Joe Beckwith
@jsbeckwith.bsky.social
Spectroscopist, microscopist, pessimist. SRA in the Cambridge Chemistry Department. Science and/or nonsense. Occasionally a post about personal matters, instantly regretted. he/him | 🏳️🌈
www.nature.com/articles/s41...
It's out at last! Work that I was totally privileged to be a part of led by @becs-andrews.bsky.social, with @jcbreiter.bsky.social @stevethechemist.bsky.social and funded by @asapresearch.parkinsonsroadmap.org
It's out at last! Work that I was totally privileged to be a part of led by @becs-andrews.bsky.social, with @jcbreiter.bsky.social @stevethechemist.bsky.social and funded by @asapresearch.parkinsonsroadmap.org
Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue - Nature Biomedical Engineering
An optical detection and analysis platform quantifies aggregate density, distribution and size in fluorescently labelled post-mortem human brain tissue.
www.nature.com
October 1, 2025 at 4:35 PM
www.nature.com/articles/s41...
It's out at last! Work that I was totally privileged to be a part of led by @becs-andrews.bsky.social, with @jcbreiter.bsky.social @stevethechemist.bsky.social and funded by @asapresearch.parkinsonsroadmap.org
It's out at last! Work that I was totally privileged to be a part of led by @becs-andrews.bsky.social, with @jcbreiter.bsky.social @stevethechemist.bsky.social and funded by @asapresearch.parkinsonsroadmap.org
Reposted by Joe Beckwith
Please share: The application for Les Houches is open (until Oct 31)
fluorescenceleshouches.wordpress.com
*This is for you, if you ever wanted to learn all about fluorescence markers & how to apply them for your biological research!*
PS: no fees this year, you just need to get there, that's all!
fluorescenceleshouches.wordpress.com
*This is for you, if you ever wanted to learn all about fluorescence markers & how to apply them for your biological research!*
PS: no fees this year, you just need to get there, that's all!
French-German WE-Heraeus-Seminar "Fluorescence markers for advanced microscopy : From photophysics to biology - 2026"
March 15-20 2026, Les Houches, France
fluorescenceleshouches.wordpress.com
September 12, 2025 at 9:03 AM
Please share: The application for Les Houches is open (until Oct 31)
fluorescenceleshouches.wordpress.com
*This is for you, if you ever wanted to learn all about fluorescence markers & how to apply them for your biological research!*
PS: no fees this year, you just need to get there, that's all!
fluorescenceleshouches.wordpress.com
*This is for you, if you ever wanted to learn all about fluorescence markers & how to apply them for your biological research!*
PS: no fees this year, you just need to get there, that's all!
Reposted by Joe Beckwith
I am finding the fact that "is it acceptable and proportional to call for trans women to be assaulted in public" is now a subject of public debate in the UK really very upsetting.
September 3, 2025 at 2:21 PM
I am finding the fact that "is it acceptable and proportional to call for trans women to be assaulted in public" is now a subject of public debate in the UK really very upsetting.
Reposted by Joe Beckwith
Out now on biorxiv! Excited to share our latest collaborative work investigating the earliest stages of Parkinson’s disease.
www.biorxiv.org/content/10.1...
Thanks to all the amazing co-authors Melissa Grant-Peters @jsbeckwith.bsky.social @stevethechemist.bsky.social Mina Ryten Sonia Gandhi
www.biorxiv.org/content/10.1...
Thanks to all the amazing co-authors Melissa Grant-Peters @jsbeckwith.bsky.social @stevethechemist.bsky.social Mina Ryten Sonia Gandhi
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease
Parkinson's disease (PD) is characterised by insoluble α-synuclein (αSyn) aggregates in Lewy bodies (LBs) within the substantia nigra, with cortical pathology appearing as the disease progresses. Late...
www.biorxiv.org
September 1, 2025 at 9:14 AM
Out now on biorxiv! Excited to share our latest collaborative work investigating the earliest stages of Parkinson’s disease.
www.biorxiv.org/content/10.1...
Thanks to all the amazing co-authors Melissa Grant-Peters @jsbeckwith.bsky.social @stevethechemist.bsky.social Mina Ryten Sonia Gandhi
www.biorxiv.org/content/10.1...
Thanks to all the amazing co-authors Melissa Grant-Peters @jsbeckwith.bsky.social @stevethechemist.bsky.social Mina Ryten Sonia Gandhi
Reposted by Joe Beckwith
Single-Molecule Friends! Just 10 more days to apply for an exciting joint postdoc with @KlenermanLab, feel free to research out www.ch.cam.ac.uk/job/52425
Postdoctoral Research Associate in Single-Molecule Imaging and Super-Resolution Microscopy (Fixed Term) | Yusuf Hamied Department of Chemistry
Fixed-term: The funds for this post are available for 2 years in the first instance. Fixed-term: The funds for this post are available for 2 years in the first instance. Applications are invited for a...
www.ch.cam.ac.uk
September 1, 2025 at 8:22 AM
Single-Molecule Friends! Just 10 more days to apply for an exciting joint postdoc with @KlenermanLab, feel free to research out www.ch.cam.ac.uk/job/52425
Reposted by Joe Beckwith
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease https://www.biorxiv.org/content/10.1101/2025.08.25.671921v1
August 28, 2025 at 4:15 PM
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease https://www.biorxiv.org/content/10.1101/2025.08.25.671921v1
Reposted by Joe Beckwith
Build microscopes, solve immunology (kinda)... come and work with us! We have an exciting collaborative postdoc position in the group. www.cam.ac.uk/jobs/postdoc...
Postdoctoral Research Associate in Single-Molecule Imaging and Super-Resolution Microscopy (Fixed Term)
Fixed-term: The funds for this post are available for 2 years in the first instance. Fixed-term: The funds for this post are available for 2 years in the first instance. Applications are invited for
www.cam.ac.uk
August 14, 2025 at 10:41 AM
Build microscopes, solve immunology (kinda)... come and work with us! We have an exciting collaborative postdoc position in the group. www.cam.ac.uk/jobs/postdoc...
Cool work from a cool lab!
How do you quantify cell structures which are deformed between different observations? Our preprint shows how to perform Simultaneous QUAntification of Structure and Structural Heterogeneity (SQUASSH) on 3D fluorescence microscopy data. (1/5)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Extracting biological structure and heterogeneity from the nano to the macro scale
Fluorescence microscopy is an essential tool in biology. It has revealed great variability at multiple scales, in macromolecular complexes, cells, and organisms. Understanding this variability will re...
www.biorxiv.org
August 12, 2025 at 7:36 PM
Cool work from a cool lab!
Reposted by Joe Beckwith
Please repost: PhD position with my lab and @weisslab.bsky.social in a great collaboration on bacterial adhesion #microsky. See drive.google.com/file/d/1GJD4...
July 9, 2025 at 5:56 PM
Please repost: PhD position with my lab and @weisslab.bsky.social in a great collaboration on bacterial adhesion #microsky. See drive.google.com/file/d/1GJD4...
Reposted by Joe Beckwith
Hello microscopy and imaging experts and enthusiasts!
We are looking for a staff scientist to join us here in Geneva to work on microscopy and image analysis projects! See the link for the job announcement (in French and in English).
Please apply and/or repost!
jobs.unige.ch/www/wd_porta...
We are looking for a staff scientist to join us here in Geneva to work on microscopy and image analysis projects! See the link for the job announcement (in French and in English).
Please apply and/or repost!
jobs.unige.ch/www/wd_porta...
July 7, 2025 at 2:05 PM
Hello microscopy and imaging experts and enthusiasts!
We are looking for a staff scientist to join us here in Geneva to work on microscopy and image analysis projects! See the link for the job announcement (in French and in English).
Please apply and/or repost!
jobs.unige.ch/www/wd_porta...
We are looking for a staff scientist to join us here in Geneva to work on microscopy and image analysis projects! See the link for the job announcement (in French and in English).
Please apply and/or repost!
jobs.unige.ch/www/wd_porta...
Why have I done this ridiculous pose
Joseph Beckwith from Cambridge gave the first invited talk of the 2nd day of the @rsc-photochem.bsky.social ECR meeting talking about multicolour single molecule spectroscopy.
#chemsky #fluoresence
#chemsky #fluoresence
June 27, 2025 at 9:10 AM
Why have I done this ridiculous pose
Reposted by Joe Beckwith
Excited to share some recent work tracking the 3D movement of individual molecules inside the organelles of living cells (💡+ 🦠 + ⚽️💨) with the best team @joechambers.bsky.social
@jamesdmanton.bsky.social
@jsbeckwith.bsky.social @dgershlick.bsky.social @stevethechemist.bsky.social
@jamesdmanton.bsky.social
@jsbeckwith.bsky.social @dgershlick.bsky.social @stevethechemist.bsky.social
Volumetric single-molecule tracking inside subcellular structures https://www.biorxiv.org/content/10.1101/2025.06.09.658280v1
June 10, 2025 at 3:52 PM
Excited to share some recent work tracking the 3D movement of individual molecules inside the organelles of living cells (💡+ 🦠 + ⚽️💨) with the best team @joechambers.bsky.social
@jamesdmanton.bsky.social
@jsbeckwith.bsky.social @dgershlick.bsky.social @stevethechemist.bsky.social
@jamesdmanton.bsky.social
@jsbeckwith.bsky.social @dgershlick.bsky.social @stevethechemist.bsky.social
Reposted by Joe Beckwith
The 3rd Berlin Single Molecule Biophysics Course will run from 8th to 12th September at the HU-Berlin, Institute of Biology.
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at bsmbc@icloud.com. Fee waivers and bursaries available.
! Please share widely !
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at bsmbc@icloud.com. Fee waivers and bursaries available.
! Please share widely !
June 5, 2025 at 8:36 PM
The 3rd Berlin Single Molecule Biophysics Course will run from 8th to 12th September at the HU-Berlin, Institute of Biology.
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at bsmbc@icloud.com. Fee waivers and bursaries available.
! Please share widely !
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at bsmbc@icloud.com. Fee waivers and bursaries available.
! Please share widely !
www.rsc.org/events/detai...
Come to this meeting magnificently organised by @rsc-photochem.bsky.social! Abstract deadline May 30, conference is 26–27 June in London, and I am baffled and happy to be an invited speaker alongside some really great people.
#photochem #photophysics #microscopy
Come to this meeting magnificently organised by @rsc-photochem.bsky.social! Abstract deadline May 30, conference is 26–27 June in London, and I am baffled and happy to be an invited speaker alongside some really great people.
#photochem #photophysics #microscopy
Photophysics and Photochemistry Group Early Career Meeting 2025
www.rsc.org
May 1, 2025 at 10:40 AM
www.rsc.org/events/detai...
Come to this meeting magnificently organised by @rsc-photochem.bsky.social! Abstract deadline May 30, conference is 26–27 June in London, and I am baffled and happy to be an invited speaker alongside some really great people.
#photochem #photophysics #microscopy
Come to this meeting magnificently organised by @rsc-photochem.bsky.social! Abstract deadline May 30, conference is 26–27 June in London, and I am baffled and happy to be an invited speaker alongside some really great people.
#photochem #photophysics #microscopy
Reposted by Joe Beckwith
Section 28 was "the law" too - that doesn't change the fact that the people who supported it were doing so out of bigotry.
April 22, 2025 at 7:42 PM
Section 28 was "the law" too - that doesn't change the fact that the people who supported it were doing so out of bigotry.
Reposted by Joe Beckwith
Today, thousands gathered across the country - from Hastings to London to Glasgow - to say: we will always stand with trans people.
Trans rights are human rights. 🏳️⚧️
Trans rights are human rights. 🏳️⚧️
April 19, 2025 at 3:44 PM
Today, thousands gathered across the country - from Hastings to London to Glasgow - to say: we will always stand with trans people.
Trans rights are human rights. 🏳️⚧️
Trans rights are human rights. 🏳️⚧️
Reposted by Joe Beckwith
🚨We have a 4-year ERC-funded PhD position available in the beautiful city of Leuven, Belgium, for building artificial nanomachines in lipid membranes.
Check out the details and apply here: www.kuleuven.be/personeel/jo...
Feel free to email me for more information!
Check out the details and apply here: www.kuleuven.be/personeel/jo...
Feel free to email me for more information!
April 18, 2025 at 3:55 PM
🚨We have a 4-year ERC-funded PhD position available in the beautiful city of Leuven, Belgium, for building artificial nanomachines in lipid membranes.
Check out the details and apply here: www.kuleuven.be/personeel/jo...
Feel free to email me for more information!
Check out the details and apply here: www.kuleuven.be/personeel/jo...
Feel free to email me for more information!
Reposted by Joe Beckwith
Today we share our Collection on protocols describing how to build and operate a broad variety of microscopy setups.
Let us know which one is your favourite microscope?
🧪 🔬
Let us know which one is your favourite microscope?
🧪 🔬
Microscopy setup protocols
A collection of Protocols and Tutorials covering a range of microscopy approaches, and including the build of microscopy setups and the use of microscopy ...
bit.ly
April 17, 2025 at 9:32 AM
Today we share our Collection on protocols describing how to build and operate a broad variety of microscopy setups.
Let us know which one is your favourite microscope?
🧪 🔬
Let us know which one is your favourite microscope?
🧪 🔬
Reposted by Joe Beckwith
A fringe group of bigoted weirdos have dragged British media, government, and law into their hateful obsession with trans people. Grim, depressing, and dangerous. Everyone with power in the UK who's played along should be ashamed of themselves.
April 16, 2025 at 10:15 AM
A fringe group of bigoted weirdos have dragged British media, government, and law into their hateful obsession with trans people. Grim, depressing, and dangerous. Everyone with power in the UK who's played along should be ashamed of themselves.
Hi all---I sadly cannot make it to #FOM2025, would anybody want to take my registration? Feel free to ping me on here/forward to possibly interested people.
April 1, 2025 at 2:36 PM
Hi all---I sadly cannot make it to #FOM2025, would anybody want to take my registration? Feel free to ping me on here/forward to possibly interested people.
Reposted by Joe Beckwith
Just had the pleasure to experiment with a camera targeting the astronomy market, but offering great value for microscopy. Cooled, low noise (<1.5 e read-noise), high QE cameras that work with Micro-Manager can be bought for ~$1k: nicost.github.io/microscope-t...
PlayerOne cooled CMOS camera
The Sony STARVIS and STARVIS2 image sensors are back-illuminated, have high QE and low readnoise (where STARVIS2 increases full well depth over STARVIS). Even though these sensors are marketed towards...
nicost.github.io
March 29, 2025 at 12:56 AM
Just had the pleasure to experiment with a camera targeting the astronomy market, but offering great value for microscopy. Cooled, low noise (<1.5 e read-noise), high QE cameras that work with Micro-Manager can be bought for ~$1k: nicost.github.io/microscope-t...
Reposted by Joe Beckwith
Do you want to learn #BioimageAnalysis? Do you want to strengthen your skills?
We're thrilled to announce the #NEUBIAS Pasteur Course on Bioimage Analysis - May 2025! in @pasteur.fr Paris!
research.pasteur.fr/en/course/ne...
Details are on the page linked here, some info below 👇
We're thrilled to announce the #NEUBIAS Pasteur Course on Bioimage Analysis - May 2025! in @pasteur.fr Paris!
research.pasteur.fr/en/course/ne...
Details are on the page linked here, some info below 👇
NEUBIAS Pasteur course on Bioimage Analysis - 2025 - Research
Topics The exact schedule is still being finalized. Here is a description of the course content. Both tracks of the course have a specific focus on hands-on and interactive tutorials. They are meant t...
research.pasteur.fr
March 11, 2025 at 2:08 PM
Do you want to learn #BioimageAnalysis? Do you want to strengthen your skills?
We're thrilled to announce the #NEUBIAS Pasteur Course on Bioimage Analysis - May 2025! in @pasteur.fr Paris!
research.pasteur.fr/en/course/ne...
Details are on the page linked here, some info below 👇
We're thrilled to announce the #NEUBIAS Pasteur Course on Bioimage Analysis - May 2025! in @pasteur.fr Paris!
research.pasteur.fr/en/course/ne...
Details are on the page linked here, some info below 👇
Reposted by Joe Beckwith
Microscope objectives can be confusing, and detailed specs (or even basic properties) are often hard to find. Here's an introductory resource to help new builders and instrument designers with the basics. It's a work in progress so feedback is appreciated:
amsikking.github.io/microscope_o...
amsikking.github.io/microscope_o...
February 25, 2025 at 5:06 PM
Microscope objectives can be confusing, and detailed specs (or even basic properties) are often hard to find. Here's an introductory resource to help new builders and instrument designers with the basics. It's a work in progress so feedback is appreciated:
amsikking.github.io/microscope_o...
amsikking.github.io/microscope_o...
A bit late to the party, but we (Cambridge Queer in Chemistry Network) put up some posters of inspirational LGBT scientists for LGBT history month! With all that's going on, we hope it brings a little bit of joy. 🏳️🌈
February 17, 2025 at 3:41 PM
A bit late to the party, but we (Cambridge Queer in Chemistry Network) put up some posters of inspirational LGBT scientists for LGBT history month! With all that's going on, we hope it brings a little bit of joy. 🏳️🌈
Reposted by Joe Beckwith
Don't think the quiet part has ever been louder than in the "Palestinian refugees accidentally allowed into Ukrainian refugee program" story
February 13, 2025 at 8:06 AM
Don't think the quiet part has ever been louder than in the "Palestinian refugees accidentally allowed into Ukrainian refugee program" story