Jonathan Bohlen
@jonathanbohlen.bsky.social
Group leader at the Gene Center in Munich. RNA biology and protein translation in Immunity. Looking for excited and motivated students!
Dad in Science, He/His
Dad in Science, He/His
Pinned
I’m excited to announce our new paper that came out today! The second chapter of my Post-doc
@casanova_lab, published in @jclinical-invest.bsky.social
If you’re interested in the causes of autoinflammation, then this one is for you: t.co/uhVDdzqyx2
@casanova_lab, published in @jclinical-invest.bsky.social
If you’re interested in the causes of autoinflammation, then this one is for you: t.co/uhVDdzqyx2
Oh, I see! That's the 1% per year rule that some people write about? Thanks for the response and good luck carrying this forward!
December 20, 2025 at 12:07 PM
Oh, I see! That's the 1% per year rule that some people write about? Thanks for the response and good luck carrying this forward!
Hi Roman, very cool paper! Nice work. I wonder how you envision that could be applied in the clinic? Wouldn't you expect any remaining, mutated cells to relatively quick overgrow again?
December 20, 2025 at 9:56 AM
Hi Roman, very cool paper! Nice work. I wonder how you envision that could be applied in the clinic? Wouldn't you expect any remaining, mutated cells to relatively quick overgrow again?
Cool pre-print, addressing a question that I've been wondering about for a while! Congrats :)
December 18, 2025 at 6:58 AM
Cool pre-print, addressing a question that I've been wondering about for a while! Congrats :)
Danke, Björn!
December 16, 2025 at 7:48 PM
Danke, Björn!
Thanks, Kilian!
December 16, 2025 at 7:48 PM
Thanks, Kilian!
Honored to get this opportunity to build out my team and explore molecular immunology!
🥳🥂Huge congratulations to Jonathan Bohlen on being awarded an Emmy Noether Grant by @dfg.de 😊🤩
His project addresses a central open question in immunology: how mRNA translation governs the function of T cells.
www.genzentrum.uni-muenchen.de/news-events/...
@jonathanbohlen.bsky.social
His project addresses a central open question in immunology: how mRNA translation governs the function of T cells.
www.genzentrum.uni-muenchen.de/news-events/...
@jonathanbohlen.bsky.social
December 16, 2025 at 5:53 PM
Honored to get this opportunity to build out my team and explore molecular immunology!
Reposted by Jonathan Bohlen
📣Publication alert!
A team led by Roland Beckmann shows: Ribosome collisions activate the kinase ZAK and thus trigger the ribotoxic stress response — a key mechanism of the cellular stress defense. More about it here👇
www.lmu.de/en/newsroom/...
A team led by Roland Beckmann shows: Ribosome collisions activate the kinase ZAK and thus trigger the ribotoxic stress response — a key mechanism of the cellular stress defense. More about it here👇
www.lmu.de/en/newsroom/...
Colliding ribosomes signal cellular stress
LMU researchers uncover the mechanism by which ribosomes raise alarms in the cell.
www.lmu.de
November 25, 2025 at 8:52 AM
📣Publication alert!
A team led by Roland Beckmann shows: Ribosome collisions activate the kinase ZAK and thus trigger the ribotoxic stress response — a key mechanism of the cellular stress defense. More about it here👇
www.lmu.de/en/newsroom/...
A team led by Roland Beckmann shows: Ribosome collisions activate the kinase ZAK and thus trigger the ribotoxic stress response — a key mechanism of the cellular stress defense. More about it here👇
www.lmu.de/en/newsroom/...
Reposted by Jonathan Bohlen
How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
November 23, 2025 at 3:47 PM
How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
Hi Loic, why did you exclude very rare variants with frequency <0.01%? Don't we have many of these and what would you guess is their contribution? The most severe and impactful variants are usually very rare.
November 14, 2025 at 6:13 PM
Hi Loic, why did you exclude very rare variants with frequency <0.01%? Don't we have many of these and what would you guess is their contribution? The most severe and impactful variants are usually very rare.
Reposted by Jonathan Bohlen
Whipple's disease was an inflammatory condition for decades, it became an infectious disease some years ago, and it is now becoming a genetic disorder:
IRF4 haploinsufficiency in a multiplex family with Whipple’s disease url: rupress.org/jhi/article/...
IRF4 haploinsufficiency in a multiplex family with Whipple’s disease url: rupress.org/jhi/article/...
IRF4 haploinsufficiency in a multiplex family with Whipple’s disease | Journal of Human Immunity | Rockefeller University Press
We report two patients with Whipple’s disease caused by autosomal dominant IRF4 deficiency.
rupress.org
November 11, 2025 at 3:39 PM
Whipple's disease was an inflammatory condition for decades, it became an infectious disease some years ago, and it is now becoming a genetic disorder:
IRF4 haploinsufficiency in a multiplex family with Whipple’s disease url: rupress.org/jhi/article/...
IRF4 haploinsufficiency in a multiplex family with Whipple’s disease url: rupress.org/jhi/article/...
Reposted by Jonathan Bohlen
In less than 8 months, @jhumimmunity has published 56 papers (rupress.org/jhi), including 10 already on PubMed (pubmed.ncbi.nlm.nih.gov?term=j+hum+i...). Please submit studies of human inborn errors of immunity and their phenocopies (rupress.org/jhi/article-...) !
Journal of Human Immunity | Rockefeller University Press
Journal of Human Immunity (JHI) publishes papers that provide novel insights into the physiology and pathology of human immunity through the study of genetic defects and their phenocopies, including t...
rupress.org
November 11, 2025 at 3:47 PM
In less than 8 months, @jhumimmunity has published 56 papers (rupress.org/jhi), including 10 already on PubMed (pubmed.ncbi.nlm.nih.gov?term=j+hum+i...). Please submit studies of human inborn errors of immunity and their phenocopies (rupress.org/jhi/article-...) !
I think you putting the "obivous" into a formal, non-rethoric frame out there for people to point to is amazing. As long as these assertions stand there and it's only obvious to the experts why they're false, they can convince a lot of people. You're giving people tools to refute this nonsense.
November 5, 2025 at 7:16 PM
I think you putting the "obivous" into a formal, non-rethoric frame out there for people to point to is amazing. As long as these assertions stand there and it's only obvious to the experts why they're false, they can convince a lot of people. You're giving people tools to refute this nonsense.
Thank you, Zach! Someone has to clean this mess up and I can only imagine how tideous it is.
November 5, 2025 at 5:57 PM
Thank you, Zach! Someone has to clean this mess up and I can only imagine how tideous it is.
We report a 5'UTR variant in YEATS4 that confers resistance to tuberculosis through altering the translation of the YEATS4 open-reading frame! Congrats to Clement Conil and colleagues at @casanovalab.bsky.social! It was fun to help with this story! link.springer.com/article/10.1...
A human YEATS4 variant confers resistance to TST and IGRA conversion despite Mycobacterium tuberculosis exposure - Genome Medicine
Background Despite sustained exposure to Mycobacterium tuberculosis (Mtb), some individuals—so-called resisters—have persistently negative results for the tuberculin skin test (TST) and interferon-gam...
link.springer.com
October 20, 2025 at 10:45 AM
We report a 5'UTR variant in YEATS4 that confers resistance to tuberculosis through altering the translation of the YEATS4 open-reading frame! Congrats to Clement Conil and colleagues at @casanovalab.bsky.social! It was fun to help with this story! link.springer.com/article/10.1...
Reposted by Jonathan Bohlen
New in @jhumimmunity.org: Tristan van der Linden, András Spaan et al. describe and characterize six unrelated patients with #OTULIN #haploinsufficiency, in whom severe #necrosis followed infectious and/or traumatic triggers. rupress.org/jhi/article/...
#Staphylococcus #Ubiquitin
#Staphylococcus #Ubiquitin
September 30, 2025 at 5:45 PM
New in @jhumimmunity.org: Tristan van der Linden, András Spaan et al. describe and characterize six unrelated patients with #OTULIN #haploinsufficiency, in whom severe #necrosis followed infectious and/or traumatic triggers. rupress.org/jhi/article/...
#Staphylococcus #Ubiquitin
#Staphylococcus #Ubiquitin
It was a great pleasure to join the symposium, meet with great scientists and learn new things! Congrats again for the award!
September 26, 2025 at 5:10 AM
It was a great pleasure to join the symposium, meet with great scientists and learn new things! Congrats again for the award!
Reposted by Jonathan Bohlen
Huge variability documented in how publishers respond when informed about a problematic body of work by a research group. www.jclinepi.com/article/S089...
#publishers #retractions
#publishers #retractions
August 24, 2025 at 3:35 PM
Huge variability documented in how publishers respond when informed about a problematic body of work by a research group. www.jclinepi.com/article/S089...
#publishers #retractions
#publishers #retractions
Reposted by Jonathan Bohlen
A MUST-READ Review on Penetrance of Human Monogenic Inborn Errors (of Immunity, or not):
Incomplete penetrance in inborn errors of immunity: A skeleton in the closet—The sequel url: rupress.org/jhi/article/...
Incomplete penetrance in inborn errors of immunity: A skeleton in the closet—The sequel url: rupress.org/jhi/article/...
Incomplete penetrance in inborn errors of immunity: A skeleton in the closet—The sequel | Journal of Human Immunity | Rockefeller University Press
Incomplete penetrance in genetic disorders can be influenced by genetic variant quality, genetic and epigenetic modification, environment, and mosaicism.
rupress.org
August 19, 2025 at 12:53 PM
A MUST-READ Review on Penetrance of Human Monogenic Inborn Errors (of Immunity, or not):
Incomplete penetrance in inborn errors of immunity: A skeleton in the closet—The sequel url: rupress.org/jhi/article/...
Incomplete penetrance in inborn errors of immunity: A skeleton in the closet—The sequel url: rupress.org/jhi/article/...
Reposted by Jonathan Bohlen
Latest by us! An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo | Science Translational Medicine www.science.org/doi/10.1126/...
An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo
A human inborn error of immunity guided discovery and development of a prophylactic, mRNA-based antiviral.
www.science.org
August 13, 2025 at 8:06 PM
Latest by us! An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo | Science Translational Medicine www.science.org/doi/10.1126/...
Excited to participate in this symposium!
1/ Join us on 24 Sept 2025 at the @institutimagine.bsky.social in Paris for the Novo Nordisk Prize Symposium: Inborn Errors of Immunity. Registration is free at:
my.weezevent.com/novo-nordisk...
my.weezevent.com/novo-nordisk...
July 26, 2025 at 3:29 AM
Excited to participate in this symposium!
Very nice review on genetic insights to B cell development: rupress.org/jhi/article/... by @alneehus.bsky.social and @bloodgenes.bsky.social
Human genetic influences on early B cell development | Journal of Human Immunity | Rockefeller University Press
This review explores how genetic variation impacts early B cell development, highlighting key genes and pathways involved in lineage commitment, V(D)J reco
rupress.org
July 4, 2025 at 6:28 AM
Very nice review on genetic insights to B cell development: rupress.org/jhi/article/... by @alneehus.bsky.social and @bloodgenes.bsky.social
Reposted by Jonathan Bohlen
🥳Amazing publication from the Hornung lab, in collab. with the Carell lab, on the innate immune system: how modified RNA tricks the immune system. Big shout-out to the two first authors, Marleen Bérouti and Mirko Wagner! www.cell.com/cell/fulltex...
@v-hornung.bsky.social @m-berouti.bsky.social
@v-hornung.bsky.social @m-berouti.bsky.social
Innate immune system: How modified RNA tricks the immune system
Researchers at LMU have elucidated why certain RNA modifications do not trigger an immune response—a key mechanism for RNA therapeutics.
www.lmu.de
July 1, 2025 at 12:17 PM
🥳Amazing publication from the Hornung lab, in collab. with the Carell lab, on the innate immune system: how modified RNA tricks the immune system. Big shout-out to the two first authors, Marleen Bérouti and Mirko Wagner! www.cell.com/cell/fulltex...
@v-hornung.bsky.social @m-berouti.bsky.social
@v-hornung.bsky.social @m-berouti.bsky.social
Reposted by Jonathan Bohlen
@nbellono.bsky.social and colleagues observed that Elysia sea slugs steal chloroplasts from algae and store them in specialized organelles called kleptosomes. During times of starvation, this allows them to photosynthesize in support of their energy needs! 🧪
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
June 27, 2025 at 10:16 AM
@nbellono.bsky.social and colleagues observed that Elysia sea slugs steal chloroplasts from algae and store them in specialized organelles called kleptosomes. During times of starvation, this allows them to photosynthesize in support of their energy needs! 🧪
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...