Mioara Larion, Ph.D
@larionmioara.bsky.social
Principal Investigator
Lead of Cancer Metabolism Lab at @NCI.
Studying lipid metabolism in brain tumors.
Views are my own.
Lead of Cancer Metabolism Lab at @NCI.
Studying lipid metabolism in brain tumors.
Views are my own.
Pinned
So nice to participate in the annual retreat of Staff Scientist at NCI! Our work was highlighted by Dr. Adrian Lita @adrianlita.bsky.social who gave a fantastic presentation. Here is the link the the publication: pubmed.ncbi.nlm.nih.gov/38828478/
Reposted by Mioara Larion, Ph.D
“I was advised that having multiple children would detract from my scientific career. But I actually think that it has greatly benefited it.” Prof. @michellemonje.bsky.social, Neurology and Neurological Sciences at Stanford University, #BrainPrize2025.
#Neuroscience
youtu.be/f7sbSuWie5A?...
#Neuroscience
youtu.be/f7sbSuWie5A?...
Balancing a career in science and personal life
YouTube video by BrainPrize
youtu.be
October 21, 2025 at 9:18 AM
“I was advised that having multiple children would detract from my scientific career. But I actually think that it has greatly benefited it.” Prof. @michellemonje.bsky.social, Neurology and Neurological Sciences at Stanford University, #BrainPrize2025.
#Neuroscience
youtu.be/f7sbSuWie5A?...
#Neuroscience
youtu.be/f7sbSuWie5A?...
AI denoising transforms spontaneous Raman - 80 % faster cell acquisition and a realistic path to high-throughput single cell profiling. See our back cover in Advanced Optical Materials. @adrianlita.bsky.social
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
RADAR: Raman Spectral Analysis Using Deep Learning for Artifact Removal (Advanced Optical Materials 25/2025)
Raman Spectroscopy In article 10.1002/adom.202500736, Ion Petre and co-workers introduce RADAR, two lightweight deep learning models that simultaneously denoise and correct Raman spectra, reducing da...
advanced.onlinelibrary.wiley.com
September 8, 2025 at 4:05 PM
AI denoising transforms spontaneous Raman - 80 % faster cell acquisition and a realistic path to high-throughput single cell profiling. See our back cover in Advanced Optical Materials. @adrianlita.bsky.social
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Excited to be part of this study! We show that we can reduce the noise in spontaneous Raman spectra, thus making the live cell acquisition faster! advanced.onlinelibrary.wiley.com/doi/full/10....
Also the journal picked this as the back cover! @adrianlita.bsky.social
Also the journal picked this as the back cover! @adrianlita.bsky.social
RADAR: Raman Spectral Analysis Using Deep Learning for Artifact Removal
RADAR is introduced, two lightweight deep learning models for artifact removal, capable of simultaneous denoising and correction of Raman spectra, significantly accelerating high-quality data acquisi....
advanced.onlinelibrary.wiley.com
July 28, 2025 at 5:47 PM
Excited to be part of this study! We show that we can reduce the noise in spontaneous Raman spectra, thus making the live cell acquisition faster! advanced.onlinelibrary.wiley.com/doi/full/10....
Also the journal picked this as the back cover! @adrianlita.bsky.social
Also the journal picked this as the back cover! @adrianlita.bsky.social
So nice to participate in the annual retreat of Staff Scientist at NCI! Our work was highlighted by Dr. Adrian Lita @adrianlita.bsky.social who gave a fantastic presentation. Here is the link the the publication: pubmed.ncbi.nlm.nih.gov/38828478/
May 1, 2025 at 3:38 PM
So nice to participate in the annual retreat of Staff Scientist at NCI! Our work was highlighted by Dr. Adrian Lita @adrianlita.bsky.social who gave a fantastic presentation. Here is the link the the publication: pubmed.ncbi.nlm.nih.gov/38828478/
Reposted by Mioara Larion, Ph.D
Will be taking a deep dive into this today. Congrats to Joe Lobel and Nick Ingolia! #RNAsky #RNAbiology
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Deciphering disordered regions controlling mRNA decay in high-throughput - Nature
Using high-throughput functional profiling, how disordered regions control mRNA stability and translation is explored.
www.nature.com
April 24, 2025 at 10:53 AM
Will be taking a deep dive into this today. Congrats to Joe Lobel and Nick Ingolia! #RNAsky #RNAbiology
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mioara Larion, Ph.D
Reposted by Mioara Larion, Ph.D
A big congratulations to @ucsanfrancisco.bsky.social neurosurgeon and scientist Shawn Hervey-Jumper, MD on being honored with the Mitchel S. Berger, MD Endowed Professorship! 🎉 @ucsfhealth.bsky.social @ucsfcancer.bsky.social #UCSFProud
March 26, 2025 at 10:49 PM
A big congratulations to @ucsanfrancisco.bsky.social neurosurgeon and scientist Shawn Hervey-Jumper, MD on being honored with the Mitchel S. Berger, MD Endowed Professorship! 🎉 @ucsfhealth.bsky.social @ucsfcancer.bsky.social #UCSFProud
Reposted by Mioara Larion, Ph.D
Kimryn Rathmell was Awarded 2025 ACS Medal of Honor
On March 8, 2025, Dr. Kimryn Rathmell was honored with the American Cancer Society’s Medal of Honor, the highest recognition for those whose contributions have made a transformative impact in the fight against cancer. 🏅
On March 8, 2025, Dr. Kimryn Rathmell was honored with the American Cancer Society’s Medal of Honor, the highest recognition for those whose contributions have made a transformative impact in the fight against cancer. 🏅
March 12, 2025 at 6:57 PM
Kimryn Rathmell was Awarded 2025 ACS Medal of Honor
On March 8, 2025, Dr. Kimryn Rathmell was honored with the American Cancer Society’s Medal of Honor, the highest recognition for those whose contributions have made a transformative impact in the fight against cancer. 🏅
On March 8, 2025, Dr. Kimryn Rathmell was honored with the American Cancer Society’s Medal of Honor, the highest recognition for those whose contributions have made a transformative impact in the fight against cancer. 🏅
Reposted by Mioara Larion, Ph.D
Congratulations to Ludwig @unil.bsky.social’s Douglas Hanahan on being honored with the 2025 Pezcoller Foundation-@theaacr.bsky.social International Award for Extraordinary Achievement in Cancer Research for his seminal contributions to the field. Learn more here: bit.ly/3DGCnt6
#CanSky #OncoSky
#CanSky #OncoSky
March 11, 2025 at 3:41 PM
Congratulations to Ludwig @unil.bsky.social’s Douglas Hanahan on being honored with the 2025 Pezcoller Foundation-@theaacr.bsky.social International Award for Extraordinary Achievement in Cancer Research for his seminal contributions to the field. Learn more here: bit.ly/3DGCnt6
#CanSky #OncoSky
#CanSky #OncoSky
Reposted by Mioara Larion, Ph.D
November 15, 2024 at 12:59 AM
Reposted by Mioara Larion, Ph.D
I'm thrilled to share our latest research, published in Nature Communications. This work highlights how pancreatic cancer cells hijack cell polarity proteins to regulate macropinocytosis and tumor metabolism, shedding light on potential therapeutic vulnerabilities.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cell polarity proteins promote macropinocytosis in response to metabolic stress - Nature Communications
Cancer cells rely on macropinocytosis to survive in a nutrient-deprived environment. Here, Lambies et al. identified various members of the cell polarity protein network as essential regulators of mac...
www.nature.com
December 4, 2024 at 12:52 AM
I'm thrilled to share our latest research, published in Nature Communications. This work highlights how pancreatic cancer cells hijack cell polarity proteins to regulate macropinocytosis and tumor metabolism, shedding light on potential therapeutic vulnerabilities.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mioara Larion, Ph.D
Wait what?!? Metabolism regulates anti-tumor immunity? I can’t believe it 😉
December 7, 2024 at 1:27 PM
Wait what?!? Metabolism regulates anti-tumor immunity? I can’t believe it 😉
Reposted by Mioara Larion, Ph.D
📢 Postdoc Opening – Metabolism & Cancer! 📢
Looking for a motivated postdoc to explore how metabolism regulates tumor initiation at Roswell Park in Buffalo, NY! Join us to tackle big questions with cool science in a collaborative environment.
Interested? DM me! #PostdocJobs #CancerMetabolism
Looking for a motivated postdoc to explore how metabolism regulates tumor initiation at Roswell Park in Buffalo, NY! Join us to tackle big questions with cool science in a collaborative environment.
Interested? DM me! #PostdocJobs #CancerMetabolism
February 28, 2025 at 9:34 PM
📢 Postdoc Opening – Metabolism & Cancer! 📢
Looking for a motivated postdoc to explore how metabolism regulates tumor initiation at Roswell Park in Buffalo, NY! Join us to tackle big questions with cool science in a collaborative environment.
Interested? DM me! #PostdocJobs #CancerMetabolism
Looking for a motivated postdoc to explore how metabolism regulates tumor initiation at Roswell Park in Buffalo, NY! Join us to tackle big questions with cool science in a collaborative environment.
Interested? DM me! #PostdocJobs #CancerMetabolism
Reposted by Mioara Larion, Ph.D
•Single-cell tracking of tumor organoids maps cell-type transitions & #metabolism
• #Cancer stem & differentiated cells vary in glycolytic rates & exchange #lactate
•Lactate drives cancer stem cell identity by disrupting cell fate commitment
•Lactate metabolism epigenetically activates MYC oncogene
• #Cancer stem & differentiated cells vary in glycolytic rates & exchange #lactate
•Lactate drives cancer stem cell identity by disrupting cell fate commitment
•Lactate metabolism epigenetically activates MYC oncogene
February 10, 2025 at 5:54 PM
•Single-cell tracking of tumor organoids maps cell-type transitions & #metabolism
• #Cancer stem & differentiated cells vary in glycolytic rates & exchange #lactate
•Lactate drives cancer stem cell identity by disrupting cell fate commitment
•Lactate metabolism epigenetically activates MYC oncogene
• #Cancer stem & differentiated cells vary in glycolytic rates & exchange #lactate
•Lactate drives cancer stem cell identity by disrupting cell fate commitment
•Lactate metabolism epigenetically activates MYC oncogene
Reposted by Mioara Larion, Ph.D
Here I discuss the link between metabolism and immunosurveillance and how to exploit this link to improve treatment. I hope you find it interesting and useful. 🤗
Tumor-induced metabolic immunosuppression: Mechanisms and therapeutic targets: Cell Reports
www.cell.com/cell-reports...
Tumor-induced metabolic immunosuppression: Mechanisms and therapeutic targets: Cell Reports
www.cell.com/cell-reports...
Tumor-induced metabolic immunosuppression: Mechanisms and therapeutic targets
This review explores how metabolic reprogramming in cancer and immune cells impacts antitumor responses. It highlights how altered metabolism affects immune function and cancer progression, discusses therapeutic strategies targeting these pathways, and examines innovative combinations of immunotherapy, cellular therapies, and metabolic interventions to enhance treatment efficacy.
www.cell.com
January 12, 2025 at 8:19 AM
Here I discuss the link between metabolism and immunosurveillance and how to exploit this link to improve treatment. I hope you find it interesting and useful. 🤗
Tumor-induced metabolic immunosuppression: Mechanisms and therapeutic targets: Cell Reports
www.cell.com/cell-reports...
Tumor-induced metabolic immunosuppression: Mechanisms and therapeutic targets: Cell Reports
www.cell.com/cell-reports...
Reposted by Mioara Larion, Ph.D
Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity #CancerCell
"Cell-intrinsic mannose metabolism is a physiological regulator of CD8+ T cell fate, decoupling proliferation/expansion from differentiation"
www.cell.com/cancer-cell/...
"Cell-intrinsic mannose metabolism is a physiological regulator of CD8+ T cell fate, decoupling proliferation/expansion from differentiation"
www.cell.com/cancer-cell/...
December 9, 2024 at 2:29 PM
Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity #CancerCell
"Cell-intrinsic mannose metabolism is a physiological regulator of CD8+ T cell fate, decoupling proliferation/expansion from differentiation"
www.cell.com/cancer-cell/...
"Cell-intrinsic mannose metabolism is a physiological regulator of CD8+ T cell fate, decoupling proliferation/expansion from differentiation"
www.cell.com/cancer-cell/...
Reposted by Mioara Larion, Ph.D
New research from @pennmedicine.bsky.social & @wistar.org out in @CellReports finds that ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML & melanoma tumor growth & metastasis ft. Sabina Hlavaty & Kelsey Salcido (@cambupenn.bsky.social) www.cell.com/cell-reports...
January 15, 2025 at 2:33 PM
New research from @pennmedicine.bsky.social & @wistar.org out in @CellReports finds that ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML & melanoma tumor growth & metastasis ft. Sabina Hlavaty & Kelsey Salcido (@cambupenn.bsky.social) www.cell.com/cell-reports...
Reposted by Mioara Larion, Ph.D
Watch Lene Skole, the CEO of the @lundbeckfonden.bsky.social explain why The Brain Prize is awarded, and hear from the 2025 winners: @michellemonje.bsky.social @stanfordneuro.bsky.social, @hhmi.org Investigator, and Frank Winkler, Heidelberg University Hospital. Watch the full film at brainprize.org
March 6, 2025 at 12:54 PM
Watch Lene Skole, the CEO of the @lundbeckfonden.bsky.social explain why The Brain Prize is awarded, and hear from the 2025 winners: @michellemonje.bsky.social @stanfordneuro.bsky.social, @hhmi.org Investigator, and Frank Winkler, Heidelberg University Hospital. Watch the full film at brainprize.org
Reposted by Mioara Larion, Ph.D
News & Views from @vadim-demichev.bsky.social: Advances in single-cell proteomics allow quantification of half of the expressed proteome in an individual cell.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Entering the era of deep single-cell proteomics - Nature Methods
Advances in single-cell proteomics allow quantification of half of the expressed proteome in an individual cell.
www.nature.com
March 6, 2025 at 6:16 PM
News & Views from @vadim-demichev.bsky.social: Advances in single-cell proteomics allow quantification of half of the expressed proteome in an individual cell.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mioara Larion, Ph.D
Congratulations to these two outstanding physician-neuroscientists! Many people now are familiar with the fascinating fundamental research of @michellemonje.bsky.social but most people probably don't know she is a truly great physician. I'm fortunate to be inspired by her every day, in every way.
Congratulations to winners of The Brain Prize 2025!
Professors @michellemonje.bsky.social, @stanfordmedicine.bsky.social and @hhmi.org Investigator, and Frank Winkler, Heidelberg University Hospital, have pioneered the field of Cancer Neuroscience.
Learn more: brainprize.org/winners/canc...
Professors @michellemonje.bsky.social, @stanfordmedicine.bsky.social and @hhmi.org Investigator, and Frank Winkler, Heidelberg University Hospital, have pioneered the field of Cancer Neuroscience.
Learn more: brainprize.org/winners/canc...
March 5, 2025 at 5:37 PM
Congratulations to these two outstanding physician-neuroscientists! Many people now are familiar with the fascinating fundamental research of @michellemonje.bsky.social but most people probably don't know she is a truly great physician. I'm fortunate to be inspired by her every day, in every way.
Reposted by Mioara Larion, Ph.D
RESEARCH | T Walzer, A Marçais et al. (Univ Lyon):
Natural killer cells are shown to rely on exogenous pyruvate import to support effector functions 🧫✨
https://bit.ly/4brHAld
Natural killer cells are shown to rely on exogenous pyruvate import to support effector functions 🧫✨
https://bit.ly/4brHAld
Pivotal role of exogenous pyruvate in human natural killer cell metabolism - Nature Metabolism
Kern Coquillat et al. show that NK cells rely on exogenous pyruvate import to support effector functions.
bit.ly
March 6, 2025 at 6:44 PM
RESEARCH | T Walzer, A Marçais et al. (Univ Lyon):
Natural killer cells are shown to rely on exogenous pyruvate import to support effector functions 🧫✨
https://bit.ly/4brHAld
Natural killer cells are shown to rely on exogenous pyruvate import to support effector functions 🧫✨
https://bit.ly/4brHAld
Reposted by Mioara Larion, Ph.D
📢 We are excited and honored to announce that Frank Winkler received #thebrainprize2025, together with @michellemonje.bsky.social, for pioneering the field of #cancerneuroscience. 💐
@brainprize.bsky.social
#neuroscience #cancer
brainprize.org
@brainprize.bsky.social
#neuroscience #cancer
brainprize.org
The Brain Prize
The Brain Prize is the world’s largest prize for brain research that is awarded each year by the Lundbeck Foundation.
brainprize.org
March 5, 2025 at 3:18 PM
📢 We are excited and honored to announce that Frank Winkler received #thebrainprize2025, together with @michellemonje.bsky.social, for pioneering the field of #cancerneuroscience. 💐
@brainprize.bsky.social
#neuroscience #cancer
brainprize.org
@brainprize.bsky.social
#neuroscience #cancer
brainprize.org
Reposted by Mioara Larion, Ph.D
Congratulations to the Brain Prize 2025 recipients - Michelle Monje & Frank Winkler 🎉
Recognized for ground-breaking discoveries in cancer neuroscience 🧠🧪 that have transformed oncology
It was a privilege to write on their incredible findings - here with their inspiring biographies:
brainprize.org
Recognized for ground-breaking discoveries in cancer neuroscience 🧠🧪 that have transformed oncology
It was a privilege to write on their incredible findings - here with their inspiring biographies:
brainprize.org
March 5, 2025 at 4:22 PM
Congratulations to the Brain Prize 2025 recipients - Michelle Monje & Frank Winkler 🎉
Recognized for ground-breaking discoveries in cancer neuroscience 🧠🧪 that have transformed oncology
It was a privilege to write on their incredible findings - here with their inspiring biographies:
brainprize.org
Recognized for ground-breaking discoveries in cancer neuroscience 🧠🧪 that have transformed oncology
It was a privilege to write on their incredible findings - here with their inspiring biographies:
brainprize.org
Congratulations @michellemonje.bsky.social and @winklerlab.bsky.social for this well deserved recognition!
@michellemonje.bsky.social at @stanfordmedicine.bsky.social and Frank Winkler at Heidelberg University have won the 2025 @brainprize.bsky.social from the Lundbeck Foundation for their work in cancer neuroscience.
By @sydneywyatt.bsky.social
#neuroskyence
www.thetransmitter.org/community/20...
By @sydneywyatt.bsky.social
#neuroskyence
www.thetransmitter.org/community/20...
2025 Brain Prize honors pair of cancer neuroscientists
Michelle Monje and Frank Winkler share the $1.4 million award for their discovery of synapses between brain cancer cells and neurons.
www.thetransmitter.org
March 6, 2025 at 7:41 PM
Congratulations @michellemonje.bsky.social and @winklerlab.bsky.social for this well deserved recognition!