Lucas Boeck
@lucboeck.bsky.social
Group leader and pulmonologist @DBM Basel / University of Basel / University Hospital Basel; studying mechanisms underlying antibiotic treatment failures #genomics #imaging #automation #clinical studies
Reposted by Lucas Boeck
Excited for New Approaches and Concepts in Microbiology 2025 with sessions on Bacterial systems biology, Bacterial cell biology & protein machines, Microbiomes, Environment & evolution, Pathogenesis & phage, Antibiotic discovery, mechanisms, and resistance. #EESMicrobiology
June 23, 2025 at 7:23 PM
Excited for New Approaches and Concepts in Microbiology 2025 with sessions on Bacterial systems biology, Bacterial cell biology & protein machines, Microbiomes, Environment & evolution, Pathogenesis & phage, Antibiotic discovery, mechanisms, and resistance. #EESMicrobiology
Reposted by Lucas Boeck
In the fight against bacterial pathogens, researchers are combining vaccination with targeted colonization of the intestine by harmless microorganisms. This approach could potentially mark a turning point in the antibiotics crisis. www.biozentrum.unibas.ch/news/detail/...
New vaccine concept tackles harmful bacteria in the intestine
In the fight against bacterial pathogens, researchers are combining vaccination with targeted colonization of the intestine by harmless microorganisms. This approach could potentially mark a turning p...
www.biozentrum.unibas.ch
April 4, 2025 at 7:49 AM
In the fight against bacterial pathogens, researchers are combining vaccination with targeted colonization of the intestine by harmless microorganisms. This approach could potentially mark a turning point in the antibiotics crisis. www.biozentrum.unibas.ch/news/detail/...
Reposted by Lucas Boeck
Exciting PhD studentship opportunity in @andresfloto.bsky.social lab on understanding chemical permeability to advance antibiotic drug discovery www.jobs.cam.ac.uk/job/50800/. Combines experimental approaches with in silico screening and generative AI.
PhD Studentship - Understanding chemical permeability and metabolism in gram-negative organisms - Job Opportunities - University of Cambridge
PhD Studentship - Understanding chemical permeability and metabolism in gram-negative organisms in the Department of Medicine at the University of Cambridge.
www.jobs.cam.ac.uk
March 27, 2025 at 10:31 AM
Exciting PhD studentship opportunity in @andresfloto.bsky.social lab on understanding chemical permeability to advance antibiotic drug discovery www.jobs.cam.ac.uk/job/50800/. Combines experimental approaches with in silico screening and generative AI.
Reposted by Lucas Boeck
Happy to share the latest work from the lab @crick.ac.uk. Outstanding work from Di Chen and Tony Fearns showing the link between Mtb membrane damage, calcium leakage and ATG8/LC3 lipidation in macrophages. Congratulations Di and Tony!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Mycobacterium tuberculosis phagosome Ca2+ leakage triggers multimembrane ATG8/LC3 lipidation to restrict damage in human macrophages
Ca2+ leakage triggers LC3 lipidation on multimembrane as Mtb phagosome damage response, independent of autophagy.
www.science.org
March 27, 2025 at 7:13 AM
Happy to share the latest work from the lab @crick.ac.uk. Outstanding work from Di Chen and Tony Fearns showing the link between Mtb membrane damage, calcium leakage and ATG8/LC3 lipidation in macrophages. Congratulations Di and Tony!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Lucas Boeck
Apply now for our international Master of Science in Physics of Life @biozentrum.unibas.ch @unibasel.ch! Scholarships available.
More information: www.biozentrum.unibas.ch/education/de...
#Master #Students #Research #Physics #Mathematics #ComputerScience #Engineering #Basel #Switzerland
More information: www.biozentrum.unibas.ch/education/de...
#Master #Students #Research #Physics #Mathematics #ComputerScience #Engineering #Basel #Switzerland
March 20, 2025 at 8:10 AM
Apply now for our international Master of Science in Physics of Life @biozentrum.unibas.ch @unibasel.ch! Scholarships available.
More information: www.biozentrum.unibas.ch/education/de...
#Master #Students #Research #Physics #Mathematics #ComputerScience #Engineering #Basel #Switzerland
More information: www.biozentrum.unibas.ch/education/de...
#Master #Students #Research #Physics #Mathematics #ComputerScience #Engineering #Basel #Switzerland
Reposted by Lucas Boeck
NEW COMMENT!
TB trials with purely microbiological primary endpoints give greater weight to outcomes that matter most, generalise better to non trial settings, are less biased if regimens differ in duration, and are often better powered
#IDSky @catherineberry.bsky.social @sgschumacher.bsky.social
TB trials with purely microbiological primary endpoints give greater weight to outcomes that matter most, generalise better to non trial settings, are less biased if regimens differ in duration, and are often better powered
#IDSky @catherineberry.bsky.social @sgschumacher.bsky.social
It was a pleasure working with @tomayates.bsky.social on this comment in @lancetmicrobe.bsky.social
It's time for new TB treatment trials to use a more focused primary outcome definition, moving on from the composite outcome that has prevailed for the last decade
www.thelancet.com/journals/lan...
It's time for new TB treatment trials to use a more focused primary outcome definition, moving on from the composite outcome that has prevailed for the last decade
www.thelancet.com/journals/lan...
Primary efficacy endpoints in phase 3 non-inferiority trials to establish new tuberculosis treatment regimens should only include microbiological outcomes
Treatment regimens for tuberculosis remain protracted and burdensome, both for patients
to adhere to and for health-care providers to administer. Particularly, many current
regimens for drug-resistant...
www.thelancet.com
March 15, 2025 at 2:10 PM
NEW COMMENT!
TB trials with purely microbiological primary endpoints give greater weight to outcomes that matter most, generalise better to non trial settings, are less biased if regimens differ in duration, and are often better powered
#IDSky @catherineberry.bsky.social @sgschumacher.bsky.social
TB trials with purely microbiological primary endpoints give greater weight to outcomes that matter most, generalise better to non trial settings, are less biased if regimens differ in duration, and are often better powered
#IDSky @catherineberry.bsky.social @sgschumacher.bsky.social
Reposted by Lucas Boeck
Host and pathogen aficionados:
Join us in Blois!- registration deadline 1st March- Please RP-
meetings.embo.org/event/24-hos...
Join us in Blois!- registration deadline 1st March- Please RP-
meetings.embo.org/event/24-hos...
Cell biology of host-pathogen interactions
Microbial infections lead to drastic changes in the architecture and metabolism of the host cell. The inaugural FEBS EMBO Cell Biology of Host-Pathogen Interaction Advanced Course explores the mechan…
meetings.embo.org
February 23, 2025 at 12:17 AM
Host and pathogen aficionados:
Join us in Blois!- registration deadline 1st March- Please RP-
meetings.embo.org/event/24-hos...
Join us in Blois!- registration deadline 1st March- Please RP-
meetings.embo.org/event/24-hos...
Reposted by Lucas Boeck
New paper, discussing open problems in bacterial phenotype prediction with ML: arxiv.org/abs/2502.07749
Whole-Genome Phenotype Prediction with Machine Learning: Open Problems in Bacterial Genomics
How can we identify causal genetic mechanisms that govern bacterial traits? Initial efforts entrusting machine learning models to handle the task of predicting phenotype from genotype return high accu...
arxiv.org
February 18, 2025 at 1:35 PM
New paper, discussing open problems in bacterial phenotype prediction with ML: arxiv.org/abs/2502.07749
Reposted by Lucas Boeck
Researchers at the University of Basel have developed a method to test the mode of action of 1,500+ substances on cells at once, uncovering hidden drug mechanisms and potential new uses - paving the way for repurposing drugs.
Testing the effect of thousands of compounds on cellular metabolism
Researchers at the University of Basel are able to test the effects of more than 1,500 compounds on cell metabolism in parallel. Their analysis also led to the discovery of previously unknown mechanis...
www.unibas.ch
January 28, 2025 at 11:59 AM
Researchers at the University of Basel have developed a method to test the mode of action of 1,500+ substances on cells at once, uncovering hidden drug mechanisms and potential new uses - paving the way for repurposing drugs.
Reposted by Lucas Boeck
We found that many bacterial species use exogenous peptidoglycan fragments - released by lysis of neighboring cells - as a general danger signal, triggering a danger response that protects bacteria against many dangers: biofilm formation.
Details here 👇
www.nature.com/articles/s41...
Details here 👇
www.nature.com/articles/s41...
Bacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation - Nature Microbiology
Peptidoglycan released by neighbouring kin or non-kin cell lysis induces physiological changes that protect from a range of stresses, including phage predation.
www.nature.com
January 6, 2025 at 10:13 AM
We found that many bacterial species use exogenous peptidoglycan fragments - released by lysis of neighboring cells - as a general danger signal, triggering a danger response that protects bacteria against many dangers: biofilm formation.
Details here 👇
www.nature.com/articles/s41...
Details here 👇
www.nature.com/articles/s41...
Reposted by Lucas Boeck
⚠️ Bit of an alarm bell to MDR-TB regimen BPaL/M - resistance to constituent antibiotics developing and transmission of such strains already occurring
#TBSky #IDSky @nejm.org
www.nejm.org/doi/10.1056/...
#TBSky #IDSky @nejm.org
www.nejm.org/doi/10.1056/...
Transmission as a Key Driver of Resistance to the New Tuberculosis Drugs | NEJM
Whole-genome sequencing was used to show that resistance to newer antituberculosis
drugs is present in at least 27 countries and that up to a quarter of this resistance
may be due to person-to-...
www.nejm.org
January 5, 2025 at 7:57 AM
⚠️ Bit of an alarm bell to MDR-TB regimen BPaL/M - resistance to constituent antibiotics developing and transmission of such strains already occurring
#TBSky #IDSky @nejm.org
www.nejm.org/doi/10.1056/...
#TBSky #IDSky @nejm.org
www.nejm.org/doi/10.1056/...
Indeed a very beautiful start into 2025 - congrats !
Incredibly excited to share that our manuscript was just published in @nature.com ! What a way to start the new year! 🎉
https://buff.ly/4gyYCzx
We present phylowave, a framework that enables to learn the fitness dynamics of pathogens from phylogenies.
🧵 A thread... 1/n
#IDSky #IDModelling
https://buff.ly/4gyYCzx
We present phylowave, a framework that enables to learn the fitness dynamics of pathogens from phylogenies.
🧵 A thread... 1/n
#IDSky #IDModelling
Learning the fitness dynamics of pathogens from phylogenies - Nature
Phylowave, an innovative phylogenetic approach, can identify the main circulating pathogen lineages with increased fitness and the associated genetic changes, enabling the timely identification of…
buff.ly
January 2, 2025 at 11:21 AM
Indeed a very beautiful start into 2025 - congrats !
... after almost 4000 citations 🙄; many of which probably saying it was wrong, but citation is citation
It took four days from submission to publication, and nearly five years from publication to retraction. After campaigning by many, many scientists, and an investigation by Elsevier, an infamous paper on hydroxychloroquine as a COVID-19 treatment has been retracted. 🧪
www.science.org/content/arti...
www.science.org/content/arti...
Infamous paper that popularized unproven COVID-19 treatment finally retracted
Study on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds
www.science.org
December 17, 2024 at 7:59 PM
... after almost 4000 citations 🙄; many of which probably saying it was wrong, but citation is citation