Lila Allou
@lilaallou.bsky.social
Research Group Leader @MRC_LMS @imperialcollege
Reposted by Lila Allou
New lab preprint!
We find that Wee1 phosphorylates Cdh1(FZR1) and suppresses APC/C(Cdh1) activity to promote S-phase entry
A fantastic team effort from the combined forces of @lavuillemenot.bsky.social, Lucas Morales, Calin-Mihai Dragoi & Beth Pennycook
www.biorxiv.org/cgi/content/...
We find that Wee1 phosphorylates Cdh1(FZR1) and suppresses APC/C(Cdh1) activity to promote S-phase entry
A fantastic team effort from the combined forces of @lavuillemenot.bsky.social, Lucas Morales, Calin-Mihai Dragoi & Beth Pennycook
www.biorxiv.org/cgi/content/...
Wee1 opposes APC/C(Cdh1) activity to promote S-phase entry
Wee1 phosphorylates and inhibits CDK activity to inhibit mitotic entry and establish a G2 DNA damage checkpoint. Consequently, Wee1 inhibitors are in clinical trials, developed to be synthetically let...
www.biorxiv.org
December 3, 2025 at 4:03 PM
New lab preprint!
We find that Wee1 phosphorylates Cdh1(FZR1) and suppresses APC/C(Cdh1) activity to promote S-phase entry
A fantastic team effort from the combined forces of @lavuillemenot.bsky.social, Lucas Morales, Calin-Mihai Dragoi & Beth Pennycook
www.biorxiv.org/cgi/content/...
We find that Wee1 phosphorylates Cdh1(FZR1) and suppresses APC/C(Cdh1) activity to promote S-phase entry
A fantastic team effort from the combined forces of @lavuillemenot.bsky.social, Lucas Morales, Calin-Mihai Dragoi & Beth Pennycook
www.biorxiv.org/cgi/content/...
Reposted by Lila Allou
Applications are open for @dev-journal.bsky.social 2026 Pathway to Independence (PI) programme, supporting postdocs applying for group leader positions:
Mentoring
Profile raising
Leadership training
Network building
Spread the word...
www.biologists.com/grants/devel...
Mentoring
Profile raising
Leadership training
Network building
Spread the word...
www.biologists.com/grants/devel...
Development's Pathway to Independence Programme
Our grants support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conference...
www.biologists.com
December 3, 2025 at 6:56 AM
Applications are open for @dev-journal.bsky.social 2026 Pathway to Independence (PI) programme, supporting postdocs applying for group leader positions:
Mentoring
Profile raising
Leadership training
Network building
Spread the word...
www.biologists.com/grants/devel...
Mentoring
Profile raising
Leadership training
Network building
Spread the word...
www.biologists.com/grants/devel...
Reposted by Lila Allou
Congratulations to LMS group head @mpercharde.bsky.social
who has been selected as one of this year’s EMBO Young Investigators! 🌟
The prestigious EMBO Young Investigator Programme supports exceptionally talented life scientists who represent innovation and excellence in their fields.
@embo.org
who has been selected as one of this year’s EMBO Young Investigators! 🌟
The prestigious EMBO Young Investigator Programme supports exceptionally talented life scientists who represent innovation and excellence in their fields.
@embo.org
LMS group head Michelle Percharde joins EMBO Young Investigator Programme
We’re delighted to announce that Michelle Percharde, Head of the Chromatin & Development Group at the MRC Laboratory of Medical Sciences (LMS) has been selected as one of this year’s EMBO Young Invest...
lms.mrc.ac.uk
December 2, 2025 at 1:04 PM
Congratulations to LMS group head @mpercharde.bsky.social
who has been selected as one of this year’s EMBO Young Investigators! 🌟
The prestigious EMBO Young Investigator Programme supports exceptionally talented life scientists who represent innovation and excellence in their fields.
@embo.org
who has been selected as one of this year’s EMBO Young Investigators! 🌟
The prestigious EMBO Young Investigator Programme supports exceptionally talented life scientists who represent innovation and excellence in their fields.
@embo.org
Reposted by Lila Allou
Want to analyze the role of endogenous retroviruses in early human development or investigate their regulation in pluripotency and early development for your PhD?
Join the lab of @fueyoraquel.bsky.social via the IMPRS-BAC #gradschool!
👉 www.molgen.mpg.de/5094682/Fuey...
Join the lab of @fueyoraquel.bsky.social via the IMPRS-BAC #gradschool!
👉 www.molgen.mpg.de/5094682/Fuey...
November 27, 2025 at 2:06 PM
Want to analyze the role of endogenous retroviruses in early human development or investigate their regulation in pluripotency and early development for your PhD?
Join the lab of @fueyoraquel.bsky.social via the IMPRS-BAC #gradschool!
👉 www.molgen.mpg.de/5094682/Fuey...
Join the lab of @fueyoraquel.bsky.social via the IMPRS-BAC #gradschool!
👉 www.molgen.mpg.de/5094682/Fuey...
Reposted by Lila Allou
Join @mpercharde.bsky.social Lab at the MRC LMS! We have an 18mo postdoc position to cover a couple of projects (maternity leave and paper revisions). The projects are focussed on chromatin in early mouse embryos and metabolism in mouse embryonic stem cells and pluripotency.
November 27, 2025 at 2:18 PM
Join @mpercharde.bsky.social Lab at the MRC LMS! We have an 18mo postdoc position to cover a couple of projects (maternity leave and paper revisions). The projects are focussed on chromatin in early mouse embryos and metabolism in mouse embryonic stem cells and pluripotency.
Reposted by Lila Allou
🚨Post open in our lab! Come work on some cool themes involving metabolism, chromatin, early development 🤓. Pls RT
Join @mpercharde.bsky.social Lab at the MRC LMS! We have an 18mo postdoc position to cover a couple of projects (maternity leave and paper revisions). The projects are focussed on chromatin in early mouse embryos and metabolism in mouse embryonic stem cells and pluripotency.
November 27, 2025 at 2:26 PM
🚨Post open in our lab! Come work on some cool themes involving metabolism, chromatin, early development 🤓. Pls RT
Reposted by Lila Allou
Register now for the EMBO Workshop "Limb development and regeneration: Quantitative, ecological, and diversification studies" in #Tokyo, Japan, 23–27 March 2026.
Abstract submission/Registration deadline:
12/15 December 2025
https://meetings.embo.org/event/26-limb-dev
#EMBOLimbDev #EMBOevents 🧪
Abstract submission/Registration deadline:
12/15 December 2025
https://meetings.embo.org/event/26-limb-dev
#EMBOLimbDev #EMBOevents 🧪
November 25, 2025 at 4:10 PM
Register now for the EMBO Workshop "Limb development and regeneration: Quantitative, ecological, and diversification studies" in #Tokyo, Japan, 23–27 March 2026.
Abstract submission/Registration deadline:
12/15 December 2025
https://meetings.embo.org/event/26-limb-dev
#EMBOLimbDev #EMBOevents 🧪
Abstract submission/Registration deadline:
12/15 December 2025
https://meetings.embo.org/event/26-limb-dev
#EMBOLimbDev #EMBOevents 🧪
Reposted by Lila Allou
📣 We’re hiring 6 new Team Science postdocs!
Our Team Science approach brings together interdisciplinary researchers to tackle questions no single field can solve alone.
Find out more and download our brochure below
Our Team Science approach brings together interdisciplinary researchers to tackle questions no single field can solve alone.
Find out more and download our brochure below
MRC Postdoctoral Research Scientists x 6 - MRC Laboratory of Medical Sciences
Team Science Project
lms.mrc.ac.uk
November 20, 2025 at 1:43 PM
📣 We’re hiring 6 new Team Science postdocs!
Our Team Science approach brings together interdisciplinary researchers to tackle questions no single field can solve alone.
Find out more and download our brochure below
Our Team Science approach brings together interdisciplinary researchers to tackle questions no single field can solve alone.
Find out more and download our brochure below
Reposted by Lila Allou
It's always special when you find your own paper in the table of contents of the journal 😍
"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form
www.cell.com/developmenta...
"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form
www.cell.com/developmenta...
November 18, 2025 at 4:11 PM
It's always special when you find your own paper in the table of contents of the journal 😍
"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form
www.cell.com/developmenta...
"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form
www.cell.com/developmenta...
Reposted by Lila Allou
check out my journal club on the seminal discovery of local translation in neurons (Kang & Schuman. 1996), and more recently, its activity in neocortex neurodevelopment (Pilaz...Silver. 2023).
cheers to the @erin-schuman.bsky.social & @debbysilver.bsky.social labs!
www.nature.com/articles/s41...
cheers to the @erin-schuman.bsky.social & @debbysilver.bsky.social labs!
www.nature.com/articles/s41...
The on-site, on-demand, neuronal gene machine - Nature Reviews Neuroscience
In this Journal Club, Matthew Kraushar discusses a study published in 1996 that found a role for local protein translation in hippocampal synaptic plasticity.
www.nature.com
November 18, 2025 at 6:35 PM
check out my journal club on the seminal discovery of local translation in neurons (Kang & Schuman. 1996), and more recently, its activity in neocortex neurodevelopment (Pilaz...Silver. 2023).
cheers to the @erin-schuman.bsky.social & @debbysilver.bsky.social labs!
www.nature.com/articles/s41...
cheers to the @erin-schuman.bsky.social & @debbysilver.bsky.social labs!
www.nature.com/articles/s41...
Reposted by Lila Allou
Happy to share our latest preprint.
We uncover a previously uncharacterised and evolutionarily conserved chromatin architecture in premeiotic gonadal germ cells, revealed through integrated cytological and high-resolution Hi-C approaches.
www.biorxiv.org/content/10.1...
Thread🧵🔽
We uncover a previously uncharacterised and evolutionarily conserved chromatin architecture in premeiotic gonadal germ cells, revealed through integrated cytological and high-resolution Hi-C approaches.
www.biorxiv.org/content/10.1...
Thread🧵🔽
November 18, 2025 at 4:57 PM
Happy to share our latest preprint.
We uncover a previously uncharacterised and evolutionarily conserved chromatin architecture in premeiotic gonadal germ cells, revealed through integrated cytological and high-resolution Hi-C approaches.
www.biorxiv.org/content/10.1...
Thread🧵🔽
We uncover a previously uncharacterised and evolutionarily conserved chromatin architecture in premeiotic gonadal germ cells, revealed through integrated cytological and high-resolution Hi-C approaches.
www.biorxiv.org/content/10.1...
Thread🧵🔽
Reposted by Lila Allou
@mpercharde.bsky.social & I after presenting our experience of setting up the @mrc-lms.bsky.social Roving Researcher scheme to support Postdocs on leave, in the Research Culture session at #MRCBiomedicine2025
Look at that view! Blooming love London
Look at that view! Blooming love London
November 18, 2025 at 4:45 PM
@mpercharde.bsky.social & I after presenting our experience of setting up the @mrc-lms.bsky.social Roving Researcher scheme to support Postdocs on leave, in the Research Culture session at #MRCBiomedicine2025
Look at that view! Blooming love London
Look at that view! Blooming love London
Reposted by Lila Allou
Register now for our one-day symposium at the MRC Laboratory of Medical Sciences on environmental and metabolic control of early development on 4 December 2025!
Spaces are limited, register here: www.symposia.org.uk/courses/stem...
Spaces are limited, register here: www.symposia.org.uk/courses/stem...
November 14, 2025 at 4:56 PM
Register now for our one-day symposium at the MRC Laboratory of Medical Sciences on environmental and metabolic control of early development on 4 December 2025!
Spaces are limited, register here: www.symposia.org.uk/courses/stem...
Spaces are limited, register here: www.symposia.org.uk/courses/stem...
Reposted by Lila Allou
tinyurl.com/GenGenFaculty
GenGen is hiring group leaders! If you want to generate data at scale to train the next generation of AI models to make molecular biology predictive and programmable, we want to hear from you.
GenGen is hiring group leaders! If you want to generate data at scale to train the next generation of AI models to make molecular biology predictive and programmable, we want to hear from you.
Group Leader - Generative Biology and AI
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
tinyurl.com
November 7, 2025 at 9:37 AM
tinyurl.com/GenGenFaculty
GenGen is hiring group leaders! If you want to generate data at scale to train the next generation of AI models to make molecular biology predictive and programmable, we want to hear from you.
GenGen is hiring group leaders! If you want to generate data at scale to train the next generation of AI models to make molecular biology predictive and programmable, we want to hear from you.
Reposted by Lila Allou
We each carry around six million variations in our DNA.
Henry Scowcroft explores how scientists like @gregfindlay.bsky.social and @carovinuesa.bsky.social are helping unravel the effects of these variants, where even a small change can have a big impact on our lives.
www.crick.ac.uk/news/2025-10...
Henry Scowcroft explores how scientists like @gregfindlay.bsky.social and @carovinuesa.bsky.social are helping unravel the effects of these variants, where even a small change can have a big impact on our lives.
www.crick.ac.uk/news/2025-10...
Variants: the typos turning loss into hope
Across the 3 billion ‘letters’ of our DNA, we each carry around 6 million variations. Researchers are unravelling their effects on our lives.
www.crick.ac.uk
November 6, 2025 at 2:44 PM
We each carry around six million variations in our DNA.
Henry Scowcroft explores how scientists like @gregfindlay.bsky.social and @carovinuesa.bsky.social are helping unravel the effects of these variants, where even a small change can have a big impact on our lives.
www.crick.ac.uk/news/2025-10...
Henry Scowcroft explores how scientists like @gregfindlay.bsky.social and @carovinuesa.bsky.social are helping unravel the effects of these variants, where even a small change can have a big impact on our lives.
www.crick.ac.uk/news/2025-10...
Reposted by Lila Allou
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
November 10, 2025 at 11:11 AM
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
Reposted by Lila Allou
Spaces filling up for our @bsdb.bsky.social GRT symposium @mrc-lms.bsky.social on environment, metabolism and stem cell development 4th Dec 2025! Updated poster with talk titles below. Register here: www.symposia.org.uk/courses/stem...
Looking forward to seeing you there!
Looking forward to seeing you there!
November 10, 2025 at 1:54 PM
Spaces filling up for our @bsdb.bsky.social GRT symposium @mrc-lms.bsky.social on environment, metabolism and stem cell development 4th Dec 2025! Updated poster with talk titles below. Register here: www.symposia.org.uk/courses/stem...
Looking forward to seeing you there!
Looking forward to seeing you there!
Reposted by Lila Allou
Why are more and more people suffering from #allergies and autoimmune diseases? The answer may lie in the development of the immune system in newborns @petterbrodin.bsky.social @ki.se has developed a technique to map #immunesystem development from a single drop of blood.
tinyurl.com/3j22dyw8
tinyurl.com/3j22dyw8
How the immune system develops in newborn babies | Knut and Alice Wallenberg Foundation
Why are more and more people suffering from allergies and autoimmune diseases? The answer may lie in the development of the immune system in newborns. Wallenberg Scholar Petter Brodin has developed a ...
tinyurl.com
October 15, 2025 at 7:39 AM
Why are more and more people suffering from #allergies and autoimmune diseases? The answer may lie in the development of the immune system in newborns @petterbrodin.bsky.social @ki.se has developed a technique to map #immunesystem development from a single drop of blood.
tinyurl.com/3j22dyw8
tinyurl.com/3j22dyw8
Reposted by Lila Allou
We are excited to welcome @fueyoraquel.bsky.social, @sedonamurphy.bsky.social, and @jmstein.bsky.social as new group leaders at our institute!
Read more about their work:
--> www.molgen.mpg.de/2025-10-31-n...
All three are recruiting in the IMPRS PhD Call!
--> www.molgen.mpg.de/IMPRSPhDproj...
Read more about their work:
--> www.molgen.mpg.de/2025-10-31-n...
All three are recruiting in the IMPRS PhD Call!
--> www.molgen.mpg.de/IMPRSPhDproj...
Three new research groups joining the MPIMG
www.molgen.mpg.de
November 6, 2025 at 4:00 PM
We are excited to welcome @fueyoraquel.bsky.social, @sedonamurphy.bsky.social, and @jmstein.bsky.social as new group leaders at our institute!
Read more about their work:
--> www.molgen.mpg.de/2025-10-31-n...
All three are recruiting in the IMPRS PhD Call!
--> www.molgen.mpg.de/IMPRSPhDproj...
Read more about their work:
--> www.molgen.mpg.de/2025-10-31-n...
All three are recruiting in the IMPRS PhD Call!
--> www.molgen.mpg.de/IMPRSPhDproj...
Reposted by Lila Allou
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Reposted by Lila Allou
Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake
go.nature.com/47zrzYZ
go.nature.com/47zrzYZ
From MRI to Ozempic: breakthroughs that show why fundamental research must be protected
In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.
go.nature.com
October 29, 2025 at 12:11 PM
Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake
go.nature.com/47zrzYZ
go.nature.com/47zrzYZ
Reposted by Lila Allou
Blue-sky, I need your help. Is alphafold good in predicting protein-protein interactions involving beta sheets?
October 27, 2025 at 5:26 PM
Blue-sky, I need your help. Is alphafold good in predicting protein-protein interactions involving beta sheets?
Reposted by Lila Allou
I am absolutely delighted to share the invited speakers for our upcoming @bsdb.bsky.social "Molecules to Morphogenesis" meeting!
Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
October 23, 2025 at 5:25 PM
I am absolutely delighted to share the invited speakers for our upcoming @bsdb.bsky.social "Molecules to Morphogenesis" meeting!
Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
Reposted by Lila Allou
Our publication is out today!Big Thanks go to my amazing collaborators: @sedonamurphy.bsky.social for her imaging brilliance and @mattjones.bsky.social for his computational support.They both saw the potential in this project and helped me to explore what turned out to be an exciting discovery.
Here, we show that the unique regulatory landscape of ecDNA enables an ancient LINE to resurrect and act as an enhancer of Myc. This was so fun with @katerinakraft.bsky.social and @mattjones.bsky.social and others. www.nature.com/articles/s41...
Enhancer activation from transposable elements in extrachromosomal DNA - Nature Cell Biology
Kraft, Murphy, Jones et al. identify extrachromosomal DNA (ecDNA)-interacting elements (EIEs) enriched for transposable elements within ecDNA in colorectal cancer cells. They show that EIE 14 integrat...
www.nature.com
October 21, 2025 at 1:34 PM
Our publication is out today!Big Thanks go to my amazing collaborators: @sedonamurphy.bsky.social for her imaging brilliance and @mattjones.bsky.social for his computational support.They both saw the potential in this project and helped me to explore what turned out to be an exciting discovery.
Reposted by Lila Allou
My new lab at the @molgen.mpg.de will be following up on some of the nuclear organization aspects of ecDNA so please do reach out if this is of interest :)
October 21, 2025 at 9:43 AM
My new lab at the @molgen.mpg.de will be following up on some of the nuclear organization aspects of ecDNA so please do reach out if this is of interest :)