Micha Müller
@michamuller.bsky.social
PhD student in the Tanenbaum lab at the Hubrecht Institute. Previously in the Pelkmans lab at UZH.
Interested in quantitative (live-cell) imaging, single-cell barcoding technologies, single-cell Omics, virus-host competition and many other things.
Interested in quantitative (live-cell) imaging, single-cell barcoding technologies, single-cell Omics, virus-host competition and many other things.
Pinned
Micha Müller
@michamuller.bsky.social
· Jan 21
Very happy to share our preprint on visualizing the life cycle of Influenza viruses using single-molecule imaging! 🥳 We developed two techniques to visualize infections of unmodified influenza viruses in live cells from endosomal release to budding of new viruses. For more details&videos see below ⬇️
Reposted by Micha Müller
I am very excited to share our latest work where we describe a new method to profile genome-wide chromatin transitions over time in single cells. Great collaborative effort with the van Oudenaarden group @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social www.nature.com/articles/s41....
Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation - Nature Cell Biology
Kefalopoulou, Rullens et al. develop Dam&ChIC to assay chromatin state at two different time points in the same cell. The method was used to study the reorganization of LADs during cell division a...
www.nature.com
July 10, 2025 at 2:36 PM
I am very excited to share our latest work where we describe a new method to profile genome-wide chromatin transitions over time in single cells. Great collaborative effort with the van Oudenaarden group @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social www.nature.com/articles/s41....
Reposted by Micha Müller
It's possible to apply for the Hubrecht Talent Program again!
The HTP aims to promote scientific excellence in the Netherlands by supporting talented minority students in pursuing a career in scientific research.
Read more in the flyer and on www.hubrecht.eu/about-us/hub...
The HTP aims to promote scientific excellence in the Netherlands by supporting talented minority students in pursuing a career in scientific research.
Read more in the flyer and on www.hubrecht.eu/about-us/hub...
April 28, 2025 at 9:28 AM
It's possible to apply for the Hubrecht Talent Program again!
The HTP aims to promote scientific excellence in the Netherlands by supporting talented minority students in pursuing a career in scientific research.
Read more in the flyer and on www.hubrecht.eu/about-us/hub...
The HTP aims to promote scientific excellence in the Netherlands by supporting talented minority students in pursuing a career in scientific research.
Read more in the flyer and on www.hubrecht.eu/about-us/hub...
Reposted by Micha Müller
How do embryos ensure precise tissue patterning? It’s all about timing cell divisions! Our new preprint reveals how cell proliferation syncs with signaling oscillations to regulate precision of somite formation and growth. Check the full story: www.biorxiv.org/content/10.1...
March 11, 2025 at 12:29 PM
How do embryos ensure precise tissue patterning? It’s all about timing cell divisions! Our new preprint reveals how cell proliferation syncs with signaling oscillations to regulate precision of somite formation and growth. Check the full story: www.biorxiv.org/content/10.1...
Reposted by Micha Müller
Our paper is out! We delevoped a method to follow individual translating ribosomes for hours in living cells, and discovered that ribosomes are great friends and help each other in problematic situations:
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
February 3, 2025 at 8:31 AM
Our paper is out! We delevoped a method to follow individual translating ribosomes for hours in living cells, and discovered that ribosomes are great friends and help each other in problematic situations:
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Micha Müller
Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation
Ribosomes cooperate through transient collisions to ensure efficient translation.
www.cell.com
February 3, 2025 at 7:38 AM
Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Micha Müller
Our new paper is out: "Mapping the complete influenza A virus infection cycle through single vRNP imaging". Combining newly-developed single-molecule imaging approaches with in situ viral transcriptomics, we identify numerous non-canonical infection pathways.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Mapping the complete influenza A virus infection cycle through single vRNP imaging
Cell-to-cell heterogeneity is a common feature of viral infection that can generate enormous complexity, complicating understanding of infection progression and interpretation of differences between v...
www.biorxiv.org
January 21, 2025 at 9:56 AM
Our new paper is out: "Mapping the complete influenza A virus infection cycle through single vRNP imaging". Combining newly-developed single-molecule imaging approaches with in situ viral transcriptomics, we identify numerous non-canonical infection pathways.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Very happy to share our preprint on visualizing the life cycle of Influenza viruses using single-molecule imaging! 🥳 We developed two techniques to visualize infections of unmodified influenza viruses in live cells from endosomal release to budding of new viruses. For more details&videos see below ⬇️
January 21, 2025 at 10:16 AM
Very happy to share our preprint on visualizing the life cycle of Influenza viruses using single-molecule imaging! 🥳 We developed two techniques to visualize infections of unmodified influenza viruses in live cells from endosomal release to budding of new viruses. For more details&videos see below ⬇️
Reposted by Micha Müller
I am really happy to announce the first Hubrecht Symposium on March 13th 2025! We will organize these yearly events on a specific topic in molecular and developmental biology to emphasize the importance of fundamental research for Dutch science. Free of charge! www.hubrecht.eu/hubrecht-sym...
November 29, 2024 at 12:30 PM
I am really happy to announce the first Hubrecht Symposium on March 13th 2025! We will organize these yearly events on a specific topic in molecular and developmental biology to emphasize the importance of fundamental research for Dutch science. Free of charge! www.hubrecht.eu/hubrecht-sym...