Bakar Aging Research Institute
@ucsfaging.bsky.social
Reposted by Bakar Aging Research Institute
Been working on a really strange retron bacterial immune system, here's the preprint: www.biorxiv.org/content/10.1...
Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.
Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.
October 23, 2025 at 6:49 PM
Been working on a really strange retron bacterial immune system, here's the preprint: www.biorxiv.org/content/10.1...
Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.
Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.
Nancy Allen and Tien Peng's study reveals that age-dependent NF-kB activation in tissue fibroblasts contributes to #inflammaging by remodeling immune architecture and promoting exhausted T cell populations. bit.ly/4qlIR4k
October 17, 2025 at 7:17 PM
Nancy Allen and Tien Peng's study reveals that age-dependent NF-kB activation in tissue fibroblasts contributes to #inflammaging by remodeling immune architecture and promoting exhausted T cell populations. bit.ly/4qlIR4k
Kate Cavanaugh and Orion Weiner's research out now on @biorxivpreprint.bsky.social identifies a mechanical defect in embryos from aged mothers that impairs implantation. These findings could enhance embryo selection in Assisted #Reproductive Technologies. bit.ly/47tY7V8
October 17, 2025 at 6:59 PM
Kate Cavanaugh and Orion Weiner's research out now on @biorxivpreprint.bsky.social identifies a mechanical defect in embryos from aged mothers that impairs implantation. These findings could enhance embryo selection in Assisted #Reproductive Technologies. bit.ly/47tY7V8
Reposted by Bakar Aging Research Institute
In our October issue: Ferritin light chain 1 (FTL1), an iron-associated protein, is a pro-aging neuronal factor that increases with age and promotes cognitive decline. Targeting FTL1 in the brain improved cognition in old mice @VilledaLab @ucsfaging.bsky.social @UCSF www.nature.com/articles/s43...
Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment - Nature Aging
The authors identify ferritin light chain 1 (FTL1), an iron-associated protein, as a pro-aging neuronal factor that increases with age and promotes cognitive decline. Targeting FTL1 in the brain impro...
www.nature.com
October 16, 2025 at 3:42 PM
In our October issue: Ferritin light chain 1 (FTL1), an iron-associated protein, is a pro-aging neuronal factor that increases with age and promotes cognitive decline. Targeting FTL1 in the brain improved cognition in old mice @VilledaLab @ucsfaging.bsky.social @UCSF www.nature.com/articles/s43...
Sara LaHue, @geriscidoc.bsky.social, and others published in @geroscience.bsky.social an interdisciplinary effort to identify longitudinal transcriptomic changes in adults with #delirium hospitalized with #COVID-19. bit.ly/4o8wMO7
Delirium in hospitalized COVID-19 patients is associated with dynamic changes in peripheral immune gene expression - PubMed
Delirium is a neurologic syndrome characterized by inattention and cognitive impairment frequently encountered in medically ill older adults. As a hallmark of age-related brain vulnerability, delirium...
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September 24, 2025 at 11:09 PM
Sara LaHue, @geriscidoc.bsky.social, and others published in @geroscience.bsky.social an interdisciplinary effort to identify longitudinal transcriptomic changes in adults with #delirium hospitalized with #COVID-19. bit.ly/4o8wMO7
A recent manuscript published in @jclinical-invest.bsky.social led by Preeti Yadav from Mallar Bhattacharya's lab in collaboration with other BARI colleagues identifies an #immune-mesenchymal circuit that fuels fibrotic metabolism in #lung_fibrosis. bit.ly/4gmuiZM
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September 9, 2025 at 7:07 PM
A recent manuscript published in @jclinical-invest.bsky.social led by Preeti Yadav from Mallar Bhattacharya's lab in collaboration with other BARI colleagues identifies an #immune-mesenchymal circuit that fuels fibrotic metabolism in #lung_fibrosis. bit.ly/4gmuiZM
Check out the recent publication by Ken Nakamura's Lab in @elife.bsky.social!
🚨 New Publication 🚨 "Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration" in @elife.bsky.social.
Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration
Following chronic hyperactivation using chemogenetics, vulnerable substantia nigra dopamine neurons display progressive degeneration unlike neighboring ventral tegmental area dopamine neurons.
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September 3, 2025 at 6:56 PM
Check out the recent publication by Ken Nakamura's Lab in @elife.bsky.social!
Reposted by Bakar Aging Research Institute
A new study, led by Kushal (Berkeley), Nicole&Victoria (UCSF) in full collaboration with @karthikshekhar.bsky.social, "Molecular and spatial analysis of ganglion cells on retinal flatmounts identifies perivascular neurons resilient to glaucoma" sciencedirect.com/science/arti... #retina #MERFISH
August 20, 2025 at 4:06 PM
A new study, led by Kushal (Berkeley), Nicole&Victoria (UCSF) in full collaboration with @karthikshekhar.bsky.social, "Molecular and spatial analysis of ganglion cells on retinal flatmounts identifies perivascular neurons resilient to glaucoma" sciencedirect.com/science/arti... #retina #MERFISH
A recent manuscript published in @nataging.nature.com by Laura Remesal Gomez and the Villeda Lab identifies ferritin light chain 1 (FTL1) as a pro-aging neuronal factor that impairs #cognition, and as a potential target for cognitive #rejuvenation. Link to manuscript here: bit.ly/4lG46dp #GeroSky
Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment - Nature Aging
The authors identify ferritin light chain 1 (FTL1), an iron-associated protein, as a pro-aging neuronal factor that increases with age and promotes cognitive decline. Targeting FTL1 in the brain impro...
bit.ly
August 25, 2025 at 4:35 PM
A recent manuscript published in @nataging.nature.com by Laura Remesal Gomez and the Villeda Lab identifies ferritin light chain 1 (FTL1) as a pro-aging neuronal factor that impairs #cognition, and as a potential target for cognitive #rejuvenation. Link to manuscript here: bit.ly/4lG46dp #GeroSky
How do tumor cells co-opt neighboring #adipocytes to promote #tumorigenesis? @andreigoga.bsky.social and colleagues identify a direct tumor cell-adipocyte interaction that activates lipolysis in triple negative breast cancer models. #SciSky #GeroSky bit.ly/4mRZYYN @natureportfolio.nature.com
Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis - Nature Communications
Breast cancer cells interact with neighbouring adipocytes, but the mechanisms are not fully understood. Here, the authors show that triple-negative breast cancer (TNBC) cells transfer cAMP through gap...
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August 21, 2025 at 6:09 PM
How do tumor cells co-opt neighboring #adipocytes to promote #tumorigenesis? @andreigoga.bsky.social and colleagues identify a direct tumor cell-adipocyte interaction that activates lipolysis in triple negative breast cancer models. #SciSky #GeroSky bit.ly/4mRZYYN @natureportfolio.nature.com
Reposted by Bakar Aging Research Institute
Our latest on cancer metabolism by star student Tonatiuh Montoya @ctbatucsf.bsky.social @ucsfcancer.bsky.social
Liver cancers driven by the MYC oncogene are reliant on alanine metabolism. Alanine is the second most abundant amino acid and can partially substitute for glucose and glutamine. 🧪
Liver cancers driven by the MYC oncogene are reliant on alanine metabolism. Alanine is the second most abundant amino acid and can partially substitute for glucose and glutamine. 🧪
Alanine Catabolism as a Targetable Vulnerability for MYC-Driven Liver Cancer
Liver cancer is a leading cause of cancer-related death world-wide in part due to the shortage of effective therapies, and MYC overexpression defines an aggressive and especially difficult to treat su...
www.biorxiv.org
August 1, 2025 at 8:27 PM
Our latest on cancer metabolism by star student Tonatiuh Montoya @ctbatucsf.bsky.social @ucsfcancer.bsky.social
Liver cancers driven by the MYC oncogene are reliant on alanine metabolism. Alanine is the second most abundant amino acid and can partially substitute for glucose and glutamine. 🧪
Liver cancers driven by the MYC oncogene are reliant on alanine metabolism. Alanine is the second most abundant amino acid and can partially substitute for glucose and glutamine. 🧪
Interesting work from Xianhua Piao, MD, PhD on the interplay between G-protein-coupled receptor, ADGRG1, and MYC activation to promote a protective microglial state in a 5xFAD mouse model. Manuscript here: bit.ly/3HhtmbP
G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation
Microglial ADGRG1 drives a protective state in Alzheimer’s disease by activating the
transcription factor MYC, which upregulates genes associated with homeostasis, phagocytosis,
and lysosomal function...
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August 1, 2025 at 6:41 PM
Interesting work from Xianhua Piao, MD, PhD on the interplay between G-protein-coupled receptor, ADGRG1, and MYC activation to promote a protective microglial state in a 5xFAD mouse model. Manuscript here: bit.ly/3HhtmbP
Anudari Letian and the Goldberg Lab investigated how #neutrophils acquire #lipids from their environment and how this influences their functionality. Neutrophil-deficient mice showed protection against #atherosclerosis. Check on the article on bioRxiv here: bit.ly/3H9E3x5
Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth
Neutrophils are short-lived cells that are produced by the billions every day to circulate throughout the body and surveil all tissues. They are a key component of the innate immune system that play e...
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July 28, 2025 at 8:45 PM
Anudari Letian and the Goldberg Lab investigated how #neutrophils acquire #lipids from their environment and how this influences their functionality. Neutrophil-deficient mice showed protection against #atherosclerosis. Check on the article on bioRxiv here: bit.ly/3H9E3x5
We are thrilled to announce the awardees of our postdoctoral fellowships! Please join us in congratulating Ting Gong, @marioruizperez.bsky.social, Claire Huguenard, PhD, Hayden Holmlund, and Michaelangelo Gonzatti. 🎉
July 9, 2025 at 8:58 PM
We are thrilled to announce the awardees of our postdoctoral fellowships! Please join us in congratulating Ting Gong, @marioruizperez.bsky.social, Claire Huguenard, PhD, Hayden Holmlund, and Michaelangelo Gonzatti. 🎉
📣 We are thrilled to announce @denadubal.bsky.social is joining our Executive Committee! Dr. Dubal's research investigates the molecular mechanisms of #aging, #resilience, and #neurodegenerative_disease. #SciSky #GeroSky
June 13, 2025 at 10:24 PM
📣 We are thrilled to announce @denadubal.bsky.social is joining our Executive Committee! Dr. Dubal's research investigates the molecular mechanisms of #aging, #resilience, and #neurodegenerative_disease. #SciSky #GeroSky
Intriguing work by @rushika-perera.bsky.social identifies #PCSK9 as a driver of metastatic growth in #pancreatic ductal adenocarcinoma. Published in @nature.com. #SciSky go.nature.com/4ksf5Y1
PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer - Nature
PCSK9 regulates low density lipoprotein-cholesterol import and determines organ preference of metastatic pancreatic ductal adenocarcinoma, with PCSK9-low cells metastasizing to the liver and PCSK9-hig...
go.nature.com
June 6, 2025 at 10:46 PM
Intriguing work by @rushika-perera.bsky.social identifies #PCSK9 as a driver of metastatic growth in #pancreatic ductal adenocarcinoma. Published in @nature.com. #SciSky go.nature.com/4ksf5Y1
A collaboration between Mallar Bhattacharya and Paul Wolters shows that in a mouse model of IPF, early AT2 cell transdifferentiation and senescence is driven by enhanced p53 activity in response to #DNA damage. Out now on @biorxivpreprint.bsky.social: bit.ly/4dJG6DN #GeroSky #SciSky
Cellular profiling identifies an early profibrotic alveolar type 2 cell signature in lung fibrosis
Rationale Idiopathic pulmonary fibrosis (IPF) is a progressive, age-associated, lung disease characterized by short telomeres in alveolar type 2 (AT2) cells, epithelial remodeling, and fibrosis.
Obje...
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June 2, 2025 at 5:21 PM
A collaboration between Mallar Bhattacharya and Paul Wolters shows that in a mouse model of IPF, early AT2 cell transdifferentiation and senescence is driven by enhanced p53 activity in response to #DNA damage. Out now on @biorxivpreprint.bsky.social: bit.ly/4dJG6DN #GeroSky #SciSky
@nadavahituv.bsky.social and colleagues use a massively parallel jumping assay to assess the ability of retrotransposons to jump and identify nucleotide changes that have the potential to reactivate them in their latest manuscript published in @natcomms.nature.com. go.nature.com/4k7pqIK
Massively parallel jumping assay decodes Alu retrotransposition activity - Nature Communications
Here, the authors develop a high-throughput assay to measure the jumping potential of thousands of transposons in parallel.
go.nature.com
May 23, 2025 at 4:35 PM
@nadavahituv.bsky.social and colleagues use a massively parallel jumping assay to assess the ability of retrotransposons to jump and identify nucleotide changes that have the potential to reactivate them in their latest manuscript published in @natcomms.nature.com. go.nature.com/4k7pqIK
Frailty in lung transplant patients is linked to anemia and telomere dysfunction. A study by John Greenland found that epigenetic aging correlated with chronological age, and not with frailty, highlighting the importance of telomere dysfunction and anemia in this patient population. bit.ly/4mvBgyi
Frailty in lung transplant recipients is associated with anemia and telomere dysfunction but independent of epigenetic age
Frailty is a syndrome of vulnerability to stressors linked to worse outcomes pre- and post-lung transplantation. However, the biological basis of this…
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May 20, 2025 at 7:40 PM
Frailty in lung transplant patients is linked to anemia and telomere dysfunction. A study by John Greenland found that epigenetic aging correlated with chronological age, and not with frailty, highlighting the importance of telomere dysfunction and anemia in this patient population. bit.ly/4mvBgyi
Our morning concluded with a few more trainee talks and another keynote speaker, Dr. Beth Stevens. #microglial #CNS #inflammation #aging
April 14, 2025 at 8:42 PM
Our morning concluded with a few more trainee talks and another keynote speaker, Dr. Beth Stevens. #microglial #CNS #inflammation #aging
Today is a special day! It's our second BARI symposium at the de Young Museum in the beautiful Golden Gate Park.
April 14, 2025 at 4:10 PM
Today is a special day! It's our second BARI symposium at the de Young Museum in the beautiful Golden Gate Park.
Could a reawakening of the silenced X chromosome in females help slow aging-induced cognitive decline? Check out the work by @denadubal.bsky.social along with colleagues Kaitlin Casaletto, Bérénice Benayoun, and Vijay Ramani in Science Advances: bit.ly/3FlN3hj #GeroSky #SciSky
Aging activates escape of the silent X chromosome in the female mouse hippocampus
Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.
www.science.org
March 11, 2025 at 5:41 PM
Could a reawakening of the silenced X chromosome in females help slow aging-induced cognitive decline? Check out the work by @denadubal.bsky.social along with colleagues Kaitlin Casaletto, Bérénice Benayoun, and Vijay Ramani in Science Advances: bit.ly/3FlN3hj #GeroSky #SciSky
Research from Isha Jain and colleagues published in @cellpress.bsky.social shows that HypoxyStat can prevent or reverse mitochondrial disease in a preclinical mouse model. The study suggests potential transformations in therapeutic strategy for treating other mitochondrial disorders. bit.ly/4kh0csc
HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity
A small molecule that increases oxygen-hemoglobin affinity was shown to prevent and
reverse pathology in a mouse model of mitochondrial disease, thereby enabling a practical
form of hypoxia therapy.
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February 25, 2025 at 6:51 PM
Research from Isha Jain and colleagues published in @cellpress.bsky.social shows that HypoxyStat can prevent or reverse mitochondrial disease in a preclinical mouse model. The study suggests potential transformations in therapeutic strategy for treating other mitochondrial disorders. bit.ly/4kh0csc