Mac Shine
@macshine.bsky.social
Computational Neurobiologist from Sydney, Australia. https://shine-lab.org
Reposted by Mac Shine
𝗔 𝗡𝗘𝗨𝗥𝗢𝗘𝗖𝗢𝗟𝗢𝗚𝗜𝗖𝗔𝗟 𝗣𝗘𝗥𝗦𝗣𝗘𝗖𝗧𝗜𝗩𝗘 𝗢𝗡 𝗧𝗛𝗘 𝗣𝗥𝗘𝗙𝗥𝗢𝗡𝗧𝗔𝗟 𝗖𝗢𝗥𝗧𝗘𝗫
By Mars and Passingham
"Understanding anthropoid foraging challenges may thus contribute to our understanding of human cognition"
Going to the top of the reading list!
doi.org/10.1016/j.ne...
#neuroskyence
By Mars and Passingham
"Understanding anthropoid foraging challenges may thus contribute to our understanding of human cognition"
Going to the top of the reading list!
doi.org/10.1016/j.ne...
#neuroskyence
October 11, 2025 at 4:31 PM
𝗔 𝗡𝗘𝗨𝗥𝗢𝗘𝗖𝗢𝗟𝗢𝗚𝗜𝗖𝗔𝗟 𝗣𝗘𝗥𝗦𝗣𝗘𝗖𝗧𝗜𝗩𝗘 𝗢𝗡 𝗧𝗛𝗘 𝗣𝗥𝗘𝗙𝗥𝗢𝗡𝗧𝗔𝗟 𝗖𝗢𝗥𝗧𝗘𝗫
By Mars and Passingham
"Understanding anthropoid foraging challenges may thus contribute to our understanding of human cognition"
Going to the top of the reading list!
doi.org/10.1016/j.ne...
#neuroskyence
By Mars and Passingham
"Understanding anthropoid foraging challenges may thus contribute to our understanding of human cognition"
Going to the top of the reading list!
doi.org/10.1016/j.ne...
#neuroskyence
random neuroimaging question: does anyone in bluesky-land have access to the loadings for neurosynth topics in schaefer 400 (yeo7) space? #neuroskyence @misicbata.bsky.social @richardfbetzel.bsky.social @borismontreal.bsky.social @sofievalk.bsky.social
September 26, 2025 at 2:39 AM
random neuroimaging question: does anyone in bluesky-land have access to the loadings for neurosynth topics in schaefer 400 (yeo7) space? #neuroskyence @misicbata.bsky.social @richardfbetzel.bsky.social @borismontreal.bsky.social @sofievalk.bsky.social
Reposted by Mac Shine
*New preprint from the lab* – “Granularity of thalamic head direction cells”
doi.org/10.1101/2025...
🧠📈 🧪
1/11
doi.org/10.1101/2025...
🧠📈 🧪
1/11
Granularity of thalamic head direction cells
Head direction signaling is fundamental for spatial orientation and navigation. The anterodorsal nucleus of the thalamus (ADn) contains a high density of head direction (HD) cells that process sensori...
doi.org
September 15, 2025 at 3:13 PM
*New preprint from the lab* – “Granularity of thalamic head direction cells”
doi.org/10.1101/2025...
🧠📈 🧪
1/11
doi.org/10.1101/2025...
🧠📈 🧪
1/11
Reposted by Mac Shine
What changes and what stays the same as you scale from single neurons up to local populations of neurons up to whole brains?
Michael and Mac @macshine.bsky.social on the systems approach to study brains across scales.
braininspired.co/podcast/220/
Michael and Mac @macshine.bsky.social on the systems approach to study brains across scales.
braininspired.co/podcast/220/
September 10, 2025 at 12:06 PM
What changes and what stays the same as you scale from single neurons up to local populations of neurons up to whole brains?
Michael and Mac @macshine.bsky.social on the systems approach to study brains across scales.
braininspired.co/podcast/220/
Michael and Mac @macshine.bsky.social on the systems approach to study brains across scales.
braininspired.co/podcast/220/
Reposted by Mac Shine
Excited to share my latest work with @jonathanamichaels.bsky.social @diedrichsenjorn.bsky.social & @andpru.bsky.social!
We asked: How does the motor cortex account for arm posture when generating movement?
Paper 👉 www.biorxiv.org/content/10.1...
1/10
We asked: How does the motor cortex account for arm posture when generating movement?
Paper 👉 www.biorxiv.org/content/10.1...
1/10
Compositional neural dynamics during reaching
The complex mechanics of the arm make the neural control of reaching inherently posture dependent. Because previous reaching studies confound reach direction with final posture, it remains unknown how...
www.biorxiv.org
September 6, 2025 at 1:12 PM
Excited to share my latest work with @jonathanamichaels.bsky.social @diedrichsenjorn.bsky.social & @andpru.bsky.social!
We asked: How does the motor cortex account for arm posture when generating movement?
Paper 👉 www.biorxiv.org/content/10.1...
1/10
We asked: How does the motor cortex account for arm posture when generating movement?
Paper 👉 www.biorxiv.org/content/10.1...
1/10
Reposted by Mac Shine
Adaptive learning is coordinated across behaviour, time and neurobiology (from synapses and dendrites, to astrocytes and the systems level).
If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...
If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...
August 29, 2025 at 1:35 AM
Adaptive learning is coordinated across behaviour, time and neurobiology (from synapses and dendrites, to astrocytes and the systems level).
If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...
If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...
Reposted by Mac Shine
Reposted by Mac Shine
Theoretical neuroscience has room to grow — a Comment article by Ann Kennedy
@antihebbiann.bsky.social
#neuroscience #neuroskyence
www.nature.com/articles/s41...
@antihebbiann.bsky.social
#neuroscience #neuroskyence
www.nature.com/articles/s41...
Theoretical neuroscience has room to grow - Nature Reviews Neuroscience
The goal of theoretical neuroscience is to uncover principles of neural computation through careful design and interpretation of mathematical models. Here, I examine the use of top-down conceptual and...
www.nature.com
August 21, 2025 at 9:14 AM
Theoretical neuroscience has room to grow — a Comment article by Ann Kennedy
@antihebbiann.bsky.social
#neuroscience #neuroskyence
www.nature.com/articles/s41...
@antihebbiann.bsky.social
#neuroscience #neuroskyence
www.nature.com/articles/s41...
I need some help from the #neuroskyence Bluesky-verse. Anyone know the source of this ~quote from Walter J. Freeman Jr.: "the secrets of the brain are hidden by two of God’s own firewalls: neurobiology and non-linear dynamics". I read it yrs ago but can't seem to find my way back to the source.
August 18, 2025 at 3:56 AM
I need some help from the #neuroskyence Bluesky-verse. Anyone know the source of this ~quote from Walter J. Freeman Jr.: "the secrets of the brain are hidden by two of God’s own firewalls: neurobiology and non-linear dynamics". I read it yrs ago but can't seem to find my way back to the source.
Reposted by Mac Shine
🚨Pre-print alert🚨
We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭
How is this possible? Strap in! (1/9) 👇🧵
doi.org/10.1101/2025...
We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭
How is this possible? Strap in! (1/9) 👇🧵
doi.org/10.1101/2025...
Serotonin drives choice-independent reconfiguration of distributed neural activity
Serotonin (5-HT) is a central neuromodulator which is implicated in, amongst other functions, cognitive flexibility. 5-HT is released from the dorsal raphe nucleus (DRN) throughout nearly the entire f...
doi.org
August 5, 2025 at 12:32 PM
🚨Pre-print alert🚨
We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭
How is this possible? Strap in! (1/9) 👇🧵
doi.org/10.1101/2025...
We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭
How is this possible? Strap in! (1/9) 👇🧵
doi.org/10.1101/2025...
Reposted by Mac Shine
🚨 California and Hawaii under tsunami watch after 8.7M quake in Eastern Russia.
July 30, 2025 at 1:09 AM
🚨 California and Hawaii under tsunami watch after 8.7M quake in Eastern Russia.
Reposted by Mac Shine
Tsunami Warning – 7/30, 9:40am
The Tsunami Advisory has been upgraded to a Tsunami Warning. Waves of up to 3m are expected. Those near coastal areas, rivers, or lakes should evacuate to higher ground immediately. #tsunami
The Tsunami Advisory has been upgraded to a Tsunami Warning. Waves of up to 3m are expected. Those near coastal areas, rivers, or lakes should evacuate to higher ground immediately. #tsunami
July 30, 2025 at 12:53 AM
Tsunami Warning – 7/30, 9:40am
The Tsunami Advisory has been upgraded to a Tsunami Warning. Waves of up to 3m are expected. Those near coastal areas, rivers, or lakes should evacuate to higher ground immediately. #tsunami
The Tsunami Advisory has been upgraded to a Tsunami Warning. Waves of up to 3m are expected. Those near coastal areas, rivers, or lakes should evacuate to higher ground immediately. #tsunami
Reposted by Mac Shine
The point is, the monkeys making the loudest noise have the smallest balls.
pubmed.ncbi.nlm.nih.gov/26592343/
pubmed.ncbi.nlm.nih.gov/26592343/
Evolutionary trade-off between vocal tract and testes dimensions in howler monkeys - PubMed
Males often face a trade-off between investments in precopulatory and postcopulatory traits [1], particularly when male-male contest competition determines access to mates [2]. To date, studies of pre...
pubmed.ncbi.nlm.nih.gov
July 27, 2025 at 8:28 PM
The point is, the monkeys making the loudest noise have the smallest balls.
pubmed.ncbi.nlm.nih.gov/26592343/
pubmed.ncbi.nlm.nih.gov/26592343/
Reposted by Mac Shine
Dem leadership should appoint an official Alt Press Secretary to give briefings after every one that Karoline Leavett does and just break them down lie by lie
maybe THAT’S the job we give Colbert 😂
maybe THAT’S the job we give Colbert 😂
At this point, you should be embarrassed if your outlet has done nothing over these tumultuous six months to get itself barred by the administration.
The Wall Street Journal is speaking truth to power, but you're still on good terms with these assholes? Yeah, be proud of that.
The Wall Street Journal is speaking truth to power, but you're still on good terms with these assholes? Yeah, be proud of that.
Really difficult to make the argument that any reporter still in the White House pool isn't at best a scab and at worst a propagandist. www.politico.com/news/2025/07...
July 22, 2025 at 12:10 AM
Dem leadership should appoint an official Alt Press Secretary to give briefings after every one that Karoline Leavett does and just break them down lie by lie
maybe THAT’S the job we give Colbert 😂
maybe THAT’S the job we give Colbert 😂
Reposted by Mac Shine
An exciting collaboration is underway. @thetransmitter.bsky.social is partnering with @neuromatch.bsky.social to serve the computational neuroscience community and help connect neuroscientists across all career stages.
www.thetransmitter.org/neuromatch-p...
#neuroskyence
www.thetransmitter.org/neuromatch-p...
#neuroskyence
July 18, 2025 at 2:28 PM
An exciting collaboration is underway. @thetransmitter.bsky.social is partnering with @neuromatch.bsky.social to serve the computational neuroscience community and help connect neuroscientists across all career stages.
www.thetransmitter.org/neuromatch-p...
#neuroskyence
www.thetransmitter.org/neuromatch-p...
#neuroskyence
Reposted by Mac Shine
“the kindest person in the room is often the smartest.” JB Pritzker is a mensch.
July 17, 2025 at 1:20 AM
“the kindest person in the room is often the smartest.” JB Pritzker is a mensch.
Reposted by Mac Shine
July 15, 2025 at 4:50 PM
Reposted by Mac Shine
Pairs well with www.nature.com/articles/s41...
“Our results indicate that individual V1 neurons do not signal how the actual visual input deviates from the animal’s predictions, as postulated within the predictive coding framework”
Thrilling to see a major theory get tested!
“Our results indicate that individual V1 neurons do not signal how the actual visual input deviates from the animal’s predictions, as postulated within the predictive coding framework”
Thrilling to see a major theory get tested!
Cooperative thalamocortical circuit mechanism for sensory prediction errors - Nature
Experiments in mice show that a cortico-thalamic circuit generates prediction-error signals in primary visual cortex that amplify visual input that deviates from animals’ expectations.
www.nature.com
July 11, 2025 at 7:50 PM
Pairs well with www.nature.com/articles/s41...
“Our results indicate that individual V1 neurons do not signal how the actual visual input deviates from the animal’s predictions, as postulated within the predictive coding framework”
Thrilling to see a major theory get tested!
“Our results indicate that individual V1 neurons do not signal how the actual visual input deviates from the animal’s predictions, as postulated within the predictive coding framework”
Thrilling to see a major theory get tested!
Reposted by Mac Shine
Really proud to start the year by sharing our new review in @endosocjournals.bsky.social on the roles of GLP-1 in eating and obesity treatment, led by superstar postdoc @laurenjonesucl.bsky.social!
academic.oup.com/endo/article...
🧪🧠📈 #neuroscience #neuroskyence #GLP-1 #obesity #wegovy #ozempic
academic.oup.com/endo/article...
🧪🧠📈 #neuroscience #neuroskyence #GLP-1 #obesity #wegovy #ozempic
GLP-1 and the Neurobiology of Eating Control: Recent Advances
Abstract. Obesity is now considered a chronic relapsing progressive disease, associated with increased all-cause mortality that scales with body weight, af
academic.oup.com
January 21, 2025 at 11:59 AM
Really proud to start the year by sharing our new review in @endosocjournals.bsky.social on the roles of GLP-1 in eating and obesity treatment, led by superstar postdoc @laurenjonesucl.bsky.social!
academic.oup.com/endo/article...
🧪🧠📈 #neuroscience #neuroskyence #GLP-1 #obesity #wegovy #ozempic
academic.oup.com/endo/article...
🧪🧠📈 #neuroscience #neuroskyence #GLP-1 #obesity #wegovy #ozempic
Reposted by Mac Shine
I honestly think we should have a screening system for who gets to have money and influence based on asking "what was Star Wars about?" and "who were the good guys?"
Yes, Peter Thiel is functionally illiterate. Here’s his attempt at summarising the Star Wars plot to Maureen Dowd in 2017:
www.nytimes.com/2017/01/11/f...
www.nytimes.com/2017/01/11/f...
July 9, 2025 at 8:08 AM
I honestly think we should have a screening system for who gets to have money and influence based on asking "what was Star Wars about?" and "who were the good guys?"
Reposted by Mac Shine
Molecular and functional diversity of the autonomic nervous system — a Review by Tongtong Wang, Avedis Tufenkjian, Olujimi A. Ajijola & Yuki Oka
#neuroscience #neuroskyence
www.nature.com/articles/s41...
#neuroscience #neuroskyence
www.nature.com/articles/s41...
Molecular and functional diversity of the autonomic nervous system - Nature Reviews Neuroscience
The autonomic nervous system has long been viewed as a simple motor system in brain-to-body signalling. In this review, Wang and colleagues highlight diversity within autonomic neurons and their dynam...
www.nature.com
July 7, 2025 at 8:30 AM
Molecular and functional diversity of the autonomic nervous system — a Review by Tongtong Wang, Avedis Tufenkjian, Olujimi A. Ajijola & Yuki Oka
#neuroscience #neuroskyence
www.nature.com/articles/s41...
#neuroscience #neuroskyence
www.nature.com/articles/s41...
Reposted by Mac Shine
Exciting new preprint from the lab: “Adopting a human developmental visual diet yields robust, shape-based AI vision”. A most wonderful case where brain inspiration massively improved AI solutions.
Work with @zejinlu.bsky.social @sushrutthorat.bsky.social and Radek Cichy
arxiv.org/abs/2507.03168
Work with @zejinlu.bsky.social @sushrutthorat.bsky.social and Radek Cichy
arxiv.org/abs/2507.03168
arxiv.org
July 8, 2025 at 1:04 PM
Exciting new preprint from the lab: “Adopting a human developmental visual diet yields robust, shape-based AI vision”. A most wonderful case where brain inspiration massively improved AI solutions.
Work with @zejinlu.bsky.social @sushrutthorat.bsky.social and Radek Cichy
arxiv.org/abs/2507.03168
Work with @zejinlu.bsky.social @sushrutthorat.bsky.social and Radek Cichy
arxiv.org/abs/2507.03168
Reposted by Mac Shine
🚨 New paper in Journal of Vision!
We show that scene affordances—what you can do in a space—shape how we perceive and categorize scenes. This shapes your similarity preferences, predicts your categorization false alarms, and even alters neural representations. 🧵👇
🔗 doi.org/10.1167/jov....
(1/7)
We show that scene affordances—what you can do in a space—shape how we perceive and categorize scenes. This shapes your similarity preferences, predicts your categorization false alarms, and even alters neural representations. 🧵👇
🔗 doi.org/10.1167/jov....
(1/7)
Function over form: The temporal evolution of affordance-based scene categorization | JOV | ARVO Journals
doi.org
July 8, 2025 at 4:38 PM
🚨 New paper in Journal of Vision!
We show that scene affordances—what you can do in a space—shape how we perceive and categorize scenes. This shapes your similarity preferences, predicts your categorization false alarms, and even alters neural representations. 🧵👇
🔗 doi.org/10.1167/jov....
(1/7)
We show that scene affordances—what you can do in a space—shape how we perceive and categorize scenes. This shapes your similarity preferences, predicts your categorization false alarms, and even alters neural representations. 🧵👇
🔗 doi.org/10.1167/jov....
(1/7)
Reposted by Mac Shine
Attractors are usually not mechanisms - new blog post: open.substack.com/pub/kording/...
Attractors are usually not mechanisms
The mathematical objects can not be. And the "attractor models" have not been established as mechanisms in mammals
open.substack.com
July 8, 2025 at 2:40 PM
Attractors are usually not mechanisms - new blog post: open.substack.com/pub/kording/...
Reposted by Mac Shine
How does the human brain coordinate hierarchical cortical development? Our work in Nature Neuroscience identifies a role for thalamocortical structural connectivity in the expression of hierarchical periods of cortical plasticity & environmental receptivity in youth 🧵 www.nature.com/articles/s41...
July 8, 2025 at 12:00 AM
How does the human brain coordinate hierarchical cortical development? Our work in Nature Neuroscience identifies a role for thalamocortical structural connectivity in the expression of hierarchical periods of cortical plasticity & environmental receptivity in youth 🧵 www.nature.com/articles/s41...