The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

1924: First round-the-world flight 2020: Global COVID death toll reaches 1 million 2022: Hurricane Ian strikes Florida

Receptors that stimulate inflammation are commonly activated by ligands that are buried within microbial cells. The mechanisms that facilitate immunostimulatory ligand release from microbes during inf...

ASM and fellow societies filed an amicus brief with the Supreme Court, calling for the swift restoration of NIH grant funding supporting early-career scientists, such as the MOSAIC program.

The neuroprotective transfer of mitochondria from astrocytes to neurons has been primarily investigated by labelling astrocytic mitochondria with the dye MitoTracker. Here we report that MitoTracker transfers to neurons from both astrocytes and astrocyte-conditioned media, independently of mitochondrial transfer. Our observations should prompt an essential re-evaluation of the literature concerning astrocyte-neuron mitochondrial transfer and in other systems in which contact-independent transfer has been observed using mitochondrial dyes. ### Competing Interest Statement The authors have declared no competing interest. MSD (United Kingdom), https://ror.org/004nn4n27, PRJ_20446 DEVINE MSD MRC The Francis Crick Institute, https://ror.org/04tnbqb63, CC2206

From student to researcher, a career in science can come with a high price tag. This Perspective explores how persistent financial barriers limit who can succeed in science, revealing how wealth shape...

This program is an early career educational and training opportunity. It is designed to engage its Fellows in the analytical process that informs U.S. science and technology policy.