Sarah Keane
@keanelab.bsky.social
Associate Professor of Biophysics and Chemistry @Umich. Structural Biology. NMR. Biochemistry.
Congratulations to postbac Sydney Steele for receiving a poster award at the Rustbelt RNA meeting last weekend!
October 27, 2025 at 8:49 PM
Congratulations to postbac Sydney Steele for receiving a poster award at the Rustbelt RNA meeting last weekend!
Reposted by Sarah Keane
🔓Explore recent #OpenAccess work by @keanelab.bsky.social and colleagues where they describe a virtual screening approach to explore the druggability of the precursor structure of microRNA-31👀
pubs.rsc.org/en/content/articlelanding/2025/md/d5md00553a
📍 @umich.edu 🧪
pubs.rsc.org/en/content/articlelanding/2025/md/d5md00553a
📍 @umich.edu 🧪
Integrated in silico and experimental screening identifies novel ligands that target precursor microRNA-31 at the dicer cleavage site
MicroRNAs (miRNAs) regulate gene expression and the dysregulation in mature miRNA levels has been implicated in a wide variety of diseases. In particular, altered levels of mature microRNA-31…
pubs.rsc.org
October 24, 2025 at 1:05 PM
🔓Explore recent #OpenAccess work by @keanelab.bsky.social and colleagues where they describe a virtual screening approach to explore the druggability of the precursor structure of microRNA-31👀
pubs.rsc.org/en/content/articlelanding/2025/md/d5md00553a
📍 @umich.edu 🧪
pubs.rsc.org/en/content/articlelanding/2025/md/d5md00553a
📍 @umich.edu 🧪
Congratulations to the lab for placing 1st for the College of Literature, Science, and the Arts unit in the 2025 Freezer Challenge! A big thanks to Antigone and @chembiocade.bsky.social for leading the lab in sustainable practices.
September 3, 2025 at 1:51 PM
Congratulations to the lab for placing 1st for the College of Literature, Science, and the Arts unit in the 2025 Freezer Challenge! A big thanks to Antigone and @chembiocade.bsky.social for leading the lab in sustainable practices.
Two papers from Grace's thesis have been published! Our journey into the world of small molecule RNA targeting.
August 14, 2025 at 3:26 PM
Two papers from Grace's thesis have been published! Our journey into the world of small molecule RNA targeting.
And another poster award! This one to Antigone, who presented at the Karle Symposium today!!
July 25, 2025 at 11:09 PM
And another poster award! This one to Antigone, who presented at the Karle Symposium today!!
Congratulations are in order! Two members of the lab, Moriah (a @NSF funded D-RISE high school student) and Diane (a UM undergrad) were awarded poster prizes at the URAN|UM symposium today!
July 24, 2025 at 11:17 PM
Congratulations are in order! Two members of the lab, Moriah (a @NSF funded D-RISE high school student) and Diane (a UM undergrad) were awarded poster prizes at the URAN|UM symposium today!
Reposted by Sarah Keane
I am (optimistically) looking for a postdoc with solution state biomolecular NMR expertise to join our group. I can provide access to high-end instrumentation and technical assistance via our membership at the New York Structural Biology Center. #nmr #academicsky #postdoc
July 16, 2025 at 1:42 PM
I am (optimistically) looking for a postdoc with solution state biomolecular NMR expertise to join our group. I can provide access to high-end instrumentation and technical assistance via our membership at the New York Structural Biology Center. #nmr #academicsky #postdoc
Glad to see this work out in its final form! Congrats to the team!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Structural Features Within Precursor microRNA-20a Regulate Dicer-TRBP Processing
MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression of target messenger (m) RNAs. To maintain proper miR…
www.sciencedirect.com
July 10, 2025 at 11:57 PM
Glad to see this work out in its final form! Congrats to the team!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Sarah Keane
Learn more about how Eterna puzzles are being used for RNA education and outreach at the middle school, high school, and college level in the latest RCSB PDB newsletter. 🧬 🧪
cdn.rcsb.org/rcsb-pdb/gen...
cdn.rcsb.org/rcsb-pdb/gen...
July 9, 2025 at 4:13 PM
Learn more about how Eterna puzzles are being used for RNA education and outreach at the middle school, high school, and college level in the latest RCSB PDB newsletter. 🧬 🧪
cdn.rcsb.org/rcsb-pdb/gen...
cdn.rcsb.org/rcsb-pdb/gen...
Congrats Qi!!
Congratulations to Dr. Qi Zhang Named Inaugural Arrel Toews Research and Teaching Distinguished Term Professor!
July 2, 2025 at 7:07 PM
Congrats Qi!!
Grace's manuscript describing a combined virtual/experimental screening approach for identifying small molecule ligands that bind pre-miR-31 is online!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Integrated in silico and experimental screening identifies novel ligands that target precursor microRNA-31 at the Dicer cleavage site
MicroRNAs (miRNAs) regulate gene expression and the dysregulation in mature miRNA levels has been implicated in a wide variety of diseases. In particular, altered levels of mature microRNA-31 (miR-31)...
www.biorxiv.org
June 25, 2025 at 8:56 PM
Grace's manuscript describing a combined virtual/experimental screening approach for identifying small molecule ligands that bind pre-miR-31 is online!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
2nd defense of the summer! Congratulations to Dr. Aldrex Munsayac! It has been a pleasure to work with and learn from you!
June 25, 2025 at 5:14 PM
2nd defense of the summer! Congratulations to Dr. Aldrex Munsayac! It has been a pleasure to work with and learn from you!
Reposted by Sarah Keane
ACS Bio & Med Chem Au (open) Consolidated 3-Fold Isotopic Lens for Probing RNAs, Solomon K. Attionu, Lukasz T. Olenginski, Frances P. Stump, Theodore K. Dayie* pubs.acs.org/doi/10.1021/... #NMRchat 🧲
Consolidated 3-Fold Isotopic Lens for Probing RNAs
Undesired scalar and dipolar couplings are two major interactions that complicate structural and dynamic studies in solution nuclear magnetic resonance (NMR) spectroscopy. Recent developments in site-...
pubs.acs.org
June 20, 2025 at 1:07 PM
ACS Bio & Med Chem Au (open) Consolidated 3-Fold Isotopic Lens for Probing RNAs, Solomon K. Attionu, Lukasz T. Olenginski, Frances P. Stump, Theodore K. Dayie* pubs.acs.org/doi/10.1021/... #NMRchat 🧲
Reposted by Sarah Keane
Please join the chorus of voices, including my own, in support of the talented, hardworking and dedicated scientists and staff at NIH. They serve their country by deploying their training and skills to improve the health and quality of life of all Americans 🙏 🇺🇸
June 9, 2025 at 3:33 PM
Please join the chorus of voices, including my own, in support of the talented, hardworking and dedicated scientists and staff at NIH. They serve their country by deploying their training and skills to improve the health and quality of life of all Americans 🙏 🇺🇸
Congratulations to Dr. Arhin for an outstanding thesis defense earlier this week!
June 6, 2025 at 2:30 PM
Congratulations to Dr. Arhin for an outstanding thesis defense earlier this week!
Thrilled that @mnwestwood.bsky.social and I have been recognized with a PACE Fellowship for Graduate Student-Faculty Mentor Pairs! More great things to come!
June 4, 2025 at 4:59 PM
Thrilled that @mnwestwood.bsky.social and I have been recognized with a PACE Fellowship for Graduate Student-Faculty Mentor Pairs! More great things to come!
Reposted by Sarah Keane
After resigning from Michigan and bending over backwards to try and appease them, "The Florida Board of Governors voted Tuesday to reject Santa Ono as the next president of the University of Florida"
www.insidehighered.com/news/governa...
www.insidehighered.com/news/governa...
Florida Board Rejects Ono for UF Job
The Florida Board of Governors decided against confirming Santa Ono as president of the University of Florida in a contentious vote focused on diversity, equity and inclusion.
www.insidehighered.com
June 3, 2025 at 9:33 PM
After resigning from Michigan and bending over backwards to try and appease them, "The Florida Board of Governors voted Tuesday to reject Santa Ono as the next president of the University of Florida"
www.insidehighered.com/news/governa...
www.insidehighered.com/news/governa...
CONGRATULATIONS DENISE!!
cen.acs.org/biological-c...
cen.acs.org/biological-c...
2025 Talented 12: Denise Okafor
Studying protein-drug interactions to avoid side effects
cen.acs.org
May 27, 2025 at 8:18 PM
CONGRATULATIONS DENISE!!
cen.acs.org/biological-c...
cen.acs.org/biological-c...
Reposted by Sarah Keane
This is why he is The Boss
Bruce Springsteen opened his tour in England with a forceful denunciation of President Trump. “In my home, the America I love, the America I’ve written about that has been a beacon of hope and liberty for 250 years is currently in the hands of a corrupt, incompetent and treasonous administration.”
Springsteen, in England, Blasts Trump Administration as ‘Treasonous’
www.nytimes.com
May 16, 2025 at 1:58 AM
This is why he is The Boss
Reposted by Sarah Keane
It's National Limerick day! A slight deviation from our regular posts. English artist, illustrator, author and poet Edward Lear was born on this day in 1812.
To celebrate, Goss Scientific have put their own spin* on the classic limerick form.
#NationalLimerickDay #nmr
*pun intended
To celebrate, Goss Scientific have put their own spin* on the classic limerick form.
#NationalLimerickDay #nmr
*pun intended
May 12, 2025 at 10:43 AM
It's National Limerick day! A slight deviation from our regular posts. English artist, illustrator, author and poet Edward Lear was born on this day in 1812.
To celebrate, Goss Scientific have put their own spin* on the classic limerick form.
#NationalLimerickDay #nmr
*pun intended
To celebrate, Goss Scientific have put their own spin* on the classic limerick form.
#NationalLimerickDay #nmr
*pun intended
Another preprint posted! Yaping and Cade @chembiocade.bsky.social uncovered important structural elements in pre-miR-20a that impact Dicer processing. Huge thanks to both Megan @mnwestwood.bsky.social and Aldrex whose experiments rounded out this work!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Structural features within precursor microRNA-20a regulate Dicer-TRBP processing
MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression of target messenger (m) RNAs. To maintain proper miRNA expression levels, the enzymatic processing of ...
www.biorxiv.org
May 12, 2025 at 12:33 PM
Another preprint posted! Yaping and Cade @chembiocade.bsky.social uncovered important structural elements in pre-miR-20a that impact Dicer processing. Huge thanks to both Megan @mnwestwood.bsky.social and Aldrex whose experiments rounded out this work!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
New preprint from the lab - Grace has been instrumental in leading the lab into the RNA-targeting space.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
In silico discovery of compounds targeting NPSL2: a regulatory element in the human oncomiR-1 primary microRNA.
NPSL2 is a stem loop element within the oncomiR-1 polycistronic primary microRNA (miRNA) cluster. NPSL2 is predicted to mediate conformational rearrangements within oncomiR-1 to regulate the biogenesi...
www.biorxiv.org
May 9, 2025 at 3:25 PM
New preprint from the lab - Grace has been instrumental in leading the lab into the RNA-targeting space.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sarah Keane
Over the last 100 days at the NIH, the Trump administration has been dismantling science. In this Medium post linked below, I describe what the last 100 days have been like for an scientist at the bench, doing research on RNA viruses.
#science #RNA
medium.com/@jones.cpric...
#science #RNA
medium.com/@jones.cpric...
The last 100 days at the NIH
Overview: My contract at the NIH was terminated on 25 April 2025. However, my science and NIH research more broadly have been stifled ever…
medium.com
May 7, 2025 at 7:44 PM
Over the last 100 days at the NIH, the Trump administration has been dismantling science. In this Medium post linked below, I describe what the last 100 days have been like for an scientist at the bench, doing research on RNA viruses.
#science #RNA
medium.com/@jones.cpric...
#science #RNA
medium.com/@jones.cpric...
Congratulations to Megan! She received the Krimm Outstanding Graduate Student Award! @mnwestwood.bsky.social
May 3, 2025 at 11:36 AM
Congratulations to Megan! She received the Krimm Outstanding Graduate Student Award! @mnwestwood.bsky.social
Reposted by Sarah Keane
Congratulations to LSI Associate Director and Professor Janet Smith, Ph.D., who has been elected to the American Academy of Arts and Sciences in recognition of her outstanding achievements in science:
record.umich.edu/articles/fiv...
record.umich.edu/articles/fiv...
April 24, 2025 at 11:41 AM
Congratulations to LSI Associate Director and Professor Janet Smith, Ph.D., who has been elected to the American Academy of Arts and Sciences in recognition of her outstanding achievements in science:
record.umich.edu/articles/fiv...
record.umich.edu/articles/fiv...