@joneslabucsf.bsky.social
We study stem cells- germline stem cells and intestinal stem cells- in different organisms to understand conserved mechanisms that regulate their behavior!
Reposted
This Nature study shows how aging slows protein cleanup in the brain, leading microglia to fill up with old synaptic proteins. Andrew Yang (BARI) contributed key methods to reveal it. Interesting for neurodegeneration research: pubmed.ncbi.nlm.nih.gov/41565824/ #neuroscience #brainaging
Ageing promotes microglial accumulation of slow-degrading synaptic proteins - PubMed
Neurodegenerative diseases affect 1 in 12 people globally and remain incurable. Central to their pathogenesis is a loss of neuronal protein maintenance and the accumulation of protein aggregates with ageing<sup>1,2</sup>. Here we engineered bioorthogonal tools<sup>3</sup> that enabled us to tag the …
pubmed.ncbi.nlm.nih.gov
February 10, 2026 at 11:58 PM
This Nature study shows how aging slows protein cleanup in the brain, leading microglia to fill up with old synaptic proteins. Andrew Yang (BARI) contributed key methods to reveal it. Interesting for neurodegeneration research: pubmed.ncbi.nlm.nih.gov/41565824/ #neuroscience #brainaging
Reposted
Big congrats to BARI’s Tien Peng on his latest review! Diving into how fibroblasts steer stem cell plasticity & metaplasia in fibrosis, super relevant for lung aging & disease. Read it here: pubmed.ncbi.nlm.nih.gov/40839781/
Fibroblast Modulation of Stem Cell Lineage Infidelity and Metaplasia in Tissue Fibrosis - PubMed
Epithelial stem cells are segregated on the basis of region-specific identities during homeostasis. However, tissue perturbations can induce remarkable plasticity in stem cells to adopt lineage identities outside their anatomical compartments. This phenomenon has been termed lineage infidelity or me …
pubmed.ncbi.nlm.nih.gov
February 5, 2026 at 10:34 PM
Big congrats to BARI’s Tien Peng on his latest review! Diving into how fibroblasts steer stem cell plasticity & metaplasia in fibrosis, super relevant for lung aging & disease. Read it here: pubmed.ncbi.nlm.nih.gov/40839781/
Reposted
Key review by BARI member Jean Nakamura: Low-does radiotherapy for nonmalignant issues has low carcinogenic risk, particularly in older populations where these ailments hit hardest. Age, dose, & genetics matter too, read more here: www.sciencedirect.com/science/arti...
Genetic and Carcinogenic Risks of Radiotherapy for Nonmalignant Diseases
Radiotherapy is a valuable treatment option for a variety of nonmalignant diseases. As the indications for low-dose radiotherapy to benign conditions …
www.sciencedirect.com
February 4, 2026 at 4:51 PM
Key review by BARI member Jean Nakamura: Low-does radiotherapy for nonmalignant issues has low carcinogenic risk, particularly in older populations where these ailments hit hardest. Age, dose, & genetics matter too, read more here: www.sciencedirect.com/science/arti...
Reposted
Insightful review by BARI member Aimee Kao & team connects development and aging through lysosomal dysfunction and neuronal vulnerability. They highlight how proteostatic stress in high-stress life stages can lead to lysosomal clearance disorders. www.sciencedirect.com/science/arti... #Neuroscience
The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases
In the last two decades, many gene mutations have been identified that when homozygous, lead to childhood neurological disorders, but when heterozygou…
www.sciencedirect.com
February 3, 2026 at 4:57 PM
Insightful review by BARI member Aimee Kao & team connects development and aging through lysosomal dysfunction and neuronal vulnerability. They highlight how proteostatic stress in high-stress life stages can lead to lysosomal clearance disorders. www.sciencedirect.com/science/arti... #Neuroscience
Reposted
Check out BARI member Su Guo’s @naturecomms paper where they uncover PCM1’s role in regulating daughter cell fate via centrosome-endosome interplay. www.nature.com/articles/s41... #neuroscience
PCM1 coordinates centrosome asymmetry with polarized endosome dynamics to regulate daughter cell fate - Nature Communications
Pcm1 bridges centrosome asymmetry and polarized endosome trafficking to regulate radial glia progenitor fate decisions, balancing self-renewal and differentiation in zebrafish and human cortical organ...
www.nature.com
January 30, 2026 at 6:32 PM
Check out BARI member Su Guo’s @naturecomms paper where they uncover PCM1’s role in regulating daughter cell fate via centrosome-endosome interplay. www.nature.com/articles/s41... #neuroscience
Reposted
Because of technical issues with the SciENcv website, NIH is extending a period of leniency accepting old format biosketches through May 2026 (see FAQ #5):
grants.nih.gov/faqs#/common...
grants.nih.gov/faqs#/common...
Frequently Asked Questions (FAQs) | Grants & Funding
grants.nih.gov
January 29, 2026 at 8:30 PM
Because of technical issues with the SciENcv website, NIH is extending a period of leniency accepting old format biosketches through May 2026 (see FAQ #5):
grants.nih.gov/faqs#/common...
grants.nih.gov/faqs#/common...
Reposted
Fascinating perspectives on aging science in Nature Aging! BARI’s Dena Dubal offers insights on real-world translation, plus input from two of our advisory board members Vera Gorbunova & George Kuchel. Inspiring read: www.nature.com/articles/s43... #Aging #Science
Past, present and future perspectives on the science of aging - Nature Aging
As Nature Aging celebrates its fifth anniversary, the journal asks some of the researchers who contributed to the journal early on to reflect on the past and the future of aging and age-related diseas...
www.nature.com
January 29, 2026 at 6:27 PM
Fascinating perspectives on aging science in Nature Aging! BARI’s Dena Dubal offers insights on real-world translation, plus input from two of our advisory board members Vera Gorbunova & George Kuchel. Inspiring read: www.nature.com/articles/s43... #Aging #Science
Reposted
Neil Risch and his BARI team have a paper out in AJHG: Predicted loss-of-function variants linked to serious diseases often don’t show up as expected in big biobanks. Why? Residual activity from the variant allele keeps some function going (leaky penetrance).
January 28, 2026 at 4:18 PM
Neil Risch and his BARI team have a paper out in AJHG: Predicted loss-of-function variants linked to serious diseases often don’t show up as expected in big biobanks. Why? Residual activity from the variant allele keeps some function going (leaky penetrance).
Reposted
UCSF has a cool article on BARI member Hao Li’s work. They found gene-regulating proteins that drop with age, slowing repair. Boosting them made old fibroblasts act young again and increasing EZH2 in mice rejuvenated livers. Read more here: www.ucsf.edu/news/2026/01...
Tissue Repair Slows in Old Age. These Proteins Speed It Back Up
UCSF scientists engineered old fibroblast cells to turn their genes on and off in the same way as young fibroblasts. The old fibroblasts were rejuvenated: they multiplied (green) and produced more of ...
www.ucsf.edu
January 22, 2026 at 6:39 PM
UCSF has a cool article on BARI member Hao Li’s work. They found gene-regulating proteins that drop with age, slowing repair. Boosting them made old fibroblasts act young again and increasing EZH2 in mice rejuvenated livers. Read more here: www.ucsf.edu/news/2026/01...
Reposted
Congrats to BARI’s Tamara Alliston on her latest paper in Osteoarthritis and Cartilage! They show loss of MMP13 in bone cells is protective against cartilage damage in injured jaw joints (TMJ), similar to effects seen in knees: www.oarsijournal.com/article/S106...
Osteocyte-Intrinsic MMP13 exacerbates injury-induced temporomandibular joint osteoarthritis
Cartilage in the knee and temporomandibular joint (TMJ) rely on subchondral bone for
joint homeostasis, whereby osteoarthritis (OA) causes degeneration. In the knee, suppression
of osteocytic perilacu...
www.oarsijournal.com
January 21, 2026 at 4:24 PM
Congrats to BARI’s Tamara Alliston on her latest paper in Osteoarthritis and Cartilage! They show loss of MMP13 in bone cells is protective against cartilage damage in injured jaw joints (TMJ), similar to effects seen in knees: www.oarsijournal.com/article/S106...
Reposted
What a whirlwind at #JPM2026! Grateful for the inspiring chats, new ideas, and connections that make this field so exciting. From BARI in SF: thanks for coming, safe travels home, and let’s keep pushing geroscience forward together! #agingresearch
January 16, 2026 at 5:22 PM
What a whirlwind at #JPM2026! Grateful for the inspiring chats, new ideas, and connections that make this field so exciting. From BARI in SF: thanks for coming, safe travels home, and let’s keep pushing geroscience forward together! #agingresearch
Reposted
What if lowering triglycerides could help you survive low oxygen and age better? New EMBO Reports from BARI member Dengke Ma & team explores this conserved mechanism: from arctic ground squirrel brain cells to C. elegans, reducing lipid biosynthesis protects mitochondria and extends life.
January 13, 2026 at 11:11 PM
What if lowering triglycerides could help you survive low oxygen and age better? New EMBO Reports from BARI member Dengke Ma & team explores this conserved mechanism: from arctic ground squirrel brain cells to C. elegans, reducing lipid biosynthesis protects mitochondria and extends life.
Reposted
Well done to Tien Peng and team – exciting new paper out in Cell Stem Cell! The study shows how certain senescent fibroblasts drive metabolic reprogramming in lung adenocarcinoma and demonstrates that targeting them with an HSP90 inhibitor shrinks tumors.
January 7, 2026 at 7:33 PM
Well done to Tien Peng and team – exciting new paper out in Cell Stem Cell! The study shows how certain senescent fibroblasts drive metabolic reprogramming in lung adenocarcinoma and demonstrates that targeting them with an HSP90 inhibitor shrinks tumors.
Reposted
Wishing you all a brilliant 2026 from everyone at BARI! May the new year bring discoveries that change the world by advancing aging research. See how we’re building on the past to make a great future in 2026 and beyond: www.nature.com/articles/d42... #2026 #Geroscience
January 2, 2026 at 9:45 PM
Wishing you all a brilliant 2026 from everyone at BARI! May the new year bring discoveries that change the world by advancing aging research. See how we’re building on the past to make a great future in 2026 and beyond: www.nature.com/articles/d42... #2026 #Geroscience
Reposted
Big congrats to BARI’s Xian Piao and her lab for their awesome paper in Neuron! They found that microglial ADGRG1 turns on MYC to make microglia more protective and better at clearing amyloid to keep neurons healthier in Alzheimer's models. Huge win for AD research! #Alzheimers #Neuroscience
December 23, 2025 at 9:42 PM
Big congrats to BARI’s Xian Piao and her lab for their awesome paper in Neuron! They found that microglial ADGRG1 turns on MYC to make microglia more protective and better at clearing amyloid to keep neurons healthier in Alzheimer's models. Huge win for AD research! #Alzheimers #Neuroscience
Reposted
BARI congratulates fellow UCSF aging scientist Lauren Hunt for winning the 2025 Terrie Fox Wetle Rising Star Award from AFAR! Using big data to make hospice & palliative care for dementia patients – such important work. BARI is cheering you on! #AgingResearch www.afar.org/news/afar-pl...
AFAR recognizes Lauren Hunt with 2025 Terrie Fox Wetle Rising Star Award in Health Services and Aging Research - American Federation for Aging Research
AFAR is pleased to announce the recipient of our 2025 Terrie Fox Wetle Rising Star Award in Health Services and Aging Research, Lauren Hunt, PhD, RN,
www.afar.org
December 22, 2025 at 5:39 PM
BARI congratulates fellow UCSF aging scientist Lauren Hunt for winning the 2025 Terrie Fox Wetle Rising Star Award from AFAR! Using big data to make hospice & palliative care for dementia patients – such important work. BARI is cheering you on! #AgingResearch www.afar.org/news/afar-pl...
Reposted
Exciting research from BARI member Ken Nakamura! Their study out in @ScienceAdvances shows for the first time in vivo, a better understanding of how mitochondrial dysfunction can lead to α-synuclein accumulation and neurodegeneration in Parkinson’s Disease. Check out the story here: bit.ly/4aWt4n4
CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology
A CHCHD2 mouse model of Parkinson’s disease exhibits mitochondrial disruption with a metabolic shift toward glycolysis.
www.science.org
December 19, 2025 at 4:34 PM
Exciting research from BARI member Ken Nakamura! Their study out in @ScienceAdvances shows for the first time in vivo, a better understanding of how mitochondrial dysfunction can lead to α-synuclein accumulation and neurodegeneration in Parkinson’s Disease. Check out the story here: bit.ly/4aWt4n4
Reposted
Huge congrats to Jarin Tusnim, postdoc in the Piao Lab at BARI, for her Cure Alzheimer's Fund grant! Jarin is exploring how ADGRG1 helps microglia stop tau from spreading, which could lead to boosting brain protection for new AD therapies. Great work Jarin! #Alzheimers #CureAlz bit.ly/4j79J4Q
Jarin Tusnim – Cure Alzheimer's Fund
Dr. Jarin Tusnim is a postdoctoral scholar in the Department of Pediatrics at the University of California, San Francisco (UCSF). She received her B.Sc.
curealz.org
December 19, 2025 at 5:59 PM
Huge congrats to Jarin Tusnim, postdoc in the Piao Lab at BARI, for her Cure Alzheimer's Fund grant! Jarin is exploring how ADGRG1 helps microglia stop tau from spreading, which could lead to boosting brain protection for new AD therapies. Great work Jarin! #Alzheimers #CureAlz bit.ly/4j79J4Q
Exciting work! Can't wait to read it!!
Ben-Hamo-Arad, Toledano et al. reveal that #Drosophila cyst cells exist in two functionally distinct subpopulations: transient escort cells derived from #StemCell divisions & long-lived steady cyst cells that persist at the testis apex & mediate phagoptosis rupress.org/jcb/article/...
December 16, 2025 at 6:21 PM
Exciting work! Can't wait to read it!!
Reposted
So proud of our research teams at BARI - @ucsanfrancisco.bsky.social now #2 globally in this year’s Nature Index for Aging! Excited to keep challenging what’s possible for healthier aging. Check out the full list: www.nature.com/nature-index... #BARI #UCSF #Geroscience
Leading 200 institutions in ageing | | Supplements | Nature Index
The Nature Index tracks the affiliations of high-quality scientific articles. Updated monthly, the Nature Index presents research outputs by institution and country. Use the Nature Index to interrogat...
www.nature.com
December 12, 2025 at 11:16 PM
So proud of our research teams at BARI - @ucsanfrancisco.bsky.social now #2 globally in this year’s Nature Index for Aging! Excited to keep challenging what’s possible for healthier aging. Check out the full list: www.nature.com/nature-index... #BARI #UCSF #Geroscience
Excited to continue to push the field forward with so many talented scientists and clinicians! Way to go UCSF🎉!
So proud of our research teams at BARI - @ucsanfrancisco.bsky.social now #2 globally in this year’s Nature Index for Aging! Excited to keep challenging what’s possible for healthier aging. Check out the full list: www.nature.com/nature-index... #BARI #UCSF #Geroscience
Leading 200 institutions in ageing | | Supplements | Nature Index
The Nature Index tracks the affiliations of high-quality scientific articles. Updated monthly, the Nature Index presents research outputs by institution and country. Use the Nature Index to interrogat...
www.nature.com
December 13, 2025 at 2:57 AM
Excited to continue to push the field forward with so many talented scientists and clinicians! Way to go UCSF🎉!
Excited to collaborate with @fusionconf.bsky.social again to highlight the most exciting advances in #Stemcell biology🧫🔬! Great opportunity for early career researchers to share their data and network with leaders in the field. Join us in Mexico🌴😎
November 11, 2025 at 4:58 PM
Excited to collaborate with @fusionconf.bsky.social again to highlight the most exciting advances in #Stemcell biology🧫🔬! Great opportunity for early career researchers to share their data and network with leaders in the field. Join us in Mexico🌴😎
Reposted
My department at Dartmouth Medical School is hiring a tenure-track Assistant Professor. We are looking broadly for a biochemist or cell biologist. Please share this add! apply.interfolio.com/171438
@dartmouthbcb.bsky.social @futurepislack.bsky.social
@dartmouthbcb.bsky.social @futurepislack.bsky.social
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
August 27, 2025 at 8:50 PM
My department at Dartmouth Medical School is hiring a tenure-track Assistant Professor. We are looking broadly for a biochemist or cell biologist. Please share this add! apply.interfolio.com/171438
@dartmouthbcb.bsky.social @futurepislack.bsky.social
@dartmouthbcb.bsky.social @futurepislack.bsky.social
Reposted
We have finally navigated the endless red tape and gotten the donation site to support the US FlyBase groups up and running.
bsky.app/profile/flyb...
bsky.app/profile/flyb...
FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...
FlyBase:Contribute to FlyBase - FlyBase Wiki
wiki.flybase.org
August 16, 2025 at 7:11 PM
We have finally navigated the endless red tape and gotten the donation site to support the US FlyBase groups up and running.
bsky.app/profile/flyb...
bsky.app/profile/flyb...
Reposted
If you are a researcher whose lab uses FlyBase, consider a tax-deductible personal contribution. A lot of $100 contributions would help bridge the gap until we can set up a user fee system, and even $10 donations send the folks there the message we're behind them. Please share
August 27, 2025 at 12:27 AM
If you are a researcher whose lab uses FlyBase, consider a tax-deductible personal contribution. A lot of $100 contributions would help bridge the gap until we can set up a user fee system, and even $10 donations send the folks there the message we're behind them. Please share