Sarah Keane
@keanelab.bsky.social
Associate Professor of Biophysics and Chemistry @Umich. Structural Biology. NMR. Biochemistry.
Reposted by Sarah Keane
I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good.
Stay free
Stay free
Bruce Springsteen - Streets Of Minneapolis (Official Audio)
YouTube video by Bruce Springsteen
youtu.be
January 28, 2026 at 5:02 PM
I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good.
Stay free
Stay free
Reposted by Sarah Keane
Biochemist/molecular biologist Joan Steitz was born #OTD in 1941.
She (& team) figured out how our cells read/use genetic instructions to make proteins. A key person who helped crack the code on RNA—the molecule that acts like a messenger between DNA & and the proteins our bodies need. #WomenInSTEM
She (& team) figured out how our cells read/use genetic instructions to make proteins. A key person who helped crack the code on RNA—the molecule that acts like a messenger between DNA & and the proteins our bodies need. #WomenInSTEM
January 26, 2026 at 7:08 PM
Biochemist/molecular biologist Joan Steitz was born #OTD in 1941.
She (& team) figured out how our cells read/use genetic instructions to make proteins. A key person who helped crack the code on RNA—the molecule that acts like a messenger between DNA & and the proteins our bodies need. #WomenInSTEM
She (& team) figured out how our cells read/use genetic instructions to make proteins. A key person who helped crack the code on RNA—the molecule that acts like a messenger between DNA & and the proteins our bodies need. #WomenInSTEM
Reposted by Sarah Keane
Just out: NMR data processing, visualization, analysis and structure calculation with NMRFx
NMR data processing, visualization, analysis and structure calculation with NMRFx
Communications Chemistry, Published online: 05 December 2025; doi:10.1038/s42004-025-01812-8NMR spectroscopy’s effectiveness across scientific disciplines hinges on robust computational tools for data analysis. Here, the authors introduce NMRFx, a software that enhances data processing and visualization, demonstrating its utility through diverse case studies, including protein, RNA, natural product, and metabolomics analyses.
bit.ly
December 5, 2025 at 10:03 AM
Just out: NMR data processing, visualization, analysis and structure calculation with NMRFx
I'm also late in posting this work, but really proud of Megan @mnwestwood.bsky.social, Sydney, and Jocelyn for their contributions to making RNA NMR spectroscopy more accessible for novice learners! Check out their preprint here: chemrxiv.org/engage/chemr...
A practical guide to RNA NMR spectral analysis for undergraduate students
Nuclear magnetic resonance (NMR) spectroscopy is a powerful analytical tool that can be used to determine the structures of both small organic molecules and large biomacromolecules. Many undergraduate...
chemrxiv.org
November 20, 2025 at 3:01 PM
I'm also late in posting this work, but really proud of Megan @mnwestwood.bsky.social, Sydney, and Jocelyn for their contributions to making RNA NMR spectroscopy more accessible for novice learners! Check out their preprint here: chemrxiv.org/engage/chemr...
Congratulations are in order!! Cade @chembiocade.bsky.social received the Sokol, Margaret and Herman, Fellowship in the Chemical Sciences and Antigone was selected as a departmental nominee for the Rackham-wide outstanding GSI award!
November 20, 2025 at 2:56 PM
Congratulations are in order!! Cade @chembiocade.bsky.social received the Sokol, Margaret and Herman, Fellowship in the Chemical Sciences and Antigone was selected as a departmental nominee for the Rackham-wide outstanding GSI award!
Congratulations to postbac Sydney Steele for receiving a poster award at the Rustbelt RNA meeting last weekend!
October 27, 2025 at 8:49 PM
Congratulations to postbac Sydney Steele for receiving a poster award at the Rustbelt RNA meeting last weekend!
Reposted by Sarah Keane
🔓Explore recent #OpenAccess work by @keanelab.bsky.social and colleagues where they describe a virtual screening approach to explore the druggability of the precursor structure of microRNA-31👀
pubs.rsc.org/en/content/articlelanding/2025/md/d5md00553a
📍 @umich.edu 🧪
pubs.rsc.org/en/content/articlelanding/2025/md/d5md00553a
📍 @umich.edu 🧪
Integrated in silico and experimental screening identifies novel ligands that target precursor microRNA-31 at the dicer cleavage site
MicroRNAs (miRNAs) regulate gene expression and the dysregulation in mature miRNA levels has been implicated in a wide variety of diseases. In particular, altered levels of mature microRNA-31…
pubs.rsc.org
October 24, 2025 at 1:05 PM
🔓Explore recent #OpenAccess work by @keanelab.bsky.social and colleagues where they describe a virtual screening approach to explore the druggability of the precursor structure of microRNA-31👀
pubs.rsc.org/en/content/articlelanding/2025/md/d5md00553a
📍 @umich.edu 🧪
pubs.rsc.org/en/content/articlelanding/2025/md/d5md00553a
📍 @umich.edu 🧪
Congratulations to the lab for placing 1st for the College of Literature, Science, and the Arts unit in the 2025 Freezer Challenge! A big thanks to Antigone and @chembiocade.bsky.social for leading the lab in sustainable practices.
September 3, 2025 at 1:51 PM
Congratulations to the lab for placing 1st for the College of Literature, Science, and the Arts unit in the 2025 Freezer Challenge! A big thanks to Antigone and @chembiocade.bsky.social for leading the lab in sustainable practices.
Two papers from Grace's thesis have been published! Our journey into the world of small molecule RNA targeting.
August 14, 2025 at 3:26 PM
Two papers from Grace's thesis have been published! Our journey into the world of small molecule RNA targeting.
And another poster award! This one to Antigone, who presented at the Karle Symposium today!!
July 25, 2025 at 11:09 PM
And another poster award! This one to Antigone, who presented at the Karle Symposium today!!
Congratulations are in order! Two members of the lab, Moriah (a @NSF funded D-RISE high school student) and Diane (a UM undergrad) were awarded poster prizes at the URAN|UM symposium today!
July 24, 2025 at 11:17 PM
Congratulations are in order! Two members of the lab, Moriah (a @NSF funded D-RISE high school student) and Diane (a UM undergrad) were awarded poster prizes at the URAN|UM symposium today!
Reposted by Sarah Keane
I am (optimistically) looking for a postdoc with solution state biomolecular NMR expertise to join our group. I can provide access to high-end instrumentation and technical assistance via our membership at the New York Structural Biology Center. #nmr #academicsky #postdoc
July 16, 2025 at 1:42 PM
I am (optimistically) looking for a postdoc with solution state biomolecular NMR expertise to join our group. I can provide access to high-end instrumentation and technical assistance via our membership at the New York Structural Biology Center. #nmr #academicsky #postdoc
Glad to see this work out in its final form! Congrats to the team!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Structural Features Within Precursor microRNA-20a Regulate Dicer-TRBP Processing
MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression of target messenger (m) RNAs. To maintain proper miR…
www.sciencedirect.com
July 10, 2025 at 11:57 PM
Glad to see this work out in its final form! Congrats to the team!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Sarah Keane
Learn more about how Eterna puzzles are being used for RNA education and outreach at the middle school, high school, and college level in the latest RCSB PDB newsletter. 🧬 🧪
cdn.rcsb.org/rcsb-pdb/gen...
cdn.rcsb.org/rcsb-pdb/gen...
July 9, 2025 at 4:13 PM
Learn more about how Eterna puzzles are being used for RNA education and outreach at the middle school, high school, and college level in the latest RCSB PDB newsletter. 🧬 🧪
cdn.rcsb.org/rcsb-pdb/gen...
cdn.rcsb.org/rcsb-pdb/gen...
Congrats Qi!!
Congratulations to Dr. Qi Zhang Named Inaugural Arrel Toews Research and Teaching Distinguished Term Professor!
July 2, 2025 at 7:07 PM
Congrats Qi!!
Grace's manuscript describing a combined virtual/experimental screening approach for identifying small molecule ligands that bind pre-miR-31 is online!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Integrated in silico and experimental screening identifies novel ligands that target precursor microRNA-31 at the Dicer cleavage site
MicroRNAs (miRNAs) regulate gene expression and the dysregulation in mature miRNA levels has been implicated in a wide variety of diseases. In particular, altered levels of mature microRNA-31 (miR-31)...
www.biorxiv.org
June 25, 2025 at 8:56 PM
Grace's manuscript describing a combined virtual/experimental screening approach for identifying small molecule ligands that bind pre-miR-31 is online!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
2nd defense of the summer! Congratulations to Dr. Aldrex Munsayac! It has been a pleasure to work with and learn from you!
June 25, 2025 at 5:14 PM
2nd defense of the summer! Congratulations to Dr. Aldrex Munsayac! It has been a pleasure to work with and learn from you!
Reposted by Sarah Keane
ACS Bio & Med Chem Au (open) Consolidated 3-Fold Isotopic Lens for Probing RNAs, Solomon K. Attionu, Lukasz T. Olenginski, Frances P. Stump, Theodore K. Dayie* pubs.acs.org/doi/10.1021/... #NMRchat 🧲
Consolidated 3-Fold Isotopic Lens for Probing RNAs
Undesired scalar and dipolar couplings are two major interactions that complicate structural and dynamic studies in solution nuclear magnetic resonance (NMR) spectroscopy. Recent developments in site-...
pubs.acs.org
June 20, 2025 at 1:07 PM
ACS Bio & Med Chem Au (open) Consolidated 3-Fold Isotopic Lens for Probing RNAs, Solomon K. Attionu, Lukasz T. Olenginski, Frances P. Stump, Theodore K. Dayie* pubs.acs.org/doi/10.1021/... #NMRchat 🧲
Reposted by Sarah Keane
Please join the chorus of voices, including my own, in support of the talented, hardworking and dedicated scientists and staff at NIH. They serve their country by deploying their training and skills to improve the health and quality of life of all Americans 🙏 🇺🇸
June 9, 2025 at 3:33 PM
Please join the chorus of voices, including my own, in support of the talented, hardworking and dedicated scientists and staff at NIH. They serve their country by deploying their training and skills to improve the health and quality of life of all Americans 🙏 🇺🇸
Congratulations to Dr. Arhin for an outstanding thesis defense earlier this week!
June 6, 2025 at 2:30 PM
Congratulations to Dr. Arhin for an outstanding thesis defense earlier this week!
Thrilled that @mnwestwood.bsky.social and I have been recognized with a PACE Fellowship for Graduate Student-Faculty Mentor Pairs! More great things to come!
June 4, 2025 at 4:59 PM
Thrilled that @mnwestwood.bsky.social and I have been recognized with a PACE Fellowship for Graduate Student-Faculty Mentor Pairs! More great things to come!
Reposted by Sarah Keane
After resigning from Michigan and bending over backwards to try and appease them, "The Florida Board of Governors voted Tuesday to reject Santa Ono as the next president of the University of Florida"
www.insidehighered.com/news/governa...
www.insidehighered.com/news/governa...
Florida Board Rejects Ono for UF Job
The Florida Board of Governors decided against confirming Santa Ono as president of the University of Florida in a contentious vote focused on diversity, equity and inclusion.
www.insidehighered.com
June 3, 2025 at 9:33 PM
After resigning from Michigan and bending over backwards to try and appease them, "The Florida Board of Governors voted Tuesday to reject Santa Ono as the next president of the University of Florida"
www.insidehighered.com/news/governa...
www.insidehighered.com/news/governa...
CONGRATULATIONS DENISE!!
cen.acs.org/biological-c...
cen.acs.org/biological-c...
2025 Talented 12: Denise Okafor
Studying protein-drug interactions to avoid side effects
cen.acs.org
May 27, 2025 at 8:18 PM
CONGRATULATIONS DENISE!!
cen.acs.org/biological-c...
cen.acs.org/biological-c...
Reposted by Sarah Keane
This is why he is The Boss
Bruce Springsteen opened his tour in England with a forceful denunciation of President Trump. “In my home, the America I love, the America I’ve written about that has been a beacon of hope and liberty for 250 years is currently in the hands of a corrupt, incompetent and treasonous administration.”
Springsteen, in England, Blasts Trump Administration as ‘Treasonous’
www.nytimes.com
May 16, 2025 at 1:58 AM
This is why he is The Boss