Mehdi Jorfi
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mehdijorfi.bsky.social
Mehdi Jorfi
@mehdijorfi.bsky.social
160 followers 190 following 6 posts
Assistant Professor at Harvard Medical School studying neuroimmune interactions in Alzheimer’s disease.
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Reposted by Mehdi Jorfi
natrevneuro.nature.com
Immune dysfunction in Alzheimer disease — a Review by Oleg Butovsky, Neta Rosenzweig, Kilian L. Kleemann, Mehdi Jorfi, Vijay K. Kuchroo, Rudolph E. Tanzi & Howard L. Weiner

#neuroscience #neuroskyence

www.nature.com/articles/s41...
Immune dysfunction in Alzheimer disease - Nature Reviews Neuroscience
The importance of peripheral immunity in Alzheimer disease has gained much traction in recent years, mainly due to multiple genome-wide association studies identifying risk loci associated with genes ...
www.nature.com
December 1, 2025 at 9:47 AM
Reposted by Mehdi Jorfi
lukensjohnr.bsky.social
TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...
TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice
Matatall et al. uncover a mutation-specific association between clonal hematopoiesis (CH) and Alzheimer’s disease (AD) in mice and humans. TET2-mutant CH conferred lower odds of AD in humans and reduc...
www.cell.com
July 2, 2025 at 3:06 PM
Reposted by Mehdi Jorfi
natneuro.nature.com
Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration

@janos-groh.bsky.social @tum.de @synergy-munich.bsky.social @dzne.science

www.nature.com/articles/s41...
Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration - Nature Neuroscience
White matter aging leads to degenerative and inflammatory changes. Here the authors show that microglial dysfunction exacerbates glial CXCL10 expression, harmful CD8+ T cell recruitment, myelinated ax...
www.nature.com
May 22, 2025 at 4:26 PM
Reposted by Mehdi Jorfi
leonsmyth.bsky.social
Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.

@jonykipnis.bsky.social
www.nature.com/articles/s41...
Redefining CNS immune privilege - Nature Reviews Immunology
In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...
www.nature.com
May 2, 2025 at 8:05 PM
Reposted by Mehdi Jorfi
ghazeskandari.bsky.social
Congratulations to
Dr. Jean Paul Chadarevian and the entire @blurtonjoneslab.bsky.social team for this beautiful piece of work: Harnessing human iPSC-microglia for CNS-wide delivery of disease modifying proteins." 👍👍👍
www.sciencedirect.com/science/arti...
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins
Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…
www.sciencedirect.com
April 14, 2025 at 6:54 PM
Reposted by Mehdi Jorfi
kuchroolab.bsky.social
With Butovsky Lab, we show that silencing TIM-3 in brain-resident immune cells prevents neurodegeneration in a mouse model of #Alzheimer’s disease. Deletion of TIM-3 in microglia enhance phagocytic clearance of toxic amyloid beta. #Immunosky🧪 www.nature.com/articles/s41...
Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease - Nature
The immune-checkpoint molecule TIM-3 regulates microglial homeostasis, and its microglial-specific deletion reduced cognitive impairment in a mouse model of Alzheimer’s disease.
www.nature.com
April 9, 2025 at 3:29 PM
Reposted by Mehdi Jorfi
lukensjohnr.bsky.social
Harnessing microglia-based cell therapies for the treatment of neurodegenerative diseases www.sciencedirect.com/science/arti...
March 25, 2025 at 5:40 PM
Reposted by Mehdi Jorfi
lancasterlab.bsky.social
Exciting work from the Albert lab on unique signatures of human basal radial glia. And look at those beautiful organoids with their basal progenitors! 🤩
March 14, 2025 at 8:51 AM
mehdijorfi.bsky.social
Today marks the 1st anniversary of the Jorfi lab! This past year has been full of challenges, growth, and exciting discoveries. I’m so proud of everything our team has accomplished and grateful to work with such an amazing group. Looking forward to more milestones ahead!
January 8, 2025 at 9:59 PM
mehdijorfi.bsky.social
Immune mechanisms and shared immune targets in neurodegenerative diseases - Nature Reviews Neurology
The immune system plays a major part in neurodegenerative diseases. In this Review, Weiner considers the contributions of several components of the immune system in multiple neurodegenerative diseases...
www.nature.com
December 20, 2024 at 2:22 PM
mehdijorfi.bsky.social
Neuroinflammation in Alzheimer disease
Neuroinflammation in Alzheimer disease - Nature Reviews Immunology
This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...
www.nature.com
December 13, 2024 at 11:33 AM
mehdijorfi.bsky.social
I'm thrilled to see our paper featured on the cover of
Trends in Immunology! We discuss how peripheral immune cells contribute to Alzheimer’s disease and highlight new approaches to studying neuroimmune interactions.
paper: dlvr.it/TG8M2S
#neuroimmunology #neuroimmune #Alzheimer
December 11, 2024 at 8:07 PM