Sachin Sethi
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sethisachin.bsky.social
Sachin Sethi
@sethisachin.bsky.social
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Postdoc in Maimon Lab at Rockefeller University
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sethisachin.bsky.social
www.cell.com/cell/fulltex...

We had a lot of fun working on this project (led by Itzel Ishida, not on bluesky). Some interesting highlights from the paper -
Neuronal calcium spikes enable vector inversion in the Drosophila brain
In the fly central complex, PFNa neurons switch from firing classical sodium spikes when depolarized to firing non-canonical T-type calcium spikes when hyperpolarized. This bidirectional spiking allow...
www.cell.com
January 6, 2026 at 4:35 PM
Reposted by Sachin Sethi
hannah-haberkern.bsky.social
📢 Join us, the Haberkern lab, @uni-wuerzburg.de for a postdoc studying neural circuit mechanisms of navigation. You’ll spearheading neurophysiology experiments on our brand new 2P!

⏳ Apply by 28th February 2026

Details: www.haberkernlab.de/docs/ENPostd...

#neuroscience #academicjobs #postdoc
On the left, the image shows a schematic of a fly head, ring neurons and EPG neurons together with some calcium imaging frames. On the right is a photo of a fly on a ball in virtual reality and another schematic of a VR system.
December 23, 2025 at 11:27 AM
Reposted by Sachin Sethi
yvetteefisher.bsky.social
*First preprint from our lab* !!!!!
How does the brain learn to anchor its internal sense of direction to the outside world? 🧭
led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman:
“Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6...
Thread ⬇️
Schematic of how ER-EPG plasticity enables the bump of activity in EPGs to accurately track visual cues. As a fly makes a counter-clockwise turn (top to bottom) it will view visual cues (e.g. the sun) from a new angle and the EPG activity bump (red) will swing clockwise around the network by integrating self motion signals with these visual inputs. When the fly faces a different angle, distinct visual ER neurons are active. Plasticity forms a trough of weak synapses (large circles - strong synapses, small circles - weak synapses) that allow ER neurons with distinct visual tuning to move the EPG bump via disinhibition.
December 15, 2025 at 6:26 PM