banner
kabalak.bsky.social
@kabalak.bsky.social
A proteomics adventurer on the multiple social media road(s). Interested in proteolysis research, likes human plasma
After a looong journey, here the results of a deep investigation of human plasma proteolysis by MS: SLE N-terminomics paper with a complement C3 fragment at the core, EMBOJ: www.embopress.org/doi/full/10.... - highlights: a resource on proteolytically processed N-termini in human plasma #LHF1 #SLE🧪
October 30, 2025 at 10:52 AM
Reposted
See you at Palazzo dei Normanni in Palermo for the 2026 Protein Termini Conference | Co- and post-translational modifications | Proteolytic processing and degradation pathways | Microbes, plants, animals #ProteinTermini2026 #Proteostasis #ProteinModifications #PalazzoDeiNormanni #Palermo2026
October 26, 2025 at 6:59 PM
Reposted
Wer hat ihn, den berühmten Dessertmagen? 🙋🏼‍♀️

Ich fand diese Studie von vor ein paar Monaten super interessant, denn sie zeigt: Dieselben Nervenzellen, die uns nach dem Essen satt machen, setzen bei Zucker gezielt β‑Endorphin frei (= körpereigenes Opioid) das uns dazu treibt, weiter zu naschen (🐁)
Thalamic opioids from POMC satiety neurons switch on sugar appetite
High sugar–containing foods are readily consumed, even after meals and beyond fullness sensation (e.g., as desserts). Although reward-driven processing of palatable foods can promote overeating, the n...
www.science.org
July 3, 2025 at 7:34 PM
Reposted

Weather’s going wild, and now your mass spec data’s a mess too?

Coindidence? Nope!

We reveal how weather-driven air pressure fluctuations impact diaPASEF-based high troughput proteomics - and how to fix it!

Check out our new paper! #diaPASEF #Weatheromics

pubs.acs.org/doi/10.1021/...
Impact of Local Air Pressure on Ion Mobilities and Data Consistency in diaPASEF-Based High Throughput Proteomics
Data-independent acquisition (DIA) on ion mobility mass spectrometers enables deep proteome coverage and high data completeness in large-scale proteomics studies. For advanced acquisition schemes such as parallel accumulation serial fragmentation-based DIA (diaPASEF) stability of ion mobility (1/K0) over time is crucial for consistent data quality. We found that minor changes in environmental air pressure systematically affect the vacuum pressure in the TIMS analyzer, causing ion mobility shifts. By comparing experimental ion mobilities with historical weather data, we attributed observed drifts to fluctuations in the ground air pressure. Moderate air pressure changes of e.g. fifteen mbar induce ion mobility shifts of 0.025 Vs/cm2. These drifts negatively impact peptide quantification across consecutively acquired samples due to drift-dependent abundance changes and increased missing values for ions located at the boundaries of diaPASEF isolation windows, which cannot be corrected by postprocessing. To address this, we applied an in-batch mobility autocalibration feature on a run-wise basis, leading to full elimination of ion mobility drifts.
pubs.acs.org
January 24, 2025 at 3:35 PM
Reposted
Danish defense of Greenland sorted!
January 8, 2025 at 4:28 PM
A little bit more complicated than it seemed in yesterday - Greenland, USA and Denmark/Danish kingdom #greenland

nyheder.tv2.dk/udland/2025-... (Danish article)
Grønland havde kun Danmark, indtil vigtigt øjeblik ændrede det
En handel mellem USA og Danmark i 1900-tallet hjalp Danmark til at sikre sig Grønland, som i mange år havde været en dansk koloni.
nyheder.tv2.dk
January 8, 2025 at 10:13 PM
Reposted
I try super hard to be positive, but I seriously think we're at almost 9 out of 10 papers with "single cell proteomics" in the title don't feature the analysis of one actual cell in them anywhere. Case in point - super nice study. Obfuscating terminology. proteomicsnews.blogspot.com/2024/12/scpr...
SCPro - Not single cell proteomics, at all, in any way, but still pretty cool!
Here, I fixed it for ya! Even though I can clearly see why I also wouldn't have recommended Ben Orsburn as a reviewer for this one, I do a...
proteomicsnews.blogspot.com
December 3, 2024 at 4:58 PM
Reposted
I thought this poster of my facility turned out nice so I tight I’d share :)
November 22, 2024 at 8:59 PM
Reposted
Interesting ChemRxiv preprint by the group of @tbpoulsen.bsky.social with first author @esbensv.bsky.social. They used OxSTEF probes to study proteins with N-terminal cysteines in the proteome and used the method to specifically investigate difference in normoxia and hypoxia. doi.org/10.26434/che...
Chemoproteomic mapping of the N-terminal cysteinome
The oxidation status of N-terminal cysteines directly dictates protein stability via arginylation and proteasomal degradation. However, only a handful of proteins have been shown to be regulated via t...
doi.org
November 21, 2024 at 9:23 AM
Reposted
If you are interested to learn about our research towards new targets for the antibiotics of the future, check out my eye-opener video. Thanks to the Leiden Institute of Chemistry, the Faculty of Science and the KNCV for making this possible.
www.eye-openers.nl/en/seethecas...
February 22, 2024 at 4:33 PM
Reposted
Aufgefüllt und aufgeräumt!
Die #kirppudk 707 in #Tilst hat jetzt jede Menge Playmobil und Barbie, Schleichpferde, Mia&me, ...
November 26, 2023 at 3:40 PM
Reposted
Wer einen McDonald's im Ort hat, weiß, wie viel Müll dadurch überall herumliegt. Das wäre wirklich eine Verbesserung. Wären da nicht die Leute, die auch Pfandflaschen wegwerfen, weil zu viel Mühe ...
Single-use fast-food packaging hangs in the balance
France has already banned it — now industry is lobbying hard to ensure the EU doesn’t do the same.
www.politico.eu
November 22, 2023 at 9:26 AM
Reposted
Happy to share the phenomenal PhD work of Dr. Amanda Lorentzian now out in its peer-reviewed from in @NatureComms. Amanda shows that targetable genome variants and proteome features are mostly stable from diagnosis to relapse in pediatric leukemia. 1/ www.nature.com/articles/s41...
November 22, 2023 at 6:42 AM
Reposted
Two weeks left to apply!

We are hiring a postdoctoral researcher together with the group of Mario van der Stelt within the Oncode Accelerator consortium!

If you have a passion of drug discovery and experience with MS-based proteomics, consider applying!

www.universiteitleid...
Postdoctoral Researcher Mass Spectrometry
Do you have a passion for drug discovery and want to contribute to diverse research projects embedded in the Oncode-Accelerator consortium using mass-spectrometry-based chemoproteomics? Do you want to work in an international team of excellent, interdisciplinary researchers? You might be our new Postdoctoral…
www.universiteitleiden.nl
October 17, 2023 at 2:18 PM
Reposted
October 11, 2023 at 1:09 AM
There is for sure a better way to make the prime Blue Sky message more useful, but having a Google Scholar word cloud with your own publications might be a good one. So, let's see how the blue things evolve here #proteomics Kidneys in Arabidopsis would be a thing, I guess
October 9, 2023 at 7:41 AM
Reposted
“The more uncomfortable truth is that academic science has never been a trade that selects for or supports the best scientific minds in the world.”

https://www.scientificamerican.com/article/nobel-prize-debate-misses-the-mark-on-the-real-culprits-ignoring-scientific-merit/
Nobel Prize Debate Misses the Mark on the Real Culprits Ignoring Scientific Merit
The furor over a Nobel Prize winner’s derailed career lets scientists off the hook for their own responsibilities to fix a broken academic reward system
www.scientificamerican.com
October 5, 2023 at 7:58 PM
Reposted
Large-scale plasma proteomics comparisons through genetics and disease associations - www.nature.com/artic...

---
#proteomics #prot-paper
October 5, 2023 at 10:00 AM