Maite Freire
@maitefreired.bsky.social
PhD candidate @institutpasteur | Piplettes_mag✍🏻
Reposted by Maite Freire
I’m pleased to share our latest preprint (my first as 1st-author) from Jérôme Gros’ group (@jeromegros.bsky.social), now on bioRxiv. It reports actin and myosin dynamics during epithelial remodeling in avian gastrulation. (doi: doi.org/10.64898/202...)
Actin and myosin dynamics during epithelial remodeling in avian gastrulation
Epithelial remodeling is powered by contractile forces exerted by the actomyosin cytoskeleton. In invertebrates, pulsatile contractile flows of the medio-apical actomyosin cortex have been shown to be...
doi.org
December 19, 2025 at 4:33 PM
I’m pleased to share our latest preprint (my first as 1st-author) from Jérôme Gros’ group (@jeromegros.bsky.social), now on bioRxiv. It reports actin and myosin dynamics during epithelial remodeling in avian gastrulation. (doi: doi.org/10.64898/202...)
Reposted by Maite Freire
Maybe we should revise policies that push postdocs out of academic research too early. It selects for early achievers that remain in one field and risks losing the highest impact people
Multidisciplinary training, over time, produces the highest impact people
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Recent discoveries on the acquisition of the highest levels of human performance
Scientists have long debated the origins of exceptional human achievements. This literature review summarizes recent evidence from multiple domains on the acquisition of world-class performance. We re...
www.science.org
December 21, 2025 at 7:51 PM
Maybe we should revise policies that push postdocs out of academic research too early. It selects for early achievers that remain in one field and risks losing the highest impact people
Reposted by Maite Freire
Made a little #shopSmall mostly ocean art, mostly PNW local gift guide
The guide is available with more details in my linktree
linktr.ee/noncompliant...
🐙🦑🐡🧵
The guide is available with more details in my linktree
linktr.ee/noncompliant...
🐙🦑🐡🧵
November 28, 2025 at 7:20 PM
Made a little #shopSmall mostly ocean art, mostly PNW local gift guide
The guide is available with more details in my linktree
linktr.ee/noncompliant...
🐙🦑🐡🧵
The guide is available with more details in my linktree
linktr.ee/noncompliant...
🐙🦑🐡🧵
Reposted by Maite Freire
Hey #TeamTomo …would you like to try some 🍦ICECREAM!? Our @unibas.ch colleagues over at the @ivandokmanic.bsky.social lab have developed a stunningly effective tool to de-noise and de-wedge your tomograms. The contrast and details will give you brain freeze! 🍨❄️🤯
Please try, we need feedback 🧪🧶🧬🔬
Please try, we need feedback 🧪🧶🧬🔬
Our colleagues Vinith Kishore and Valentin Debarnot from the @ivandokmanic.bsky.social lab have come up with an amazing deep learning tool for denoising and filling the missing wedge in #cryoET data. I'm pleased to introduce Icecream🍧
Icecream: High-Fidelity Equivariant Cryo-Electron Tomography
Cryo-electron tomography (cryo-ET) visualizes 3D cellular architecture in near-native states. Recent deep-learning methods (CryoCARE, IsoNet, DeepDeWedge, CryoLithe) improve denoising and artifact cor...
www.biorxiv.org
October 23, 2025 at 5:57 PM
Hey #TeamTomo …would you like to try some 🍦ICECREAM!? Our @unibas.ch colleagues over at the @ivandokmanic.bsky.social lab have developed a stunningly effective tool to de-noise and de-wedge your tomograms. The contrast and details will give you brain freeze! 🍨❄️🤯
Please try, we need feedback 🧪🧶🧬🔬
Please try, we need feedback 🧪🧶🧬🔬
Reposted by Maite Freire
I'm so excited to share this with all of you!
This is the very first paper where I am the first author 🥹
Let me share some insights about our work 👇🧵(1/5):
How do persistent viral infections impact the host?
What happens when a fly becomes persistently infected by a virus?
This is the very first paper where I am the first author 🥹
Let me share some insights about our work 👇🧵(1/5):
How do persistent viral infections impact the host?
What happens when a fly becomes persistently infected by a virus?
October 17, 2025 at 2:07 PM
I'm so excited to share this with all of you!
This is the very first paper where I am the first author 🥹
Let me share some insights about our work 👇🧵(1/5):
How do persistent viral infections impact the host?
What happens when a fly becomes persistently infected by a virus?
This is the very first paper where I am the first author 🥹
Let me share some insights about our work 👇🧵(1/5):
How do persistent viral infections impact the host?
What happens when a fly becomes persistently infected by a virus?
Reposted by Maite Freire
So happy to see this in print! Led by the brilliant (almost Dr.) @castellosanjuan.bsky.social, with the amazing guidance of @rubengonzalez.bsky.social & @jarednigg.bsky.social.
We used to think persistent infections were harmless… but our latest work shows otherwise. Read it to learn more!
We used to think persistent infections were harmless… but our latest work shows otherwise. Read it to learn more!
Persistent viral #infections in #insects are not as harmless as once believed. @salehlabparis.bsky.social &co show how such infections in #FruitFlies alter survival, reproduction, behavior & gene expression, revealing the hidden costs of #viral persistence @plosbiology.org 🧪 plos.io/4olpuXm
October 13, 2025 at 8:23 PM
So happy to see this in print! Led by the brilliant (almost Dr.) @castellosanjuan.bsky.social, with the amazing guidance of @rubengonzalez.bsky.social & @jarednigg.bsky.social.
We used to think persistent infections were harmless… but our latest work shows otherwise. Read it to learn more!
We used to think persistent infections were harmless… but our latest work shows otherwise. Read it to learn more!
www.piplettes-pasteur.com/videos?wix-v...
Thanks Aline&Max for making me look more profesional than ever✨
Thanks Aline&Max for making me look more profesional than ever✨
Videos | Piplettes Magazine
www.piplettes-pasteur.com
October 8, 2025 at 7:12 AM
www.piplettes-pasteur.com/videos?wix-v...
Thanks Aline&Max for making me look more profesional than ever✨
Thanks Aline&Max for making me look more profesional than ever✨
Congrats 🫶🏻 @camimille.bsky.social
🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫
Thread coming soon!
Thread coming soon!
Nitrate-responsive Mycobacterial Intracytoplasmic Membranes dampen Inflammation during Mycobacterium tuberculosis Infection https://www.biorxiv.org/content/10.1101/2025.09.17.676823v1
September 19, 2025 at 5:15 PM
Congrats 🫶🏻 @camimille.bsky.social
Reposted by Maite Freire
🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫
Thread coming soon!
Thread coming soon!
Nitrate-responsive Mycobacterial Intracytoplasmic Membranes dampen Inflammation during Mycobacterium tuberculosis Infection https://www.biorxiv.org/content/10.1101/2025.09.17.676823v1
September 18, 2025 at 4:58 PM
🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫
Thread coming soon!
Thread coming soon!
Reposted by Maite Freire
After years of hard work and months of growing MTB @camimille.bsky.social submitted her story ! Check this out if you wanna discover new intrabacterial structures and their function ! 🦠🔬✨
🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫
Thread coming soon!
Thread coming soon!
Nitrate-responsive Mycobacterial Intracytoplasmic Membranes dampen Inflammation during Mycobacterium tuberculosis Infection https://www.biorxiv.org/content/10.1101/2025.09.17.676823v1
September 18, 2025 at 5:52 PM
After years of hard work and months of growing MTB @camimille.bsky.social submitted her story ! Check this out if you wanna discover new intrabacterial structures and their function ! 🦠🔬✨
Lift Out just feel otherworldly🌚
September 17, 2025 at 3:14 PM
Lift Out just feel otherworldly🌚
Reposted by Maite Freire
When your flagellum has had enough of your shit
Most striking, in some instances of spontaneous flagellar detachment, the flagellum can glide on its own - mercilessly leaving the cell body behind, stabbing it on the way if need be (don't do this at home).
September 11, 2025 at 5:20 PM
When your flagellum has had enough of your shit
Reposted by Maite Freire
Thanks to @maitefreired.bsky.social for doing all the work, to @bastinlab.bsky.social @beaplab.bsky.social & Nicole King for comments on the manuscript, and to @currentbiology.bsky.social for a smooth and constructive peer-review experience 🙌
September 9, 2025 at 6:12 PM
Thanks to @maitefreired.bsky.social for doing all the work, to @bastinlab.bsky.social @beaplab.bsky.social & Nicole King for comments on the manuscript, and to @currentbiology.bsky.social for a smooth and constructive peer-review experience 🙌
Reposted by Maite Freire
... and might be especially key in confined microenvironments such as the soil, where protists are often trapped in thin liquid layers in pores between grains. (Choanos are commonly found in soil, but their ecology and motility in this environment are pretty much unknown; pic: tinyurl.com/9vh488bk)
September 9, 2025 at 6:12 PM
... and might be especially key in confined microenvironments such as the soil, where protists are often trapped in thin liquid layers in pores between grains. (Choanos are commonly found in soil, but their ecology and motility in this environment are pretty much unknown; pic: tinyurl.com/9vh488bk)
Reposted by Maite Freire
Gliding is conserved in at least 2 choano species we looked at (C. flexa and S. rosetta). We don't know in which natural context it is deployed, but we think it is likely to be involved in interactions with surfaces such as biofilms...
September 9, 2025 at 6:12 PM
Gliding is conserved in at least 2 choano species we looked at (C. flexa and S. rosetta). We don't know in which natural context it is deployed, but we think it is likely to be involved in interactions with surfaces such as biofilms...
Reposted by Maite Freire
Most striking, in some instances of spontaneous flagellar detachment, the flagellum can glide on its own - mercilessly leaving the cell body behind, stabbing it on the way if need be (don't do this at home).
September 9, 2025 at 6:12 PM
Most striking, in some instances of spontaneous flagellar detachment, the flagellum can glide on its own - mercilessly leaving the cell body behind, stabbing it on the way if need be (don't do this at home).
Reposted by Maite Freire
Do choanos defy the laws of physics? Not quite. Multiple pieces of evidence suggest the motor force for gliding resides in the flagellum (like in Chlamydomonas): (1) flagellar ablation prevents gliding (2) inhibition of the molecular motors of intraflagellar transport abolish it too.
September 9, 2025 at 6:12 PM
Do choanos defy the laws of physics? Not quite. Multiple pieces of evidence suggest the motor force for gliding resides in the flagellum (like in Chlamydomonas): (1) flagellar ablation prevents gliding (2) inhibition of the molecular motors of intraflagellar transport abolish it too.
Reposted by Maite Freire
In this new study, @maitefreired.bsky.social has shown that moderate confinement activates *yet another* mode of motility: choanos straighten their flagellum, and start moving over the substrate at pretty high speed (~1 µm/sec) without any visible cell deformation. They glide!
September 9, 2025 at 6:12 PM
In this new study, @maitefreired.bsky.social has shown that moderate confinement activates *yet another* mode of motility: choanos straighten their flagellum, and start moving over the substrate at pretty high speed (~1 µm/sec) without any visible cell deformation. They glide!
Reposted by Maite Freire
What about choanos? They are best-known as flagellar swimmers. In 2021, we showed they are additionally capable of amoeboid motility, crawling via cell protrusions under strong geometric confinement. (elifesciences.org/articles/61037)
September 9, 2025 at 6:12 PM
What about choanos? They are best-known as flagellar swimmers. In 2021, we showed they are additionally capable of amoeboid motility, crawling via cell protrusions under strong geometric confinement. (elifesciences.org/articles/61037)
Reposted by Maite Freire
Gliding in diverse protists involves different parts of the cell - eg, flagella & IFT motors in the alga Chlamydomonas (pic: tinyurl.com/ye2jsbs5) - suggesting multiple evolutionary origins. Interestingly, gliding has also only been described so far in lineages very distant from animals and fungi.
September 9, 2025 at 6:12 PM
Gliding in diverse protists involves different parts of the cell - eg, flagella & IFT motors in the alga Chlamydomonas (pic: tinyurl.com/ye2jsbs5) - suggesting multiple evolutionary origins. Interestingly, gliding has also only been described so far in lineages very distant from animals and fungi.
Reposted by Maite Freire
Do diatoms disprove physics? Not really. They also exert a force on the substrate, but this time, the action occurs at the molecular scale: movement is powered by adhesive transmembrane proteins stuck to the substrate and coupled to intracellular molecular motors. (fig: tinyurl.com/ytd55aw5)
September 9, 2025 at 6:12 PM
Do diatoms disprove physics? Not really. They also exert a force on the substrate, but this time, the action occurs at the molecular scale: movement is powered by adhesive transmembrane proteins stuck to the substrate and coupled to intracellular molecular motors. (fig: tinyurl.com/ytd55aw5)
Reposted by Maite Freire
Even more mysterious than ducks, some protists can move over a surface without visible cell deformation: no beating flagellum, no crawling protrusions - as if propelled by some superpower. This motility is called "gliding". See an exemple in a diatoms below (www.youtube.com/watch?v=e4zL...).
September 9, 2025 at 6:12 PM
Even more mysterious than ducks, some protists can move over a surface without visible cell deformation: no beating flagellum, no crawling protrusions - as if propelled by some superpower. This motility is called "gliding". See an exemple in a diatoms below (www.youtube.com/watch?v=e4zL...).
Reposted by Maite Freire
(In reality, as most of us realized at some point when we were kids, ducks pedal hard below the surface.)
September 9, 2025 at 6:12 PM
(In reality, as most of us realized at some point when we were kids, ducks pedal hard below the surface.)
Reposted by Maite Freire
Like most biological problems, this one is best introduced by contemplating ducks. Ducks on a lake can seem to glide effortlessly without exerting any visible force, defying the laws of physics.
September 9, 2025 at 6:12 PM
Like most biological problems, this one is best introduced by contemplating ducks. Ducks on a lake can seem to glide effortlessly without exerting any visible force, defying the laws of physics.
So nice to see this out🙌🏻🙌🏻🙌🏻
New short paper from our lab @currentbiology.bsky.social, in which we discover of a new mode of cell motility for choanoflagellates: flagellar gliding. www.cell.com/current-biol... - A 🧵
Flagellar gliding in choanoflagellates
Freire-Delgado and Brunet discover a new mode of cell motility in choanoflagellates,
the closest relatives of animals. Under mild confinement, choanoflagellate move over
surfaces without cell deformat...
www.cell.com
September 9, 2025 at 6:22 PM
So nice to see this out🙌🏻🙌🏻🙌🏻