Melé Lab
@melelab.bsky.social
We are the Melé Lab, the Transcriptomics and Functional Genomics Lab (TFGL) at the Barcelona Supercomputing Center (BSC).
Account by lab members
Account by lab members
Reposted by Melé Lab
Thrilled to share! 🧬🌍 Our 800M+ long-read RNA-seq dataset from 8 diverse populations reveals big gaps in gene annotations for non-European transcripts. Let’s build global inclusive annotations.
@bsc-cns.bsky.social @crg.eu
@melelab.bsky.social
www.nature.com/articles/s41...
@bsc-cns.bsky.social @crg.eu
@melelab.bsky.social
www.nature.com/articles/s41...
Long-read transcriptomics of a diverse human cohort reveals ancestry bias in gene annotation - Nature Communications
Current human gene annotations are predominantly based on individuals of European ancestry. Here, the authors use long-read RNA sequencing across diverse human populations to reveal ancestry-specific ...
www.nature.com
December 5, 2025 at 8:08 AM
Thrilled to share! 🧬🌍 Our 800M+ long-read RNA-seq dataset from 8 diverse populations reveals big gaps in gene annotations for non-European transcripts. Let’s build global inclusive annotations.
@bsc-cns.bsky.social @crg.eu
@melelab.bsky.social
www.nature.com/articles/s41...
@bsc-cns.bsky.social @crg.eu
@melelab.bsky.social
www.nature.com/articles/s41...
Reposted by Melé Lab
El mapa de los genes humanos tiene un ‘agujero negro’: “Hemos dejado fuera a gran parte de la humanidad”
El mapa de los genes humanos tiene un ‘agujero negro’: “Hemos dejado fuera a gran parte de la humanidad”
Investigadores españoles han encontrado más de cuatrocientos posibles nuevos genes que todavía no figuran en los catálogos oficiales porque se construyeron principalmente con datos de individuos de as...
www.eldiario.es
December 3, 2025 at 10:02 AM
El mapa de los genes humanos tiene un ‘agujero negro’: “Hemos dejado fuera a gran parte de la humanidad”
Reposted by Melé Lab
Human gene maps contain major blind spots that leaves out a vast majority of the world's biological diversity, according to a new study led by the CRG's @rodericguigo.bsky.social with @bsc-cns.bsky.social. The researchers uncovered tens of thousands of new transcripts and entirely new genes.
Long-read transcriptomics of a diverse human cohort reveals ancestry bias in gene annotation - Nature Communications
Current human gene annotations are predominantly based on individuals of European ancestry. Here, the authors use long-read RNA sequencing across diverse human populations to reveal ancestry-specific ...
www.nature.com
December 3, 2025 at 1:38 PM
Human gene maps contain major blind spots that leaves out a vast majority of the world's biological diversity, according to a new study led by the CRG's @rodericguigo.bsky.social with @bsc-cns.bsky.social. The researchers uncovered tens of thousands of new transcripts and entirely new genes.
📣 Yesterday our study uncovering the ancestry bias in gene annotations was finally published in @natcomms.nature.com!
www.nature.com/articles/s41...
If you work in human genetics or transcriptomics, do not miss our tweetorial!👇
@guigolab.bsky.social @bsc-cns.bsky.social @crg.eu
www.nature.com/articles/s41...
If you work in human genetics or transcriptomics, do not miss our tweetorial!👇
@guigolab.bsky.social @bsc-cns.bsky.social @crg.eu
December 4, 2025 at 3:48 PM
📣 Yesterday our study uncovering the ancestry bias in gene annotations was finally published in @natcomms.nature.com!
www.nature.com/articles/s41...
If you work in human genetics or transcriptomics, do not miss our tweetorial!👇
@guigolab.bsky.social @bsc-cns.bsky.social @crg.eu
www.nature.com/articles/s41...
If you work in human genetics or transcriptomics, do not miss our tweetorial!👇
@guigolab.bsky.social @bsc-cns.bsky.social @crg.eu
Reposted by Melé Lab
the @melelab.bsky.social is hiring postdoctoral researchers !! come and work with us in sunny Barcelona!! auspire.eu/research-tea...
BSC-PF2
Computational Transcriptomics Barcelona Supercomputing Center | RMIT University
Research fields: Transcriptomics; Genomics; Human Genetics; Machine Learning; Single-cell Transcriptomics; Long-read T...
auspire.eu
December 4, 2025 at 7:45 AM
the @melelab.bsky.social is hiring postdoctoral researchers !! come and work with us in sunny Barcelona!! auspire.eu/research-tea...
📣 We are hiring postdoctoral researchers!! Come and work with our wonderful team in sunny Barcelona.
👇
auspire.eu/research-tea...
👇
auspire.eu/research-tea...
BSC-PF2
Computational Transcriptomics Barcelona Supercomputing Center | RMIT University
Research fields: Transcriptomics; Genomics; Human Genetics; Machine Learning; Single-cell Transcriptomics; Long-read T...
auspire.eu
December 3, 2025 at 9:33 AM
📣 We are hiring postdoctoral researchers!! Come and work with our wonderful team in sunny Barcelona.
👇
auspire.eu/research-tea...
👇
auspire.eu/research-tea...
📢Menopause affects half the population — yet it's been one of the most overlooked areas in aging research.
We found that aging in the female reproductive system unfolds in unexpected, organ-specific ways. 🔗 www.biorxiv.org/content/10.1...
1/8🧵
We found that aging in the female reproductive system unfolds in unexpected, organ-specific ways. 🔗 www.biorxiv.org/content/10.1...
1/8🧵
May 23, 2025 at 12:19 PM
📢Menopause affects half the population — yet it's been one of the most overlooked areas in aging research.
We found that aging in the female reproductive system unfolds in unexpected, organ-specific ways. 🔗 www.biorxiv.org/content/10.1...
1/8🧵
We found that aging in the female reproductive system unfolds in unexpected, organ-specific ways. 🔗 www.biorxiv.org/content/10.1...
1/8🧵
Reposted by Melé Lab
Our lab had dual presence at #BoG25 @cshlmeetings.bsky.social!
🧬 Silvia González-López spoke on chromatin dynamics & transcriptional regulation.
🌍 @fairlie.bsky.social presented ancestry-aware gene annotations — a @guigolab.bsky.social × @melelab.bsky.social collab:
www.biorxiv.org/content/10.1...
🧬 Silvia González-López spoke on chromatin dynamics & transcriptional regulation.
🌍 @fairlie.bsky.social presented ancestry-aware gene annotations — a @guigolab.bsky.social × @melelab.bsky.social collab:
www.biorxiv.org/content/10.1...
May 14, 2025 at 7:46 AM
Our lab had dual presence at #BoG25 @cshlmeetings.bsky.social!
🧬 Silvia González-López spoke on chromatin dynamics & transcriptional regulation.
🌍 @fairlie.bsky.social presented ancestry-aware gene annotations — a @guigolab.bsky.social × @melelab.bsky.social collab:
www.biorxiv.org/content/10.1...
🧬 Silvia González-López spoke on chromatin dynamics & transcriptional regulation.
🌍 @fairlie.bsky.social presented ancestry-aware gene annotations — a @guigolab.bsky.social × @melelab.bsky.social collab:
www.biorxiv.org/content/10.1...
Reposted by Melé Lab
Excited to share our new preprint: The impact of sex, age, and genetic ancestry on DNA methylation across tissues. Briefly, we explored how sex, age, and genetic ancestry shape DNA methylation across tissues and individuals. Want to know a bit more? Follow this “bluetorial”!
doi.org/10.1101/2025...
doi.org/10.1101/2025...
The impact of sex, age, and genetic ancestry on DNA methylation across tissues
Background: Understanding the consequences of individual DNA methylation variation is crucial for the study of human biology and disease. However, the collective impact of demographic traits on DNA me...
www.biorxiv.org
May 5, 2025 at 3:44 PM
Excited to share our new preprint: The impact of sex, age, and genetic ancestry on DNA methylation across tissues. Briefly, we explored how sex, age, and genetic ancestry shape DNA methylation across tissues and individuals. Want to know a bit more? Follow this “bluetorial”!
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Do you work in 💫human genetics💫?
Have you ever worried about what’s inside your gene annotation GTF⁉️
WELL, YOU SHOULD! 😱
Especially when studying a genetically diverse 🌍 cohort!
🔴We discover that gene annotations are European-biased 👉 impacting downstream analyses!
Don't miss this thread🧵⬇️
1/13
Have you ever worried about what’s inside your gene annotation GTF⁉️
WELL, YOU SHOULD! 😱
Especially when studying a genetically diverse 🌍 cohort!
🔴We discover that gene annotations are European-biased 👉 impacting downstream analyses!
Don't miss this thread🧵⬇️
1/13
Long-read transcriptomics of a diverse human cohort reveals widespread ancestry bias in gene annotation
Accurate gene annotations are fundamental for interpreting genetic variation, cellular function, and disease mechanisms. However, current human gene annotations are largely derived from transcriptomic...
www.biorxiv.org
March 20, 2025 at 1:20 PM
Do you work in 💫human genetics💫?
Have you ever worried about what’s inside your gene annotation GTF⁉️
WELL, YOU SHOULD! 😱
Especially when studying a genetically diverse 🌍 cohort!
🔴We discover that gene annotations are European-biased 👉 impacting downstream analyses!
Don't miss this thread🧵⬇️
1/13
Have you ever worried about what’s inside your gene annotation GTF⁉️
WELL, YOU SHOULD! 😱
Especially when studying a genetically diverse 🌍 cohort!
🔴We discover that gene annotations are European-biased 👉 impacting downstream analyses!
Don't miss this thread🧵⬇️
1/13
Really interesting talk by our talented PhD student @mariasopenarios.bsky.social at #WomensHealth2025 conference!
Last week, I presented my work on sex differences in immune aging at the Women's Health conference, @eventswcs.bsky.social. Great discussions and inspiring science highlighting the need for more research with a gender and sex perspective! #WomensHealth2025
@melelab.bsky.social @bsc-cns.bsky.social
@melelab.bsky.social @bsc-cns.bsky.social
February 7, 2025 at 12:15 PM
Really interesting talk by our talented PhD student @mariasopenarios.bsky.social at #WomensHealth2025 conference!
AMAZING JOB by our postdoc Oleksandra presenting her results at #WomensHealth2025
Honoured to have presented our work on menopause at the first conference on Women’s Health at @eventswcs.bsky.social ! Grateful for the insightful discussions and the chance to highlight how aging differentially affects female tissues. Excited to keep the conversation going! #womenshealth2025
February 4, 2025 at 1:55 PM
AMAZING JOB by our postdoc Oleksandra presenting her results at #WomensHealth2025