Matt Padula
@mattpadula.bsky.social
Semi-accurate impersonation of an Associate Professor at Uni of Technology Sydney. Does proteomics, fixes mass specs, does 2D-PAGE. Rides mountain bikes when he should be working. Brutal Metal listener. Dealing with ongoing cancer. EiC of Proteomes.
Am I the only (grumpy) person annoyed when an email starts with "I hope this email finds you well"?
So tempted to reply with "Actually it doesn't find me well. Still have cancer."
Just get to the point of why you are contacting me please.
So tempted to reply with "Actually it doesn't find me well. Still have cancer."
Just get to the point of why you are contacting me please.
November 15, 2025 at 3:45 AM
Am I the only (grumpy) person annoyed when an email starts with "I hope this email finds you well"?
So tempted to reply with "Actually it doesn't find me well. Still have cancer."
Just get to the point of why you are contacting me please.
So tempted to reply with "Actually it doesn't find me well. Still have cancer."
Just get to the point of why you are contacting me please.
Reposted by Matt Padula
Proteoform Mapping Calls for a Combined Effort From Bottom‐Up and Top‐Down Proteomics analyticalsciencejou...
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#proteomics #prot-paper
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#proteomics #prot-paper
November 13, 2025 at 10:00 AM
Proteoform Mapping Calls for a Combined Effort From Bottom‐Up and Top‐Down Proteomics analyticalsciencejou...
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#proteomics #prot-paper
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#proteomics #prot-paper
Reposted by Matt Padula
"Biomarker studies are the greatest reproducibility crisis in science" (M. Uhlén, 2025).
November 11, 2025 at 6:02 PM
"Biomarker studies are the greatest reproducibility crisis in science" (M. Uhlén, 2025).
Reposted by Matt Padula
Thinking about putting this sign outside my facilities door . 🤔
November 5, 2025 at 2:13 AM
Thinking about putting this sign outside my facilities door . 🤔
Reposted by Matt Padula
To be honest, when I see conferences announced that have a majority of male invited speakers, I think the organisers are not trying hard enough. We have so many excellent #FemalesinMS and resources available there is really no excuse for it anymore #massspec #teammassspec #lipidomics #metabolomics
October 27, 2025 at 10:45 PM
To be honest, when I see conferences announced that have a majority of male invited speakers, I think the organisers are not trying hard enough. We have so many excellent #FemalesinMS and resources available there is really no excuse for it anymore #massspec #teammassspec #lipidomics #metabolomics
Reposted by Matt Padula
🎤 Get ready for more ANZMetSoc ECR Rapid-Fire!
Hear 3min talks from 2 of 10 #ECR speakers:
Emily Sunnucks (UT Sydney) on multi-omics & death 🧩Chrystal O’Connor (Lincoln Uni, NZ) on Indigenous-guided metabolomics 🌿
📅 Oct 29
🏆 Vote People’s Choice: tinyurl.com/ECR-Rapid-Fire
#ANZMetSoc #Metabolomics
Hear 3min talks from 2 of 10 #ECR speakers:
Emily Sunnucks (UT Sydney) on multi-omics & death 🧩Chrystal O’Connor (Lincoln Uni, NZ) on Indigenous-guided metabolomics 🌿
📅 Oct 29
🏆 Vote People’s Choice: tinyurl.com/ECR-Rapid-Fire
#ANZMetSoc #Metabolomics
October 21, 2025 at 5:51 AM
🎤 Get ready for more ANZMetSoc ECR Rapid-Fire!
Hear 3min talks from 2 of 10 #ECR speakers:
Emily Sunnucks (UT Sydney) on multi-omics & death 🧩Chrystal O’Connor (Lincoln Uni, NZ) on Indigenous-guided metabolomics 🌿
📅 Oct 29
🏆 Vote People’s Choice: tinyurl.com/ECR-Rapid-Fire
#ANZMetSoc #Metabolomics
Hear 3min talks from 2 of 10 #ECR speakers:
Emily Sunnucks (UT Sydney) on multi-omics & death 🧩Chrystal O’Connor (Lincoln Uni, NZ) on Indigenous-guided metabolomics 🌿
📅 Oct 29
🏆 Vote People’s Choice: tinyurl.com/ECR-Rapid-Fire
#ANZMetSoc #Metabolomics
Reposted by Matt Padula
Correlation isn’t causation, as the mantra goes—but statistical noise in correlational data can reveal causal information. When X and Y are causally linked, their noise tends to be asymmetric & this can guide #CausalInference. Check out our 📃👇 doi.org/10.1111/nous... #philsky #philsci #StatsSky #HPS
October 21, 2025 at 9:20 AM
Correlation isn’t causation, as the mantra goes—but statistical noise in correlational data can reveal causal information. When X and Y are causally linked, their noise tends to be asymmetric & this can guide #CausalInference. Check out our 📃👇 doi.org/10.1111/nous... #philsky #philsci #StatsSky #HPS
Reposted by Matt Padula
AlphaDIA enables DIA transfer learning for feature-free proteomics - @mannlab.bsky.social @jalew188.bsky.social go.nature.com/4qmEQMM
AlphaDIA enables DIA transfer learning for feature-free proteomics - Nature Biotechnology
An open-source platform for data-independent acquisition proteomics adapts predicted libraries to experimental settings.
go.nature.com
October 21, 2025 at 4:53 PM
AlphaDIA enables DIA transfer learning for feature-free proteomics - @mannlab.bsky.social @jalew188.bsky.social go.nature.com/4qmEQMM
I'll just leave this here: jocnf.pubpub.org/pub/qag76ip8...
Principles for proper peer review
jocnf.pubpub.org
October 8, 2025 at 5:19 AM
I'll just leave this here: jocnf.pubpub.org/pub/qag76ip8...
Reposted by Matt Padula
Read more in @natcomms.nature.com by:
@clairerich.bsky.social
@lanamcclements.bsky.social
@mattpadula.bsky.social
@louisecole.bsky.social
🏫
@utsengage.bsky.social
@centenaryinstitute.bsky.social
@hmriaustralia.bsky.social
@garvaninstitute.bsky.social
www.nature.com/articles/s41...
@clairerich.bsky.social
@lanamcclements.bsky.social
@mattpadula.bsky.social
@louisecole.bsky.social
🏫
@utsengage.bsky.social
@centenaryinstitute.bsky.social
@hmriaustralia.bsky.social
@garvaninstitute.bsky.social
www.nature.com/articles/s41...
Matrix directs trophoblast differentiation in a bioprinted organoid model of early placental development - Nature Communications
The placenta plays vital roles in supporting fetal development. Here, Richards et al. develop a high-throughput bioprinted trophoblast organoid model to recapitulate the microenvironment of the e...
www.nature.com
September 22, 2025 at 12:59 PM
Medical update: last infusion of six cycles of chemo. It's done. Oncologist is predicting more sometime, but cancer gone AFAIAC. PET scan in November.
Feel tired but that's likely poor sleep. Have to ignore it cause I'm racing the MTB on Sunday....
Feel tired but that's likely poor sleep. Have to ignore it cause I'm racing the MTB on Sunday....
September 19, 2025 at 11:34 PM
Medical update: last infusion of six cycles of chemo. It's done. Oncologist is predicting more sometime, but cancer gone AFAIAC. PET scan in November.
Feel tired but that's likely poor sleep. Have to ignore it cause I'm racing the MTB on Sunday....
Feel tired but that's likely poor sleep. Have to ignore it cause I'm racing the MTB on Sunday....
Reposted by Matt Padula
Proteomics Webinar: DIA with FragPipe, DIA-NN, and Skyline
Presenters: Eduard Sabidó and Brendan MacLean
When: Tuesday, September 16, 8am (Pacific Time)
Register Now ... skyline.ms/project/home...
#massspec #proteomics
Presenters: Eduard Sabidó and Brendan MacLean
When: Tuesday, September 16, 8am (Pacific Time)
Register Now ... skyline.ms/project/home...
#massspec #proteomics
Start Page: /home/software/Skyline/events/2025 Webinars/Webinar 26
skyline.ms
September 15, 2025 at 8:26 AM
Proteomics Webinar: DIA with FragPipe, DIA-NN, and Skyline
Presenters: Eduard Sabidó and Brendan MacLean
When: Tuesday, September 16, 8am (Pacific Time)
Register Now ... skyline.ms/project/home...
#massspec #proteomics
Presenters: Eduard Sabidó and Brendan MacLean
When: Tuesday, September 16, 8am (Pacific Time)
Register Now ... skyline.ms/project/home...
#massspec #proteomics
This is really interesting and worth five minutes of your time to read.
www.smh.com.au/world/north-...
www.smh.com.au/world/north-...
The dangerous logic behind the killing of Charlie Kirk
Political extremism isn’t caused by other people saying things you don’t like. It’s caused by those people having no constructive way to air their frustrations.
www.smh.com.au
September 15, 2025 at 8:08 AM
This is really interesting and worth five minutes of your time to read.
www.smh.com.au/world/north-...
www.smh.com.au/world/north-...
Reposted by Matt Padula
Pre-analytical drivers of bias in bead-enriched plasma proteomics | EMBO Molecular Medicine www.embopress.org/do...
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#proteomics #prot-paper
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#proteomics #prot-paper
September 13, 2025 at 8:40 AM
Pre-analytical drivers of bias in bead-enriched plasma proteomics | EMBO Molecular Medicine www.embopress.org/do...
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#proteomics #prot-paper
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#proteomics #prot-paper
UTS executive and council should read this. But I doubt they will.
theconversation.com/universities...
theconversation.com/universities...
Universities have lost their way, but cost-cutting and consultants are not the answer
Last week in Sydney, we saw a melodrama acted out that could stand in for the state of Australian universities more generally.
theconversation.com
August 27, 2025 at 12:00 AM
UTS executive and council should read this. But I doubt they will.
theconversation.com/universities...
theconversation.com/universities...
Reposted by Matt Padula
Post-Translationally Modified Proteoforms as Biomarkers: From Discovery to Clinical Use academic.oup.com/cli...
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#proteomics #prot-paper
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#proteomics #prot-paper
August 25, 2025 at 7:40 AM
Post-Translationally Modified Proteoforms as Biomarkers: From Discovery to Clinical Use academic.oup.com/cli...
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#proteomics #prot-paper
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#proteomics #prot-paper
Steve Vai: I’m not a very disciplined person; it was a passion. Because passion is a much more powerful engine of creation than discipline.
August 23, 2025 at 1:35 AM
Steve Vai: I’m not a very disciplined person; it was a passion. Because passion is a much more powerful engine of creation than discipline.
Reposted by Matt Padula
MASSyPupX: A FREE, open-source platform for off-site processing of shotgun DDA and DIA proteomics data.
✅ Runs on USB, PC, or server
✅ Pre-installed tools & libraries
✅ Perfect for education, collaboration & resource-limited labs
doi.org/10.1016/j.jp...
#Proteomics #DDA #DIA #Bioinformatics #FOSS
✅ Runs on USB, PC, or server
✅ Pre-installed tools & libraries
✅ Perfect for education, collaboration & resource-limited labs
doi.org/10.1016/j.jp...
#Proteomics #DDA #DIA #Bioinformatics #FOSS
August 6, 2025 at 4:41 PM
MASSyPupX: A FREE, open-source platform for off-site processing of shotgun DDA and DIA proteomics data.
✅ Runs on USB, PC, or server
✅ Pre-installed tools & libraries
✅ Perfect for education, collaboration & resource-limited labs
doi.org/10.1016/j.jp...
#Proteomics #DDA #DIA #Bioinformatics #FOSS
✅ Runs on USB, PC, or server
✅ Pre-installed tools & libraries
✅ Perfect for education, collaboration & resource-limited labs
doi.org/10.1016/j.jp...
#Proteomics #DDA #DIA #Bioinformatics #FOSS
Reposted by Matt Padula
Joe Rogan gets universities better than a lot of university administrators.
Universities are supposed to be places where you tackle challenging ideas, and have your ideas challenged.
If you take that away, you don't have a university anymore. No matter what you put on your letterhead.
Universities are supposed to be places where you tackle challenging ideas, and have your ideas challenged.
If you take that away, you don't have a university anymore. No matter what you put on your letterhead.
July 30, 2025 at 8:09 PM
Joe Rogan gets universities better than a lot of university administrators.
Universities are supposed to be places where you tackle challenging ideas, and have your ideas challenged.
If you take that away, you don't have a university anymore. No matter what you put on your letterhead.
Universities are supposed to be places where you tackle challenging ideas, and have your ideas challenged.
If you take that away, you don't have a university anymore. No matter what you put on your letterhead.
When analysing peptides from in-gel digests by LC-MS/MS, has anyone noticed a 1+ ion of m/z 1342.93 after washing the column with 80% ACN? We are leaving the pump at 80% ACN at 1uL/min for 5 mins after our usual 0-40% ACN gradient. Doesn't correspond to any contaminants. #massspechelp
July 31, 2025 at 7:05 AM
When analysing peptides from in-gel digests by LC-MS/MS, has anyone noticed a 1+ ion of m/z 1342.93 after washing the column with 80% ACN? We are leaving the pump at 80% ACN at 1uL/min for 5 mins after our usual 0-40% ACN gradient. Doesn't correspond to any contaminants. #massspechelp
The fraud isn't the surprising bit. The fact that people were to scared to speak up. That's fucked. What kind of culture is that? Too bad it's common. www.smh.com.au/national/fol...
‘Follow the mice’: How whistleblowers, secret lab videos brought down top scientist
Staff were scared taking on the celebrated leader who’d won millions in government funding, but eventually, they had enough.
www.smh.com.au
July 27, 2025 at 1:56 AM
The fraud isn't the surprising bit. The fact that people were to scared to speak up. That's fucked. What kind of culture is that? Too bad it's common. www.smh.com.au/national/fol...