Genevieve Kendall, PhD
@kendalllab.bsky.social
PI at Nationwide Children’s Hospital and Assistant Professor at Ohio State. Studying fusion-driven pediatric sarcomas using a cross-species comparative oncology approach. 🐟🧬🐭 Views are mine.
Reposted by Genevieve Kendall, PhD
1/9 Thrilled to share that our paper, “Origin of Ewing sarcoma by embryonic reprogramming of neural crest to mesoderm,” is now published in @cp-cellreports.bsky.social! @amatrudalab.bsky.social @crumplab.bsky.social www.cell.com/cell-reports...
Origin of Ewing sarcoma by embryonic reprogramming of neural crest to mesoderm
Using a zebrafish genetic model of Ewing sarcoma, Vasileva et al. provide evidence
for a neural crest origin of the disease. These findings offer new insight into how
a single oncogenic fusion can hij...
www.cell.com
October 9, 2025 at 9:06 PM
1/9 Thrilled to share that our paper, “Origin of Ewing sarcoma by embryonic reprogramming of neural crest to mesoderm,” is now published in @cp-cellreports.bsky.social! @amatrudalab.bsky.social @crumplab.bsky.social www.cell.com/cell-reports...
Reposted by Genevieve Kendall, PhD
Transdifferentiation of endothelial progenitor cells into rhabdomyosarcoma defined by hedgehog signaling competence: Cell Reports www.cell.com/cell-reports...
Latest from @hatleylab.bsky.social
Latest from @hatleylab.bsky.social
Transdifferentiation of endothelial progenitor cells into rhabdomyosarcoma defined by hedgehog signaling competence
Gadek et al. show that embryonal rhabdomyosarcoma formation is defined by the presence
of primary cilia and limits SHH pathway competency in early endothelial progenitor
cells that disappear during em...
www.cell.com
September 25, 2025 at 1:46 PM
Transdifferentiation of endothelial progenitor cells into rhabdomyosarcoma defined by hedgehog signaling competence: Cell Reports www.cell.com/cell-reports...
Latest from @hatleylab.bsky.social
Latest from @hatleylab.bsky.social
Reposted by Genevieve Kendall, PhD
A first-in-human study of universal donor CAR NK cells for acute myeloid leukemia could pave a path for a new approach to treating cancer.
#NKCells #CancerResearch #PedSky #AML
https://bit.ly/47RkgO4
#NKCells #CancerResearch #PedSky #AML
https://bit.ly/47RkgO4
September 22, 2025 at 6:54 PM
A first-in-human study of universal donor CAR NK cells for acute myeloid leukemia could pave a path for a new approach to treating cancer.
#NKCells #CancerResearch #PedSky #AML
https://bit.ly/47RkgO4
#NKCells #CancerResearch #PedSky #AML
https://bit.ly/47RkgO4
Reposted by Genevieve Kendall, PhD
Zebrafish people! The @ZDMSociety annual meeting is in Boston this year, with a great lineup. Abstract submission is closing May 27th. Go register now for this always fun conference #zebrafish www.zdmsociety.org/zdm18-home
May 21, 2025 at 8:23 AM
Zebrafish people! The @ZDMSociety annual meeting is in Boston this year, with a great lineup. Abstract submission is closing May 27th. Go register now for this always fun conference #zebrafish www.zdmsociety.org/zdm18-home
Reposted by Genevieve Kendall, PhD
Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com) paper, Miranda Hunter (@mrndhntr.bsky.social) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2
August 28, 2025 at 3:15 PM
Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com) paper, Miranda Hunter (@mrndhntr.bsky.social) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2
Very proud of our partner papers in @cp-cellreports.bsky.social and @cp-cellrepmethods.bsky.social from collaborative work in my lab and Benjamin Stanton's lab focused on fusion-positive #rhabdomyosarcoma. #TeamFishAndChIPs
Transforming the Approach to Cancer Epigenomic Studies – Pediatrics Nationwide
pediatricsnationwide.org
July 25, 2025 at 5:30 PM
Very proud of our partner papers in @cp-cellreports.bsky.social and @cp-cellrepmethods.bsky.social from collaborative work in my lab and Benjamin Stanton's lab focused on fusion-positive #rhabdomyosarcoma. #TeamFishAndChIPs
Reposted by Genevieve Kendall, PhD
🚨🚨🚨 Tol2kit announcement! We have rebuilt the wiki that was corrupted a few months ago! We’re in the process of also linking it to the original address. Please visit us here:
tol2kitkwan.genetics.utah.edu
Thank you for your patience!!
#zebrafish #transgenesis #plasmids #sharing
tol2kitkwan.genetics.utah.edu
Thank you for your patience!!
#zebrafish #transgenesis #plasmids #sharing
tol2kit for kwan lab
tol2kitkwan.genetics.utah.edu
July 7, 2025 at 6:01 PM
🚨🚨🚨 Tol2kit announcement! We have rebuilt the wiki that was corrupted a few months ago! We’re in the process of also linking it to the original address. Please visit us here:
tol2kitkwan.genetics.utah.edu
Thank you for your patience!!
#zebrafish #transgenesis #plasmids #sharing
tol2kitkwan.genetics.utah.edu
Thank you for your patience!!
#zebrafish #transgenesis #plasmids #sharing
Reposted by Genevieve Kendall, PhD
Our study, led by Dr. Patricia Tiburcio, showed that blocking protein recycling may help fight anaplastic Wilms Tumor—a rare, aggressive childhood kidney cancer. Combining bortezomib with dactinomycin made tumors more sensitive to treatment in the lab. doi.org/10.1016/j.xc...
June 24, 2025 at 1:43 PM
Our study, led by Dr. Patricia Tiburcio, showed that blocking protein recycling may help fight anaplastic Wilms Tumor—a rare, aggressive childhood kidney cancer. Combining bortezomib with dactinomycin made tumors more sensitive to treatment in the lab. doi.org/10.1016/j.xc...
Reposted by Genevieve Kendall, PhD
We are excited to announce the winner of the George Streisinger Award, the 2025 MBL Course Directors! The Streisinger Award will be presented to them at the 19th IZFC in Madison, WI, where they will also present the Award Lecture. Congratulations to all of them!
June 13, 2025 at 12:50 PM
We are excited to announce the winner of the George Streisinger Award, the 2025 MBL Course Directors! The Streisinger Award will be presented to them at the 19th IZFC in Madison, WI, where they will also present the Award Lecture. Congratulations to all of them!
Reposted by Genevieve Kendall, PhD
Abstract deadline for #ZDM18 in Boston ends tonight (EST) for those to be considered for oral talks. More details here: www.zdmsociety.org/zdm18-abstra... #ZebrafishMeeting
ZDM18 Abstract Submission — ZDMS
www.zdmsociety.org
June 2, 2025 at 5:34 PM
Abstract deadline for #ZDM18 in Boston ends tonight (EST) for those to be considered for oral talks. More details here: www.zdmsociety.org/zdm18-abstra... #ZebrafishMeeting
Reposted by Genevieve Kendall, PhD
Zebrafish + behavior?
You come to the right place!
Join us for the ZDMS webinar on Wednesday, June 4th at 10AM ET. Four incredible speakers will be sharing their expertise!
Sign up here 👇
www.zdmsociety.org/2025-zdms-ri...
#zebrafish #neuroscience
You come to the right place!
Join us for the ZDMS webinar on Wednesday, June 4th at 10AM ET. Four incredible speakers will be sharing their expertise!
Sign up here 👇
www.zdmsociety.org/2025-zdms-ri...
#zebrafish #neuroscience
June 2, 2025 at 11:52 AM
Zebrafish + behavior?
You come to the right place!
Join us for the ZDMS webinar on Wednesday, June 4th at 10AM ET. Four incredible speakers will be sharing their expertise!
Sign up here 👇
www.zdmsociety.org/2025-zdms-ri...
#zebrafish #neuroscience
You come to the right place!
Join us for the ZDMS webinar on Wednesday, June 4th at 10AM ET. Four incredible speakers will be sharing their expertise!
Sign up here 👇
www.zdmsociety.org/2025-zdms-ri...
#zebrafish #neuroscience
Reposted by Genevieve Kendall, PhD
To dissect the gene regulatory networks used to build organisms, we need Perturb-seq-like tools that work in whole animals.
For this purpose, we developed MIC-Drop-seq, a tool that couples high-throughput CRISPR in zebrafish embryos with single-cell RNAseq.
www.biorxiv.org/content/10.1...
For this purpose, we developed MIC-Drop-seq, a tool that couples high-throughput CRISPR in zebrafish embryos with single-cell RNAseq.
www.biorxiv.org/content/10.1...
MIC-Drop-seq: Scalable single-cell phenotyping of mutant vertebrate embryos
Pooled perturbation screens can reveal cellular regulatory networks, yet scaling these techniques for large-scale screens in animals remains challenging. To address this, we developed MIC-Drop-seq, wh...
www.biorxiv.org
June 2, 2025 at 4:13 PM
To dissect the gene regulatory networks used to build organisms, we need Perturb-seq-like tools that work in whole animals.
For this purpose, we developed MIC-Drop-seq, a tool that couples high-throughput CRISPR in zebrafish embryos with single-cell RNAseq.
www.biorxiv.org/content/10.1...
For this purpose, we developed MIC-Drop-seq, a tool that couples high-throughput CRISPR in zebrafish embryos with single-cell RNAseq.
www.biorxiv.org/content/10.1...
Reposted by Genevieve Kendall, PhD
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Conservation of regulatory elements with highly diverged sequences across large evolutionary distances
Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...
rdcu.be
May 27, 2025 at 12:19 PM
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Reposted by Genevieve Kendall, PhD
Free Webinar - Cancer research using zebrafish models, #ZDMS 2025 Cancer RIG Meet-up on Wednesday 28 May (10-11.30AM EST) exciting stories by rising stars of zebrafish cancer research field us06web.zoom.us/meeting/regi....
May 13, 2025 at 10:41 AM
Free Webinar - Cancer research using zebrafish models, #ZDMS 2025 Cancer RIG Meet-up on Wednesday 28 May (10-11.30AM EST) exciting stories by rising stars of zebrafish cancer research field us06web.zoom.us/meeting/regi....
Reposted by Genevieve Kendall, PhD
Attention ZDMS Members and greater fish community:
A message from the Local Organizing Committee for #ZDM18!
The Zebrafish Disease Models Society is excited to host ZDM18 in Boston in October! Read this thread for more about the conference and its upcoming deadlines. (1/8)
A message from the Local Organizing Committee for #ZDM18!
The Zebrafish Disease Models Society is excited to host ZDM18 in Boston in October! Read this thread for more about the conference and its upcoming deadlines. (1/8)
May 7, 2025 at 11:54 AM
Attention ZDMS Members and greater fish community:
A message from the Local Organizing Committee for #ZDM18!
The Zebrafish Disease Models Society is excited to host ZDM18 in Boston in October! Read this thread for more about the conference and its upcoming deadlines. (1/8)
A message from the Local Organizing Committee for #ZDM18!
The Zebrafish Disease Models Society is excited to host ZDM18 in Boston in October! Read this thread for more about the conference and its upcoming deadlines. (1/8)
Reposted by Genevieve Kendall, PhD
This year’s 11 NextGen Stars will share their findings on cancer cartography, the dark proteome, cancer-resistant tissues, and more at #AACR25. Learn more about their work and its future implications on the #AACRBlog: www.aacr.org/blog/2025/04...
April 26, 2025 at 4:18 PM
This year’s 11 NextGen Stars will share their findings on cancer cartography, the dark proteome, cancer-resistant tissues, and more at #AACR25. Learn more about their work and its future implications on the #AACRBlog: www.aacr.org/blog/2025/04...
The Kendall Lab is at #AACR25! Jack Kucinski is presenting in the Developmental Origins and Drivers of Pediatric Cancers poster session on Monday afternoon. Chinmay Sankhe and Delia Calderon are presenting at the Pediatric Cancer Models poster session on Tuesday morning. Hope to see you there!
April 26, 2025 at 7:16 PM
The Kendall Lab is at #AACR25! Jack Kucinski is presenting in the Developmental Origins and Drivers of Pediatric Cancers poster session on Monday afternoon. Chinmay Sankhe and Delia Calderon are presenting at the Pediatric Cancer Models poster session on Tuesday morning. Hope to see you there!
Reposted by Genevieve Kendall, PhD
I really enjoyed my conversation with Rita Fior for our inaugural feature on zebrafish in translational research!
April 26, 2025 at 3:08 PM
I really enjoyed my conversation with Rita Fior for our inaugural feature on zebrafish in translational research!
Reposted by Genevieve Kendall, PhD
Just finished up the materials for a intro to R workshop I'm running for folks at work. Thought I would post the GitHub to the materials here as well in case it was of use to anyone else: github.com/MVesuviusC/R...
🧬 🖥️ #bioinformatics #genomics #tidyverse #R #rstats #programming #r4ds
🧬 🖥️ #bioinformatics #genomics #tidyverse #R #rstats #programming #r4ds
GitHub - MVesuviusC/R_workshop
Contribute to MVesuviusC/R_workshop development by creating an account on GitHub.
github.com
March 27, 2025 at 7:24 PM
Just finished up the materials for a intro to R workshop I'm running for folks at work. Thought I would post the GitHub to the materials here as well in case it was of use to anyone else: github.com/MVesuviusC/R...
🧬 🖥️ #bioinformatics #genomics #tidyverse #R #rstats #programming #r4ds
🧬 🖥️ #bioinformatics #genomics #tidyverse #R #rstats #programming #r4ds
Reposted by Genevieve Kendall, PhD
This issue of #GENETICS offers updates on 6 model organism databases & knowledgebases: buff.ly/Mn0hIzl
🔎 AgBioData Consortium
🔎 Candida Genome Database
🔎 Saccharomyces Genome Database
🔎 SpudDB
🔎 Unified Phenotype Ontology
🔎 Zebrafish Information Network
Remember to cite your community resources!
🔎 AgBioData Consortium
🔎 Candida Genome Database
🔎 Saccharomyces Genome Database
🔎 SpudDB
🔎 Unified Phenotype Ontology
🔎 Zebrafish Information Network
Remember to cite your community resources!
March 26, 2025 at 1:00 PM
This issue of #GENETICS offers updates on 6 model organism databases & knowledgebases: buff.ly/Mn0hIzl
🔎 AgBioData Consortium
🔎 Candida Genome Database
🔎 Saccharomyces Genome Database
🔎 SpudDB
🔎 Unified Phenotype Ontology
🔎 Zebrafish Information Network
Remember to cite your community resources!
🔎 AgBioData Consortium
🔎 Candida Genome Database
🔎 Saccharomyces Genome Database
🔎 SpudDB
🔎 Unified Phenotype Ontology
🔎 Zebrafish Information Network
Remember to cite your community resources!
Reposted by Genevieve Kendall, PhD
Now @michaelhoffman.bsky.social starting his talk on inferring transcription factor binding from different data modalities. Loved the reference to Cunningham’s law #AACRprecmed25
March 13, 2025 at 2:37 PM
Now @michaelhoffman.bsky.social starting his talk on inferring transcription factor binding from different data modalities. Loved the reference to Cunningham’s law #AACRprecmed25
Reposted by Genevieve Kendall, PhD
Now: @alice.soragnilab.com: Patient-derived tumor organoid models to identify drug susceptibilities in rare cancers #AACRprecmed25 🧪🧬🖥️
March 12, 2025 at 2:39 PM
Now: @alice.soragnilab.com: Patient-derived tumor organoid models to identify drug susceptibilities in rare cancers #AACRprecmed25 🧪🧬🖥️
Reposted by Genevieve Kendall, PhD
This first AACR meeting on functional and genomic precision medicine has officially started! Dr. Mardis gave the introductory remarks followed by our first plenary speaker, Dr. Flaherty, who will focus on the collision of genomic and functional precision medicine #AACRPM25
March 11, 2025 at 9:15 PM
This first AACR meeting on functional and genomic precision medicine has officially started! Dr. Mardis gave the introductory remarks followed by our first plenary speaker, Dr. Flaherty, who will focus on the collision of genomic and functional precision medicine #AACRPM25
Reposted by Genevieve Kendall, PhD
A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb.
https://go.nature.com/41a7Zzj
https://go.nature.com/41a7Zzj
Rare genetic disorder treated in womb for the first time
The child, who is now almost three years old, shows no signs of the often fatal motor neuron disease.
go.nature.com
February 20, 2025 at 11:17 AM
A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb.
https://go.nature.com/41a7Zzj
https://go.nature.com/41a7Zzj