Lukas Groschner
@lukasgroschner.bsky.social
Brains, biophysics, behaviour.
https://www.groschner-lab.org
https://www.groschner-lab.org
Reposted by Lukas Groschner
I am super happy to share that our project on training biophysical models with Jaxley is now published in Nature Methods: www.nature.com/articles/s41...
Jaxley: differentiable simulation enables large-scale training of detailed biophysical models of neural dynamics - Nature Methods
Jaxley is a versatile platform for biophysical modeling in neuroscience. It allows efficiently simulating large-scale biophysical models on CPUs, GPUs and TPUs. Model parameters can be optimized with ...
www.nature.com
November 13, 2025 at 12:38 PM
I am super happy to share that our project on training biophysical models with Jaxley is now published in Nature Methods: www.nature.com/articles/s41...
Reposted by Lukas Groschner
Our work on training biophysical models with Jaxley is now out in @natmethods.nature.com. Led by @deismic.bsky.social, with @philipp.hertie.ai, @ppjgoncalves.bsky.social & @jakhmack.bsky.social et al.
Paper: www.nature.com/articles/s41...
Paper: www.nature.com/articles/s41...
Jaxley: differentiable simulation enables large-scale training of detailed biophysical models of neural dynamics - Nature Methods
Jaxley is a versatile platform for biophysical modeling in neuroscience. It allows efficiently simulating large-scale biophysical models on CPUs, GPUs and TPUs. Model parameters can be optimized with ...
www.nature.com
November 13, 2025 at 1:08 PM
Our work on training biophysical models with Jaxley is now out in @natmethods.nature.com. Led by @deismic.bsky.social, with @philipp.hertie.ai, @ppjgoncalves.bsky.social & @jakhmack.bsky.social et al.
Paper: www.nature.com/articles/s41...
Paper: www.nature.com/articles/s41...
Come join us in July 2026 for the 14th European Conference on Mathematical & Theoretical Biology in Graz, Austria!
Registration opens now: ecmtb2026.org
#ECMTB’26
@smbmathbiology.bsky.social
Registration opens now: ecmtb2026.org
#ECMTB’26
@smbmathbiology.bsky.social
European Conference on Mathematical & Theoretical Biology 2026
ECMTB is coming to Graz, Austria in July 2026. Registration and Call for Contributions are open!
ecmtb2026.org
November 11, 2025 at 6:47 PM
Come join us in July 2026 for the 14th European Conference on Mathematical & Theoretical Biology in Graz, Austria!
Registration opens now: ecmtb2026.org
#ECMTB’26
@smbmathbiology.bsky.social
Registration opens now: ecmtb2026.org
#ECMTB’26
@smbmathbiology.bsky.social
Reposted by Lukas Groschner
We’re hiring! 🚨
Assistant Professor (TT) in Theoretical or Computational Biological Physics @univmiami.bsky.social 😀
Come build the future of interdisciplinary biophysics with us!
Apply by Dec 15 → tinyurl.com/5n9bk836
#Biophysics #PhysicsJobs #AcademicJobs #UMiami
Assistant Professor (TT) in Theoretical or Computational Biological Physics @univmiami.bsky.social 😀
Come build the future of interdisciplinary biophysics with us!
Apply by Dec 15 → tinyurl.com/5n9bk836
#Biophysics #PhysicsJobs #AcademicJobs #UMiami
November 8, 2025 at 5:54 PM
We’re hiring! 🚨
Assistant Professor (TT) in Theoretical or Computational Biological Physics @univmiami.bsky.social 😀
Come build the future of interdisciplinary biophysics with us!
Apply by Dec 15 → tinyurl.com/5n9bk836
#Biophysics #PhysicsJobs #AcademicJobs #UMiami
Assistant Professor (TT) in Theoretical or Computational Biological Physics @univmiami.bsky.social 😀
Come build the future of interdisciplinary biophysics with us!
Apply by Dec 15 → tinyurl.com/5n9bk836
#Biophysics #PhysicsJobs #AcademicJobs #UMiami
Reposted by Lukas Groschner
Apply to become a CSHL-Simons Fellow in Neuroscience!
Run your own lab, pursue bold ideas, join a highly collaborative community!
All areas including experimental or computational neuro, including NeuroAI & systems
PhD required; ≤~1 yr postdoc
www.cshl.edu/about-us/car...
Run your own lab, pursue bold ideas, join a highly collaborative community!
All areas including experimental or computational neuro, including NeuroAI & systems
PhD required; ≤~1 yr postdoc
www.cshl.edu/about-us/car...
Fellows Positions | Cold Spring Harbor Laboratory
CSHL Simons Fellow in NEUROSCIENCE Cold Spring Harbor Laboratory (CSHL) is seeking to fill a Cold Spring Harbor Laboratory Fellow position in the area of NEUROSCIENCE (experimental and/or computationa...
www.cshl.edu
October 24, 2025 at 7:16 PM
Apply to become a CSHL-Simons Fellow in Neuroscience!
Run your own lab, pursue bold ideas, join a highly collaborative community!
All areas including experimental or computational neuro, including NeuroAI & systems
PhD required; ≤~1 yr postdoc
www.cshl.edu/about-us/car...
Run your own lab, pursue bold ideas, join a highly collaborative community!
All areas including experimental or computational neuro, including NeuroAI & systems
PhD required; ≤~1 yr postdoc
www.cshl.edu/about-us/car...
Reposted by Lukas Groschner
Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....
Male CNS Connectome
A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system —a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the ...
www.janelia.org
October 5, 2025 at 3:40 PM
Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....
Reposted by Lukas Groschner
📢 🚨 Technical Assistant Opportunity in Neuroscience 📢 🚨
Join us at @lmumuenchen.bsky.social and support research on how neural circuits 🧠 drive adaptive behavior!
⏳ Deadline: 15. November 2025
Learn more and apply: www.fens.org/careers/job-...
Join us at @lmumuenchen.bsky.social and support research on how neural circuits 🧠 drive adaptive behavior!
⏳ Deadline: 15. November 2025
Learn more and apply: www.fens.org/careers/job-...
October 13, 2025 at 6:03 AM
📢 🚨 Technical Assistant Opportunity in Neuroscience 📢 🚨
Join us at @lmumuenchen.bsky.social and support research on how neural circuits 🧠 drive adaptive behavior!
⏳ Deadline: 15. November 2025
Learn more and apply: www.fens.org/careers/job-...
Join us at @lmumuenchen.bsky.social and support research on how neural circuits 🧠 drive adaptive behavior!
⏳ Deadline: 15. November 2025
Learn more and apply: www.fens.org/careers/job-...
Reposted by Lukas Groschner
We are recruiting PhD students! Join us in exploring the multiple dimensions of biological intelligence at our international and fully funded graduate program IMPRS-BI in the Munich area, Germany!
🔔 Application period: 1 October to 10 November
🧪 Apply here: imprs-bi.mpg.de
🔔 Application period: 1 October to 10 November
🧪 Apply here: imprs-bi.mpg.de
October 1, 2025 at 7:44 AM
We are recruiting PhD students! Join us in exploring the multiple dimensions of biological intelligence at our international and fully funded graduate program IMPRS-BI in the Munich area, Germany!
🔔 Application period: 1 October to 10 November
🧪 Apply here: imprs-bi.mpg.de
🔔 Application period: 1 October to 10 November
🧪 Apply here: imprs-bi.mpg.de
Reposted by Lukas Groschner
🚨Preprint🚨
What started as an attempt to compare CT scans of diverse fly brains, ended up a new concept for analysis & segmentation of difficult tomographic data. No ground truths, no training, just maths. This is TopoTome, topological data analysis of 3D images
www.biorxiv.org/content/10.1...
What started as an attempt to compare CT scans of diverse fly brains, ended up a new concept for analysis & segmentation of difficult tomographic data. No ground truths, no training, just maths. This is TopoTome, topological data analysis of 3D images
www.biorxiv.org/content/10.1...
September 30, 2025 at 9:58 AM
🚨Preprint🚨
What started as an attempt to compare CT scans of diverse fly brains, ended up a new concept for analysis & segmentation of difficult tomographic data. No ground truths, no training, just maths. This is TopoTome, topological data analysis of 3D images
www.biorxiv.org/content/10.1...
What started as an attempt to compare CT scans of diverse fly brains, ended up a new concept for analysis & segmentation of difficult tomographic data. No ground truths, no training, just maths. This is TopoTome, topological data analysis of 3D images
www.biorxiv.org/content/10.1...
Reposted by Lukas Groschner
How is valence computed in the brain? Check out our new preprint about a single cell that integrates excitatory and inhibitory input across modalities according to valence and impacts behavioral decisions. An exciting collaboration across many labs. Enjoy reading!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A multisensory, bidirectional, valence encoder guides behavioral decisions
A key function of the brain is to categorize sensory cues as repulsive or attractive and respond accordingly. While we have some understanding of how sensory information is processed in the sensory pe...
www.biorxiv.org
September 27, 2025 at 5:46 AM
How is valence computed in the brain? Check out our new preprint about a single cell that integrates excitatory and inhibitory input across modalities according to valence and impacts behavioral decisions. An exciting collaboration across many labs. Enjoy reading!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Lukas Groschner
Open Call for Expressions of Interest: become a Max Planck Director & redefine what’s possible in science! We offer scientific independence, long-term stable funding & exceptional infrastructure. Lead your own department & open new frontiers of research. Apply by 31 Oct 2025 → www.mpg.de/directors
Directors
The Max Planck Society offers Directors a unique platform for groundbreaking research and leadership in diverse scientific fields.
www.mpg.de
September 17, 2025 at 3:25 PM
Open Call for Expressions of Interest: become a Max Planck Director & redefine what’s possible in science! We offer scientific independence, long-term stable funding & exceptional infrastructure. Lead your own department & open new frontiers of research. Apply by 31 Oct 2025 → www.mpg.de/directors
Reposted by Lukas Groschner
The final version of our paper on how ants and possibly other insects use a crazy mechanism involving extensive transcriptional interference to regulate odorant receptor expression is now open access in my favorite journal, @currentbiology.bsky.social
authors.elsevier.com/sd/article/S...
authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
September 19, 2025 at 3:44 PM
The final version of our paper on how ants and possibly other insects use a crazy mechanism involving extensive transcriptional interference to regulate odorant receptor expression is now open access in my favorite journal, @currentbiology.bsky.social
authors.elsevier.com/sd/article/S...
authors.elsevier.com/sd/article/S...
Reposted by Lukas Groschner
How does the brain decide? 🧠
Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc.
After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up.
rdcu.be/eGUrv
Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc.
After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up.
rdcu.be/eGUrv
Transitions in dynamical regime and neural mode during perceptual decisions - Nature
Simultaneous recordings were made of hundreds of neurons in the rat frontal cortex and striatum, showing that decision commitment involves a rapid, coordinated transition in dynamical regime and neura...
www.nature.com
September 17, 2025 at 8:12 PM
How does the brain decide? 🧠
Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc.
After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up.
rdcu.be/eGUrv
Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc.
After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up.
rdcu.be/eGUrv
Reposted by Lukas Groschner
Apply now to become a speaker at our Institute! We invite excellent postdocs in neuroscience, ecology and other fields related to our research to apply for our Emerging Scientist Talk Series. Apply by October 24: www.bi.mpg.de/ess
@chr-mayer.bsky.social @fleyes.bsky.social @michaelahau.bsky.social
@chr-mayer.bsky.social @fleyes.bsky.social @michaelahau.bsky.social
September 19, 2025 at 6:08 AM
Apply now to become a speaker at our Institute! We invite excellent postdocs in neuroscience, ecology and other fields related to our research to apply for our Emerging Scientist Talk Series. Apply by October 24: www.bi.mpg.de/ess
@chr-mayer.bsky.social @fleyes.bsky.social @michaelahau.bsky.social
@chr-mayer.bsky.social @fleyes.bsky.social @michaelahau.bsky.social
Reposted by Lukas Groschner
Excited to share our latest work - expressing the bacterial sodium channel in fly Kenyon cells surprisingly *decreases* their excitability, thanks partly to decreased endogenous sodium channels. This prevents learning and decreases odor-evoked calcium influx doi.org/10.1113/JP28...
Ectopic sodium channel expression decreases excitability of Drosophila Kenyon cells
Abstract figure legend: We tested the effects of expressing the bacterial voltage-gated sodium channel NaChBac in the Kenyon cells of the Drosophila memory centre, the mushroom body. NaChBac expressi...
doi.org
September 1, 2025 at 4:50 PM
Excited to share our latest work - expressing the bacterial sodium channel in fly Kenyon cells surprisingly *decreases* their excitability, thanks partly to decreased endogenous sodium channels. This prevents learning and decreases odor-evoked calcium influx doi.org/10.1113/JP28...
Reposted by Lukas Groschner
FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...
FlyBase:Contribute to FlyBase - FlyBase Wiki
wiki.flybase.org
August 15, 2025 at 12:45 PM
FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...
Reposted by Lukas Groschner
How do brain circuits evolve? We started looking for some answers by using synapse-resolution cross-species comparative connectomics on an entire olfactory circuit 👇
bit.ly/44aVm9E
bit.ly/44aVm9E
June 12, 2025 at 11:04 AM
How do brain circuits evolve? We started looking for some answers by using synapse-resolution cross-species comparative connectomics on an entire olfactory circuit 👇
bit.ly/44aVm9E
bit.ly/44aVm9E
Reposted by Lukas Groschner
FlyBase, a Drosophila database, will lose a third of its team in early October because the Harvard grant that covered the employees’ salaries was canceled. Scientists warn that losing FlyBase could devastate fly research.
By @claudia-lopez.bsky.social
www.thetransmitter.org/community/ha...
By @claudia-lopez.bsky.social
www.thetransmitter.org/community/ha...
Harvard University lays off fly database team
The layoffs jeopardize this resource, which has served more than 4,000 labs for about three decades.
www.thetransmitter.org
August 13, 2025 at 7:32 PM
FlyBase, a Drosophila database, will lose a third of its team in early October because the Harvard grant that covered the employees’ salaries was canceled. Scientists warn that losing FlyBase could devastate fly research.
By @claudia-lopez.bsky.social
www.thetransmitter.org/community/ha...
By @claudia-lopez.bsky.social
www.thetransmitter.org/community/ha...
Reposted by Lukas Groschner
Exciting new paper from the Bahl lab @bahllab.bsky.social @zwitscherarmin.bsky.social and Katja Slangewal about parallel and convergent processing pathways of different visual features in the larval zebrafish brain🐟
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Parallel and convergent pathways for multifeature visual processing in larval zebrafish sensorimotor decision-making
Animals continuously extract and evaluate diverse sensory information from the environment to guide behavior. Yet, how neural circuits integrate multiple, potentially conflicting, inputs during decisi...
www.biorxiv.org
August 12, 2025 at 6:18 PM
Exciting new paper from the Bahl lab @bahllab.bsky.social @zwitscherarmin.bsky.social and Katja Slangewal about parallel and convergent processing pathways of different visual features in the larval zebrafish brain🐟
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Lukas Groschner
We need more papers that start with Steve Urkel quotes. Thank you @kylethieringer.com and @tuthill.bsky.social for this wonderful and fun review of our recent paper describing limb feedback in the visual system!
doi.org/10.1016/j.cu...
doi.org/10.1016/j.cu...
August 4, 2025 at 3:47 PM
We need more papers that start with Steve Urkel quotes. Thank you @kylethieringer.com and @tuthill.bsky.social for this wonderful and fun review of our recent paper describing limb feedback in the visual system!
doi.org/10.1016/j.cu...
doi.org/10.1016/j.cu...
Reposted by Lukas Groschner
Excited to share our Nature Neuroscience paper!
We explored how the human #retina keeps signals in sync despite big differences in axon length.
Great collaboration with @iobswiss.bsky.social + @bel-bsse.bsky.social — special thanks to @ffranke.bsky.social
#neuroskyence
🧠👁️⏱️
bsky.app/profile/natn...
We explored how the human #retina keeps signals in sync despite big differences in axon length.
Great collaboration with @iobswiss.bsky.social + @bel-bsse.bsky.social — special thanks to @ffranke.bsky.social
#neuroskyence
🧠👁️⏱️
bsky.app/profile/natn...
The human brain synchronizes visual signals by adjusting axonal conduction speed in the retina—revealing a previously
unknown mechanism for precise perceptual timing
@anbucci.bsky.social @ffranke.bsky.social @iobswiss.bsky.social
www.nature.com/articles/s41...
unknown mechanism for precise perceptual timing
@anbucci.bsky.social @ffranke.bsky.social @iobswiss.bsky.social
www.nature.com/articles/s41...
Synchronization of visual perception within the human fovea - Nature Neuroscience
Combining behavioral data, electrophysiology and modeling, the authors show that the human brain synchronizes visual signals by adjusting axonal conduction speed in the retina, revealing a previously ...
www.nature.com
July 24, 2025 at 9:40 AM
Excited to share our Nature Neuroscience paper!
We explored how the human #retina keeps signals in sync despite big differences in axon length.
Great collaboration with @iobswiss.bsky.social + @bel-bsse.bsky.social — special thanks to @ffranke.bsky.social
#neuroskyence
🧠👁️⏱️
bsky.app/profile/natn...
We explored how the human #retina keeps signals in sync despite big differences in axon length.
Great collaboration with @iobswiss.bsky.social + @bel-bsse.bsky.social — special thanks to @ffranke.bsky.social
#neuroskyence
🧠👁️⏱️
bsky.app/profile/natn...
Reposted by Lukas Groschner
1/N What are the organizational principles underlying crossmodal cortical connections?
We address this in this new preprint, led by @alexegeaweiss.bsky.social & @bturner-bridger.bsky.social in collab w/ @petrznam.bsky.social @crick.ac.uk
www.biorxiv.org/content/10.1...
We address this in this new preprint, led by @alexegeaweiss.bsky.social & @bturner-bridger.bsky.social in collab w/ @petrznam.bsky.social @crick.ac.uk
www.biorxiv.org/content/10.1...
August 1, 2025 at 10:10 AM
1/N What are the organizational principles underlying crossmodal cortical connections?
We address this in this new preprint, led by @alexegeaweiss.bsky.social & @bturner-bridger.bsky.social in collab w/ @petrznam.bsky.social @crick.ac.uk
www.biorxiv.org/content/10.1...
We address this in this new preprint, led by @alexegeaweiss.bsky.social & @bturner-bridger.bsky.social in collab w/ @petrznam.bsky.social @crick.ac.uk
www.biorxiv.org/content/10.1...
Reposted by Lukas Groschner
1/ Mapping synaptic connectivity between individual neurons is extremely laborious. We developed BRISC, a new method that makes it possible to map inputs onto 100s of neurons in the same animal in a matter of weeks! Led by Alex Becalick and @antblot.bsky.social. 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Barcoded Rabies In Situ Connectomics for high-throughput reconstruction of neural circuits
Sequencing of oligonucleotide barcodes holds promise as a high-throughput approach for reconstructing synaptic connectivity at scale. Rabies viruses can act as a vehicle for barcode transmission, than...
www.biorxiv.org
July 21, 2025 at 7:58 AM
1/ Mapping synaptic connectivity between individual neurons is extremely laborious. We developed BRISC, a new method that makes it possible to map inputs onto 100s of neurons in the same animal in a matter of weeks! Led by Alex Becalick and @antblot.bsky.social. 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Lukas Groschner
New paper from our lab! This was such a fun project to be a part of - proof that sometimes following a spurious observations down the rabbit hole leads to awesome findings.
www.cell.com/current-biol...
www.cell.com/current-biol...
A cell type in the visual system that receives feedback about limb movement
Hartman et al. describe a cell type in the Drosophila visual system that is activated
during head grooming through visual and non-visual signals arising from foreleg movements.
These neurons inhibit a...
www.cell.com
July 17, 2025 at 3:08 PM
New paper from our lab! This was such a fun project to be a part of - proof that sometimes following a spurious observations down the rabbit hole leads to awesome findings.
www.cell.com/current-biol...
www.cell.com/current-biol...
Reposted by Lukas Groschner
🚨🚨🚨 OPEN POSTDOC POSITION 🚨🚨🚨 in my lab!
Are you interested in understanding how the brain moves our arms?
Reach to your computer and apply!
www.mosbergerlab.com/open-positions
Are you interested in understanding how the brain moves our arms?
Reach to your computer and apply!
www.mosbergerlab.com/open-positions
Open Positions — Mosberger Lab
www.mosbergerlab.com
June 25, 2025 at 5:18 PM
🚨🚨🚨 OPEN POSTDOC POSITION 🚨🚨🚨 in my lab!
Are you interested in understanding how the brain moves our arms?
Reach to your computer and apply!
www.mosbergerlab.com/open-positions
Are you interested in understanding how the brain moves our arms?
Reach to your computer and apply!
www.mosbergerlab.com/open-positions