Lars Henning
@larshenningmd.bsky.social
80% gynecological oncologist Västerås 🇸🇪. 20% HTA-unit Camtö Örebro Hospital. Views my own. Too dumb and lazy for doing research but interested how to evaluate medical research&evidence.
Words matter. Dislike lifscience like QoL&D engl, swed, germ
Words matter. Dislike lifscience like QoL&D engl, swed, germ
Pinned
Lars Henning
@larshenningmd.bsky.social
· Dec 22
vardgivare.regionorebrolan.se/rapport-om-l...
Skrev i senaste "Rapport om läkemedel" från Läkemedelskommitén Örebro om Camtös systematiska översikt över torkat svinsköldkörtelextrakt mot hypotyreos och en kartläggning av dess förskrivning i Sverige. Så snygg illustrerat. Tacksam för kritisk läsning.
Skrev i senaste "Rapport om läkemedel" från Läkemedelskommitén Örebro om Camtös systematiska översikt över torkat svinsköldkörtelextrakt mot hypotyreos och en kartläggning av dess förskrivning i Sverige. Så snygg illustrerat. Tacksam för kritisk läsning.
Reposted by Lars Henning
A pleasingly meta-meta-analysis with a very displeasing outcome: jamanetwork.com/journals/jam...
Inclusion of Retracted Studies in Systematic Reviews and Meta-Analyses of Interventions
This systematic review and meta-analysis identifies reports of systematic reviews that included retracted studies in their meta-analyses, and assesses the impact of these retracted studies on the resu...
jamanetwork.com
February 13, 2026 at 2:58 AM
A pleasingly meta-meta-analysis with a very displeasing outcome: jamanetwork.com/journals/jam...
On the positive side this 👇 stresses the importance as part of critical reading to check references in scientifical publications. Much too often they didnt make any sense already in the pre-AI-era
Academics and technologists are sounding the alarm about a growing crisis in scholarship as we know it: AI-generated citations of nonexistent papers that have infested real journals. Despite being fake, the sources are widely assumed to be authentic the more they appear in published literature.
AI Is Inventing Academic Papers That Don't Exist -- And They're Being Cited in Real Journals
Academic articles from authors using large language model are creating an ecosystem of fake research that threatens human knowledge itself.
www.rollingstone.com
December 18, 2025 at 5:38 AM
On the positive side this 👇 stresses the importance as part of critical reading to check references in scientifical publications. Much too often they didnt make any sense already in the pre-AI-era
To achieve the same benefit with less intervention is one of the big beauties in medicine. This one 👇 has huge implications for global health.
One HPV vaccine dose delivers equivalent protection against HPV16 and HPV18 infection as two doses, with no safety issues.
by Kreimer AR, Porras C (...) Herrero R et 26 al. in N Engl J Med #MedSky
👉 get more here
📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2506765
by Kreimer AR, Porras C (...) Herrero R et 26 al. in N Engl J Med #MedSky
👉 get more here
📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2506765
December 12, 2025 at 9:24 PM
To achieve the same benefit with less intervention is one of the big beauties in medicine. This one 👇 has huge implications for global health.
Den här historien bekräftar ett tidlöst citat från f.d. tyske förbundskanslern Helmut Schmidt "Den som drabbas av visioner bör gå till en läkare"
lakartidningen.se/nyheter/visi...
lakartidningen.se/nyheter/visi...
Vision e-hälsa – drömmen om digitalisering som sprack
2025 skulle Sverige vara bäst i världen på digitalisering inom sjukvården. Så blev det tyst. Vad hände?
lakartidningen.se
December 12, 2025 at 5:19 AM
Den här historien bekräftar ett tidlöst citat från f.d. tyske förbundskanslern Helmut Schmidt "Den som drabbas av visioner bör gå till en läkare"
lakartidningen.se/nyheter/visi...
lakartidningen.se/nyheter/visi...
Mycket positivt att TLV tydlig markera emot olämplig förskrivning av licensläkemedel. www.tlv.se/download/18....
För kapitlet om svinsköldkörtelextrakt (s 44-45) måste rimligen CAMTÖ's systematiska översikt varit en inspiration där jag fick bidra till.
För kapitlet om svinsköldkörtelextrakt (s 44-45) måste rimligen CAMTÖ's systematiska översikt varit en inspiration där jag fick bidra till.
www.tlv.se
December 11, 2025 at 6:38 AM
Mycket positivt att TLV tydlig markera emot olämplig förskrivning av licensläkemedel. www.tlv.se/download/18....
För kapitlet om svinsköldkörtelextrakt (s 44-45) måste rimligen CAMTÖ's systematiska översikt varit en inspiration där jag fick bidra till.
För kapitlet om svinsköldkörtelextrakt (s 44-45) måste rimligen CAMTÖ's systematiska översikt varit en inspiration där jag fick bidra till.
"Surrendering to demands for higher drugprices (25% if I understood correctly) means that the NHS and patients will bear the cost, without any guarantee of greater innovation or improved health outcomes"
Who are the winners and losers of the UK-US pharma deal?
Behind the UK’s “landmark” pharma deal with the US lies a costly surrender — higher drug prices, weaker safeguards, and vague promises of investment, write @elstorreele.bsky.social and @martinmckee.bsky.social
www.bmj.com/content/391/...
Behind the UK’s “landmark” pharma deal with the US lies a costly surrender — higher drug prices, weaker safeguards, and vague promises of investment, write @elstorreele.bsky.social and @martinmckee.bsky.social
www.bmj.com/content/391/...
December 5, 2025 at 5:26 PM
"Surrendering to demands for higher drugprices (25% if I understood correctly) means that the NHS and patients will bear the cost, without any guarantee of greater innovation or improved health outcomes"
Its 1st of december and fortunately time again to delve into Anna's new learnfull advent calendar on research Integrity.
Happy Advent! !!!🎄✨
Welcome to a new edition of the Research Integrity Advent Calendar.
Each day brings a small challenge: spot the problem, detect inconsistencies, and sharpen your skills.
Enjoy the season and the daily puzzles!
Day 1. papermills.tilda.ws/advent2025
Welcome to a new edition of the Research Integrity Advent Calendar.
Each day brings a small challenge: spot the problem, detect inconsistencies, and sharpen your skills.
Enjoy the season and the daily puzzles!
Day 1. papermills.tilda.ws/advent2025
December 1, 2025 at 10:02 PM
Its 1st of december and fortunately time again to delve into Anna's new learnfull advent calendar on research Integrity.
Reposted by Lars Henning
We just preprinted a huge meta-meta-analysis examining the effects of exercise on cognition, memory, and executive function
In short
- 2239 effect sizes
- extreme between-study heterogeneity
- extensive publication bias
- some subgroup/exercise-specific effects
More below (doi.org/10.31234/osf...)
In short
- 2239 effect sizes
- extreme between-study heterogeneity
- extensive publication bias
- some subgroup/exercise-specific effects
More below (doi.org/10.31234/osf...)
OSF
doi.org
December 1, 2025 at 4:19 PM
We just preprinted a huge meta-meta-analysis examining the effects of exercise on cognition, memory, and executive function
In short
- 2239 effect sizes
- extreme between-study heterogeneity
- extensive publication bias
- some subgroup/exercise-specific effects
More below (doi.org/10.31234/osf...)
In short
- 2239 effect sizes
- extreme between-study heterogeneity
- extensive publication bias
- some subgroup/exercise-specific effects
More below (doi.org/10.31234/osf...)
A lilliputian step for mankind, a giant step for the Green Party in Germany accepting the obvious that treatments with at best placebo-effect in clinical trials like homeopathy should not get reimbursed.
November 29, 2025 at 11:11 AM
A lilliputian step for mankind, a giant step for the Green Party in Germany accepting the obvious that treatments with at best placebo-effect in clinical trials like homeopathy should not get reimbursed.
Viktig artikel i @svenskadagbladet1.bsky.social om Trumpism med betydelse om prissättning av läkemedel i Europa
Trump: Européer ska betala mer för medicin
www.svd.se/a/JOWXqR/tru...
Trump: Européer ska betala mer för medicin
www.svd.se/a/JOWXqR/tru...
November 29, 2025 at 9:34 AM
Viktig artikel i @svenskadagbladet1.bsky.social om Trumpism med betydelse om prissättning av läkemedel i Europa
Trump: Européer ska betala mer för medicin
www.svd.se/a/JOWXqR/tru...
Trump: Européer ska betala mer för medicin
www.svd.se/a/JOWXqR/tru...
New expression of concerrn in @bmj.com possibly causing waves of concern among Swedish scientists who earn their careers by harvesting the formidable Swedish registries. When its not ok anymore to assume causal effects in observational trials where will be the fun left?
www.bmj.com/content/391/...
www.bmj.com/content/391/...
www.bmj.com
November 26, 2025 at 7:35 PM
New expression of concerrn in @bmj.com possibly causing waves of concern among Swedish scientists who earn their careers by harvesting the formidable Swedish registries. When its not ok anymore to assume causal effects in observational trials where will be the fun left?
www.bmj.com/content/391/...
www.bmj.com/content/391/...
In my opinion the authors of any systematical review should not have such a tragicomical lengthy conflict of interest section like in this case
Presented today at #KidneyWk ✅:
📚Effects of Sodium Glucose Cotransporter 2 Inhibitors by Diabetes Status and Level of Albuminuria: A Meta- Analysis, from @jama.com.
🔗Free to read online:
ja.ma/4ooJqJ9
📚Effects of Sodium Glucose Cotransporter 2 Inhibitors by Diabetes Status and Level of Albuminuria: A Meta- Analysis, from @jama.com.
🔗Free to read online:
ja.ma/4ooJqJ9
November 26, 2025 at 3:01 PM
In my opinion the authors of any systematical review should not have such a tragicomical lengthy conflict of interest section like in this case
"A massive Swedish study examined hormonal birth control risks. But the nuances of such studies get lost on social media."
Comment: nuances were lost also in traditional media-outlets and the initial press-release by Uppsala University
Comment: nuances were lost also in traditional media-outlets and the initial press-release by Uppsala University
A Swedish study found hormonal birth control is safe overall but shows a small breast cancer risk increase during use. TikTok claims it causes cancer as dangerous as smoking. Originally published by @kffhealthnews.org
Misinformation About Birth Control and Breast Cancer Swirls
A massive Swedish study examined hormonal birth control risks. But the nuances of such studies get lost on social media.
f.mtr.cool
November 24, 2025 at 5:18 PM
"A massive Swedish study examined hormonal birth control risks. But the nuances of such studies get lost on social media."
Comment: nuances were lost also in traditional media-outlets and the initial press-release by Uppsala University
Comment: nuances were lost also in traditional media-outlets and the initial press-release by Uppsala University
Superintresting and learnfull blogg on HPV-vaccination which illustrated clearly how challenging triangulation for longterm clinical effects with meaningful surrogate endpoints are. My greatest respect for not using the Danish ø a single time
We've had to wait a long time to get to this point! With this new pair of Cochrane systematic reviews, the weight of the evidence has tipped very heavily in favor of HPV vaccination.
My new post @plos.org absolutelymaybe.plos.org/2025/11/24/t...
#Vaccines
My new post @plos.org absolutelymaybe.plos.org/2025/11/24/t...
#Vaccines
This Evidence Fundamentally Shifts the Debate About the HPV Vaccine - Absolutely Maybe
We’ve had to wait a long time to get to this point. If cervical cancer develops after HPV infection, it will take…
absolutelymaybe.plos.org
November 24, 2025 at 1:29 PM
Superintresting and learnfull blogg on HPV-vaccination which illustrated clearly how challenging triangulation for longterm clinical effects with meaningful surrogate endpoints are. My greatest respect for not using the Danish ø a single time
Reposted by Lars Henning
We've had to wait a long time to get to this point! With this new pair of Cochrane systematic reviews, the weight of the evidence has tipped very heavily in favor of HPV vaccination.
My new post @plos.org absolutelymaybe.plos.org/2025/11/24/t...
#Vaccines
My new post @plos.org absolutelymaybe.plos.org/2025/11/24/t...
#Vaccines
This Evidence Fundamentally Shifts the Debate About the HPV Vaccine - Absolutely Maybe
We’ve had to wait a long time to get to this point. If cervical cancer develops after HPV infection, it will take…
absolutelymaybe.plos.org
November 24, 2025 at 10:24 AM
We've had to wait a long time to get to this point! With this new pair of Cochrane systematic reviews, the weight of the evidence has tipped very heavily in favor of HPV vaccination.
My new post @plos.org absolutelymaybe.plos.org/2025/11/24/t...
#Vaccines
My new post @plos.org absolutelymaybe.plos.org/2025/11/24/t...
#Vaccines
This is the kind of paper which is unethical to have behind paywall as it is directed to cancerpatients and their families. Reading might decrease unnecessary anxiety and stress and might improve quality of life and intimacy with loved ones while on chemotherapy. Recommended read.
November 21, 2025 at 10:04 AM
This is the kind of paper which is unethical to have behind paywall as it is directed to cancerpatients and their families. Reading might decrease unnecessary anxiety and stress and might improve quality of life and intimacy with loved ones while on chemotherapy. Recommended read.
www.dagensmedicin.se/alla-nyheter...
En av våra cancerpatienter får idag utan krångel en blodtransfusion i hemtrakten i Fagersta. Jag blev nästan gråtfärdig. Många take home messages här i artikeln:
- fördel med små enheter och eget ansvar
-Alltid bra att utgå från patientens behov & få jobb gjort
En av våra cancerpatienter får idag utan krångel en blodtransfusion i hemtrakten i Fagersta. Jag blev nästan gråtfärdig. Många take home messages här i artikeln:
- fördel med små enheter och eget ansvar
-Alltid bra att utgå från patientens behov & få jobb gjort
”Vi pratar inte pengar” – modellen som gjort Fagersta till ett föredöme i nära vård
När andra fastnar i ekonomi gjorde Fagersta tvärtom: de slutade prata pengar och började samarbeta. Resultatet är ett närvårdsteam som på bara tre år gjort nära vård till vardag – och förändrat patien...
www.dagensmedicin.se
November 21, 2025 at 8:17 AM
www.dagensmedicin.se/alla-nyheter...
En av våra cancerpatienter får idag utan krångel en blodtransfusion i hemtrakten i Fagersta. Jag blev nästan gråtfärdig. Många take home messages här i artikeln:
- fördel med små enheter och eget ansvar
-Alltid bra att utgå från patientens behov & få jobb gjort
En av våra cancerpatienter får idag utan krångel en blodtransfusion i hemtrakten i Fagersta. Jag blev nästan gråtfärdig. Många take home messages här i artikeln:
- fördel med små enheter och eget ansvar
-Alltid bra att utgå från patientens behov & få jobb gjort
Reposted by Lars Henning
This is a problem for scientific communication. A total lack of causation can never be proven for anything. You cannot prove that playing cello in your underwear doesn't cause autism. These charlatans exploit that.
This is completely disgusting. Today, the CDC updated their vaccine safety page. It now says:
“The claim "vaccines do not cause autism" is not an evidence-based claim because studies have not ruled out the possibility that infant vaccines cause autism”.
“The claim "vaccines do not cause autism" is not an evidence-based claim because studies have not ruled out the possibility that infant vaccines cause autism”.
November 20, 2025 at 6:30 AM
This is a problem for scientific communication. A total lack of causation can never be proven for anything. You cannot prove that playing cello in your underwear doesn't cause autism. These charlatans exploit that.
To fail in critical assessment of the published scientifical litterature (which implies to identify the shitty garbage part of published research) costs life
CDC has overhauled its website to assert that “the claim ‘vaccines do not cause autism’ is not an evidence-based claim”
November 20, 2025 at 5:53 AM
To fail in critical assessment of the published scientifical litterature (which implies to identify the shitty garbage part of published research) costs life
Its bad that this important patient-centered article is not open-access. The only advice i give to my patients on chemotherapy (not backed by evidence) is that they might avoid to kiss a person with fever. And that they should try to gather some cool moments of gold while on this toxic treatment.
“While you are on chemotherapy …” Myths:
- Avoid large social gatherings
- Wash clothes w body fluids STAT
- Use a separate toilet
- Avoid all EtOH
- Avoid certain foods, coffee
--> lack evidence, cause harm academic.oup.com/jnci/article... great article from @csoncol.bsky.social #oncology
- Avoid large social gatherings
- Wash clothes w body fluids STAT
- Use a separate toilet
- Avoid all EtOH
- Avoid certain foods, coffee
--> lack evidence, cause harm academic.oup.com/jnci/article... great article from @csoncol.bsky.social #oncology
“While you are on chemotherapy …”: common recommendations that lack evidence and may cause harm
Abstract. Patients on chemotherapy often use multiple resources to obtain information on wide-ranging issues, including prognosis, treatments, diet, exerci
academic.oup.com
November 18, 2025 at 5:28 AM
Its bad that this important patient-centered article is not open-access. The only advice i give to my patients on chemotherapy (not backed by evidence) is that they might avoid to kiss a person with fever. And that they should try to gather some cool moments of gold while on this toxic treatment.
Reposted by Lars Henning
Are methodological and causal inference errors creating a false impression that the gut microbiome causes autism? In this strong analysis, Mitchell, Dahly, and Bishop question the evidence.
They show that triangulation in science requires multiple robust lines of research.
They show that triangulation in science requires multiple robust lines of research.
The link between the gut #microbiome and autism is not backed by science, researchers say.
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
November 14, 2025 at 12:49 PM
Are methodological and causal inference errors creating a false impression that the gut microbiome causes autism? In this strong analysis, Mitchell, Dahly, and Bishop question the evidence.
They show that triangulation in science requires multiple robust lines of research.
They show that triangulation in science requires multiple robust lines of research.
9th of december free 2-hour introduction online workshop on the INSPECT-SR tool for assessing trustworthiness of randomised controlled trials (RCTs. 👇
November 6, 2025 at 6:02 PM
9th of december free 2-hour introduction online workshop on the INSPECT-SR tool for assessing trustworthiness of randomised controlled trials (RCTs. 👇
Detection for fabricated or unlikely data in RCT's should be mandatory for HTA-units as well 👇
i agree. Problem is that peer review is not geared up for detection of fabricated data. Sadly I think we need to be more alert to this. Inclusion of raw data v helpful in this case - and the discrepancies in age hit you as soon as you open the file. But deposited data should be .csv! @bmj.com
November 3, 2025 at 11:28 AM
Detection for fabricated or unlikely data in RCT's should be mandatory for HTA-units as well 👇
Reposted by Lars Henning
10/ Protecting every child protects the world. 🌍
That’s what vaccine equity means — a safer, fairer future for all.
Learn more:
🔹 The Lancet: tinyurl.com/3vbkwrfx
🔹 Nature: tinyurl.com/yc3v84uj
🔹 Gavi: gavi.org
#GlobalHealth
That’s what vaccine equity means — a safer, fairer future for all.
Learn more:
🔹 The Lancet: tinyurl.com/3vbkwrfx
🔹 Nature: tinyurl.com/yc3v84uj
🔹 Gavi: gavi.org
#GlobalHealth
November 2, 2025 at 12:07 PM
10/ Protecting every child protects the world. 🌍
That’s what vaccine equity means — a safer, fairer future for all.
Learn more:
🔹 The Lancet: tinyurl.com/3vbkwrfx
🔹 Nature: tinyurl.com/yc3v84uj
🔹 Gavi: gavi.org
#GlobalHealth
That’s what vaccine equity means — a safer, fairer future for all.
Learn more:
🔹 The Lancet: tinyurl.com/3vbkwrfx
🔹 Nature: tinyurl.com/yc3v84uj
🔹 Gavi: gavi.org
#GlobalHealth
Reposted by Lars Henning
Who did this?!
November 1, 2025 at 8:38 PM
Who did this?!