Bakar Aging Research Institute
@ucsfaging.bsky.social
In case you missed it: Diana Laird and her lab dropped this awesome Science paper. A deep dive comparing human and mouse ovaries over time, spotlighting conserved aging features to enhance our translational understanding. A major win for reproductive health! www.science.org/doi/epdf/10....
Comparative analysis of human and mouse ovaries across age
The mouse is a tractable model for human ovarian biology; however, its utility is limited by incomplete understanding of how transcription and signaling differ interspecifically and with age. We compa...
www.science.org
December 26, 2025 at 10:50 PM
In case you missed it: Diana Laird and her lab dropped this awesome Science paper. A deep dive comparing human and mouse ovaries over time, spotlighting conserved aging features to enhance our translational understanding. A major win for reproductive health! www.science.org/doi/epdf/10....
In case you missed it: BARI’s John Greenland and lab found frailty in lung transplant recipients links to shorter telomeres and anemia – but not epigenetic age or inflammation. Not all aging hallmarks hit equally! Read the interesting details here: www.amjtransplant.org/action/showP...
www.amjtransplant.org
December 26, 2025 at 8:53 PM
In case you missed it: BARI’s John Greenland and lab found frailty in lung transplant recipients links to shorter telomeres and anemia – but not epigenetic age or inflammation. Not all aging hallmarks hit equally! Read the interesting details here: www.amjtransplant.org/action/showP...
Big congrats to BARI’s Xian Piao and her lab for their awesome paper in Neuron! They found that microglial ADGRG1 turns on MYC to make microglia more protective and better at clearing amyloid to keep neurons healthier in Alzheimer's models. Huge win for AD research! #Alzheimers #Neuroscience
December 23, 2025 at 9:42 PM
Big congrats to BARI’s Xian Piao and her lab for their awesome paper in Neuron! They found that microglial ADGRG1 turns on MYC to make microglia more protective and better at clearing amyloid to keep neurons healthier in Alzheimer's models. Huge win for AD research! #Alzheimers #Neuroscience
BARI congratulates fellow UCSF aging scientist Lauren Hunt for winning the 2025 Terrie Fox Wetle Rising Star Award from AFAR! Using big data to make hospice & palliative care for dementia patients – such important work. BARI is cheering you on! #AgingResearch www.afar.org/news/afar-pl...
AFAR recognizes Lauren Hunt with 2025 Terrie Fox Wetle Rising Star Award in Health Services and Aging Research - American Federation for Aging Research
AFAR is pleased to announce the recipient of our 2025 Terrie Fox Wetle Rising Star Award in Health Services and Aging Research, Lauren Hunt, PhD, RN,
www.afar.org
December 22, 2025 at 5:39 PM
BARI congratulates fellow UCSF aging scientist Lauren Hunt for winning the 2025 Terrie Fox Wetle Rising Star Award from AFAR! Using big data to make hospice & palliative care for dementia patients – such important work. BARI is cheering you on! #AgingResearch www.afar.org/news/afar-pl...
Huge congrats to Jarin Tusnim, postdoc in the Piao Lab at BARI, for her Cure Alzheimer's Fund grant! Jarin is exploring how ADGRG1 helps microglia stop tau from spreading, which could lead to boosting brain protection for new AD therapies. Great work Jarin! #Alzheimers #CureAlz bit.ly/4j79J4Q
Jarin Tusnim – Cure Alzheimer's Fund
Dr. Jarin Tusnim is a postdoctoral scholar in the Department of Pediatrics at the University of California, San Francisco (UCSF). She received her B.Sc.
curealz.org
December 19, 2025 at 5:59 PM
Huge congrats to Jarin Tusnim, postdoc in the Piao Lab at BARI, for her Cure Alzheimer's Fund grant! Jarin is exploring how ADGRG1 helps microglia stop tau from spreading, which could lead to boosting brain protection for new AD therapies. Great work Jarin! #Alzheimers #CureAlz bit.ly/4j79J4Q
Exciting research from BARI member Ken Nakamura! Their study out in @ScienceAdvances shows for the first time in vivo, a better understanding of how mitochondrial dysfunction can lead to α-synuclein accumulation and neurodegeneration in Parkinson’s Disease. Check out the story here: bit.ly/4aWt4n4
CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology
A CHCHD2 mouse model of Parkinson’s disease exhibits mitochondrial disruption with a metabolic shift toward glycolysis.
www.science.org
December 19, 2025 at 4:34 PM
Exciting research from BARI member Ken Nakamura! Their study out in @ScienceAdvances shows for the first time in vivo, a better understanding of how mitochondrial dysfunction can lead to α-synuclein accumulation and neurodegeneration in Parkinson’s Disease. Check out the story here: bit.ly/4aWt4n4
So proud of our research teams at BARI - @ucsanfrancisco.bsky.social now #2 globally in this year’s Nature Index for Aging! Excited to keep challenging what’s possible for healthier aging. Check out the full list: www.nature.com/nature-index... #BARI #UCSF #Geroscience
Leading 200 institutions in ageing | | Supplements | Nature Index
The Nature Index tracks the affiliations of high-quality scientific articles. Updated monthly, the Nature Index presents research outputs by institution and country. Use the Nature Index to interrogat...
www.nature.com
December 12, 2025 at 11:16 PM
So proud of our research teams at BARI - @ucsanfrancisco.bsky.social now #2 globally in this year’s Nature Index for Aging! Excited to keep challenging what’s possible for healthier aging. Check out the full list: www.nature.com/nature-index... #BARI #UCSF #Geroscience
Reposted by Bakar Aging Research Institute
Been working on a really strange retron bacterial immune system, here's the preprint: www.biorxiv.org/content/10.1...
Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.
Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.
October 23, 2025 at 6:49 PM
Been working on a really strange retron bacterial immune system, here's the preprint: www.biorxiv.org/content/10.1...
Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.
Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.
Nancy Allen and Tien Peng's study reveals that age-dependent NF-kB activation in tissue fibroblasts contributes to #inflammaging by remodeling immune architecture and promoting exhausted T cell populations. bit.ly/4qlIR4k
October 17, 2025 at 7:17 PM
Nancy Allen and Tien Peng's study reveals that age-dependent NF-kB activation in tissue fibroblasts contributes to #inflammaging by remodeling immune architecture and promoting exhausted T cell populations. bit.ly/4qlIR4k
Kate Cavanaugh and Orion Weiner's research out now on @biorxivpreprint.bsky.social identifies a mechanical defect in embryos from aged mothers that impairs implantation. These findings could enhance embryo selection in Assisted #Reproductive Technologies. bit.ly/47tY7V8
October 17, 2025 at 6:59 PM
Kate Cavanaugh and Orion Weiner's research out now on @biorxivpreprint.bsky.social identifies a mechanical defect in embryos from aged mothers that impairs implantation. These findings could enhance embryo selection in Assisted #Reproductive Technologies. bit.ly/47tY7V8
Reposted by Bakar Aging Research Institute
In our October issue: Ferritin light chain 1 (FTL1), an iron-associated protein, is a pro-aging neuronal factor that increases with age and promotes cognitive decline. Targeting FTL1 in the brain improved cognition in old mice @VilledaLab @ucsfaging.bsky.social @UCSF www.nature.com/articles/s43...
Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment - Nature Aging
The authors identify ferritin light chain 1 (FTL1), an iron-associated protein, as a pro-aging neuronal factor that increases with age and promotes cognitive decline. Targeting FTL1 in the brain impro...
www.nature.com
October 16, 2025 at 3:42 PM
In our October issue: Ferritin light chain 1 (FTL1), an iron-associated protein, is a pro-aging neuronal factor that increases with age and promotes cognitive decline. Targeting FTL1 in the brain improved cognition in old mice @VilledaLab @ucsfaging.bsky.social @UCSF www.nature.com/articles/s43...
Sara LaHue, @geriscidoc.bsky.social, and others published in @geroscience.bsky.social an interdisciplinary effort to identify longitudinal transcriptomic changes in adults with #delirium hospitalized with #COVID-19. bit.ly/4o8wMO7
Delirium in hospitalized COVID-19 patients is associated with dynamic changes in peripheral immune gene expression - PubMed
Delirium is a neurologic syndrome characterized by inattention and cognitive impairment frequently encountered in medically ill older adults. As a hallmark of age-related brain vulnerability, delirium...
bit.ly
September 24, 2025 at 11:09 PM
Sara LaHue, @geriscidoc.bsky.social, and others published in @geroscience.bsky.social an interdisciplinary effort to identify longitudinal transcriptomic changes in adults with #delirium hospitalized with #COVID-19. bit.ly/4o8wMO7
A recent manuscript published in @jclinical-invest.bsky.social led by Preeti Yadav from Mallar Bhattacharya's lab in collaboration with other BARI colleagues identifies an #immune-mesenchymal circuit that fuels fibrotic metabolism in #lung_fibrosis. bit.ly/4gmuiZM
bit.ly
September 9, 2025 at 7:07 PM
A recent manuscript published in @jclinical-invest.bsky.social led by Preeti Yadav from Mallar Bhattacharya's lab in collaboration with other BARI colleagues identifies an #immune-mesenchymal circuit that fuels fibrotic metabolism in #lung_fibrosis. bit.ly/4gmuiZM
Check out the recent publication by Ken Nakamura's Lab in @elife.bsky.social!
🚨 New Publication 🚨 "Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration" in @elife.bsky.social.
Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration
Following chronic hyperactivation using chemogenetics, vulnerable substantia nigra dopamine neurons display progressive degeneration unlike neighboring ventral tegmental area dopamine neurons.
bit.ly
September 3, 2025 at 6:56 PM
Check out the recent publication by Ken Nakamura's Lab in @elife.bsky.social!
Reposted by Bakar Aging Research Institute
A new study, led by Kushal (Berkeley), Nicole&Victoria (UCSF) in full collaboration with @karthikshekhar.bsky.social, "Molecular and spatial analysis of ganglion cells on retinal flatmounts identifies perivascular neurons resilient to glaucoma" sciencedirect.com/science/arti... #retina #MERFISH
August 20, 2025 at 4:06 PM
A new study, led by Kushal (Berkeley), Nicole&Victoria (UCSF) in full collaboration with @karthikshekhar.bsky.social, "Molecular and spatial analysis of ganglion cells on retinal flatmounts identifies perivascular neurons resilient to glaucoma" sciencedirect.com/science/arti... #retina #MERFISH
A recent manuscript published in @nataging.nature.com by Laura Remesal Gomez and the Villeda Lab identifies ferritin light chain 1 (FTL1) as a pro-aging neuronal factor that impairs #cognition, and as a potential target for cognitive #rejuvenation. Link to manuscript here: bit.ly/4lG46dp #GeroSky
Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment - Nature Aging
The authors identify ferritin light chain 1 (FTL1), an iron-associated protein, as a pro-aging neuronal factor that increases with age and promotes cognitive decline. Targeting FTL1 in the brain impro...
bit.ly
August 25, 2025 at 4:35 PM
A recent manuscript published in @nataging.nature.com by Laura Remesal Gomez and the Villeda Lab identifies ferritin light chain 1 (FTL1) as a pro-aging neuronal factor that impairs #cognition, and as a potential target for cognitive #rejuvenation. Link to manuscript here: bit.ly/4lG46dp #GeroSky
How do tumor cells co-opt neighboring #adipocytes to promote #tumorigenesis? @andreigoga.bsky.social and colleagues identify a direct tumor cell-adipocyte interaction that activates lipolysis in triple negative breast cancer models. #SciSky #GeroSky bit.ly/4mRZYYN @natureportfolio.nature.com
Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis - Nature Communications
Breast cancer cells interact with neighbouring adipocytes, but the mechanisms are not fully understood. Here, the authors show that triple-negative breast cancer (TNBC) cells transfer cAMP through gap...
bit.ly
August 21, 2025 at 6:09 PM
How do tumor cells co-opt neighboring #adipocytes to promote #tumorigenesis? @andreigoga.bsky.social and colleagues identify a direct tumor cell-adipocyte interaction that activates lipolysis in triple negative breast cancer models. #SciSky #GeroSky bit.ly/4mRZYYN @natureportfolio.nature.com
Reposted by Bakar Aging Research Institute
Our latest on cancer metabolism by star student Tonatiuh Montoya @ctbatucsf.bsky.social @ucsfcancer.bsky.social
Liver cancers driven by the MYC oncogene are reliant on alanine metabolism. Alanine is the second most abundant amino acid and can partially substitute for glucose and glutamine. 🧪
Liver cancers driven by the MYC oncogene are reliant on alanine metabolism. Alanine is the second most abundant amino acid and can partially substitute for glucose and glutamine. 🧪
Alanine Catabolism as a Targetable Vulnerability for MYC-Driven Liver Cancer
Liver cancer is a leading cause of cancer-related death world-wide in part due to the shortage of effective therapies, and MYC overexpression defines an aggressive and especially difficult to treat su...
www.biorxiv.org
August 1, 2025 at 8:27 PM
Our latest on cancer metabolism by star student Tonatiuh Montoya @ctbatucsf.bsky.social @ucsfcancer.bsky.social
Liver cancers driven by the MYC oncogene are reliant on alanine metabolism. Alanine is the second most abundant amino acid and can partially substitute for glucose and glutamine. 🧪
Liver cancers driven by the MYC oncogene are reliant on alanine metabolism. Alanine is the second most abundant amino acid and can partially substitute for glucose and glutamine. 🧪
Interesting work from Xianhua Piao, MD, PhD on the interplay between G-protein-coupled receptor, ADGRG1, and MYC activation to promote a protective microglial state in a 5xFAD mouse model. Manuscript here: bit.ly/3HhtmbP
G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation
Microglial ADGRG1 drives a protective state in Alzheimer’s disease by activating the
transcription factor MYC, which upregulates genes associated with homeostasis, phagocytosis,
and lysosomal function...
bit.ly
August 1, 2025 at 6:41 PM
Interesting work from Xianhua Piao, MD, PhD on the interplay between G-protein-coupled receptor, ADGRG1, and MYC activation to promote a protective microglial state in a 5xFAD mouse model. Manuscript here: bit.ly/3HhtmbP
Anudari Letian and the Goldberg Lab investigated how #neutrophils acquire #lipids from their environment and how this influences their functionality. Neutrophil-deficient mice showed protection against #atherosclerosis. Check on the article on bioRxiv here: bit.ly/3H9E3x5
Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth
Neutrophils are short-lived cells that are produced by the billions every day to circulate throughout the body and surveil all tissues. They are a key component of the innate immune system that play e...
bit.ly
July 28, 2025 at 8:45 PM
Anudari Letian and the Goldberg Lab investigated how #neutrophils acquire #lipids from their environment and how this influences their functionality. Neutrophil-deficient mice showed protection against #atherosclerosis. Check on the article on bioRxiv here: bit.ly/3H9E3x5
We are thrilled to announce the awardees of our postdoctoral fellowships! Please join us in congratulating Ting Gong, @marioruizperez.bsky.social, Claire Huguenard, PhD, Hayden Holmlund, and Michaelangelo Gonzatti. 🎉
July 9, 2025 at 8:58 PM
We are thrilled to announce the awardees of our postdoctoral fellowships! Please join us in congratulating Ting Gong, @marioruizperez.bsky.social, Claire Huguenard, PhD, Hayden Holmlund, and Michaelangelo Gonzatti. 🎉
📣 We are thrilled to announce @denadubal.bsky.social is joining our Executive Committee! Dr. Dubal's research investigates the molecular mechanisms of #aging, #resilience, and #neurodegenerative_disease. #SciSky #GeroSky
June 13, 2025 at 10:24 PM
📣 We are thrilled to announce @denadubal.bsky.social is joining our Executive Committee! Dr. Dubal's research investigates the molecular mechanisms of #aging, #resilience, and #neurodegenerative_disease. #SciSky #GeroSky
Intriguing work by @rushika-perera.bsky.social identifies #PCSK9 as a driver of metastatic growth in #pancreatic ductal adenocarcinoma. Published in @nature.com. #SciSky go.nature.com/4ksf5Y1
PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer - Nature
PCSK9 regulates low density lipoprotein-cholesterol import and determines organ preference of metastatic pancreatic ductal adenocarcinoma, with PCSK9-low cells metastasizing to the liver and PCSK9-hig...
go.nature.com
June 6, 2025 at 10:46 PM
Intriguing work by @rushika-perera.bsky.social identifies #PCSK9 as a driver of metastatic growth in #pancreatic ductal adenocarcinoma. Published in @nature.com. #SciSky go.nature.com/4ksf5Y1
A collaboration between Mallar Bhattacharya and Paul Wolters shows that in a mouse model of IPF, early AT2 cell transdifferentiation and senescence is driven by enhanced p53 activity in response to #DNA damage. Out now on @biorxivpreprint.bsky.social: bit.ly/4dJG6DN #GeroSky #SciSky
Cellular profiling identifies an early profibrotic alveolar type 2 cell signature in lung fibrosis
Rationale Idiopathic pulmonary fibrosis (IPF) is a progressive, age-associated, lung disease characterized by short telomeres in alveolar type 2 (AT2) cells, epithelial remodeling, and fibrosis.
Obje...
bit.ly
June 2, 2025 at 5:21 PM
A collaboration between Mallar Bhattacharya and Paul Wolters shows that in a mouse model of IPF, early AT2 cell transdifferentiation and senescence is driven by enhanced p53 activity in response to #DNA damage. Out now on @biorxivpreprint.bsky.social: bit.ly/4dJG6DN #GeroSky #SciSky