Kärt Mätlik
@kmatlik.bsky.social
Group Leader at Tallinn University of Technology. Neuroscience, chromatin biology, development 🇪🇪 she/her
Our new review on histone bivalency in neurons is out in this issue of Genes & Development!
In this Review, Mätlik et al. discuss the influence of histone bivalency (activating H3K4me3 + repressive H3K27me3) on neuronal development and maturation. #openaccess
Learn more here:
➡️ tinyurl.com/gd352306
Learn more here:
➡️ tinyurl.com/gd352306
April 17, 2025 at 5:49 PM
Our new review on histone bivalency in neurons is out in this issue of Genes & Development!
Reposted by Kärt Mätlik
Going to the 2025 #MIT #European #Career #Fair this weekend, & wondering how to #fund your future #research?
Visit the 🇪🇺 European Union's stand to find out all about European Research Council's #grants!
Info 👉 europa.eu/!M4MWm8
#EURAXESS #Europe #Science #Grant #Funding @mitofficial.bsky.social
Visit the 🇪🇺 European Union's stand to find out all about European Research Council's #grants!
Info 👉 europa.eu/!M4MWm8
#EURAXESS #Europe #Science #Grant #Funding @mitofficial.bsky.social
February 26, 2025 at 3:00 PM
Reposted by Kärt Mätlik
Check out our new review led by our neuroscience graduate student Anna Voss @annavoss.bsky.social! Anna put together lots of useful tables of these gene families in mouse and human genomes in here. We hope you'll love these H2B genes as much as we do when you read this article!
Research on histone H2B has grown enormously in recent years. Here, Erica Korb (@korblab.bsky.social) and @annavoss.bsky.social discuss H2B genes, proteins, variants, and modifications, and propose a canonical human H2B sequence.
Read for FREE till April 11th:
authors.elsevier.com/a/1keJqcQbJF...
Read for FREE till April 11th:
authors.elsevier.com/a/1keJqcQbJF...
February 24, 2025 at 5:00 PM
Check out our new review led by our neuroscience graduate student Anna Voss @annavoss.bsky.social! Anna put together lots of useful tables of these gene families in mouse and human genomes in here. We hope you'll love these H2B genes as much as we do when you read this article!
Had such a wonderful time in your lab, Mary Beth!
Wonderful dinner celebrating a remarkably successful postdoc Kart Matlik and sending her off to begin her Group Leader position in Estonia
February 21, 2025 at 2:46 AM
Had such a wonderful time in your lab, Mary Beth!
Reposted by Kärt Mätlik
The first paper out of the Snell lab is live! This review was led by my postdoc Dr. Nichelle Jackson. We dove into the cerebellar contribution to dystonia, specifically focusing on Purkinje cell and cerebellar nuclei dysfunction and calcium handling. www.frontierspartnerships.org/journals/dys...
Frontiers Publishing Partnerships | Cerebellar contributions to dystonia: unraveling the role of Purkinje cells and cerebellar nuclei
Dystonias are a group of neurodegenerative disorders that result in altered physiology associated with motor movements. Both the basal ganglia and the cerebe...
www.frontierspartnerships.org
February 19, 2025 at 10:22 PM
The first paper out of the Snell lab is live! This review was led by my postdoc Dr. Nichelle Jackson. We dove into the cerebellar contribution to dystonia, specifically focusing on Purkinje cell and cerebellar nuclei dysfunction and calcium handling. www.frontierspartnerships.org/journals/dys...
Reposted by Kärt Mätlik
Reposted by Kärt Mätlik
Here is a growing list of conferences and schools in gene regulation for 2025 generegulation.org/conferences-.... You can order/filter this list by the date, deadline, location. Please reply here to suggest new events*
*should be specific to gene regulation
*should be specific to gene regulation
Conferences & Schools – 2025 – Gene Regulation – Teif Lab
generegulation.org
January 14, 2025 at 7:14 PM
Here is a growing list of conferences and schools in gene regulation for 2025 generegulation.org/conferences-.... You can order/filter this list by the date, deadline, location. Please reply here to suggest new events*
*should be specific to gene regulation
*should be specific to gene regulation
Reposted by Kärt Mätlik
New preprint from our lab. Led by the outstanding @anitaada.bsky.social and @raquelgarza.bsky.social. Funded by @asapresearch.bsky.social and @vetenskapsradet.bsky.social.
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
www.biorxiv.org/content/10.1...
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
www.biorxiv.org/content/10.1...
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human development...
www.biorxiv.org
January 18, 2025 at 8:58 AM
New preprint from our lab. Led by the outstanding @anitaada.bsky.social and @raquelgarza.bsky.social. Funded by @asapresearch.bsky.social and @vetenskapsradet.bsky.social.
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
www.biorxiv.org/content/10.1...
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
www.biorxiv.org/content/10.1...
Reposted by Kärt Mätlik
📢New Yorkers! We're meeting for the second session of the 'Postdoc Night Science NYC' club on January 30th 5-7pm. This time we'll be at NYU (Washington Square campus), with the topic of 'A hypothesis is a liability'. Space is limited so please register: docs.google.com/forms/d/1Shc...
January 16, 2025 at 4:27 AM
📢New Yorkers! We're meeting for the second session of the 'Postdoc Night Science NYC' club on January 30th 5-7pm. This time we'll be at NYU (Washington Square campus), with the topic of 'A hypothesis is a liability'. Space is limited so please register: docs.google.com/forms/d/1Shc...
Reposted by Kärt Mätlik
Do you know a UK-based wheelchair user who works in a lab and would be willing to user-test our prototype of what is believed to be the first-ever lab coat adapted for wheelchair users?
Please share far & wide! Interest form: forms.office.com/e/66FhcQjqRT
More info: www.ucl.ac.uk/ucl-east/new...
Please share far & wide! Interest form: forms.office.com/e/66FhcQjqRT
More info: www.ucl.ac.uk/ucl-east/new...
January 7, 2025 at 2:52 PM
Do you know a UK-based wheelchair user who works in a lab and would be willing to user-test our prototype of what is believed to be the first-ever lab coat adapted for wheelchair users?
Please share far & wide! Interest form: forms.office.com/e/66FhcQjqRT
More info: www.ucl.ac.uk/ucl-east/new...
Please share far & wide! Interest form: forms.office.com/e/66FhcQjqRT
More info: www.ucl.ac.uk/ucl-east/new...
Reposted by Kärt Mätlik
This is what happens when you return research results to biobank participants:
✅ The 2nd most googled “How to…?” question in Estonia 2024: “How to become a biobank participant?”
✅ "Estonian Biobank" among Top 10 search terms.
Huge thanks to the entire UniTartu & EstBB teams! ✨
✅ The 2nd most googled “How to…?” question in Estonia 2024: “How to become a biobank participant?”
✅ "Estonian Biobank" among Top 10 search terms.
Huge thanks to the entire UniTartu & EstBB teams! ✨
December 13, 2024 at 10:28 AM
This is what happens when you return research results to biobank participants:
✅ The 2nd most googled “How to…?” question in Estonia 2024: “How to become a biobank participant?”
✅ "Estonian Biobank" among Top 10 search terms.
Huge thanks to the entire UniTartu & EstBB teams! ✨
✅ The 2nd most googled “How to…?” question in Estonia 2024: “How to become a biobank participant?”
✅ "Estonian Biobank" among Top 10 search terms.
Huge thanks to the entire UniTartu & EstBB teams! ✨
Reposted by Kärt Mätlik
Million Veteran Program & FinnGen teams are pleased to release v1 meta-analysis of MVP, FinnGen and UKBB GWAS data. This first version includes ~300 binary disease definitions across >1.5 M individuals.
Browse scans at: mvp-ukbb.finngen.fi
Browse scans at: mvp-ukbb.finngen.fi
December 5, 2024 at 12:53 PM
Million Veteran Program & FinnGen teams are pleased to release v1 meta-analysis of MVP, FinnGen and UKBB GWAS data. This first version includes ~300 binary disease definitions across >1.5 M individuals.
Browse scans at: mvp-ukbb.finngen.fi
Browse scans at: mvp-ukbb.finngen.fi
Reposted by Kärt Mätlik
Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
1/8
High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction - BMC Genomics
The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...
bmcgenomics.biomedcentral.com
December 3, 2024 at 8:38 AM
Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
1/8
Reposted by Kärt Mätlik
Would you like to see @biorxivpreprint.bsky.social add a share to blue sky button?! I know I would! Share this post to let @richardsever.bsky.social @erictopol.bsky.social and others at bioarxiv know!
December 2, 2024 at 12:10 PM
Would you like to see @biorxivpreprint.bsky.social add a share to blue sky button?! I know I would! Share this post to let @richardsever.bsky.social @erictopol.bsky.social and others at bioarxiv know!
Reposted by Kärt Mätlik
Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!
A panoramic view of cell population dynamics in mammalian aging
To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...
tinyurl.com
November 29, 2024 at 4:17 PM
Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!
Reposted by Kärt Mätlik
🔺🔺🔺RED TRIANGLE ALERT 🔺🔺🔺
Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!!
Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals!
SMCs & RNA-Pol are the only thing they have in common
www.nature.com/articles/s41...
Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!!
Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals!
SMCs & RNA-Pol are the only thing they have in common
www.nature.com/articles/s41...
Evolution and function of chromatin domains across the tree of life - Nature Structural & Molecular Biology
Szalay et al. discuss cross-kingdom similarities and differences in 3D chromatin folding in relation to gene regulation, including in bacteria, archaea, mammals and plants. This comparison reveals cer...
www.nature.com
November 28, 2024 at 12:48 PM
🔺🔺🔺RED TRIANGLE ALERT 🔺🔺🔺
Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!!
Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals!
SMCs & RNA-Pol are the only thing they have in common
www.nature.com/articles/s41...
Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!!
Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals!
SMCs & RNA-Pol are the only thing they have in common
www.nature.com/articles/s41...
Reposted by Kärt Mätlik
I was deeply disappointed by the lack of nature/science/climate/enviro on many major end-of-year book lists—so I decided to make my own!
Introducing: ✨🎁📚 The 2024 Holiday Gift Guide to Nature & Science Books ✨🎁📚
Please share: Let's make this go viral in time for Black Friday / holiday shopping!
Introducing: ✨🎁📚 The 2024 Holiday Gift Guide to Nature & Science Books ✨🎁📚
Please share: Let's make this go viral in time for Black Friday / holiday shopping!
November 27, 2024 at 7:08 PM
I was deeply disappointed by the lack of nature/science/climate/enviro on many major end-of-year book lists—so I decided to make my own!
Introducing: ✨🎁📚 The 2024 Holiday Gift Guide to Nature & Science Books ✨🎁📚
Please share: Let's make this go viral in time for Black Friday / holiday shopping!
Introducing: ✨🎁📚 The 2024 Holiday Gift Guide to Nature & Science Books ✨🎁📚
Please share: Let's make this go viral in time for Black Friday / holiday shopping!
Reposted by Kärt Mätlik
Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elements - Nature Genetics
ChIP-DIP (ChIP done in parallel) is a highly multiplex assay for protein–DNA binding, scalable to hundreds of proteins including modified histones, chromatin regulators and transcription factors, offe...
www.nature.com
November 27, 2024 at 4:13 AM
Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kärt Mätlik
OK, I've made a Starter Pack on Neuroepigenetics, Chromatin, and Gene Regulation! Please share and let me know who else should be added to this list.
go.bsky.app/6LWE4dr
go.bsky.app/6LWE4dr
November 25, 2024 at 6:37 PM
OK, I've made a Starter Pack on Neuroepigenetics, Chromatin, and Gene Regulation! Please share and let me know who else should be added to this list.
go.bsky.app/6LWE4dr
go.bsky.app/6LWE4dr
Reposted by Kärt Mätlik
(please amplify) 4% of scientists face an important barrier to an the ENTIRE FIELD of single-cell genomics and here is why
November 25, 2024 at 3:22 PM
(please amplify) 4% of scientists face an important barrier to an the ENTIRE FIELD of single-cell genomics and here is why
Reposted by Kärt Mätlik
Excited to publish a broad set of enhancers to target interneuron types in the brain, along with a broad set of collaborators. Part of the BI armamentarium. Together this will help revolutionize the targeting of brain circuits.https://www.biorxiv.org/content/10.1101/2024.07.17.603924v2
November 24, 2024 at 3:01 AM
Excited to publish a broad set of enhancers to target interneuron types in the brain, along with a broad set of collaborators. Part of the BI armamentarium. Together this will help revolutionize the targeting of brain circuits.https://www.biorxiv.org/content/10.1101/2024.07.17.603924v2