Guigó Lab
@guigolab.bsky.social
📢🎓Join our lab at @crg.eu through the International PhD Programme!
We’re looking for a student motivated to uncover the rules of genome architecture through bioinformatics and machine learning 🧬💻
🔵Apply here: www.crg.eu/en/content/t...
We’re looking for a student motivated to uncover the rules of genome architecture through bioinformatics and machine learning 🧬💻
🔵Apply here: www.crg.eu/en/content/t...
October 23, 2025 at 1:56 PM
📢🎓Join our lab at @crg.eu through the International PhD Programme!
We’re looking for a student motivated to uncover the rules of genome architecture through bioinformatics and machine learning 🧬💻
🔵Apply here: www.crg.eu/en/content/t...
We’re looking for a student motivated to uncover the rules of genome architecture through bioinformatics and machine learning 🧬💻
🔵Apply here: www.crg.eu/en/content/t...
Reposted by Guigó Lab
Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 24, 2025 at 3:12 PM
Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
🌍✨ Master’s project in our Lab @crg.eu
🌱🧬 Help build the Biodiversity Long-Read Transcriptomic Catalogue @ebpgenome.bsky.social with @pacbio.bsky.social & @nanoporetech.com
💻 Python/R, Linux, seq data
💶 600€/mo + travel
📩 fabio.zanarello@crg.eu / roderic.guigo@crg.eu
ℹ️ www.crg.eu/en/content/t...
🌱🧬 Help build the Biodiversity Long-Read Transcriptomic Catalogue @ebpgenome.bsky.social with @pacbio.bsky.social & @nanoporetech.com
💻 Python/R, Linux, seq data
💶 600€/mo + travel
📩 fabio.zanarello@crg.eu / roderic.guigo@crg.eu
ℹ️ www.crg.eu/en/content/t...
Centre for Genomic Regulation Website
www.crg.eu
September 22, 2025 at 11:29 AM
🌍✨ Master’s project in our Lab @crg.eu
🌱🧬 Help build the Biodiversity Long-Read Transcriptomic Catalogue @ebpgenome.bsky.social with @pacbio.bsky.social & @nanoporetech.com
💻 Python/R, Linux, seq data
💶 600€/mo + travel
📩 fabio.zanarello@crg.eu / roderic.guigo@crg.eu
ℹ️ www.crg.eu/en/content/t...
🌱🧬 Help build the Biodiversity Long-Read Transcriptomic Catalogue @ebpgenome.bsky.social with @pacbio.bsky.social & @nanoporetech.com
💻 Python/R, Linux, seq data
💶 600€/mo + travel
📩 fabio.zanarello@crg.eu / roderic.guigo@crg.eu
ℹ️ www.crg.eu/en/content/t...
🚨 We are hiring a Postdoc @crg.eu! 🧬
Within the EU-funded #PrecisionTox project. We are developing computational methods to predict toxicity by integrating RNA-seq data from humans and model species 🪱🪰🐸🐠. The project will help replace animal testing.
🔗 Apply now: recruitment.crg.eu/content/jobs...
Within the EU-funded #PrecisionTox project. We are developing computational methods to predict toxicity by integrating RNA-seq data from humans and model species 🪱🪰🐸🐠. The project will help replace animal testing.
🔗 Apply now: recruitment.crg.eu/content/jobs...
Post-Doctoral Researcher for Precision Tox | CRG Online Recruitment Portal
The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.
recruitment.crg.eu
July 28, 2025 at 10:09 AM
🚨 We are hiring a Postdoc @crg.eu! 🧬
Within the EU-funded #PrecisionTox project. We are developing computational methods to predict toxicity by integrating RNA-seq data from humans and model species 🪱🪰🐸🐠. The project will help replace animal testing.
🔗 Apply now: recruitment.crg.eu/content/jobs...
Within the EU-funded #PrecisionTox project. We are developing computational methods to predict toxicity by integrating RNA-seq data from humans and model species 🪱🪰🐸🐠. The project will help replace animal testing.
🔗 Apply now: recruitment.crg.eu/content/jobs...
🎉 We’ve earned Bronze LEAF Accreditation for our efforts to make lab work more sustainable @crg.eu! By joining @ucl.ac.uk Laboratory Efficiency Assessment Framework, we are committed to improving efficiency and reducing our environmental impact. 🌱🔬
July 24, 2025 at 2:56 PM
🎉 We’ve earned Bronze LEAF Accreditation for our efforts to make lab work more sustainable @crg.eu! By joining @ucl.ac.uk Laboratory Efficiency Assessment Framework, we are committed to improving efficiency and reducing our environmental impact. 🌱🔬
🎓 Huge congrats to our two @bist.eu Master’s students, Igor Trujnara and @rebeccawallis.bsky.social who successfully defended their theses this week!
🧬💻Igor explored Large Language Models for genome annotation, while Rebecca investigated microbial biodiversity in Pyrenean lakes🏔️.
@crg.eu @upf.edu
🧬💻Igor explored Large Language Models for genome annotation, while Rebecca investigated microbial biodiversity in Pyrenean lakes🏔️.
@crg.eu @upf.edu
July 18, 2025 at 7:07 PM
🎓 Huge congrats to our two @bist.eu Master’s students, Igor Trujnara and @rebeccawallis.bsky.social who successfully defended their theses this week!
🧬💻Igor explored Large Language Models for genome annotation, while Rebecca investigated microbial biodiversity in Pyrenean lakes🏔️.
@crg.eu @upf.edu
🧬💻Igor explored Large Language Models for genome annotation, while Rebecca investigated microbial biodiversity in Pyrenean lakes🏔️.
@crg.eu @upf.edu
🚴🏻🚴🏻♀️🚴🏻♂️ Read about Ana, Fabio & Nadja’s journey to the LongTREC Summer School in Norwich!
#LongTREC #ScienceOnTheMove #SustainableScience #Bioinformatics #ScienceLife
#LongTREC #ScienceOnTheMove #SustainableScience #Bioinformatics #ScienceLife
Checkout our latest blogpost, with a recap of @anaconesa.bsky.social amazing trip to reach Norwich!
conesalab.uv.es/longtrec_of_...
conesalab.uv.es/longtrec_of_...
Sustainability on Action | Genomics of Gene Expression
It all began as the best ideas begin, with a simple yet effective What if… ? One day Ana asked us and herself, What if we were more active towards sustainability when travelling? How can I bring…
conesalab.uv.es
July 16, 2025 at 7:45 AM
🚴🏻🚴🏻♀️🚴🏻♂️ Read about Ana, Fabio & Nadja’s journey to the LongTREC Summer School in Norwich!
#LongTREC #ScienceOnTheMove #SustainableScience #Bioinformatics #ScienceLife
#LongTREC #ScienceOnTheMove #SustainableScience #Bioinformatics #ScienceLife
Great to see our PhD student Fabio Zanarello sharing his work yesterday at LongTREC summer school!
#LongReadsTranscriptomics #LongTREC #GenomeAnnotation #Bioinformatics #EarthBioGenomeProject
@crg.eu
#LongReadsTranscriptomics #LongTREC #GenomeAnnotation #Bioinformatics #EarthBioGenomeProject
@crg.eu
Fabio Zanarello has a goal in his session: explain how #LongReads sequencing is integrated in the non-model genome annotation workflow.
#LongReadsTranscriptomics #LongTREC #GenomeAnnotation #Bioinformatics #EarthBioGenomeProject
#LongReadsTranscriptomics #LongTREC #GenomeAnnotation #Bioinformatics #EarthBioGenomeProject
July 16, 2025 at 7:40 AM
Great to see our PhD student Fabio Zanarello sharing his work yesterday at LongTREC summer school!
#LongReadsTranscriptomics #LongTREC #GenomeAnnotation #Bioinformatics #EarthBioGenomeProject
@crg.eu
#LongReadsTranscriptomics #LongTREC #GenomeAnnotation #Bioinformatics #EarthBioGenomeProject
@crg.eu
Reposted by Guigó Lab
We made it!!!! València-London by train. London-Norwich by bike!!!
July 12, 2025 at 8:51 PM
We made it!!!! València-London by train. London-Norwich by bike!!!
Reposted by Guigó Lab
First journey done! 🌟 Our amazing cyclists arrived safely in Cambridge — still smiling! 😄🚴♀️ More than the ride: sustainability, team spirit & pushing limits. They’re recharging now… and ready for the next leg! #LongCyclingForScience #TeamSpirit
@anaconesa.bsky.social #LeadingByExample
@anaconesa.bsky.social #LeadingByExample
July 11, 2025 at 10:06 PM
First journey done! 🌟 Our amazing cyclists arrived safely in Cambridge — still smiling! 😄🚴♀️ More than the ride: sustainability, team spirit & pushing limits. They’re recharging now… and ready for the next leg! #LongCyclingForScience #TeamSpirit
@anaconesa.bsky.social #LeadingByExample
@anaconesa.bsky.social #LeadingByExample
Reposted by Guigó Lab
Not everyone can or wants to cycle for 2–3 days, but we can all take a moment to ask ourselves:
💡 “How much am I impacting the planet with this trip?”
💡 “What can I do to reduce that impact?”
@anaconesa.bsky.social
#LongCyclingForScience #SustainableScience #LongReadsTranscriptomics
💡 “How much am I impacting the planet with this trip?”
💡 “What can I do to reduce that impact?”
@anaconesa.bsky.social
#LongCyclingForScience #SustainableScience #LongReadsTranscriptomics
July 12, 2025 at 4:28 PM
Not everyone can or wants to cycle for 2–3 days, but we can all take a moment to ask ourselves:
💡 “How much am I impacting the planet with this trip?”
💡 “What can I do to reduce that impact?”
@anaconesa.bsky.social
#LongCyclingForScience #SustainableScience #LongReadsTranscriptomics
💡 “How much am I impacting the planet with this trip?”
💡 “What can I do to reduce that impact?”
@anaconesa.bsky.social
#LongCyclingForScience #SustainableScience #LongReadsTranscriptomics
🚴 From @crg.eu to the roads of Europe, our PhD student Fabio and the #LongTREC team are combining cutting-edge science with sustainable travel.
Now in London, and heading next to Cambridge! #LongCyclingForScience
Now in London, and heading next to Cambridge! #LongCyclingForScience
Our #LongTREC cycling superstars have reached London! And they have brought the stunning sunny weather with them ☀️! Next stop : Cambridge.
#LongReadsTranscriptomics #LongCyclingForScience #SustainableScience
#LongReadsTranscriptomics #LongCyclingForScience #SustainableScience
July 11, 2025 at 3:39 PM
🚴 From @crg.eu to the roads of Europe, our PhD student Fabio and the #LongTREC team are combining cutting-edge science with sustainable travel.
Now in London, and heading next to Cambridge! #LongCyclingForScience
Now in London, and heading next to Cambridge! #LongCyclingForScience
🚴♂️🌍 Excited to see our PhD student Fabio Zanarello featured in the #LongTREC video series! 👏
Don’t miss the video and learn more about #LongTREC #LongReadsTranscriptomics and #LongCyclingForScience.
#SustainableScience #Bioinformatics #PhDLife
@crg.eu
Don’t miss the video and learn more about #LongTREC #LongReadsTranscriptomics and #LongCyclingForScience.
#SustainableScience #Bioinformatics #PhDLife
@crg.eu
Continuing our LongTREC video series, we’re excited to feature Fabio Zanarello from @crg.eu in this next episode.
#LongReadsTranscriptomics #LongCyclingForScience #SustainableScience
#LongReadsTranscriptomics #LongCyclingForScience #SustainableScience
July 11, 2025 at 3:36 PM
🚴♂️🌍 Excited to see our PhD student Fabio Zanarello featured in the #LongTREC video series! 👏
Don’t miss the video and learn more about #LongTREC #LongReadsTranscriptomics and #LongCyclingForScience.
#SustainableScience #Bioinformatics #PhDLife
@crg.eu
Don’t miss the video and learn more about #LongTREC #LongReadsTranscriptomics and #LongCyclingForScience.
#SustainableScience #Bioinformatics #PhDLife
@crg.eu
Reposted by Guigó Lab
This is going to be so much fun!!! Do not miss our #LongCyclingForSciene adventure! from Valencia to Norwich by train & bike, posting about science and bcsustainability @pacbio.bsky.social @nanoporetech.com @iscb.bsky.social @csic.es @hitseq.bsky.social @bcbhubcsic.bsky.social @sebibc.bsky.social
We’re kicking off a video series to showcase our network and its mission.
🎥 Watch @anaconesa.bsky.social introducing our project and why raising sustainability awareness in science is so important.
@i2sysbio.es @csic.es
#LongCyclingForScience 🚴🌎
#LongReadsTranscriptomics 🔬 #Outreach4Science ✍
🎥 Watch @anaconesa.bsky.social introducing our project and why raising sustainability awareness in science is so important.
@i2sysbio.es @csic.es
#LongCyclingForScience 🚴🌎
#LongReadsTranscriptomics 🔬 #Outreach4Science ✍
July 10, 2025 at 6:00 PM
This is going to be so much fun!!! Do not miss our #LongCyclingForSciene adventure! from Valencia to Norwich by train & bike, posting about science and bcsustainability @pacbio.bsky.social @nanoporetech.com @iscb.bsky.social @csic.es @hitseq.bsky.social @bcbhubcsic.bsky.social @sebibc.bsky.social
📊 RNA localization matters for gene regulation. We present a method to estimate transcript distributions between nucleus & cytosol using nuclear, cytosolic and whole-cell RNAseq.
🔵🧬 doi.org/10.1093/narg...
@crg.eu @rodericguigo.bsky.social
🔵🧬 doi.org/10.1093/narg...
@crg.eu @rodericguigo.bsky.social
Studying relative RNA localization from nucleus to the cytosol
Abstract. The precise coordination of important biological processes, such as differentiation and development, relies heavily on the regulation of gene exp
doi.org
July 2, 2025 at 6:42 AM
📊 RNA localization matters for gene regulation. We present a method to estimate transcript distributions between nucleus & cytosol using nuclear, cytosolic and whole-cell RNAseq.
🔵🧬 doi.org/10.1093/narg...
@crg.eu @rodericguigo.bsky.social
🔵🧬 doi.org/10.1093/narg...
@crg.eu @rodericguigo.bsky.social
Reposted by Guigó Lab
I am so happy to learn that I won the Early Career Award for an outstanding presentation at the ESHG!!
Thanks to @melelab.bsky.social, @guigolab.bsky.social and to my awesome colleagues that also attended the conference for their support @rubenchazarra.bsky.social @ramirezjmiguel.bsky.social
Thanks to @melelab.bsky.social, @guigolab.bsky.social and to my awesome colleagues that also attended the conference for their support @rubenchazarra.bsky.social @ramirezjmiguel.bsky.social
May 30, 2025 at 10:57 AM
I am so happy to learn that I won the Early Career Award for an outstanding presentation at the ESHG!!
Thanks to @melelab.bsky.social, @guigolab.bsky.social and to my awesome colleagues that also attended the conference for their support @rubenchazarra.bsky.social @ramirezjmiguel.bsky.social
Thanks to @melelab.bsky.social, @guigolab.bsky.social and to my awesome colleagues that also attended the conference for their support @rubenchazarra.bsky.social @ramirezjmiguel.bsky.social
Our lab had dual presence at #BoG25 @cshlmeetings.bsky.social!
🧬 Silvia González-López spoke on chromatin dynamics & transcriptional regulation.
🌍 @fairlie.bsky.social presented ancestry-aware gene annotations — a @guigolab.bsky.social × @melelab.bsky.social collab:
www.biorxiv.org/content/10.1...
🧬 Silvia González-López spoke on chromatin dynamics & transcriptional regulation.
🌍 @fairlie.bsky.social presented ancestry-aware gene annotations — a @guigolab.bsky.social × @melelab.bsky.social collab:
www.biorxiv.org/content/10.1...
May 14, 2025 at 7:46 AM
Our lab had dual presence at #BoG25 @cshlmeetings.bsky.social!
🧬 Silvia González-López spoke on chromatin dynamics & transcriptional regulation.
🌍 @fairlie.bsky.social presented ancestry-aware gene annotations — a @guigolab.bsky.social × @melelab.bsky.social collab:
www.biorxiv.org/content/10.1...
🧬 Silvia González-López spoke on chromatin dynamics & transcriptional regulation.
🌍 @fairlie.bsky.social presented ancestry-aware gene annotations — a @guigolab.bsky.social × @melelab.bsky.social collab:
www.biorxiv.org/content/10.1...
Exciting day in the lab, congratulations to Dr. Ntasis on successfully defending! 🎓🥳
May 12, 2025 at 8:18 PM
Exciting day in the lab, congratulations to Dr. Ntasis on successfully defending! 🎓🥳
Reposted by Guigó Lab
Had a great time at the Computational Symposium- such a valuable opportunity to connect with colleagues, hear about exciting projects, and share progress on my master’s research! Presenting my work on the Pyrenean Lake microbiome has been invaluable for gathering feedback and ideas for my analysis 🙂
May 8, 2025 at 10:23 AM
Had a great time at the Computational Symposium- such a valuable opportunity to connect with colleagues, hear about exciting projects, and share progress on my master’s research! Presenting my work on the Pyrenean Lake microbiome has been invaluable for gathering feedback and ideas for my analysis 🙂
Reposted by Guigó Lab
A new hub has been added to the Public Hubs listing, EPIration - an atlas of candidate enhancer-gene interactions in human tissues and cell lines.
View this hub using the following URL:
genome.ucsc.edu/cgi-...
We want to thank the @guigolab.bsky.social for making this data available.
View this hub using the following URL:
genome.ucsc.edu/cgi-...
We want to thank the @guigolab.bsky.social for making this data available.
March 25, 2025 at 10:23 PM
A new hub has been added to the Public Hubs listing, EPIration - an atlas of candidate enhancer-gene interactions in human tissues and cell lines.
View this hub using the following URL:
genome.ucsc.edu/cgi-...
We want to thank the @guigolab.bsky.social for making this data available.
View this hub using the following URL:
genome.ucsc.edu/cgi-...
We want to thank the @guigolab.bsky.social for making this data available.
🚀 Our new paper is out! The BioGenome Portal: an open-source customizable platform for managing biodiversity genomics data 🧬🌍
doi.org/10.1093/narg...
@crg.eu @rodericguigo.bsky.social
#genomics #biodiversity
doi.org/10.1093/narg...
@crg.eu @rodericguigo.bsky.social
#genomics #biodiversity
The BioGenome Portal: a web-based platform for biodiversity genomics data management
Abstract. Biodiversity genomics projects are underway with the aim of sequencing the genomes of all eukaryotic species on Earth. Here we describe the BioGe
academic.oup.com
March 22, 2025 at 6:30 PM
🚀 Our new paper is out! The BioGenome Portal: an open-source customizable platform for managing biodiversity genomics data 🧬🌍
doi.org/10.1093/narg...
@crg.eu @rodericguigo.bsky.social
#genomics #biodiversity
doi.org/10.1093/narg...
@crg.eu @rodericguigo.bsky.social
#genomics #biodiversity
Reposted by Guigó Lab
This has been a fantastic collaboration with @guigolab.bsky.social and led by @pclavell.bsky.social & @fairlie.bsky.social where we show something we suspected for some time: human gene annotations are European-biased, read this thread to know more about this work @bsc-cns.bsky.social @crg.eu
Do you work in 💫human genetics💫?
Have you ever worried about what’s inside your gene annotation GTF⁉️
WELL, YOU SHOULD! 😱
Especially when studying a genetically diverse 🌍 cohort!
🔴We discover that gene annotations are European-biased 👉 impacting downstream analyses!
Don't miss this thread🧵⬇️
1/13
Have you ever worried about what’s inside your gene annotation GTF⁉️
WELL, YOU SHOULD! 😱
Especially when studying a genetically diverse 🌍 cohort!
🔴We discover that gene annotations are European-biased 👉 impacting downstream analyses!
Don't miss this thread🧵⬇️
1/13
Long-read transcriptomics of a diverse human cohort reveals widespread ancestry bias in gene annotation
Accurate gene annotations are fundamental for interpreting genetic variation, cellular function, and disease mechanisms. However, current human gene annotations are largely derived from transcriptomic...
www.biorxiv.org
March 20, 2025 at 3:23 PM
This has been a fantastic collaboration with @guigolab.bsky.social and led by @pclavell.bsky.social & @fairlie.bsky.social where we show something we suspected for some time: human gene annotations are European-biased, read this thread to know more about this work @bsc-cns.bsky.social @crg.eu
Reposted by Guigó Lab
I never thought that I would wear again the lab coat 🥼 but I did it to sequence RNA with @nanoporetech.com at @guigolab.bsky.social . Thanks to @scarbonells.bsky.social , Carme and Zighi for their great teachings and patience in the wetlab. They definitely have solutions for everything!
Do you work in 💫human genetics💫?
Have you ever worried about what’s inside your gene annotation GTF⁉️
WELL, YOU SHOULD! 😱
Especially when studying a genetically diverse 🌍 cohort!
🔴We discover that gene annotations are European-biased 👉 impacting downstream analyses!
Don't miss this thread🧵⬇️
1/13
Have you ever worried about what’s inside your gene annotation GTF⁉️
WELL, YOU SHOULD! 😱
Especially when studying a genetically diverse 🌍 cohort!
🔴We discover that gene annotations are European-biased 👉 impacting downstream analyses!
Don't miss this thread🧵⬇️
1/13
Long-read transcriptomics of a diverse human cohort reveals widespread ancestry bias in gene annotation
Accurate gene annotations are fundamental for interpreting genetic variation, cellular function, and disease mechanisms. However, current human gene annotations are largely derived from transcriptomic...
www.biorxiv.org
March 20, 2025 at 2:51 PM
I never thought that I would wear again the lab coat 🥼 but I did it to sequence RNA with @nanoporetech.com at @guigolab.bsky.social . Thanks to @scarbonells.bsky.social , Carme and Zighi for their great teachings and patience in the wetlab. They definitely have solutions for everything!