Bakar Aging Research Institute
@ucsfaging.bsky.social
BARI spotlight: Dr. Martin Kampmann leads Cell study using CRISPR in iPSC neurons to decode tau handling, spotting ways to block toxic buildup in age-related diseases like Alzheimer’s. Read the article here: www.cell.com/cell/fulltex...
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4
ubiquitinates tau, that CUL5 expression is correlated with resilience in human Alzheimer’s
disease, and that electr...
www.cell.com
February 12, 2026 at 4:32 PM
BARI spotlight: Dr. Martin Kampmann leads Cell study using CRISPR in iPSC neurons to decode tau handling, spotting ways to block toxic buildup in age-related diseases like Alzheimer’s. Read the article here: www.cell.com/cell/fulltex...
This Nature study shows how aging slows protein cleanup in the brain, leading microglia to fill up with old synaptic proteins. Andrew Yang (BARI) contributed key methods to reveal it. Interesting for neurodegeneration research: pubmed.ncbi.nlm.nih.gov/41565824/ #neuroscience #brainaging
Ageing promotes microglial accumulation of slow-degrading synaptic proteins - PubMed
Neurodegenerative diseases affect 1 in 12 people globally and remain incurable. Central to their pathogenesis is a loss of neuronal protein maintenance and the accumulation of protein aggregates with ageing<sup>1,2</sup>. Here we engineered bioorthogonal tools<sup>3</sup> that enabled us to tag the …
pubmed.ncbi.nlm.nih.gov
February 10, 2026 at 11:58 PM
This Nature study shows how aging slows protein cleanup in the brain, leading microglia to fill up with old synaptic proteins. Andrew Yang (BARI) contributed key methods to reveal it. Interesting for neurodegeneration research: pubmed.ncbi.nlm.nih.gov/41565824/ #neuroscience #brainaging
Big congrats to BARI’s Tien Peng on his latest review! Diving into how fibroblasts steer stem cell plasticity & metaplasia in fibrosis, super relevant for lung aging & disease. Read it here: pubmed.ncbi.nlm.nih.gov/40839781/
Fibroblast Modulation of Stem Cell Lineage Infidelity and Metaplasia in Tissue Fibrosis - PubMed
Epithelial stem cells are segregated on the basis of region-specific identities during homeostasis. However, tissue perturbations can induce remarkable plasticity in stem cells to adopt lineage identities outside their anatomical compartments. This phenomenon has been termed lineage infidelity or me …
pubmed.ncbi.nlm.nih.gov
February 5, 2026 at 10:34 PM
Big congrats to BARI’s Tien Peng on his latest review! Diving into how fibroblasts steer stem cell plasticity & metaplasia in fibrosis, super relevant for lung aging & disease. Read it here: pubmed.ncbi.nlm.nih.gov/40839781/
Key review by BARI member Jean Nakamura: Low-does radiotherapy for nonmalignant issues has low carcinogenic risk, particularly in older populations where these ailments hit hardest. Age, dose, & genetics matter too, read more here: www.sciencedirect.com/science/arti...
Genetic and Carcinogenic Risks of Radiotherapy for Nonmalignant Diseases
Radiotherapy is a valuable treatment option for a variety of nonmalignant diseases. As the indications for low-dose radiotherapy to benign conditions …
www.sciencedirect.com
February 4, 2026 at 4:51 PM
Key review by BARI member Jean Nakamura: Low-does radiotherapy for nonmalignant issues has low carcinogenic risk, particularly in older populations where these ailments hit hardest. Age, dose, & genetics matter too, read more here: www.sciencedirect.com/science/arti...
Insightful review by BARI member Aimee Kao & team connects development and aging through lysosomal dysfunction and neuronal vulnerability. They highlight how proteostatic stress in high-stress life stages can lead to lysosomal clearance disorders. www.sciencedirect.com/science/arti... #Neuroscience
The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases
In the last two decades, many gene mutations have been identified that when homozygous, lead to childhood neurological disorders, but when heterozygou…
www.sciencedirect.com
February 3, 2026 at 4:57 PM
Insightful review by BARI member Aimee Kao & team connects development and aging through lysosomal dysfunction and neuronal vulnerability. They highlight how proteostatic stress in high-stress life stages can lead to lysosomal clearance disorders. www.sciencedirect.com/science/arti... #Neuroscience
Check out BARI member Su Guo’s @naturecomms paper where they uncover PCM1’s role in regulating daughter cell fate via centrosome-endosome interplay. www.nature.com/articles/s41... #neuroscience
PCM1 coordinates centrosome asymmetry with polarized endosome dynamics to regulate daughter cell fate - Nature Communications
Pcm1 bridges centrosome asymmetry and polarized endosome trafficking to regulate radial glia progenitor fate decisions, balancing self-renewal and differentiation in zebrafish and human cortical organ...
www.nature.com
January 30, 2026 at 6:32 PM
Check out BARI member Su Guo’s @naturecomms paper where they uncover PCM1’s role in regulating daughter cell fate via centrosome-endosome interplay. www.nature.com/articles/s41... #neuroscience
Fascinating perspectives on aging science in Nature Aging! BARI’s Dena Dubal offers insights on real-world translation, plus input from two of our advisory board members Vera Gorbunova & George Kuchel. Inspiring read: www.nature.com/articles/s43... #Aging #Science
Past, present and future perspectives on the science of aging - Nature Aging
As Nature Aging celebrates its fifth anniversary, the journal asks some of the researchers who contributed to the journal early on to reflect on the past and the future of aging and age-related diseas...
www.nature.com
January 29, 2026 at 6:27 PM
Fascinating perspectives on aging science in Nature Aging! BARI’s Dena Dubal offers insights on real-world translation, plus input from two of our advisory board members Vera Gorbunova & George Kuchel. Inspiring read: www.nature.com/articles/s43... #Aging #Science
Neil Risch and his BARI team have a paper out in AJHG: Predicted loss-of-function variants linked to serious diseases often don’t show up as expected in big biobanks. Why? Residual activity from the variant allele keeps some function going (leaky penetrance).
January 28, 2026 at 4:18 PM
Neil Risch and his BARI team have a paper out in AJHG: Predicted loss-of-function variants linked to serious diseases often don’t show up as expected in big biobanks. Why? Residual activity from the variant allele keeps some function going (leaky penetrance).
UCSF has a cool article on BARI member Hao Li’s work. They found gene-regulating proteins that drop with age, slowing repair. Boosting them made old fibroblasts act young again and increasing EZH2 in mice rejuvenated livers. Read more here: www.ucsf.edu/news/2026/01...
Tissue Repair Slows in Old Age. These Proteins Speed It Back Up
UCSF scientists engineered old fibroblast cells to turn their genes on and off in the same way as young fibroblasts. The old fibroblasts were rejuvenated: they multiplied (green) and produced more of ...
www.ucsf.edu
January 22, 2026 at 6:39 PM
UCSF has a cool article on BARI member Hao Li’s work. They found gene-regulating proteins that drop with age, slowing repair. Boosting them made old fibroblasts act young again and increasing EZH2 in mice rejuvenated livers. Read more here: www.ucsf.edu/news/2026/01...
Congrats to BARI’s Tamara Alliston on her latest paper in Osteoarthritis and Cartilage! They show loss of MMP13 in bone cells is protective against cartilage damage in injured jaw joints (TMJ), similar to effects seen in knees: www.oarsijournal.com/article/S106...
Osteocyte-Intrinsic MMP13 exacerbates injury-induced temporomandibular joint osteoarthritis
Cartilage in the knee and temporomandibular joint (TMJ) rely on subchondral bone for
joint homeostasis, whereby osteoarthritis (OA) causes degeneration. In the knee, suppression
of osteocytic perilacu...
www.oarsijournal.com
January 21, 2026 at 4:24 PM
Congrats to BARI’s Tamara Alliston on her latest paper in Osteoarthritis and Cartilage! They show loss of MMP13 in bone cells is protective against cartilage damage in injured jaw joints (TMJ), similar to effects seen in knees: www.oarsijournal.com/article/S106...
What a whirlwind at #JPM2026! Grateful for the inspiring chats, new ideas, and connections that make this field so exciting. From BARI in SF: thanks for coming, safe travels home, and let’s keep pushing geroscience forward together! #agingresearch
January 16, 2026 at 5:22 PM
What a whirlwind at #JPM2026! Grateful for the inspiring chats, new ideas, and connections that make this field so exciting. From BARI in SF: thanks for coming, safe travels home, and let’s keep pushing geroscience forward together! #agingresearch
Aging mice are precious (and expensive!) – so why not get max data from each? BARI member Hanna Martens & team share a JoVE protocol for multi-organ collection. Over 15 organs from a single mouse. Smart & ethical: app.jove.com/t/69128/mult... #agingscience
Multi-Organ Collection from Mouse Models for Aging Studies
University of California, San Francisco. This protocol provides a standardized method for organ collection in young and aged mice to assess age-related anatomical and histological changes across mult...
app.jove.com
January 15, 2026 at 7:33 PM
Aging mice are precious (and expensive!) – so why not get max data from each? BARI member Hanna Martens & team share a JoVE protocol for multi-organ collection. Over 15 organs from a single mouse. Smart & ethical: app.jove.com/t/69128/mult... #agingscience
What if lowering triglycerides could help you survive low oxygen and age better? New EMBO Reports from BARI member Dengke Ma & team explores this conserved mechanism: from arctic ground squirrel brain cells to C. elegans, reducing lipid biosynthesis protects mitochondria and extends life.
January 13, 2026 at 11:11 PM
What if lowering triglycerides could help you survive low oxygen and age better? New EMBO Reports from BARI member Dengke Ma & team explores this conserved mechanism: from arctic ground squirrel brain cells to C. elegans, reducing lipid biosynthesis protects mitochondria and extends life.
Well done to Tien Peng and team – exciting new paper out in Cell Stem Cell! The study shows how certain senescent fibroblasts drive metabolic reprogramming in lung adenocarcinoma and demonstrates that targeting them with an HSP90 inhibitor shrinks tumors.
January 7, 2026 at 7:33 PM
Well done to Tien Peng and team – exciting new paper out in Cell Stem Cell! The study shows how certain senescent fibroblasts drive metabolic reprogramming in lung adenocarcinoma and demonstrates that targeting them with an HSP90 inhibitor shrinks tumors.
Wishing you all a brilliant 2026 from everyone at BARI! May the new year bring discoveries that change the world by advancing aging research. See how we’re building on the past to make a great future in 2026 and beyond: www.nature.com/articles/d42... #2026 #Geroscience
January 2, 2026 at 9:45 PM
Wishing you all a brilliant 2026 from everyone at BARI! May the new year bring discoveries that change the world by advancing aging research. See how we’re building on the past to make a great future in 2026 and beyond: www.nature.com/articles/d42... #2026 #Geroscience
In case you missed it: Diana Laird and her lab dropped this awesome Science paper. A deep dive comparing human and mouse ovaries over time, spotlighting conserved aging features to enhance our translational understanding. A major win for reproductive health! www.science.org/doi/epdf/10....
Comparative analysis of human and mouse ovaries across age
The mouse is a tractable model for human ovarian biology; however, its utility is limited by incomplete understanding of how transcription and signaling differ interspecifically and with age. We compa...
www.science.org
December 26, 2025 at 10:50 PM
In case you missed it: Diana Laird and her lab dropped this awesome Science paper. A deep dive comparing human and mouse ovaries over time, spotlighting conserved aging features to enhance our translational understanding. A major win for reproductive health! www.science.org/doi/epdf/10....
In case you missed it: BARI’s John Greenland and lab found frailty in lung transplant recipients links to shorter telomeres and anemia – but not epigenetic age or inflammation. Not all aging hallmarks hit equally! Read the interesting details here: www.amjtransplant.org/action/showP...
www.amjtransplant.org
December 26, 2025 at 8:53 PM
In case you missed it: BARI’s John Greenland and lab found frailty in lung transplant recipients links to shorter telomeres and anemia – but not epigenetic age or inflammation. Not all aging hallmarks hit equally! Read the interesting details here: www.amjtransplant.org/action/showP...
Big congrats to BARI’s Xian Piao and her lab for their awesome paper in Neuron! They found that microglial ADGRG1 turns on MYC to make microglia more protective and better at clearing amyloid to keep neurons healthier in Alzheimer's models. Huge win for AD research! #Alzheimers #Neuroscience
December 23, 2025 at 9:42 PM
Big congrats to BARI’s Xian Piao and her lab for their awesome paper in Neuron! They found that microglial ADGRG1 turns on MYC to make microglia more protective and better at clearing amyloid to keep neurons healthier in Alzheimer's models. Huge win for AD research! #Alzheimers #Neuroscience
BARI congratulates fellow UCSF aging scientist Lauren Hunt for winning the 2025 Terrie Fox Wetle Rising Star Award from AFAR! Using big data to make hospice & palliative care for dementia patients – such important work. BARI is cheering you on! #AgingResearch www.afar.org/news/afar-pl...
AFAR recognizes Lauren Hunt with 2025 Terrie Fox Wetle Rising Star Award in Health Services and Aging Research - American Federation for Aging Research
AFAR is pleased to announce the recipient of our 2025 Terrie Fox Wetle Rising Star Award in Health Services and Aging Research, Lauren Hunt, PhD, RN,
www.afar.org
December 22, 2025 at 5:39 PM
BARI congratulates fellow UCSF aging scientist Lauren Hunt for winning the 2025 Terrie Fox Wetle Rising Star Award from AFAR! Using big data to make hospice & palliative care for dementia patients – such important work. BARI is cheering you on! #AgingResearch www.afar.org/news/afar-pl...
Huge congrats to Jarin Tusnim, postdoc in the Piao Lab at BARI, for her Cure Alzheimer's Fund grant! Jarin is exploring how ADGRG1 helps microglia stop tau from spreading, which could lead to boosting brain protection for new AD therapies. Great work Jarin! #Alzheimers #CureAlz bit.ly/4j79J4Q
Jarin Tusnim – Cure Alzheimer's Fund
Dr. Jarin Tusnim is a postdoctoral scholar in the Department of Pediatrics at the University of California, San Francisco (UCSF). She received her B.Sc.
curealz.org
December 19, 2025 at 5:59 PM
Huge congrats to Jarin Tusnim, postdoc in the Piao Lab at BARI, for her Cure Alzheimer's Fund grant! Jarin is exploring how ADGRG1 helps microglia stop tau from spreading, which could lead to boosting brain protection for new AD therapies. Great work Jarin! #Alzheimers #CureAlz bit.ly/4j79J4Q
Exciting research from BARI member Ken Nakamura! Their study out in @ScienceAdvances shows for the first time in vivo, a better understanding of how mitochondrial dysfunction can lead to α-synuclein accumulation and neurodegeneration in Parkinson’s Disease. Check out the story here: bit.ly/4aWt4n4
CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology
A CHCHD2 mouse model of Parkinson’s disease exhibits mitochondrial disruption with a metabolic shift toward glycolysis.
www.science.org
December 19, 2025 at 4:34 PM
Exciting research from BARI member Ken Nakamura! Their study out in @ScienceAdvances shows for the first time in vivo, a better understanding of how mitochondrial dysfunction can lead to α-synuclein accumulation and neurodegeneration in Parkinson’s Disease. Check out the story here: bit.ly/4aWt4n4
So proud of our research teams at BARI - @ucsanfrancisco.bsky.social now #2 globally in this year’s Nature Index for Aging! Excited to keep challenging what’s possible for healthier aging. Check out the full list: www.nature.com/nature-index... #BARI #UCSF #Geroscience
Leading 200 institutions in ageing | | Supplements | Nature Index
The Nature Index tracks the affiliations of high-quality scientific articles. Updated monthly, the Nature Index presents research outputs by institution and country. Use the Nature Index to interrogat...
www.nature.com
December 12, 2025 at 11:16 PM
So proud of our research teams at BARI - @ucsanfrancisco.bsky.social now #2 globally in this year’s Nature Index for Aging! Excited to keep challenging what’s possible for healthier aging. Check out the full list: www.nature.com/nature-index... #BARI #UCSF #Geroscience
Reposted by Bakar Aging Research Institute
Been working on a really strange retron bacterial immune system, here's the preprint: www.biorxiv.org/content/10.1...
Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.
Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.
October 23, 2025 at 6:49 PM
Been working on a really strange retron bacterial immune system, here's the preprint: www.biorxiv.org/content/10.1...
Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.
Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.
Nancy Allen and Tien Peng's study reveals that age-dependent NF-kB activation in tissue fibroblasts contributes to #inflammaging by remodeling immune architecture and promoting exhausted T cell populations. bit.ly/4qlIR4k
October 17, 2025 at 7:17 PM
Nancy Allen and Tien Peng's study reveals that age-dependent NF-kB activation in tissue fibroblasts contributes to #inflammaging by remodeling immune architecture and promoting exhausted T cell populations. bit.ly/4qlIR4k
Kate Cavanaugh and Orion Weiner's research out now on @biorxivpreprint.bsky.social identifies a mechanical defect in embryos from aged mothers that impairs implantation. These findings could enhance embryo selection in Assisted #Reproductive Technologies. bit.ly/47tY7V8
October 17, 2025 at 6:59 PM
Kate Cavanaugh and Orion Weiner's research out now on @biorxivpreprint.bsky.social identifies a mechanical defect in embryos from aged mothers that impairs implantation. These findings could enhance embryo selection in Assisted #Reproductive Technologies. bit.ly/47tY7V8