Maggie Chasse, PhD
@maggiechasse.bsky.social
Zon lab NCI K00 postdoc | pediatric sarcoma PhD | Luger lab chromatin biochem MS | transcription and melanoma in #zebrafish 🐠 | she/her
Pinned
An attractor state zone precedes neural crest fate in melanoma initiation https://www.biorxiv.org/content/10.1101/2024.10.22.618007v1
An attractor state zone precedes neural crest fate in melanoma initiation https://www.biorxiv.org/content/10.1101/2024.10.22.618007v1
The field cancerization theory suggests that a group of cells containing oncogenic mutations are pre
www.biorxiv.org
The best hello; the hardest goodbye. So thankful for a beautiful 13 years. 💕
November 13, 2025 at 10:52 PM
The best hello; the hardest goodbye. So thankful for a beautiful 13 years. 💕
Reposted by Maggie Chasse, PhD
In the spirit of Halloween, we’ve resurrected our social media presence! We look forward to reconnecting with the community and celebrating all those that are part of it 😊 #RockOn
October 31, 2025 at 7:05 PM
In the spirit of Halloween, we’ve resurrected our social media presence! We look forward to reconnecting with the community and celebrating all those that are part of it 😊 #RockOn
The most wonderful group of scientists, and now friends, to organize a trainee focused meeting to kick off SMR 2025!
October 25, 2025 at 3:22 PM
The most wonderful group of scientists, and now friends, to organize a trainee focused meeting to kick off SMR 2025!
Reposted by Maggie Chasse, PhD
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
October 6, 2025 at 11:21 AM
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
I was about to tag @nucleosomepolice.bsky.social but she beat me to it. 😂😂
I'm still mad someone decided to call them H2A, H2B, H3, H4.
September 30, 2025 at 9:27 PM
I was about to tag @nucleosomepolice.bsky.social but she beat me to it. 😂😂
One of my cats is very regal and one is very much not. This custom poorly drawn pet portrait perfectly captures their dichotomy 😂😂
September 27, 2025 at 8:00 PM
One of my cats is very regal and one is very much not. This custom poorly drawn pet portrait perfectly captures their dichotomy 😂😂
My yearly PSA to vote Grazer, a true feminist icon. 👑 @fatbearweek.bsky.social
September 24, 2025 at 12:28 PM
My yearly PSA to vote Grazer, a true feminist icon. 👑 @fatbearweek.bsky.social
Reposted by Maggie Chasse, PhD
We are hiring! The Wattrus lab at MGH is seeking talented postdoc applicants to join our group and study differences in regeneration and wound healing across species using fish models. We are a fun group - come and join us! Fishy friends, please spread the word! #zebrafish #medaka #zebrafishjobs
September 2, 2025 at 4:00 PM
We are hiring! The Wattrus lab at MGH is seeking talented postdoc applicants to join our group and study differences in regeneration and wound healing across species using fish models. We are a fun group - come and join us! Fishy friends, please spread the word! #zebrafish #medaka #zebrafishjobs
Reposted by Maggie Chasse, PhD
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
September 1, 2025 at 2:59 PM
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
Reposted by Maggie Chasse, PhD
My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
Mechanical confinement governs phenotypic plasticity in melanoma - Nature
Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state ...
www.nature.com
August 27, 2025 at 5:18 PM
My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
Finding moments of peace 💕💕
August 24, 2025 at 5:42 PM
Finding moments of peace 💕💕
Reposted by Maggie Chasse, PhD
🎓 Planning to apply to STEM graduate programs?
Join us for our webinar: “Applying to Grad Programs in STEM” on Thursday, 8/28 at 5.30pm ET.
Gain key insights on:
✅ Grad school application timeline
✅ How to choose the right program
🔗 Register: eventbrite.com/e/gsmi-2025-...
Join us for our webinar: “Applying to Grad Programs in STEM” on Thursday, 8/28 at 5.30pm ET.
Gain key insights on:
✅ Grad school application timeline
✅ How to choose the right program
🔗 Register: eventbrite.com/e/gsmi-2025-...
August 17, 2025 at 9:43 PM
🎓 Planning to apply to STEM graduate programs?
Join us for our webinar: “Applying to Grad Programs in STEM” on Thursday, 8/28 at 5.30pm ET.
Gain key insights on:
✅ Grad school application timeline
✅ How to choose the right program
🔗 Register: eventbrite.com/e/gsmi-2025-...
Join us for our webinar: “Applying to Grad Programs in STEM” on Thursday, 8/28 at 5.30pm ET.
Gain key insights on:
✅ Grad school application timeline
✅ How to choose the right program
🔗 Register: eventbrite.com/e/gsmi-2025-...
Reposted by Maggie Chasse, PhD
few outcomes, except for 99% of FDA-approved drugs, 174 recipients of 104 Nobel Prizes, training ~30K MDs and ~10K PhDs per year to enter the workforce, and a 34% reduction in age-adjusted cancer deaths since 1990 -- the largest decrease in history
Now do the Department of Defense budget, Andrew.
“Washington has thrown billions at NIH for decades with little accountability and few measurable outcomes,” HHS spokesperson Andrew Nixon said in a statement to Future Pulse.
www.politico.com/newsletters/...
“Washington has thrown billions at NIH for decades with little accountability and few measurable outcomes,” HHS spokesperson Andrew Nixon said in a statement to Future Pulse.
www.politico.com/newsletters/...
NIH spending battle’s ripple effect
www.politico.com
July 29, 2025 at 3:26 AM
few outcomes, except for 99% of FDA-approved drugs, 174 recipients of 104 Nobel Prizes, training ~30K MDs and ~10K PhDs per year to enter the workforce, and a 34% reduction in age-adjusted cancer deaths since 1990 -- the largest decrease in history
Reposted by Maggie Chasse, PhD
Very proud of our partner papers in @cp-cellreports.bsky.social and @cp-cellrepmethods.bsky.social from collaborative work in my lab and Benjamin Stanton's lab focused on fusion-positive #rhabdomyosarcoma. #TeamFishAndChIPs
Transforming the Approach to Cancer Epigenomic Studies – Pediatrics Nationwide
pediatricsnationwide.org
July 25, 2025 at 5:30 PM
Very proud of our partner papers in @cp-cellreports.bsky.social and @cp-cellrepmethods.bsky.social from collaborative work in my lab and Benjamin Stanton's lab focused on fusion-positive #rhabdomyosarcoma. #TeamFishAndChIPs
Reposted by Maggie Chasse, PhD
🚨🚨🚨 Tol2kit announcement! We have rebuilt the wiki that was corrupted a few months ago! We’re in the process of also linking it to the original address. Please visit us here:
tol2kitkwan.genetics.utah.edu
Thank you for your patience!!
#zebrafish #transgenesis #plasmids #sharing
tol2kitkwan.genetics.utah.edu
Thank you for your patience!!
#zebrafish #transgenesis #plasmids #sharing
tol2kit for kwan lab
tol2kitkwan.genetics.utah.edu
July 7, 2025 at 6:01 PM
🚨🚨🚨 Tol2kit announcement! We have rebuilt the wiki that was corrupted a few months ago! We’re in the process of also linking it to the original address. Please visit us here:
tol2kitkwan.genetics.utah.edu
Thank you for your patience!!
#zebrafish #transgenesis #plasmids #sharing
tol2kitkwan.genetics.utah.edu
Thank you for your patience!!
#zebrafish #transgenesis #plasmids #sharing
10th percentile for ESI 😅
“With these considerations, we expect to fund through the 4th percentile.”
There it is, in black and white, the destruction of cancer research in the US.
There it is, in black and white, the destruction of cancer research in the US.
Funding policy for 2025 from NCI. Was just released: 4 percentile…maybe!
www.cancer.gov/grants-train...
www.cancer.gov/grants-train...
July 24, 2025 at 1:47 PM
10th percentile for ESI 😅
Camp Zon 2025 has officially kicked off! Bittersweet to be my final year directing this amazing program — cannot wait for the next two weeks! #Zebrafish #Outreach 🐠
July 11, 2025 at 1:57 PM
Camp Zon 2025 has officially kicked off! Bittersweet to be my final year directing this amazing program — cannot wait for the next two weeks! #Zebrafish #Outreach 🐠
Reposted by Maggie Chasse, PhD
Defund the police: something that never really happened, but everybody talked about.
Defund the scientists: something that's actually happening, but almost nobody's talking about in those terms.
Defund the scientists: something that's actually happening, but almost nobody's talking about in those terms.
July 8, 2025 at 11:55 PM
Defund the police: something that never really happened, but everybody talked about.
Defund the scientists: something that's actually happening, but almost nobody's talking about in those terms.
Defund the scientists: something that's actually happening, but almost nobody's talking about in those terms.
Reposted by Maggie Chasse, PhD
the year 4 "can't wait to be a PI" to the year 5 "hopefully I can at least keep my current job for another year or two" senior postdoctoral fellow in 2025 pipeline
June 28, 2025 at 3:40 PM
the year 4 "can't wait to be a PI" to the year 5 "hopefully I can at least keep my current job for another year or two" senior postdoctoral fellow in 2025 pipeline
Reposted by Maggie Chasse, PhD
🆕 Our back-to-back papers reveal a surprising villain in ICB resistance: NK cells.
🧬 Targeting regulatory NK cells may boost T cell–driven immunotherapy.
#Immunotherapy #CancerResearch #ICB #NKcells #Melanoma #CD8Tcells
🧬 Targeting regulatory NK cells may boost T cell–driven immunotherapy.
#Immunotherapy #CancerResearch #ICB #NKcells #Melanoma #CD8Tcells
Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype
AbstractImmune checkpoint blockade (ICB) has revolutionized cancer treatment. Unfortunately, the inability of lymphocytes to infiltrate the tumor nest, a phenomenon known as immune exclusion, drastica...
aacrjournals.org
June 18, 2025 at 1:36 PM
🆕 Our back-to-back papers reveal a surprising villain in ICB resistance: NK cells.
🧬 Targeting regulatory NK cells may boost T cell–driven immunotherapy.
#Immunotherapy #CancerResearch #ICB #NKcells #Melanoma #CD8Tcells
🧬 Targeting regulatory NK cells may boost T cell–driven immunotherapy.
#Immunotherapy #CancerResearch #ICB #NKcells #Melanoma #CD8Tcells
Reposted by Maggie Chasse, PhD
Your silence most offends me
June 13, 2025 at 6:07 PM
Your silence most offends me
