Nature - The theft probably helps the cells to spread around the body, and preventing it could provide a path to treatment, researchers say.

Nature Metabolism, Published online: 10 March 2025; doi:10.1038/s42255-025-01233-wThrough a functional CRISPR/Cas9 screening, Pretto et al. identify Elovl1 as a target to improve antitumour immunity by remodelling T cell lipid metabolism.

Nature Metabolism, Published online: 10 March 2025; doi:10.1038/s42255-025-01240-xA new study identifies a mechanism by which Elovl1 deletion disrupts the canonical feedback inhibition of cholesterol synthesis in T cells. By fundamentally rewiring…

Mitochondrial diseases are historically difficult to study. They cause multi-systemic defects with prevalent impairment of hard-to-access tissues such…

Lactate elevations are a hallmark of human disease, but the mechanisms regulating lactate levels remain poorly understood. Here, Lee et al. elucidate the mechanisms of lactate homeostasis. These invol...

Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

A non-invasive in vivo positron emission tomography imaging approach detects inflammatory disease using various preclinical models.

Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

Publishing highly cited papers helps postdoctoral researchers to land a faculty job.

Immune cells lose their cancer-fighting prowess after taking tumours’ organelles on board.

Colorectal cancer has been linked to multiple environmental factors, however, the role of diet remains incompletely understood. Here, the authors complete a diet-wide association study and identify a potentially protective role of dairy intake in colorectal cancer incidence, driven largely by calcium.

Inter-organ communication (IOC) is a complex mechanism involved in maintaining metabolic homeostasis and healthy aging. Dysregulation of distinct forms of IOC is linked to metabolic derangements and age-related pathologies, implicating these processes as a potential target for therapeutic intervention to promote healthy aging. In this review, we delve into IOC mediated by hormonal signaling, circulating factors, organelle signaling, and neuronal networks and examine their roles in regulating metabolism and aging. Given the role of the hypothalamus as a high-order control center for aging and longevity, we particularly emphasize the importance of its communication with peripheral organs and pave the way for a better understanding of this critical machinery in metabolism and aging.