Kristian Frandsen
@kristianfrandsen.bsky.social
Researcher at Technical University of Denmark (DTU) Bioengineering Enzyme Discovery | former Assistant Prof. Univ. of Copenhagen Section for Glycobiology and France's National Research Institute for Agriculture, Food and Environment in Marseille #INRAE
Pinned
Reposted by Kristian Frandsen
PSA: If you're trying to run the Boltz ColabFold notebook and finding that it's crashing with this error, it's because you need to switch to an A100 GPU; the notebook no longer works with T4/L4 GPUs
June 8, 2025 at 9:14 AM
PSA: If you're trying to run the Boltz ColabFold notebook and finding that it's crashing with this error, it's because you need to switch to an A100 GPU; the notebook no longer works with T4/L4 GPUs
Here we present that anions and citrate inhibit #LPMO by directly chealating the active-site copper, (high-resolution crystal structure, PDB 8S3F).
#glycotime
febs.onlinelibrary.wiley.com/doi/10.1111/...
#glycotime
febs.onlinelibrary.wiley.com/doi/10.1111/...
FEBS Press
The fungal lytic polysaccharide monooxygenase LsAA9A binds chloride in its crystallization mother liquor, leading to LsAA9A inhibition. Other halides except for fluoride inhibit LsAA9A activity at hi...
febs.onlinelibrary.wiley.com
June 3, 2025 at 9:32 PM
Here we present that anions and citrate inhibit #LPMO by directly chealating the active-site copper, (high-resolution crystal structure, PDB 8S3F).
#glycotime
febs.onlinelibrary.wiley.com/doi/10.1111/...
#glycotime
febs.onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Kristian Frandsen
Possible new way to increase BBB permeability transiently? At least in vitro…
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A claudin5-binding peptide enhances the permeability of the blood-brain barrier in vitro
A claudin5 binding peptide enhances transport across the blood-brain barrier by transiently permeabilizing tight junctions.
www.science.org
January 25, 2025 at 3:30 AM
Possible new way to increase BBB permeability transiently? At least in vitro…
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Kristian Frandsen
Mahamid and Woodruff labs use cryo-ET to look at mitotic centrosomes: Stunned to see the pericentriolar matrix taking shape, and what seem to be ‚S size’ gamma-tubulin complex oligomers capping the end of 11-pf microtubules.
www.cell.com/developmenta...
www.cell.com/developmenta...
Molecular architectures of centrosomes in C. elegans embryos visualized by cryo-electron tomography
Tollervey et al. use cryo-electron tomography to capture 3D snapshots of centrosomes at molecular resolution in their near-native state inside embryonic C. elegans cells in different stages of cell division. They characterize structural features of centrioles during their assembly and of a disordered matrix that nucleates and organizes mitotic spindle microtubules.
www.cell.com
December 25, 2024 at 1:00 PM
Mahamid and Woodruff labs use cryo-ET to look at mitotic centrosomes: Stunned to see the pericentriolar matrix taking shape, and what seem to be ‚S size’ gamma-tubulin complex oligomers capping the end of 11-pf microtubules.
www.cell.com/developmenta...
www.cell.com/developmenta...
Reposted by Kristian Frandsen
First short talk by Eva Smorodina from University of Oslo.
Structural modeling of antibody variant epitope specificity with complementary experimental and computational techniques.
Structural modeling of antibody variant epitope specificity with complementary experimental and computational techniques.
December 9, 2024 at 8:56 AM
First short talk by Eva Smorodina from University of Oslo.
Structural modeling of antibody variant epitope specificity with complementary experimental and computational techniques.
Structural modeling of antibody variant epitope specificity with complementary experimental and computational techniques.
Reposted by Kristian Frandsen
A great day for computational structural biology!
2024 Nobel Prize lectures in chemistry by David Baker, Demis Hassabis and John Jumper:
www.youtube.com/watch?v=HnT1...
🧪🧬
2024 Nobel Prize lectures in chemistry by David Baker, Demis Hassabis and John Jumper:
www.youtube.com/watch?v=HnT1...
🧪🧬
2024 Nobel Prize lectures in chemistry | David Baker, Demis Hassabis and John Jumper
YouTube video by Nobel Prize
www.youtube.com
December 8, 2024 at 6:08 PM
A great day for computational structural biology!
2024 Nobel Prize lectures in chemistry by David Baker, Demis Hassabis and John Jumper:
www.youtube.com/watch?v=HnT1...
🧪🧬
2024 Nobel Prize lectures in chemistry by David Baker, Demis Hassabis and John Jumper:
www.youtube.com/watch?v=HnT1...
🧪🧬
Reposted by Kristian Frandsen
Fancy glycan of the week 🍬: here ⬇️ is THE fanciest tetrantennary+SDa antigen bisected N-glycan I have ever seen! Found in bovine pregnancy-associated glycoproteins (PAGs) during midpregnancy, see doi.org/10.1093/glyc...
This (and its core-fucosylated companion) will be soon on glycoshape.org 😀👍
This (and its core-fucosylated companion) will be soon on glycoshape.org 😀👍
December 4, 2024 at 6:48 PM
Fancy glycan of the week 🍬: here ⬇️ is THE fanciest tetrantennary+SDa antigen bisected N-glycan I have ever seen! Found in bovine pregnancy-associated glycoproteins (PAGs) during midpregnancy, see doi.org/10.1093/glyc...
This (and its core-fucosylated companion) will be soon on glycoshape.org 😀👍
This (and its core-fucosylated companion) will be soon on glycoshape.org 😀👍
Reposted by Kristian Frandsen
And the main conclusions for this years multimer predictions
December 2, 2024 at 2:50 PM
And the main conclusions for this years multimer predictions
Reposted by Kristian Frandsen
Have you looked in the mirror recently? We took a good look at stereochemistry and how D- and L-ligands bind ... its all about disorder! Exited to share a true REPIN collaborative work led by @estellaan.bsky.social, A. Due and J. Olsen. Thanks for support NNF and DFF.
rdcu.be/d1F6q
rdcu.be/d1F6q
Stereochemistry in the disorder–order continuum of protein interactions
Nature - Studies on protein–protein interactions using proteins containing d- or l-amino acids show that stereoselectivity of binding varies with the degree of disorder within the complex.
rdcu.be
November 28, 2024 at 7:44 AM
Have you looked in the mirror recently? We took a good look at stereochemistry and how D- and L-ligands bind ... its all about disorder! Exited to share a true REPIN collaborative work led by @estellaan.bsky.social, A. Due and J. Olsen. Thanks for support NNF and DFF.
rdcu.be/d1F6q
rdcu.be/d1F6q
Reposted by Kristian Frandsen
🚨 New from PDBe!
Check out the revamped PDBeChem service with enhanced Ligand Pages!
🔍 Explore detailed ligand data, interaction stats, bound structures, related ligands, and more—all in one place.
👉 Read more in the news:
https://buff.ly/4g8eF6E
Check out the revamped PDBeChem service with enhanced Ligand Pages!
🔍 Explore detailed ligand data, interaction stats, bound structures, related ligands, and more—all in one place.
👉 Read more in the news:
https://buff.ly/4g8eF6E
November 27, 2024 at 3:37 PM
🚨 New from PDBe!
Check out the revamped PDBeChem service with enhanced Ligand Pages!
🔍 Explore detailed ligand data, interaction stats, bound structures, related ligands, and more—all in one place.
👉 Read more in the news:
https://buff.ly/4g8eF6E
Check out the revamped PDBeChem service with enhanced Ligand Pages!
🔍 Explore detailed ligand data, interaction stats, bound structures, related ligands, and more—all in one place.
👉 Read more in the news:
https://buff.ly/4g8eF6E
Reposted by Kristian Frandsen
The paper ”Stereochemistry in the disorder–order continuum of protein interactions” from my colleagues @estellaan.bsky.social, Johan Olsen, @bbkrage.bsky.social et al is now out:
doi.org/10.1038/s415... 🍝 🧪 🧬 🧶
doi.org/10.1038/s415... 🍝 🧪 🧬 🧶
November 27, 2024 at 5:21 PM
The paper ”Stereochemistry in the disorder–order continuum of protein interactions” from my colleagues @estellaan.bsky.social, Johan Olsen, @bbkrage.bsky.social et al is now out:
doi.org/10.1038/s415... 🍝 🧪 🧬 🧶
doi.org/10.1038/s415... 🍝 🧪 🧬 🧶
Reposted by Kristian Frandsen
#GoodThingsComeToThoseWait Sorry it's taking us a while. Promise that the wait will be well worth it! #OpenFold3 Love all the great work that's already been done #HelixFold3 #Ligo #Chai1 #Protenix #Boltz1
November 20, 2024 at 10:34 AM
#GoodThingsComeToThoseWait Sorry it's taking us a while. Promise that the wait will be well worth it! #OpenFold3 Love all the great work that's already been done #HelixFold3 #Ligo #Chai1 #Protenix #Boltz1
Reposted by Kristian Frandsen
Really looking forward to welcoming & meeting the participants of our #EMBOStructBio course this morning!
Many of our speakers/tutors are here:
@moalquraishi.bsky.social
@sykhalid.bsky.social
@ezgikaraca.bsky.social
@amjjbonvin.bsky.social
@gchojnowski.bsky.social
@drmelissagraewert.bsky.social
Many of our speakers/tutors are here:
@moalquraishi.bsky.social
@sykhalid.bsky.social
@ezgikaraca.bsky.social
@amjjbonvin.bsky.social
@gchojnowski.bsky.social
@drmelissagraewert.bsky.social
November 18, 2024 at 7:07 AM
Really looking forward to welcoming & meeting the participants of our #EMBOStructBio course this morning!
Many of our speakers/tutors are here:
@moalquraishi.bsky.social
@sykhalid.bsky.social
@ezgikaraca.bsky.social
@amjjbonvin.bsky.social
@gchojnowski.bsky.social
@drmelissagraewert.bsky.social
Many of our speakers/tutors are here:
@moalquraishi.bsky.social
@sykhalid.bsky.social
@ezgikaraca.bsky.social
@amjjbonvin.bsky.social
@gchojnowski.bsky.social
@drmelissagraewert.bsky.social
Reposted by Kristian Frandsen
If you like crystallography💎 (who doesn't) and the bitter-sweet pain of hard-to-work-with-ligands😭, then check out our latest publication,👇
“Structural and biochemical analysis of ligand binding in yeast Niemann–Pick type C1–related protein”
1/
“Structural and biochemical analysis of ligand binding in yeast Niemann–Pick type C1–related protein”
1/
November 19, 2024 at 2:03 PM
If you like crystallography💎 (who doesn't) and the bitter-sweet pain of hard-to-work-with-ligands😭, then check out our latest publication,👇
“Structural and biochemical analysis of ligand binding in yeast Niemann–Pick type C1–related protein”
1/
“Structural and biochemical analysis of ligand binding in yeast Niemann–Pick type C1–related protein”
1/
Reposted by Kristian Frandsen
Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!
November 17, 2024 at 4:20 PM
Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!
Reposted by Kristian Frandsen
Proud of new work tinyurl.com/yhz4c6ry from the lab by Zhicheng (Chen) Cui using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/
G. Napolitano,A. Esposito, and A. Ballabio.
G. Napolitano,A. Esposito, and A. Ballabio.
November 16, 2024 at 4:31 PM
Proud of new work tinyurl.com/yhz4c6ry from the lab by Zhicheng (Chen) Cui using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/
G. Napolitano,A. Esposito, and A. Ballabio.
G. Napolitano,A. Esposito, and A. Ballabio.