Leonardo Dalla Porta
@ldallap.bsky.social
Physicist by training working in Neuroscience (PhD). Into brain states and their transitions. Newbie climber
https://ldallap.github.io/
https://ldallap.github.io/
Pinned
Leonardo Dalla Porta
@ldallap.bsky.social
· Dec 17
Intra-and Interhemispheric Signatures of Criticality at the Onset of Synchronization
The cerebral cortex must flexibly alternate between locally segregated activity that supports specialization and long-range interactions that enable integration. How cortical networks balance these co...
biorxiv.org
I am more than pleased to share our new work with you:
"Intra- and Interhemispheric Signatures of Criticality at the Onset of Synchronization"
biorxiv.org/content/10.6...
Short 🧵 1/9:
"Intra- and Interhemispheric Signatures of Criticality at the Onset of Synchronization"
biorxiv.org/content/10.6...
Short 🧵 1/9:
Development of structure–function coupling in human brain networks during youth
www.pnas.org/doi/10.1073/...
Structure–function coupling in macroscale human brain networks
www.nature.com/articles/s41...
www.pnas.org/doi/10.1073/...
Structure–function coupling in macroscale human brain networks
www.nature.com/articles/s41...
Development of structure–function coupling in human brain networks during youth | PNAS
The protracted development of structural and functional brain connectivity within
distributed association networks coincides with improvements in h...
www.pnas.org
February 9, 2026 at 10:05 AM
Development of structure–function coupling in human brain networks during youth
www.pnas.org/doi/10.1073/...
Structure–function coupling in macroscale human brain networks
www.nature.com/articles/s41...
www.pnas.org/doi/10.1073/...
Structure–function coupling in macroscale human brain networks
www.nature.com/articles/s41...
@overleaf.com Subscription overpriced; free version extremely downgraded from what it used to be.
February 3, 2026 at 9:48 AM
@overleaf.com Subscription overpriced; free version extremely downgraded from what it used to be.
Neuroscience history:
Were McCormick et al. (1985) the first to coin the terms "regular" and "fast" spiking?
Comparative Electrophysiology of Pyramidal andSparsely Spiny Stellate Neurons of the Neocortex. J Neurophysiol.
Were McCormick et al. (1985) the first to coin the terms "regular" and "fast" spiking?
Comparative Electrophysiology of Pyramidal andSparsely Spiny Stellate Neurons of the Neocortex. J Neurophysiol.
January 28, 2026 at 3:42 PM
Neuroscience history:
Were McCormick et al. (1985) the first to coin the terms "regular" and "fast" spiking?
Comparative Electrophysiology of Pyramidal andSparsely Spiny Stellate Neurons of the Neocortex. J Neurophysiol.
Were McCormick et al. (1985) the first to coin the terms "regular" and "fast" spiking?
Comparative Electrophysiology of Pyramidal andSparsely Spiny Stellate Neurons of the Neocortex. J Neurophysiol.
Reposted by Leonardo Dalla Porta
Just published my review of neuroscience in 2025, on The Spike.
The 10th of these, would you believe?
This year we have foundation models, breakthroughs in using light to understand the brain, a gene therapy, and more
Enjoy!
medium.com/the-spike/20...
The 10th of these, would you believe?
This year we have foundation models, breakthroughs in using light to understand the brain, a gene therapy, and more
Enjoy!
medium.com/the-spike/20...
2025: A Review of the Year in Neuroscience
Enlightening the brain
medium.com
December 30, 2025 at 3:52 PM
Just published my review of neuroscience in 2025, on The Spike.
The 10th of these, would you believe?
This year we have foundation models, breakthroughs in using light to understand the brain, a gene therapy, and more
Enjoy!
medium.com/the-spike/20...
The 10th of these, would you believe?
This year we have foundation models, breakthroughs in using light to understand the brain, a gene therapy, and more
Enjoy!
medium.com/the-spike/20...
Reposted by Leonardo Dalla Porta
This is your brain on Ritalin. Got your attention? Stimulant medications like Ritalin (methylphenidate) do, but not in the way you might think. They don't act directly on the brain’s attention systems! Find out what's really happening in @cellpress.bsky.social. doi.org/10.1016/j.ce...
December 24, 2025 at 4:46 PM
This is your brain on Ritalin. Got your attention? Stimulant medications like Ritalin (methylphenidate) do, but not in the way you might think. They don't act directly on the brain’s attention systems! Find out what's really happening in @cellpress.bsky.social. doi.org/10.1016/j.ce...
Reposted by Leonardo Dalla Porta
Finally got the job ad—looking for 2 PhD students to start spring next year:
www.gao-unit.com/join-us/
If comp neuro, ML, and AI4Neuro is your thing, or you just nerd out over brain recordings, apply!
I'm at neurips. DM me here / on the conference app or email if you want to meet 🏖️🌮
www.gao-unit.com/join-us/
If comp neuro, ML, and AI4Neuro is your thing, or you just nerd out over brain recordings, apply!
I'm at neurips. DM me here / on the conference app or email if you want to meet 🏖️🌮
December 3, 2025 at 9:37 AM
Finally got the job ad—looking for 2 PhD students to start spring next year:
www.gao-unit.com/join-us/
If comp neuro, ML, and AI4Neuro is your thing, or you just nerd out over brain recordings, apply!
I'm at neurips. DM me here / on the conference app or email if you want to meet 🏖️🌮
www.gao-unit.com/join-us/
If comp neuro, ML, and AI4Neuro is your thing, or you just nerd out over brain recordings, apply!
I'm at neurips. DM me here / on the conference app or email if you want to meet 🏖️🌮
Reposted by Leonardo Dalla Porta
Do we need to study animals in the wild to fully understand the brain? Maybe. OTOH, I sit in front a computer all day.
bigthink.com/neuropsych/n...
#neuroscience
bigthink.com/neuropsych/n...
#neuroscience
The next revolution in neuroscience is happening outside the lab
By tracking brain activity as primates move freely in the wild, neuroethology could reshape what we think we know about our own minds.
bigthink.com
December 17, 2025 at 7:09 PM
Do we need to study animals in the wild to fully understand the brain? Maybe. OTOH, I sit in front a computer all day.
bigthink.com/neuropsych/n...
#neuroscience
bigthink.com/neuropsych/n...
#neuroscience
Reposted by Leonardo Dalla Porta
New preprint out!
How does criticality propagate from local neuronal circuits to whole-brain dynamics?
We tackle this with a multiscale, connectome-based mouse model @ldallap.bsky.social . 🧵/n
👉 biorxiv.org/content/10.6...
How does criticality propagate from local neuronal circuits to whole-brain dynamics?
We tackle this with a multiscale, connectome-based mouse model @ldallap.bsky.social . 🧵/n
👉 biorxiv.org/content/10.6...
December 17, 2025 at 10:59 AM
New preprint out!
How does criticality propagate from local neuronal circuits to whole-brain dynamics?
We tackle this with a multiscale, connectome-based mouse model @ldallap.bsky.social . 🧵/n
👉 biorxiv.org/content/10.6...
How does criticality propagate from local neuronal circuits to whole-brain dynamics?
We tackle this with a multiscale, connectome-based mouse model @ldallap.bsky.social . 🧵/n
👉 biorxiv.org/content/10.6...
I am more than pleased to share our new work with you:
"Intra- and Interhemispheric Signatures of Criticality at the Onset of Synchronization"
biorxiv.org/content/10.6...
Short 🧵 1/9:
"Intra- and Interhemispheric Signatures of Criticality at the Onset of Synchronization"
biorxiv.org/content/10.6...
Short 🧵 1/9:
Intra-and Interhemispheric Signatures of Criticality at the Onset of Synchronization
The cerebral cortex must flexibly alternate between locally segregated activity that supports specialization and long-range interactions that enable integration. How cortical networks balance these co...
biorxiv.org
December 17, 2025 at 11:02 AM
I am more than pleased to share our new work with you:
"Intra- and Interhemispheric Signatures of Criticality at the Onset of Synchronization"
biorxiv.org/content/10.6...
Short 🧵 1/9:
"Intra- and Interhemispheric Signatures of Criticality at the Onset of Synchronization"
biorxiv.org/content/10.6...
Short 🧵 1/9:
Reposted by Leonardo Dalla Porta
Cell assemblies are drawing increasing attention in neuroscience, but one could argue that they are just an epiphenomenon. Is the activity of cell assemblies relevant for the brain?
The short answer is yes. The long answer is in our paper, now online at PLOS Biology. 🧵👇 1/10
doi.org/10.1371/jour...
The short answer is yes. The long answer is in our paper, now online at PLOS Biology. 🧵👇 1/10
doi.org/10.1371/jour...
Adaptive communication between cell assemblies and “reader” neurons shapes flexible brain dynamics
Cell assemblies have been proposed as key units of brain activity, underlying diverse functions, but their basic features are not well understood. This study shows that interactions between cell assem...
doi.org
December 6, 2025 at 9:26 PM
Cell assemblies are drawing increasing attention in neuroscience, but one could argue that they are just an epiphenomenon. Is the activity of cell assemblies relevant for the brain?
The short answer is yes. The long answer is in our paper, now online at PLOS Biology. 🧵👇 1/10
doi.org/10.1371/jour...
The short answer is yes. The long answer is in our paper, now online at PLOS Biology. 🧵👇 1/10
doi.org/10.1371/jour...
State-dependent brain responsiveness, from local circuits to the whole brain
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
State-dependent brain responsiveness, from local circuits to the whole brain
elifesciences.org
December 11, 2025 at 12:40 PM
State-dependent brain responsiveness, from local circuits to the whole brain
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
Reposted by Leonardo Dalla Porta
The brain computes by processing information over time through interactions between connectivity and dynamics that are hard to model. Here we infer these interactions from data and find they better predict cognitive performance! www.nature.com/articles/s41... w/ @lindenmp.bsky.social
December 2, 2025 at 11:39 PM
The brain computes by processing information over time through interactions between connectivity and dynamics that are hard to model. Here we infer these interactions from data and find they better predict cognitive performance! www.nature.com/articles/s41... w/ @lindenmp.bsky.social
Reposted by Leonardo Dalla Porta
Cholinergic heterogeneity facilitates synchronization and information flow in a whole-brain model https://www.biorxiv.org/content/10.1101/2025.10.28.685048v1
October 29, 2025 at 10:15 AM
Cholinergic heterogeneity facilitates synchronization and information flow in a whole-brain model https://www.biorxiv.org/content/10.1101/2025.10.28.685048v1
I'm really happy to share our latest work:
“Cholinergic heterogeneity facilitates synchronization and information flow in a whole-brain model”
www.biorxiv.org/content/10.1...
“Cholinergic heterogeneity facilitates synchronization and information flow in a whole-brain model”
www.biorxiv.org/content/10.1...
Cholinergic heterogeneity facilitates synchronization and information flow in a whole-brain model
The human brain displays substantial regional variability in molecular, anatomical, and physiological organization. Yet, how this heterogeneity shapes large-scale neuronal dynamics remains poorly unde...
www.biorxiv.org
October 29, 2025 at 12:58 PM
I'm really happy to share our latest work:
“Cholinergic heterogeneity facilitates synchronization and information flow in a whole-brain model”
www.biorxiv.org/content/10.1...
“Cholinergic heterogeneity facilitates synchronization and information flow in a whole-brain model”
www.biorxiv.org/content/10.1...
Reposted by Leonardo Dalla Porta
#Hemispherotomy is a surgical treatment for #epilepsy by disconnecting a portion of the #cortex. Michele Colombo, Jacopo Favaro, @anilseth.bsky.social, Marcello Massimini &co show that the isolated cortex has #EEG patterns resembling deep #sleep or #anesthesia @plosbiology.org 🧪 plos.io/3J9ci8X
October 17, 2025 at 4:33 PM
#Hemispherotomy is a surgical treatment for #epilepsy by disconnecting a portion of the #cortex. Michele Colombo, Jacopo Favaro, @anilseth.bsky.social, Marcello Massimini &co show that the isolated cortex has #EEG patterns resembling deep #sleep or #anesthesia @plosbiology.org 🧪 plos.io/3J9ci8X
Have you ever wondered what is the brain activity left in a cortical hemisphere after structural isolation?
Check it out:
journals.plos.org/plosbiology/...
Check it out:
journals.plos.org/plosbiology/...
Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans
Hemispherotomy is a neurosurgical procedure for treating refractory epilepsy by disconnecting a significant portion of the cortex. This study shows that the isolated cortex exhibits EEG patterns resem...
journals.plos.org
October 17, 2025 at 11:49 AM
Have you ever wondered what is the brain activity left in a cortical hemisphere after structural isolation?
Check it out:
journals.plos.org/plosbiology/...
Check it out:
journals.plos.org/plosbiology/...
Now out in Advanced Intelligent Systems: Exploiting underlying data geometry, we classify brain states efficiently using Riemannian manifolds. A lightweight and interpretable alternative to DNNs. Spearheaded by
@arnauya.bsky.social!
Check it out: advanced.onlinelibrary.wiley.com/doi/10.1002/...
@arnauya.bsky.social!
Check it out: advanced.onlinelibrary.wiley.com/doi/10.1002/...
Riemannian Geometry for the Classification of Brain States with Intracortical Brain Recordings
Geometric machine learning is applied to decode brain states from invasive intracortical neural recordings, extending Riemannian methods to the invasive regime where data is scarcer and less stationa...
advanced.onlinelibrary.wiley.com
October 14, 2025 at 12:05 PM
Now out in Advanced Intelligent Systems: Exploiting underlying data geometry, we classify brain states efficiently using Riemannian manifolds. A lightweight and interpretable alternative to DNNs. Spearheaded by
@arnauya.bsky.social!
Check it out: advanced.onlinelibrary.wiley.com/doi/10.1002/...
@arnauya.bsky.social!
Check it out: advanced.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Leonardo Dalla Porta
www.biorxiv.org/content/10.1... Brainwide hemodynamics predict EEG neural rhythms across sleep and wakefulness in humans | bioRxiv
Brainwide hemodynamics predict EEG neural rhythms across sleep and wakefulness in humans
The brain exhibits rich oscillatory dynamics that play critical roles in vigilance and cognition, such as the neural rhythms that define sleep. These rhythms continuously fluctuate, signaling major ch...
www.biorxiv.org
July 27, 2025 at 3:27 AM
www.biorxiv.org/content/10.1... Brainwide hemodynamics predict EEG neural rhythms across sleep and wakefulness in humans | bioRxiv
Reposted by Leonardo Dalla Porta
Attractors are usually not mechanisms - new blog post: open.substack.com/pub/kording/...
Attractors are usually not mechanisms
The mathematical objects can not be. And the "attractor models" have not been established as mechanisms in mammals
open.substack.com
July 8, 2025 at 2:40 PM
Attractors are usually not mechanisms - new blog post: open.substack.com/pub/kording/...
Reposted by Leonardo Dalla Porta
Are you at the @cnsorg.bsky.social conference?
Do you like networks? Brain-like networks? Pretty and structure rich networks? 🙇♂️🧠🕸
Come to my Poster 204 this afternoon (or anytime today)!!
The poster is right next to the coffee! ☕️ 😉
#CNS2025 #CNS2025Florence 🇮🇹🍝
Do you like networks? Brain-like networks? Pretty and structure rich networks? 🙇♂️🧠🕸
Come to my Poster 204 this afternoon (or anytime today)!!
The poster is right next to the coffee! ☕️ 😉
#CNS2025 #CNS2025Florence 🇮🇹🍝
July 7, 2025 at 10:05 AM
Are you at the @cnsorg.bsky.social conference?
Do you like networks? Brain-like networks? Pretty and structure rich networks? 🙇♂️🧠🕸
Come to my Poster 204 this afternoon (or anytime today)!!
The poster is right next to the coffee! ☕️ 😉
#CNS2025 #CNS2025Florence 🇮🇹🍝
Do you like networks? Brain-like networks? Pretty and structure rich networks? 🙇♂️🧠🕸
Come to my Poster 204 this afternoon (or anytime today)!!
The poster is right next to the coffee! ☕️ 😉
#CNS2025 #CNS2025Florence 🇮🇹🍝
Reposted by Leonardo Dalla Porta
Doing this might make you smarter ... (www.vice.com/en/article/d...) News coverage of our study on unsupervised learning in mice by @zhong-lin.bsky.social + @marius10p.bsky.social
#neuroscience #AI
www.nature.com/articles/s41...
#neuroscience #AI
www.nature.com/articles/s41...
Doing This Might Actually Make You Smarter
You’re scrolling through TikTok with the sound off. Waiting in line for a coffee. Watching a guy try to parallel park for the third time...
www.vice.com
July 2, 2025 at 5:18 PM
Doing this might make you smarter ... (www.vice.com/en/article/d...) News coverage of our study on unsupervised learning in mice by @zhong-lin.bsky.social + @marius10p.bsky.social
#neuroscience #AI
www.nature.com/articles/s41...
#neuroscience #AI
www.nature.com/articles/s41...
Reposted by Leonardo Dalla Porta
I recently had the great pleasure of interviewing Michael Bruchas about an absolutely banger recent paper from his group that tracked down cells in the brainstem that subtlety and precisely control the output of the locus coeruleus. Check out my interview here. I hope you like it as much as I did!
Far from being a passive neighbor to the locus coeruleus, the pericoeruleus appears to act as a kind of micromanager of arousal, selectively inhibiting different subgroups of locus coeruleus neurons, writes @macshine.bsky.social.
#neuroskyence
www.thetransmitter.org/attention/th...
#neuroskyence
www.thetransmitter.org/attention/th...
The brain’s quiet conductor: How hidden cells fine-tune arousal
New research published today suggests that the pericoeruleus acts as a kind of micromanager of arousal, selectively inhibiting different subgroups of locus coeruleus neurons depending on the…
www.thetransmitter.org
May 8, 2025 at 3:22 AM
I recently had the great pleasure of interviewing Michael Bruchas about an absolutely banger recent paper from his group that tracked down cells in the brainstem that subtlety and precisely control the output of the locus coeruleus. Check out my interview here. I hope you like it as much as I did!
Reposted by Leonardo Dalla Porta
I'd put these on the NeuroAI vision board:
@tyrellturing.bsky.social's Deep learning framework
www.nature.com/articles/s41...
@tonyzador.bsky.social's Next-gen AI through neuroAI
www.nature.com/articles/s41...
@adriendoerig.bsky.social's Neuroconnectionist framework
www.nature.com/articles/s41...
@tyrellturing.bsky.social's Deep learning framework
www.nature.com/articles/s41...
@tonyzador.bsky.social's Next-gen AI through neuroAI
www.nature.com/articles/s41...
@adriendoerig.bsky.social's Neuroconnectionist framework
www.nature.com/articles/s41...
April 28, 2025 at 11:15 PM
I'd put these on the NeuroAI vision board:
@tyrellturing.bsky.social's Deep learning framework
www.nature.com/articles/s41...
@tonyzador.bsky.social's Next-gen AI through neuroAI
www.nature.com/articles/s41...
@adriendoerig.bsky.social's Neuroconnectionist framework
www.nature.com/articles/s41...
@tyrellturing.bsky.social's Deep learning framework
www.nature.com/articles/s41...
@tonyzador.bsky.social's Next-gen AI through neuroAI
www.nature.com/articles/s41...
@adriendoerig.bsky.social's Neuroconnectionist framework
www.nature.com/articles/s41...
Reposted by Leonardo Dalla Porta
🧠🌡️ New preprint out!
BRAIN TEMPERATURE may be a key factor in understanding and treating Alzheimer’s disease and brain cancer:
doi.org/10.31219/osf...
'Temperature matters: Insights into brain thermoregulation and its impact on neural activity and health'
BRAIN TEMPERATURE may be a key factor in understanding and treating Alzheimer’s disease and brain cancer:
doi.org/10.31219/osf...
'Temperature matters: Insights into brain thermoregulation and its impact on neural activity and health'
April 16, 2025 at 6:33 AM
🧠🌡️ New preprint out!
BRAIN TEMPERATURE may be a key factor in understanding and treating Alzheimer’s disease and brain cancer:
doi.org/10.31219/osf...
'Temperature matters: Insights into brain thermoregulation and its impact on neural activity and health'
BRAIN TEMPERATURE may be a key factor in understanding and treating Alzheimer’s disease and brain cancer:
doi.org/10.31219/osf...
'Temperature matters: Insights into brain thermoregulation and its impact on neural activity and health'