Lisanne Mout
@lisannemout.bsky.social
PostDoctoral Researcher at Princess Margaret Cancer Center 🇨🇦, chromatin, prostate cancer, transposable elements, baker and cyclist
Reposted by Lisanne Mout
We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...
POSTDOCTORAL FELLOW - Toronto (City), Ontario (CA) job with Taipale Lab, Donnelly Centre, University of Toronto | 12849004
The Taipale lab in the Donnelly CCBR and University of Toronto is looking for a highly motivated Postdoctoral Fellow
www.nature.com
November 19, 2025 at 5:51 PM
We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...
Reposted by Lisanne Mout
1/ You run ChIP-seq to find where your transcription factor binds. You run RNA-seq to see which genes change expression. Now, you ask a "simple" question, what are the "direct targets"?
November 10, 2025 at 2:45 PM
1/ You run ChIP-seq to find where your transcription factor binds. You run RNA-seq to see which genes change expression. Now, you ask a "simple" question, what are the "direct targets"?
Reposted by Lisanne Mout
Lunch today halfway around the world in Hangzhou and met a new asst professor who was very thankful for this resource. Please help out folks like them and other early career scientists with examples of job apps. Submit yours!
github.com/RILAB/statem...
github.com/RILAB/statem...
GitHub - RILAB/statements: Successful Job Applications and Grants
Successful Job Applications and Grants. Contribute to RILAB/statements development by creating an account on GitHub.
github.com
October 21, 2025 at 6:55 AM
Lunch today halfway around the world in Hangzhou and met a new asst professor who was very thankful for this resource. Please help out folks like them and other early career scientists with examples of job apps. Submit yours!
github.com/RILAB/statem...
github.com/RILAB/statem...
Reposted by Lisanne Mout
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature
Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
www.nature.com
September 10, 2025 at 3:21 PM
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Reposted by Lisanne Mout
8 Resources to study Transcription factor binding, enhancers and histone modification distribution
1. ENCODE www.encodeproject.org/
1. ENCODE www.encodeproject.org/
September 5, 2025 at 2:15 PM
8 Resources to study Transcription factor binding, enhancers and histone modification distribution
1. ENCODE www.encodeproject.org/
1. ENCODE www.encodeproject.org/
Reposted by Lisanne Mout
Included in this is SickKids in Toronto, by the way. So Canadian kids with cancer will also be affected by this.
Imagine voting for kids with brain tumors to lose access to clinical trials.
Imagine voting for kids with brain tumors to lose access to clinical trials.
“A respected network of hospitals and cancer centers is halting enrollment in clinical trials for children with brain cancer after the federal government said it would no longer provide funding to the group”
Pediatric Brain Cancer Group to Lose Federal Funding
www.nytimes.com
August 30, 2025 at 5:09 AM
Included in this is SickKids in Toronto, by the way. So Canadian kids with cancer will also be affected by this.
Imagine voting for kids with brain tumors to lose access to clinical trials.
Imagine voting for kids with brain tumors to lose access to clinical trials.
Reposted by Lisanne Mout
“‘She uncovered the social experience of women in science’ — the lab assistants who never became managers, the geologists poring over data in government offices while their male peers were doing fieldwork, those who despite their advanced degrees didn’t get hired or promoted, or who were sidelined…”
Here's a #GiftLink for those who want to read the full NYT obit of historian of science & gender, Margaret Rossiter. www.nytimes.com/2025/08/29/s... #histSTM 🧪🗃️
August 30, 2025 at 3:26 PM
“‘She uncovered the social experience of women in science’ — the lab assistants who never became managers, the geologists poring over data in government offices while their male peers were doing fieldwork, those who despite their advanced degrees didn’t get hired or promoted, or who were sidelined…”
Reposted by Lisanne Mout
Two PhD positions available in our lab to study #chromatin, #epigenetics and cancer
August 13, 2025 at 12:27 PM
Two PhD positions available in our lab to study #chromatin, #epigenetics and cancer
Reposted by Lisanne Mout
Thrilled to share our latest work, just published in @nature.com ⬇
www.nature.com/articles/s41...
We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)
www.nature.com/articles/s41...
We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)
NASP modulates histone turnover to drive PARP inhibitor resistance - Nature
PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.
www.nature.com
August 13, 2025 at 3:44 PM
Thrilled to share our latest work, just published in @nature.com ⬇
www.nature.com/articles/s41...
We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)
www.nature.com/articles/s41...
We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)
Reposted by Lisanne Mout
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
July 28, 2025 at 9:10 AM
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Reposted by Lisanne Mout
Please pread the word.
We have just launched the Hubrecht International PhD Program (HIPP).
Are you looking for a PhD position in molecular and developmental biology or related subject in an international, very supportive and collaborative environment?
Then apply to the HIPP!! 👇
We have just launched the Hubrecht International PhD Program (HIPP).
Are you looking for a PhD position in molecular and developmental biology or related subject in an international, very supportive and collaborative environment?
Then apply to the HIPP!! 👇
🧬 Looking for a PhD position in molecular or developmental biology? 🔬
✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/
✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/
July 10, 2025 at 6:56 PM
Please pread the word.
We have just launched the Hubrecht International PhD Program (HIPP).
Are you looking for a PhD position in molecular and developmental biology or related subject in an international, very supportive and collaborative environment?
Then apply to the HIPP!! 👇
We have just launched the Hubrecht International PhD Program (HIPP).
Are you looking for a PhD position in molecular and developmental biology or related subject in an international, very supportive and collaborative environment?
Then apply to the HIPP!! 👇
Reposted by Lisanne Mout
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Range extender mediates long-distance enhancer activity - Nature
The REX element is associated with long-range enhancer–promoter interactions.
www.nature.com
July 2, 2025 at 4:17 PM
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Reposted by Lisanne Mout
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease - Nature Reviews Molecular Cell Biology
Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...
www.nature.com
June 30, 2025 at 1:12 PM
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Lisanne Mout
1/ Working with big data in R?
Your wrangling just got a massive upgrade.
duckplyr is now in the tidyverse—and it’s fast. Really fast. 🧵
Your wrangling just got a massive upgrade.
duckplyr is now in the tidyverse—and it’s fast. Really fast. 🧵
June 26, 2025 at 1:15 PM
1/ Working with big data in R?
Your wrangling just got a massive upgrade.
duckplyr is now in the tidyverse—and it’s fast. Really fast. 🧵
Your wrangling just got a massive upgrade.
duckplyr is now in the tidyverse—and it’s fast. Really fast. 🧵
Reposted by Lisanne Mout
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...
🔗 All positions: ki.se/en/about-ki/...
June 25, 2025 at 10:01 AM
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...
🔗 All positions: ki.se/en/about-ki/...
Reposted by Lisanne Mout
Do you have a primary interest in fundamental mechanisms of human biology, biochemistry, metabolism, genetics, or medicinal and analytical chemistry and looking for a postdoctoral fellowship? 🧪 www.nature.com/naturecareer...
Postdoctoral Associate – Nima Sharifi Laboratory - Miami, Florida (US) job with University of Miami Desai Sethi Urology Institute | 12840300
The Nima Sharifi Laboratory is seeking to recruit outstanding postdoctoral associates with a primary interest in the fundamental mechanisms of huma...
www.nature.com
June 25, 2025 at 12:10 PM
Do you have a primary interest in fundamental mechanisms of human biology, biochemistry, metabolism, genetics, or medicinal and analytical chemistry and looking for a postdoctoral fellowship? 🧪 www.nature.com/naturecareer...
Reposted by Lisanne Mout
@saramostafavi.bsky.social (@Genentech) & I (@Stanford) r excited to announce co-advised postdoc positions for candidates with deep expertise in ML for bio (especially sequence to function models, causal perturbational models & single cell models). See details below. Pls RT 1/
June 19, 2025 at 8:55 PM
@saramostafavi.bsky.social (@Genentech) & I (@Stanford) r excited to announce co-advised postdoc positions for candidates with deep expertise in ML for bio (especially sequence to function models, causal perturbational models & single cell models). See details below. Pls RT 1/
Reposted by Lisanne Mout
Are you @ the late stages of your postdoc ? Want to pursue a PI career ?
Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...
Peer-networking / Career orientation and more !!!
Please distribute :) 🙂
Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...
Peer-networking / Career orientation and more !!!
Please distribute :) 🙂
June 12, 2025 at 12:58 PM
Are you @ the late stages of your postdoc ? Want to pursue a PI career ?
Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...
Peer-networking / Career orientation and more !!!
Please distribute :) 🙂
Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...
Peer-networking / Career orientation and more !!!
Please distribute :) 🙂
Reposted by Lisanne Mout
Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...
www.richmondscientific.com/how-a-discov...
How a discovery in Yellowstone National Park led to the development of PCR - Richmond Scientific
A discovery in Yellowstone National Park led to the development of PCR, the gold-standard COVID-19 tests used to fight the global pandemic.
www.richmondscientific.com
June 8, 2025 at 9:09 PM
Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...
www.richmondscientific.com/how-a-discov...
Reposted by Lisanne Mout
Job opportunity at our institute at the University of Amsterdam:
www.academictransfer.com/en/jobs/3519...
www.academictransfer.com/en/jobs/3519...
Assistant Professor Computational Analysis of Single-cell and Spatial Omics Data
Are you passionate about developing omics data analysis methodology? Are you fascinated by the opportunities of omics data at single-cell or spatial resolution? Would you like to work at the forefront...
www.academictransfer.com
May 12, 2025 at 7:54 PM
Job opportunity at our institute at the University of Amsterdam:
www.academictransfer.com/en/jobs/3519...
www.academictransfer.com/en/jobs/3519...
Reposted by Lisanne Mout
Check out our latest paper! Out now in Genome Biology! Many thanks to all coauthors for their invaluable contributions on this lengthy journey pubmed.ncbi.nlm.nih.gov/40346709/
Endometrial tumorigenesis involves epigenetic plasticity demarcating non-coding somatic mutations and 3D-genome alterations - PubMed
In summary, we identify a complex genomic-epigenomic interplay in EC development and progression, altering 3D genome organization to enhance expression of the critical driver ERα.
pubmed.ncbi.nlm.nih.gov
May 10, 2025 at 1:41 PM
Check out our latest paper! Out now in Genome Biology! Many thanks to all coauthors for their invaluable contributions on this lengthy journey pubmed.ncbi.nlm.nih.gov/40346709/
Reposted by Lisanne Mout
Circular RNA in aggressive tumours
Abundant circRMST molecules were found in aggressive prostate and lung cancers, interacting with transcription factors SOX2 & NKX2-1 to drive oncogene ASCL1 expression, reported by @pmresearch-uhn.bsky.social & @danafarber.bsky.social
www.cell.com/cancer-cell/...
Abundant circRMST molecules were found in aggressive prostate and lung cancers, interacting with transcription factors SOX2 & NKX2-1 to drive oncogene ASCL1 expression, reported by @pmresearch-uhn.bsky.social & @danafarber.bsky.social
www.cell.com/cancer-cell/...
April 17, 2025 at 3:48 PM
Circular RNA in aggressive tumours
Abundant circRMST molecules were found in aggressive prostate and lung cancers, interacting with transcription factors SOX2 & NKX2-1 to drive oncogene ASCL1 expression, reported by @pmresearch-uhn.bsky.social & @danafarber.bsky.social
www.cell.com/cancer-cell/...
Abundant circRMST molecules were found in aggressive prostate and lung cancers, interacting with transcription factors SOX2 & NKX2-1 to drive oncogene ASCL1 expression, reported by @pmresearch-uhn.bsky.social & @danafarber.bsky.social
www.cell.com/cancer-cell/...
Reposted by Lisanne Mout
The Americans are doing to Kseniia what the Russians did to Brittney Griner for having 0.7 grams of cannabis oil. Except no one is coming to negotiate her freedom and Harvard is sitting on their hands. I am so ashamed. Please share this story.
www.nytimes.com/2025/04/11/s...
www.nytimes.com/2025/04/11/s...
She Worked in a Harvard Lab to Reverse Aging, Until ICE Jailed Her (Gift Article)
President Trump’s immigration crackdown ensnared Kseniia Petrova, a scientist who fled Russia after protesting its invasion of Ukraine. She fears arrest if she is deported there.
www.nytimes.com
April 11, 2025 at 5:55 PM
The Americans are doing to Kseniia what the Russians did to Brittney Griner for having 0.7 grams of cannabis oil. Except no one is coming to negotiate her freedom and Harvard is sitting on their hands. I am so ashamed. Please share this story.
www.nytimes.com/2025/04/11/s...
www.nytimes.com/2025/04/11/s...
Reposted by Lisanne Mout
1/ As a biologist, you work with a lot of data. But do you know how to use it to its fullest? Learning to program can change your research and career! Let's explore the top tips to get you started.
March 26, 2025 at 1:15 PM
1/ As a biologist, you work with a lot of data. But do you know how to use it to its fullest? Learning to program can change your research and career! Let's explore the top tips to get you started.
Reposted by Lisanne Mout
The latest research from the He Lab (www.hansenhelab.org) reinforces the importance of integrating epigenomic assays into clinical practice to enhance cancer patient care. Congratulations to the entire team!
@uhnresearch.bsky.social @pmresearch-uhn.bsky.social
doi.org/10.1038/s415...
@uhnresearch.bsky.social @pmresearch-uhn.bsky.social
doi.org/10.1038/s415...
The landscape of N6-methyladenosine in localized primary prostate cancer - Nature Genetics
Transcriptome-wide m6A RNA methylation profile in 162 primary prostate tumors identifies m6A association with prognostic clinical features and disease aggression.
doi.org
March 24, 2025 at 7:55 PM
The latest research from the He Lab (www.hansenhelab.org) reinforces the importance of integrating epigenomic assays into clinical practice to enhance cancer patient care. Congratulations to the entire team!
@uhnresearch.bsky.social @pmresearch-uhn.bsky.social
doi.org/10.1038/s415...
@uhnresearch.bsky.social @pmresearch-uhn.bsky.social
doi.org/10.1038/s415...