
forms.gle/Sq79TJihHnFW...
Are you a comp chem trainee attending Spring ACS in San Diego? Would you like to expand your network with mentors in industry & academia at the COMP Mentor Lunch?
Fill out this form if you are interested in attending!
forms.gle/Sq79TJihHnFW...
forms.gle
March 23, 2025 at 12:38 AM
🚨 PLEASE RT 🚨
Are you a comp chem trainee attending Spring ACS in San Diego? Would you like to expand your network with mentors in industry & academia at the COMP Mentor Lunch?
Fill out this form if you are interested in attending!
forms.gle/Sq79TJihHnFW...
Are you a comp chem trainee attending Spring ACS in San Diego? Would you like to expand your network with mentors in industry & academia at the COMP Mentor Lunch?
Fill out this form if you are interested in attending!
forms.gle/Sq79TJihHnFW...
Reposted by mia
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
March 22, 2025 at 10:44 AM
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
Reposted by mia
Unassigned nitrogens in nmr data often indicate biologically relevant motion in proteins, and this can be used train deep learning models of protein dynamics!
Hannah Wayment-Steele
@ginaelnesr.bsky.social @sokrypton.org
www.biorxiv.org/content/10.1...
Hannah Wayment-Steele
@ginaelnesr.bsky.social @sokrypton.org
www.biorxiv.org/content/10.1...
March 20, 2025 at 9:35 PM
Unassigned nitrogens in nmr data often indicate biologically relevant motion in proteins, and this can be used train deep learning models of protein dynamics!
Hannah Wayment-Steele
@ginaelnesr.bsky.social @sokrypton.org
www.biorxiv.org/content/10.1...
Hannah Wayment-Steele
@ginaelnesr.bsky.social @sokrypton.org
www.biorxiv.org/content/10.1...
Reposted by mia
This was a massive team effort and I'm forever grateful for the full list of authors helping me to drive this one into the endzone! Thank you to Anthony Bogetti, Carla Calvó-Tussell, @mackevinbraza.bsky.social, @lcasalino88.bsky.social, Amanda Gramm, Sean Braet, @miarosenfeld.bsky.social,... (1/2)
Nevertheless, we persisted ❤️
📣 NEW BIORXIV ALERT!! 🚨
Using WE MD, linguistic pathway clustering, dynamical network analyses, and HDXMS we reveal a hidden allosteric network within the SARS2 spike S1 domain and predict how the D614G mutation impacts this network!
www.biorxiv.org/content/10.1...
📣 NEW BIORXIV ALERT!! 🚨
Using WE MD, linguistic pathway clustering, dynamical network analyses, and HDXMS we reveal a hidden allosteric network within the SARS2 spike S1 domain and predict how the D614G mutation impacts this network!
www.biorxiv.org/content/10.1...
D614G reshapes allosteric networks and opening mechanisms of SARS-CoV-2 spikes
The SARS-CoV-2 spike glycoprotein binds human epithelial cells and enables infection through a key conformational transition that exposes its receptor binding domain (RBD). Experimental evidence indic...
www.biorxiv.org
March 13, 2025 at 4:26 PM
This was a massive team effort and I'm forever grateful for the full list of authors helping me to drive this one into the endzone! Thank you to Anthony Bogetti, Carla Calvó-Tussell, @mackevinbraza.bsky.social, @lcasalino88.bsky.social, Amanda Gramm, Sean Braet, @miarosenfeld.bsky.social,... (1/2)
thrilled I got to plan this year's ACS COMP social in my science home town 🌊♥️💻🧪
hope to see y'all there!!!
hope to see y'all there!!!
Mark your calendars for the ACS COMP Saturday Social on March 22, 2025! Free 🌮 & 🍻 for COMP members!
If you didn’t get the RSVP link in your email inbox, DM us with a screenshot of your COMP membership and we’ll shoot you the RSVP link 😁
#ACSSpring2025 #chemsky
If you didn’t get the RSVP link in your email inbox, DM us with a screenshot of your COMP membership and we’ll shoot you the RSVP link 😁
#ACSSpring2025 #chemsky
March 13, 2025 at 11:14 PM
thrilled I got to plan this year's ACS COMP social in my science home town 🌊♥️💻🧪
hope to see y'all there!!!
hope to see y'all there!!!
Reposted by mia
This stupid SOB is practically rooting for the measles virus. He will apparently do almost anything to avoid vaccination:
RFK Jr.: It Would Be Better if ‘Everybody Got Measles’
“The measles gave you lifetime protection against measles infection,” Robert F. Kennedy Jr. told Sean Hannity on Fox News.
www.thedailybeast.com
March 12, 2025 at 7:50 PM
This stupid SOB is practically rooting for the measles virus. He will apparently do almost anything to avoid vaccination:
reality of ML+bio research: real methodological innovation is rare, expert application is common. & that's okay! most progress comes from skillfully using existing tools. lets be honest abt contributions & stop repackaging established methods with domain expertise as "novel computational frameworks"
March 12, 2025 at 8:59 PM
reality of ML+bio research: real methodological innovation is rare, expert application is common. & that's okay! most progress comes from skillfully using existing tools. lets be honest abt contributions & stop repackaging established methods with domain expertise as "novel computational frameworks"
Reposted by mia
What's easier to learn: cryo-EM or MD simulations? Ben Orlando and I couldn't decide, so we are accepting post-doc applications from both fields! Come work with us to explore the intersection between cryo-EM and MD at Michigan State! careers.msu.edu/jobs/researc...
Research Associate-Fixed Term - East Lansing, Michigan, United States
Position Summary
A Postdoctoral Research Fellow position is available in the Department of Biochemistry and Molecular Biology (BMB) at Michigan State University. The fellow will work at the interface ...
careers.msu.edu
February 18, 2025 at 8:48 PM
What's easier to learn: cryo-EM or MD simulations? Ben Orlando and I couldn't decide, so we are accepting post-doc applications from both fields! Come work with us to explore the intersection between cryo-EM and MD at Michigan State! careers.msu.edu/jobs/researc...
Reposted by mia
Mentioned in the below article, Science is running a "Trump tracker" that's attempting to keep up with the ongoing firings at scientific agencies within the US: www.science.org/content/arti...
February 18, 2025 at 2:55 PM
Mentioned in the below article, Science is running a "Trump tracker" that's attempting to keep up with the ongoing firings at scientific agencies within the US: www.science.org/content/arti...
Reposted by mia
@biophysicalsoc.bsky.social you need to be sharing at the conference this week like our lives depend on it. Because they do.
Speak up. Stand up. Get out there and protect out democracy
Speak up. Stand up. Get out there and protect out democracy
Welcome to the Bluesky account for Stand Up for Science 2025!
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
February 18, 2025 at 3:00 AM
@biophysicalsoc.bsky.social you need to be sharing at the conference this week like our lives depend on it. Because they do.
Speak up. Stand up. Get out there and protect out democracy
Speak up. Stand up. Get out there and protect out democracy
Reposted by mia
If anyone has the resources to resist, its HHMI. Ending this program with no notice and literally scrubbing evidence it ever existed from the website is shocking and dosappointing
February 5, 2025 at 8:46 PM
If anyone has the resources to resist, its HHMI. Ending this program with no notice and literally scrubbing evidence it ever existed from the website is shocking and dosappointing
i’m hiring! come work with our amazing neuralplexer development team at iambic therapeutics to help increase the conformational accuracy of our protein structure predictions!
pls share with folks you think may be interested, & feel free to reach out with questions
jobs.ashbyhq.com/iambic-thera...
pls share with folks you think may be interested, & feel free to reach out with questions
jobs.ashbyhq.com/iambic-thera...
Graduate Research Intern - Machine Learning for Protein Structure Prediction
JOB SUMMARY
We are seeking a graduate student for a research internship at Iambic Therapeutics to contribute to the development of NeuralPLexer, our protein structure prediction platform. This intern...
jobs.ashbyhq.com
January 8, 2025 at 10:40 PM
i’m hiring! come work with our amazing neuralplexer development team at iambic therapeutics to help increase the conformational accuracy of our protein structure predictions!
pls share with folks you think may be interested, & feel free to reach out with questions
jobs.ashbyhq.com/iambic-thera...
pls share with folks you think may be interested, & feel free to reach out with questions
jobs.ashbyhq.com/iambic-thera...
Reposted by mia
An example of how the limited and biased availability of data narrows the range of functional biology PLMs tap into for prediction and design
research.arcadiascience.com/pub/result-p...
research.arcadiascience.com/pub/result-p...
December 22, 2024 at 4:07 PM
An example of how the limited and biased availability of data narrows the range of functional biology PLMs tap into for prediction and design
research.arcadiascience.com/pub/result-p...
research.arcadiascience.com/pub/result-p...
move over ligand RMSD < 2 Å 😤 ConfBench is on the scene!
if you're interested in the evaluation of conformational accuracy of structure prediction methods, take a look at our first stab at a systematic conformational benchmark in the NP3 technical report below! 🧵
www.iambic.ai/post/np3-tec...
if you're interested in the evaluation of conformational accuracy of structure prediction methods, take a look at our first stab at a systematic conformational benchmark in the NP3 technical report below! 🧵
www.iambic.ai/post/np3-tec...
December 17, 2024 at 4:37 AM
move over ligand RMSD < 2 Å 😤 ConfBench is on the scene!
if you're interested in the evaluation of conformational accuracy of structure prediction methods, take a look at our first stab at a systematic conformational benchmark in the NP3 technical report below! 🧵
www.iambic.ai/post/np3-tec...
if you're interested in the evaluation of conformational accuracy of structure prediction methods, take a look at our first stab at a systematic conformational benchmark in the NP3 technical report below! 🧵
www.iambic.ai/post/np3-tec...
Reposted by mia
Friends don't let friends make bad graphs repo has been updated!
Friends don't let friends use boxplot for binomial (bimodal) data. Is your box plot hiding something from you?
#DataVisualization
github.com/cxli233/Frie...
Friends don't let friends use boxplot for binomial (bimodal) data. Is your box plot hiding something from you?
#DataVisualization
github.com/cxli233/Frie...
December 10, 2024 at 4:35 PM
Friends don't let friends make bad graphs repo has been updated!
Friends don't let friends use boxplot for binomial (bimodal) data. Is your box plot hiding something from you?
#DataVisualization
github.com/cxli233/Frie...
Friends don't let friends use boxplot for binomial (bimodal) data. Is your box plot hiding something from you?
#DataVisualization
github.com/cxli233/Frie...
Reposted by mia
Three BioML starter packs now!
Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc
Pack 3: go.bsky.app/NAKYUok
DM if you want to be included (or nominate people who should be!)
Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc
Pack 3: go.bsky.app/NAKYUok
DM if you want to be included (or nominate people who should be!)
December 3, 2024 at 3:27 AM
Three BioML starter packs now!
Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc
Pack 3: go.bsky.app/NAKYUok
DM if you want to be included (or nominate people who should be!)
Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc
Pack 3: go.bsky.app/NAKYUok
DM if you want to be included (or nominate people who should be!)
Reposted by mia
Improving SOTA at the top CS conferences these days
November 30, 2024 at 5:18 PM
Improving SOTA at the top CS conferences these days
Reposted by mia
SARS-CoV-2 NTD variants that escape host immunity possibly by introducing new epitope-blocking glycosylation sites #glycotime @cobarnes27.bsky.social
#MedSky🧪 #IDSky #Immunosky in this study the variant XEC exhibits extensive immune evasion, and its new NTD mutations, which may introduce new glycosylation, can cause potency reduction of anti-RBD antibodies, probably through allosteric effects @yunlong_cao
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Enhanced immune evasion of SARS-CoV-2 variants KP.3.1.1 and XEC through N-terminal domain mutations
KP.3, a subvariant of JN.1, has rapidly emerged as the dominant strain of SARS-CoV-2
in several countries, and has been designated as a Variant Under Monitoring. Previous
studies indicate that the uni...
www.thelancet.com
November 26, 2024 at 5:24 PM
SARS-CoV-2 NTD variants that escape host immunity possibly by introducing new epitope-blocking glycosylation sites #glycotime @cobarnes27.bsky.social