Marty Yang
@martyyang.bsky.social
Postdoc in Bhaduri Lab @ UCLA
https://pubmed.ncbi.nlm.nih.gov/?term=Marty+G+Yang&sort=pubdate
https://pubmed.ncbi.nlm.nih.gov/?term=Marty+G+Yang&sort=pubdate
Pinned
Marty Yang
@martyyang.bsky.social
· Nov 15
Excited to share the first story from my post-doc, co-led with Megan Ostrowski! Many thanks to @vram142.bsky.social and all our wonderful co-authors and collaborators for making this project a huge success: www.cell.com/cell/fulltex...
Reposted by Marty Yang
Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...
Conservation and alteration of mammalian striatal interneurons - Nature
An analysis of cell-type diversity in brain samples from a variety of mammalian species, both during development and in adult animals, reveals that the TAC3 initial class of striatal interneurons is c...
www.nature.com
November 7, 2025 at 6:06 PM
Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...
Reposted by Marty Yang
Very pleased to share this work from my time as a graduate student with the Greenberg lab. We investigate the molecular function of ZMYND11, a tumor suppressor and chromatin reader which is also a cause of syndromic intellectual disability. Preprint available now: www.biorxiv.org/content/10.1...
ZMYND11 Restrains KMT2A to Enable a Neuronal Developmental Program
Mutations in the chromatin reader and tumor suppressor ZMYND11 are the cause of ZMYND11-related syndromic intellectual disability (ZRSID), a disorder characterized by symptoms such as language and mot...
www.biorxiv.org
November 4, 2025 at 11:37 PM
Very pleased to share this work from my time as a graduate student with the Greenberg lab. We investigate the molecular function of ZMYND11, a tumor suppressor and chromatin reader which is also a cause of syndromic intellectual disability. Preprint available now: www.biorxiv.org/content/10.1...
Reposted by Marty Yang
🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity!
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
October 22, 2025 at 8:41 PM
🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity!
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have:
(1) more corticospinal neurons (CSNs)
(2) better hand dexterity
(3) more dexterous climbing, which is linked to CSN number🧵
Reposted by Marty Yang
The first (of hopefully many) reports to come from our collaboration with @hjp.bsky.social
We present a new type of cell fitness assay that allows you to both quantify and explain differences across human donors in cell proliferation and sensitivity to environmental toxicants.
We present a new type of cell fitness assay that allows you to both quantify and explain differences across human donors in cell proliferation and sensitivity to environmental toxicants.
Cell villages and Dirichlet modeling map human cell fitness genetics https://www.biorxiv.org/content/10.1101/2025.09.26.678880v1
September 30, 2025 at 7:17 PM
The first (of hopefully many) reports to come from our collaboration with @hjp.bsky.social
We present a new type of cell fitness assay that allows you to both quantify and explain differences across human donors in cell proliferation and sensitivity to environmental toxicants.
We present a new type of cell fitness assay that allows you to both quantify and explain differences across human donors in cell proliferation and sensitivity to environmental toxicants.
Reposted by Marty Yang
Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes
Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remod...
www.science.org
October 2, 2025 at 10:55 PM
Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Marty Yang
Super excited to get this out. This collab started a few years ago and is the first paper from it. Here, with experimental and computational approaches we:
1. establish that cell villages can be just as accurate (one might argue more accurate!) than arrayed-based designs
bsky.app/profile/bior...
1. establish that cell villages can be just as accurate (one might argue more accurate!) than arrayed-based designs
bsky.app/profile/bior...
Cell villages and Dirichlet modeling map human cell fitness genetics https://www.biorxiv.org/content/10.1101/2025.09.26.678880v1
September 29, 2025 at 4:47 PM
Super excited to get this out. This collab started a few years ago and is the first paper from it. Here, with experimental and computational approaches we:
1. establish that cell villages can be just as accurate (one might argue more accurate!) than arrayed-based designs
bsky.app/profile/bior...
1. establish that cell villages can be just as accurate (one might argue more accurate!) than arrayed-based designs
bsky.app/profile/bior...
Reposted by Marty Yang
Dissecting Gene Regulatory Networks Governing Human Cortical Cell Fate https://www.biorxiv.org/content/10.1101/2025.09.23.678137v1
September 24, 2025 at 7:31 AM
Dissecting Gene Regulatory Networks Governing Human Cortical Cell Fate https://www.biorxiv.org/content/10.1101/2025.09.23.678137v1
Reposted by Marty Yang
Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up!
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)
The eukaryotic replisome intrinsically generates asymmetric daughter chromatin fibers
DNA replication is molecularly asymmetric, due to distinct mechanisms for lagging and leading strand DNA synthesis. Whether chromatin assembly on newly replicated strands is also asymmetric remains un...
www.biorxiv.org
September 20, 2025 at 4:10 PM
Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up!
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)
Reposted by Marty Yang
I'm really happy to announce that my two main postdoctoral works have been published in the same issue of Developmental Cell! First, the final form of the mouse cortical organoid protocol (tinyurl.com/bddfmx8n), which I recently presented at Development presents (tinyurl.com/36udcpme) and…
tinyurl.com
August 27, 2025 at 4:25 PM
I'm really happy to announce that my two main postdoctoral works have been published in the same issue of Developmental Cell! First, the final form of the mouse cortical organoid protocol (tinyurl.com/bddfmx8n), which I recently presented at Development presents (tinyurl.com/36udcpme) and…
Reposted by Marty Yang
A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro: Developmental Cell www.cell.com/developmenta...
August 27, 2025 at 3:09 PM
A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro: Developmental Cell www.cell.com/developmenta...
Reposted by Marty Yang
This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇
August 18, 2025 at 1:00 PM
This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇
Reposted by Marty Yang
Fascinating new work by @federicamosti.bsky.social
@debbysilver.bsky.social on
human-specific neurodevelopment, linking ‘Human Accelerated Regions’ to chromatin architecture, cortical cell fate and expansion and folding of brains 🧪🧠🧬
www.biorxiv.org/content/10.1...
@debbysilver.bsky.social on
human-specific neurodevelopment, linking ‘Human Accelerated Regions’ to chromatin architecture, cortical cell fate and expansion and folding of brains 🧪🧠🧬
www.biorxiv.org/content/10.1...
Species-specific chromatin architecture and neurogenesis mediated by a human enhancer
Genomic modifications underlie the evolution of human features, including a larger neocortex and enhanced cognition. Human Accelerated Regions (HARs) are highly-conserved loci containing human-specifi...
www.biorxiv.org
August 9, 2025 at 6:45 AM
Fascinating new work by @federicamosti.bsky.social
@debbysilver.bsky.social on
human-specific neurodevelopment, linking ‘Human Accelerated Regions’ to chromatin architecture, cortical cell fate and expansion and folding of brains 🧪🧠🧬
www.biorxiv.org/content/10.1...
@debbysilver.bsky.social on
human-specific neurodevelopment, linking ‘Human Accelerated Regions’ to chromatin architecture, cortical cell fate and expansion and folding of brains 🧪🧠🧬
www.biorxiv.org/content/10.1...
Reposted by Marty Yang
Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.
August 6, 2025 at 3:14 PM
Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.
Reposted by Marty Yang
The Anne West lab at Duke is hiring a postdoc to work on nuclear cell biology in neurogenesis. Please help me spread the word! Applications to west@neuro.duke.edu.
July 27, 2025 at 8:27 PM
The Anne West lab at Duke is hiring a postdoc to work on nuclear cell biology in neurogenesis. Please help me spread the word! Applications to west@neuro.duke.edu.
Reposted by Marty Yang
Two parallel lineage-committed progenitors contribute to the developing brain https://www.biorxiv.org/content/10.1101/2025.07.02.662771v1
July 3, 2025 at 12:31 PM
Two parallel lineage-committed progenitors contribute to the developing brain https://www.biorxiv.org/content/10.1101/2025.07.02.662771v1
Reposted by Marty Yang
🧵Excited to share our new preprint introducing iHOTT - an autologous tumor-immune co-culture model that captures patient-specific responses in #Glioblastoma
💥Now on
@biorxivpreprint
: biorxiv.org/content/10.1...
Led by Dr. Shivani Baisiwala, Neurosurgery Resident in the lab
💥Now on
@biorxivpreprint
: biorxiv.org/content/10.1...
Led by Dr. Shivani Baisiwala, Neurosurgery Resident in the lab
biorxiv.org
June 24, 2025 at 2:24 AM
🧵Excited to share our new preprint introducing iHOTT - an autologous tumor-immune co-culture model that captures patient-specific responses in #Glioblastoma
💥Now on
@biorxivpreprint
: biorxiv.org/content/10.1...
Led by Dr. Shivani Baisiwala, Neurosurgery Resident in the lab
💥Now on
@biorxivpreprint
: biorxiv.org/content/10.1...
Led by Dr. Shivani Baisiwala, Neurosurgery Resident in the lab
Reposted by Marty Yang
Very happy to share the peer-reviewed version of our paper in which we study the formation and function of pair-wise and multi-way enhancer-promoter interactions in gene regulation (see thread below): www.nature.com/articles/s41...
May 13, 2025 at 9:41 AM
Very happy to share the peer-reviewed version of our paper in which we study the formation and function of pair-wise and multi-way enhancer-promoter interactions in gene regulation (see thread below): www.nature.com/articles/s41...
Reposted by Marty Yang
Excited to share our latest manuscript, a collaboration with @justinperryphd.bsky.social led by Weill Cornell Neuroscience PhD student @annbaako.bsky.social. Ann developed a new, improved mouse PSC model for studying tissue-resident macrophage differentiation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Modeling tissue-resident macrophage development from mouse pluripotent stem cells
Tissue-resident macrophages (TRMs) are innate immune cells that participate in tissue development, homeostasis, and immune surveillance. Extensive efforts have been made to recapitulate TRM developmen...
www.biorxiv.org
May 13, 2025 at 7:37 PM
Excited to share our latest manuscript, a collaboration with @justinperryphd.bsky.social led by Weill Cornell Neuroscience PhD student @annbaako.bsky.social. Ann developed a new, improved mouse PSC model for studying tissue-resident macrophage differentiation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Marty Yang
It’s out! The first paper from my postdoc – and first from the @bhadurilab.bsky.social – is now live @natneuro.nature.com . 🧠✨
Using a new meta-atlas generation strategy, we identified functional gene networks that more fully explain how cell types are formed in the human cortex. (1/13)
Using a new meta-atlas generation strategy, we identified functional gene networks that more fully explain how cell types are formed in the human cortex. (1/13)
Parallel meta-analyses of the human cortex in development (seven datasets) and adulthood (16 datasets) generated over 500 gene co-expression networks that can describe mechanisms of cortical development, centering on peak stages of neurogenesis 🧠🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Integrated analysis of molecular atlases unveils modules driving developmental cell subtype specification in the human cortex - Nature Neuroscience
Nano et al. introduce a pipeline to generate meta-atlases of the human brain from existing single-cell datasets and extract gene modules linked to cell fate specification. Perturbing these programs in...
www.nature.com
May 2, 2025 at 12:39 AM
It’s out! The first paper from my postdoc – and first from the @bhadurilab.bsky.social – is now live @natneuro.nature.com . 🧠✨
Using a new meta-atlas generation strategy, we identified functional gene networks that more fully explain how cell types are formed in the human cortex. (1/13)
Using a new meta-atlas generation strategy, we identified functional gene networks that more fully explain how cell types are formed in the human cortex. (1/13)
Preprint from @bhadurilab.bsky.social: Thalamic NRXN1-Mediated Input to Human Cortical Progenitors Drives Upper Layer Neurogenesis (www.biorxiv.org/content/10.1...)
Thalamic NRXN1-Mediated Input to Human Cortical Progenitors Drives Upper Layer Neurogenesis
According to the protocortex hypothesis, extrinsic thalamic signaling is necessary for refining cortical areas and cell types, but the mechanism by which these inputs shape the development and expansi...
www.biorxiv.org
April 27, 2025 at 4:32 PM
Preprint from @bhadurilab.bsky.social: Thalamic NRXN1-Mediated Input to Human Cortical Progenitors Drives Upper Layer Neurogenesis (www.biorxiv.org/content/10.1...)
Reposted by Marty Yang
What contributes to human specific neural specification? Check out these two wonderful preprints from a wonderful scientist Ava carter! 1. www.biorxiv.org/content/10.1...; 2. www.biorxiv.org/content/10.1...
Stay tuned! third preprint is on its way!
Stay tuned! third preprint is on its way!
Human-chimpanzee tetraploid system defines mechanisms of species-specific neural gene regulation
A major challenge in human evolutionary biology is to pinpoint genetic differences that underlie human-specific traits, such as increased neuron number and differences in cognitive behaviors. We used ...
www.biorxiv.org
April 2, 2025 at 7:24 PM
What contributes to human specific neural specification? Check out these two wonderful preprints from a wonderful scientist Ava carter! 1. www.biorxiv.org/content/10.1...; 2. www.biorxiv.org/content/10.1...
Stay tuned! third preprint is on its way!
Stay tuned! third preprint is on its way!
Reposted by Marty Yang
💫 New preprint from the lab: Comparing great ape cerebral organoids, we found that human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution. Fantastic work from super-talented PhD student Theresa Schütze!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 13, 2025 at 10:11 AM
💫 New preprint from the lab: Comparing great ape cerebral organoids, we found that human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution. Fantastic work from super-talented PhD student Theresa Schütze!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Marty Yang
Delighted to share our most recent preprint led by the incredible @MilJessenya and @Jalbsoto! In this study, we generated a metabolomic atlas of human cortical development and discovered that the pentose phosphate pathway regulates radial glia cell fate. www.biorxiv.org/content/10.1...
Metabolic Atlas of Early Human Cortex Identifies Regulators of Cell Fate Transitions
Characterization of cell type emergence during human cortical development, which enables unique human cognition, has focused primarily on anatomical and transcriptional characterizations. Metabolic pr...
www.biorxiv.org
March 13, 2025 at 4:36 AM
Delighted to share our most recent preprint led by the incredible @MilJessenya and @Jalbsoto! In this study, we generated a metabolomic atlas of human cortical development and discovered that the pentose phosphate pathway regulates radial glia cell fate. www.biorxiv.org/content/10.1...
Reposted by Marty Yang
Our collaborative project with Matthias Stadtfeld and Jason Mezey labs has now been published. We examined how genetic variation impacts regulation of DNA methylation at the control regions of imprinted genes in naive pluripotent stem cells.
www.cell.com/stem-cell-re...
www.cell.com/stem-cell-re...
Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naive pluripotent stem cells
Pluripotent stem cells are susceptible to acquiring detrimental epigenetic abnormalities, posing a hurdle to their safe use in biomedical applications. Using pluripotent cells with defined genetic backgrounds, Stadtfeld and colleagues show that genetic variation is a major driver of epigenome stability and identify candidate regulators. These findings will enable novel approaches to stabilize the epigenome of pluripotent cells in culture.
www.cell.com
March 13, 2025 at 8:01 PM
Our collaborative project with Matthias Stadtfeld and Jason Mezey labs has now been published. We examined how genetic variation impacts regulation of DNA methylation at the control regions of imprinted genes in naive pluripotent stem cells.
www.cell.com/stem-cell-re...
www.cell.com/stem-cell-re...
Reposted by Marty Yang
⚡Next #FragileNucleosome meeting is less than a week away! Three amazing ECR scientists, 🔬@anajaneva.bsky.social, 🧠@anastasiahains.bsky.social, & 🧬@martyyang.bsky.social will discuss their research next Wed!
🗓️Don't forget to register:
us06web.zoom.us/webinar/regi...
🗓️Don't forget to register:
us06web.zoom.us/webinar/regi...
February 6, 2025 at 11:54 AM
⚡Next #FragileNucleosome meeting is less than a week away! Three amazing ECR scientists, 🔬@anajaneva.bsky.social, 🧠@anastasiahains.bsky.social, & 🧬@martyyang.bsky.social will discuss their research next Wed!
🗓️Don't forget to register:
us06web.zoom.us/webinar/regi...
🗓️Don't forget to register:
us06web.zoom.us/webinar/regi...