Matilde Galli
@matildegalli.bsky.social
Cell cycle / Developmental timing / polyploidy
Favorite model: C. elegans
Group leader @hubrechtinstitute.bsky.social
Favorite model: C. elegans
Group leader @hubrechtinstitute.bsky.social
I'm excited to share our work on the regulation of endomitosis in worm intestines:
www.biorxiv.org/content/10.1...
We find that cells are able to uncouple nuclear division from cell division by transcriptional repression of key cytokinesis regulators
www.biorxiv.org/content/10.1...
We find that cells are able to uncouple nuclear division from cell division by transcriptional repression of key cytokinesis regulators
Transcriptional repression of central spindle factors controls endomitosis in the C. elegans intestine
During development, many cell types transition from canonical to non-canonical cell cycles, suchas endomitosis and endoreplication, in which they duplicate their DNA but do not divide, giving rise to ...
www.biorxiv.org
August 5, 2025 at 10:27 AM
I'm excited to share our work on the regulation of endomitosis in worm intestines:
www.biorxiv.org/content/10.1...
We find that cells are able to uncouple nuclear division from cell division by transcriptional repression of key cytokinesis regulators
www.biorxiv.org/content/10.1...
We find that cells are able to uncouple nuclear division from cell division by transcriptional repression of key cytokinesis regulators
Great thread summarizing a recent provocative (and insightful!) paper "Cell cycle duration determines oncogenic transformation capacity" (pubmed.ncbi.nlm.nih.gov/40307557/)
We clearly need to understand more about cell cycle timings in different cell types!
We clearly need to understand more about cell cycle timings in different cell types!
To better treat cancer, we need to understand its underlying biology. Despite decades of research, some fundamental questions remain unanswered. One is why certain key tumor suppressor or oncogenes lead to cancer predominantly in single tissue: e.g. Rb in the retina, or APC in the colon 1/n 🧪
July 27, 2025 at 12:07 PM
Great thread summarizing a recent provocative (and insightful!) paper "Cell cycle duration determines oncogenic transformation capacity" (pubmed.ncbi.nlm.nih.gov/40307557/)
We clearly need to understand more about cell cycle timings in different cell types!
We clearly need to understand more about cell cycle timings in different cell types!
My friend @aniekj.bsky.social is not going to like this 😅
(Unless fly people have something similar with worms?)
#worm25
(Unless fly people have something similar with worms?)
#worm25
July 2, 2025 at 7:05 PM
My friend @aniekj.bsky.social is not going to like this 😅
(Unless fly people have something similar with worms?)
#worm25
(Unless fly people have something similar with worms?)
#worm25
🤔 Equal treatment...
Perhaps reconsider extension rules for eligibility for applying to ERC @erc.europa.eu grants?
LGBTIQ (non-biological) parents get 0 months extension (compared 18-months for biological mothers)
FYI: the Dutch Research Council (NWO) gives 6 months to all non-biological parents
Perhaps reconsider extension rules for eligibility for applying to ERC @erc.europa.eu grants?
LGBTIQ (non-biological) parents get 0 months extension (compared 18-months for biological mothers)
FYI: the Dutch Research Council (NWO) gives 6 months to all non-biological parents
Diversity is our strength❤️🧡💛💚💙💜
On #IDAHOT, we reaffirm our commitment to end violence and discrimination against LGBTIQ people — and raise the progressive flag at our headquarters.
Respect for fundamental rights and equal treatment are key pillars of our Union.
On #IDAHOT, we reaffirm our commitment to end violence and discrimination against LGBTIQ people — and raise the progressive flag at our headquarters.
Respect for fundamental rights and equal treatment are key pillars of our Union.
May 17, 2025 at 8:20 AM
🤔 Equal treatment...
Perhaps reconsider extension rules for eligibility for applying to ERC @erc.europa.eu grants?
LGBTIQ (non-biological) parents get 0 months extension (compared 18-months for biological mothers)
FYI: the Dutch Research Council (NWO) gives 6 months to all non-biological parents
Perhaps reconsider extension rules for eligibility for applying to ERC @erc.europa.eu grants?
LGBTIQ (non-biological) parents get 0 months extension (compared 18-months for biological mothers)
FYI: the Dutch Research Council (NWO) gives 6 months to all non-biological parents
Reposted by Matilde Galli
Fun Q&A with Curr Bio in which I discuss mammoths, Don Quijote, and why you should not fall in love with a hypothesis authors.elsevier.com/a/1l2MF3QW8S...
authors.elsevier.com
May 5, 2025 at 3:13 PM
Fun Q&A with Curr Bio in which I discuss mammoths, Don Quijote, and why you should not fall in love with a hypothesis authors.elsevier.com/a/1l2MF3QW8S...
Reposted by Matilde Galli
🔥New Night Science paper!!
Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.
Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.
April 2, 2025 at 11:28 AM
🔥New Night Science paper!!
Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.
Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.
Such a fun movie from the @hubrechtinstitute.bsky.social featuring two PhD students in my lab @sonvelt.bsky.social and @divm-science.bsky.social
We challenged our researchers to describe their work in 10 words or less. See how they did in this video!
March 24, 2025 at 11:56 AM
Such a fun movie from the @hubrechtinstitute.bsky.social featuring two PhD students in my lab @sonvelt.bsky.social and @divm-science.bsky.social
Wow, this is so cool 🤯
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
March 21, 2025 at 7:01 PM
Wow, this is so cool 🤯
Reposted by Matilde Galli
Together with fellow @biologists.bsky.social EiCs we've written about the unprecedented cuts & policy changes to research in the US
We stand with our US colleagues during this challenging time
Science transcends borders—setbacks in one nation affect us all
journals.biologists.com/dev/article/...
We stand with our US colleagues during this challenging time
Science transcends borders—setbacks in one nation affect us all
journals.biologists.com/dev/article/...
Science under siege: protecting scientific progress in turbulent times
As Editors-in-Chief of The Company of Biologists' journals, we have been watching with growing concern the policy changes in the United States of America (USA) and the challenges that these are creati...
journals.biologists.com
March 13, 2025 at 9:13 PM
Together with fellow @biologists.bsky.social EiCs we've written about the unprecedented cuts & policy changes to research in the US
We stand with our US colleagues during this challenging time
Science transcends borders—setbacks in one nation affect us all
journals.biologists.com/dev/article/...
We stand with our US colleagues during this challenging time
Science transcends borders—setbacks in one nation affect us all
journals.biologists.com/dev/article/...
Today I say goodbye to my last two wisdom teeth. I hope there is still some wisdom left in me
March 13, 2025 at 4:59 PM
Today I say goodbye to my last two wisdom teeth. I hope there is still some wisdom left in me
Reposted by Matilde Galli
This Editorial by Brandon S. Gaut and Claudia A. M. Russo provides some nice insight into how #SocietyJournals work, and why it pays for Scientists to publish with #SocietyOwned Journals. 👇
A Message From the Editors-in-Chief
academic.oup.com/mbe/article/...
#PlantScience #SciencePublishing
A Message From the Editors-in-Chief
academic.oup.com/mbe/article/...
#PlantScience #SciencePublishing
A Message From the Editors-in-Chief
We have been Co-Editor-in-Chiefs of Molecular Biology and Evolution (MBE) for 2 years now. In that time, we have learned a great deal about the science of
academic.oup.com
March 12, 2025 at 7:57 AM
This Editorial by Brandon S. Gaut and Claudia A. M. Russo provides some nice insight into how #SocietyJournals work, and why it pays for Scientists to publish with #SocietyOwned Journals. 👇
A Message From the Editors-in-Chief
academic.oup.com/mbe/article/...
#PlantScience #SciencePublishing
A Message From the Editors-in-Chief
academic.oup.com/mbe/article/...
#PlantScience #SciencePublishing
Reposted by Matilde Galli
Many US students don’t know how to seek opportunities outside the US. With some help from our colleagues in EU and Canada, we could put together a consolidated website of PhD opportunities and scholarships outside the US, organized by field. There might still be time for this year in some places.
I’m having similar conversations and sharing international opportunities a lot. I’m sure for a lot of US based trainees that feels overwhelming. I moved to Europe for my postdoc.Happy to chat with any trainees about my experience if it would be helpful.
Heartbreaking chats this week with students thinking of giving up on their dreams of getting a PhD. They worry about getting in PhD programs and careers post PhD. My suggestions: don’t be hasty, think broadly incl EU & Canada, & careers beyond traditional academia. What’re you telling your students?
March 1, 2025 at 4:17 AM
Many US students don’t know how to seek opportunities outside the US. With some help from our colleagues in EU and Canada, we could put together a consolidated website of PhD opportunities and scholarships outside the US, organized by field. There might still be time for this year in some places.
Today, I registered for the 2025 International Worm Meeting and I also voted for my favorite invertebrate here (I voted for another worm than on the pic😉) www.theguardian.com/environment/...
Nominate your invertebrate species of the year
We’re asking readers from around the world to nominate their favourite spineless species for our second Invertebrate of the Year competition
www.theguardian.com
February 26, 2025 at 7:55 PM
Today, I registered for the 2025 International Worm Meeting and I also voted for my favorite invertebrate here (I voted for another worm than on the pic😉) www.theguardian.com/environment/...
It's interesting to see that European countries have such different views on the value of science.. (especially as an Italian living in the Netherlands, I feel a bit split..)
media.springernature.com/full/springe...
media.springernature.com/full/springe...
February 24, 2025 at 2:45 PM
It's interesting to see that European countries have such different views on the value of science.. (especially as an Italian living in the Netherlands, I feel a bit split..)
media.springernature.com/full/springe...
media.springernature.com/full/springe...
A very clear (and scary) summary of what's happening at US research institutions and universities
Here’s a gift link. This is a good one to share with your non-scientist friends and family www.nytimes.com/2025/02/14/o...
February 15, 2025 at 10:14 AM
A very clear (and scary) summary of what's happening at US research institutions and universities
Reposted by Matilde Galli
Join us in Paris 6-9 May 2025 for the #EvoDevoTempo conference (2nd edition) with a fantastic line up of speakers confirmed!!
Organized by @mdiazcuadros.bsky.social
@vanderhaeghenp2.bsky.social
@bassemh.bsky.social and me.
Please RT to spread the word
meetings.embo.org/event/25-dev...
Organized by @mdiazcuadros.bsky.social
@vanderhaeghenp2.bsky.social
@bassemh.bsky.social and me.
Please RT to spread the word
meetings.embo.org/event/25-dev...
Developmental timing across species: From mechanisms to evolutionary insights
Like choreography, development consists of a highly ordered suite of steps and transitions. Modifying developmental tempo can affect final size and composition of tissues, as well as their plasticity…
meetings.embo.org
December 20, 2024 at 4:32 PM
Join us in Paris 6-9 May 2025 for the #EvoDevoTempo conference (2nd edition) with a fantastic line up of speakers confirmed!!
Organized by @mdiazcuadros.bsky.social
@vanderhaeghenp2.bsky.social
@bassemh.bsky.social and me.
Please RT to spread the word
meetings.embo.org/event/25-dev...
Organized by @mdiazcuadros.bsky.social
@vanderhaeghenp2.bsky.social
@bassemh.bsky.social and me.
Please RT to spread the word
meetings.embo.org/event/25-dev...
An inspiring interview for future scientists: my friend and colleague Francesca Mattiroli @fmattiroli.bsky.social recently got tenured at the Hubrecht and reflects on her journey ❤️
www.hubrecht.eu/francesca-ma...
www.hubrecht.eu/francesca-ma...
Francesca Mattiroli got tenure: ‘Science is a team sport’ - Hubrecht Institute
She always dreamed of becoming a scientist. Francesca Mattiroli, has passed tenure evaluation with flying colors. She will expand her chromatin research.
www.hubrecht.eu
January 24, 2025 at 4:00 PM
An inspiring interview for future scientists: my friend and colleague Francesca Mattiroli @fmattiroli.bsky.social recently got tenured at the Hubrecht and reflects on her journey ❤️
www.hubrecht.eu/francesca-ma...
www.hubrecht.eu/francesca-ma...
Wow 😳! I thought science in The Netherlands was in a bad spot after the Dutch elections but I guess it could be worse..
www.science.org/content/arti...
www.science.org/content/arti...
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
www.science.org
January 23, 2025 at 11:40 AM
Wow 😳! I thought science in The Netherlands was in a bad spot after the Dutch elections but I guess it could be worse..
www.science.org/content/arti...
www.science.org/content/arti...
Reposted by Matilde Galli
Very happy to share our preprint on visualizing the life cycle of Influenza viruses using single-molecule imaging! 🥳 We developed two techniques to visualize infections of unmodified influenza viruses in live cells from endosomal release to budding of new viruses. For more details&videos see below ⬇️
January 21, 2025 at 10:16 AM
Very happy to share our preprint on visualizing the life cycle of Influenza viruses using single-molecule imaging! 🥳 We developed two techniques to visualize infections of unmodified influenza viruses in live cells from endosomal release to budding of new viruses. For more details&videos see below ⬇️
Reposted by Matilde Galli
I am really happy to announce the first Hubrecht Symposium on March 13th 2025! We will organize these yearly events on a specific topic in molecular and developmental biology to emphasize the importance of fundamental research for Dutch science. Free of charge! www.hubrecht.eu/hubrecht-sym...
November 29, 2024 at 12:30 PM
I am really happy to announce the first Hubrecht Symposium on March 13th 2025! We will organize these yearly events on a specific topic in molecular and developmental biology to emphasize the importance of fundamental research for Dutch science. Free of charge! www.hubrecht.eu/hubrecht-sym...